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Your search keyword '"Debora Santoro"' showing total 2 results
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2. A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome: two-year outcomes

Author

Christian P. Speer, Debora Santoro, Dorothea Del Buono, Zbynek Straňák, Dominique Singer, Richard Plavka, Paul Clarke, David G. Sweet, Laura Fabbri, Guido Varoli, Mark A. Turner, Rangmar Goelz, Ben Stenson, and Annalisa Piccinno

Subjects
Pediatrics, medicine.medical_specialty, Infant, Premature, Diseases, Clinical study, 03 medical and health sciences, 0302 clinical medicine, Corrected Age, Child Development, 030225 pediatrics, Medicine, Humans, 030212 general & internal medicine, Respiratory system, Respiratory Distress Syndrome, Newborn, Pulmonary Surfactant-Associated Protein B, Respiratory distress, business.industry, Infant, Newborn, Obstetrics and Gynecology, Infant, First in human, Pulmonary Surfactant-Associated Protein C, Peptide Fragments, Child, Preschool, Pediatrics, Perinatology and Child Health, Phosphatidylcholines, Gestation, General health, Synthetic surfactant, business
Abstract

Objective: To assess at 24 months corrected age (CA) the neurological, respiratory, and general health status of children born prematurely from 27 +0 to 33 +6 weeks’ gestation who were treated in a first-in-human study with a new fully synthetic surfactant (CHF5633) enriched with SP-B and SP-C proteins. Outcome measures: Children were assessed using Bayley Scales of Infant Development (BSID), with a score below normal defined as BSID-II Mental Development Index score

Published
2022

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