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Your search keyword '"De Matteis, Alessandra"' showing total 12 results
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12 results on '"De Matteis, Alessandra"'

2. Sudden Death: A Practical Autopsy Approach to Unexplained Mediastinitis Due to Fatal Untreated Neck Infections—A Systematic Review.

Author

Maiese, Aniello, Del Duca, Fabio, Ghamlouch, Alessandro, Treves, Biancamaria, Manetti, Alice Chiara, Napoletano, Gabriele, De Matteis, Alessandra, Dimattia, Francesca, Wan, Huan, Pignataro, Lorenzo, and La Russa, Raffaele

Subjects
SUDDEN death, AUTOPSY, FASCIAE (Anatomy), LITERATURE reviews, MEDIASTINITIS, NECK
Abstract

Neck infections are often prone to being underestimated and can manifest insidiously. The spread of infection can lead to translocation into thoracic areas, causing descending necrotizing mediastinitis (DNM). However, the application of the post-mortem approach in such cases is not well-described in the literature. A literature review was carried out according to the PRISMA methods. Nine papers were included in the final review, revealing different levels of involvement of neck layers that can be linked to different causes. Expertise with respect to the anatomy of the fasciae and spaces of the neck enables an understanding of the pathogenesis of DNM. However, a clear autoptic description was not provided in any of the articles. Therefore, we also employed a practical post-mortem approach to cases of death due to DNM. It is fundamental for pathologists to identify the exact head and neck structures involved. Providing dissectors with support from an otolaryngologist could be useful. This paper could help address such difficult cases. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Sudden Cardiac Death, Post-Mortem Investigation: A Proposing Panel of First Line and Second Line Genetic Tests.

Author

Del Duca, Fabio, Ghamlouch, Alessandro, Manetti, Alice Chiara, Napoletano, Gabriele, Sonnini, Elena, Treves, Biancamaria, De Matteis, Alessandra, La Russa, Raffaele, Sheppard, Mary N., Fineschi, Vittorio, and Maiese, Aniello

Subjects
CARDIAC arrest, GENETIC testing, FORENSIC medicine, CLINICAL medicine, SUDDEN onset of disease, GENETIC disorders, CLINICAL pathology, SURGICAL pathology
Abstract

Investigating the causes of Sudden cardiac death (SCD) is always difficult; in fact, genetic cardiac conditions associated with SCD could be "silent" even during autopsy investigation. In these cases, it is important to exclude other aetiology and assist to ask for genetic investigations. Herein, the purpose of this review is to collect the most-implicated genes in SCD and generate a panel with indications for first line and second line investigations. A systematic review of genetic disorders that may cause SCD in the general population was carried out according to the Preferred Reporting Item for Systematic Review (PRISMA) standards. We subsequently listed the genes that may be tested in the case of sudden cardiac death when the autopsy results are negative or with no evidence of acquired cardiac conditions. To make genetic tests more specific and efficient, it is useful and demanded to corroborate autopsy findings with the molecular investigation as evident in the panel proposed. The genes for first line investigations are HCM, MYBPC3, MYH7, TNNT2, TNNI3, while in case of DCM, the most implicated genes are LMNA and TTN, and in second line for these CDM, ACTN2, TPM1, C1QPB could be investigated. In cases of ACM/ARVC, the molecular investigation includes DSP, DSG2, DSC2, RYR2, PKP2. The channelopathies are associated with the following genes: SCN5A, KCNQ1, KCNH2, KCNE1, RYR2. Our work underlines the importance of genetic tests in forensic medicine and clinical pathology; moreover, it could be helpful not only to assist the pathologists to reach a diagnosis, but also to prevent other cases of SCD in the family of the descendant and to standardise the type of analysis performed in similar cases worldwide. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Cause of Death in Charred Bodies: Reflections and Operational Insights Based on a Large Cases Study

Author

Maiese, Aniello, primary, Ciallella, Costantino, additional, dell’Aquila, Massimiliano, additional, De Matteis, Alessandra, additional, Toni, Chiara, additional, Scatena, Andrea, additional, La Russa, Raffaele, additional, Mezzetti, Eleonora, additional, Di Paolo, Marco, additional, Turillazzi, Emanuela, additional, Frati, Paola, additional, and Fineschi, Vittorio, additional

Published
2022
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10. 6‐Monoacetylmorphine‐antibody distribution in tissues from heroin‐related death cases: An experimental study to investigate the distributive response

Author

Maiese, Aniello, primary, La Russa, Raffaele, additional, David, Maria Chiara, additional, Cantatore, Santina, additional, Manetti, Alice Chiara, additional, De Matteis, Alessandra, additional, Ciallella, Costantino, additional, Frati, Paola, additional, and Fineschi, Vittorio, additional

Published
2022
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