13 results on '"Deckmann, Iohanna"'
Search Results
2. Common pregnancy complications and polyphenols intake: an overview.
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Deckmann, Iohanna, Santos-Terra, Júlio, Martel, Fátima, and Vieira Carletti, Jaqueline
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PREGNANCY complications , *PREGNANCY , *PREECLAMPSIA , *FETAL growth retardation , *POLYPHENOLS , *GESTATIONAL diabetes , *DIETARY supplements - Abstract
During pregnancy, the body undergoes a great amount of changes in order to support a healthy developing fetus. In this context, maternal dietary supplementation is widely encouraged to provide adequate nutrition for the newborn. In the past few years, studies have emerged highlighting the benefits of polyphenols intake during pregnancy. Indeed, despite differences among reports, such as experimental model, polyphenol employed, dosage and regimen of administration, there is no doubt that the ingestion of these molecules has a protective effect in relation to three pregnancy-associated diseases or conditions: preeclampsia, gestational diabetes and fetal growth restriction. In this review, we describe the effects of different polyphenols and polyphenol-rich extracts or juices on the main outcomes of these common pregnancy-associated complications, obtained in human, animal and in vitro studies. Therefore, this work provides a critical analysis of the literature, and a summary of evidences, from which future research using polyphenols can be designed and evaluated. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Common pregnancy complications and polyphenols intake: an overview
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Deckmann, Iohanna, primary, Santos-Terra, Júlio, additional, Martel, Fátima, additional, and Vieira Carletti, Jaqueline, additional
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- 2023
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4. GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder
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Fontes‐Dutra, Mellanie, primary, Righes Marafiga, Joseane, additional, Santos‐Terra, Júlio, additional, Deckmann, Iohanna, additional, Brum Schwingel, Gustavo, additional, Rabelo, Bruna, additional, Kazmierzak de Moraes, Rafael, additional, Rockenbach, Marília, additional, Vendramin Pasquetti, Mayara, additional, Gottfried, Carmem, additional, and Calcagnotto, Maria Elisa, additional
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- 2022
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5. Resveratrol Treatment of Autism Spectrum Disorder—A Pilot Study
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Marchezan, Josemar, primary, Deckmann, Iohanna, additional, da Fonseca, Guilherme Cordenonsi, additional, Margis, Rogerio, additional, Riesgo, Rudimar, additional, and Gottfried, Carmem, additional
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- 2022
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6. GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
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Fontes‐Dutra, Mellanie, Righes Marafiga, Joseane, Santos‐Terra, Júlio, Deckmann, Iohanna, Brum Schwingel, Gustavo, Rabelo, Bruna, Kazmierzak de Moraes, Rafael, Rockenbach, Marília, Vendramin Pasquetti, Mayara, Gottfried, Carmem, and Calcagnotto, Maria Elisa
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SOMATOSENSORY cortex ,VALPROIC acid ,AUTISM spectrum disorders ,NEURAL transmission ,ANIMAL disease models - Abstract
Autism spectrum disorder (ASD) is characterized by impaired social communication and interaction associated with repetitive or stereotyped behaviour. Prenatal valproic acid (VPA) exposure in rodents is a commonly used model of ASD. Resveratrol (RSV) has been shown to prevent interneuronal and behavioural impairments in the VPA model. We investigated the effects of prenatal VPA exposure and RSV on the GABAergic synaptic transmission, brain oscillations and on the genic expression of interneuron‐associated transcription factor LHX6 in the primary somatosensory area (PSSA). Prenatal VPA exposure decreased the sIPSC and mIPSC frequencies and the sIPSC decay kinetics onto layers 4/5 pyramidal cells of PSSA. About 40% of VPA animals exhibited absence‐like spike–wave discharge (SWD) events associated with behaviour arrest and increased power spectrum density of delta, beta and gamma cortical oscillations. VPA animals had reduced LHX6 expression in PSSA, but VPA animals treated with RSV had no changes on synaptic inhibition or LHX6 expression in the PSSA. SWD events associated with behaviour arrest and the abnormal increment of cortical oscillations were also absent in VPA animals treated with RSV. These findings provide new venues to investigate the role of both RSV and VPA in the pathophysiology of ASD and highlight the VPA animal model as an interesting tool to investigate pathways related to the aetiology and possible future therapies to this neuropsychiatric disorder. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism
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Santos-Terra, Júlio, primary, Deckmann, Iohanna, additional, Carello-Collar, Giovanna, additional, Nunes, Gustavo Della-Flora, additional, Bauer-Negrini, Guilherme, additional, Schwingel, Gustavo Brum, additional, Fontes-Dutra, Mellanie, additional, Riesgo, Rudimar, additional, and Gottfried, Carmem, additional
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- 2022
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8. The role of T-cells in neurobehavioural development: Insights from the immunodeficient nude mice
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Bauer-Negrini, Guilherme, primary, Deckmann, Iohanna, additional, Schwingel, Gustavo Brum, additional, Hirsch, Mauro Mozael, additional, Fontes-Dutra, Mellanie, additional, Carello-Collar, Giovanna, additional, Halliwell, Diane E., additional, Paraskevaidi, Maria, additional, Morais, Camilo L.M., additional, Martin, Francis L., additional, Riesgo, Rudimar, additional, Gottfried, Carmem, additional, and Bambini-Junior, Victorio, additional
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- 2022
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9. Alteração de permeabilidade de barreira hematoencefálica e possíveis mecanismos subjacentes no contexto do transtorno do espectro autista : efeito preventivo do resveratrol
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Deckmann, Iohanna and Gottfried, Carmem Juracy Silveira
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Aquaporinas ,Transtorno do espectro autista ,Ácido valpróico ,Resveratrol ,Central nervous system ,Aquaporin ,Valproic acid ,Barreira hematoencefálica ,Autism spectrum disorder ,Astrocyte ,Neural barriers ,Blood-brain barrier - Abstract
O Transtorno do Espectro Autista (TEA) pode apresentar uma infinidade de condições clínicas associadas, como maior volume encefálico nos primeiros anos de vida em uma parcela dos pacientes; dessa forma, nos propusemos a avaliar, em modelo animal de autismo, processos possivelmente associados à formação de macrocefalia, bem como revisar na literatura os possíveis mecanismos subjacentes a essa dinâmica. No Capítulo I, avaliamos o conteúdo encefálico de água, a permeabilidade da barreira hematoencefálica (BHE), a expressão das aquaporina (AQP) 1 e 4 e da proteína ácida fibrilar glial (GFAP, um marcador de astrócitos) no modelo animal de TEA por exposição ao ácido valproico (VPA), e o potencial efeito do resveratrol (RSV). O tratamento com RSV preveniu a maior permeabilidade da BHE e o edema encefálico presentes no grupo VPA. A exposição ao VPA diminuiu os níveis da AQP1 no plexo coroide, na área somatossensorial primária, na região da amígdala e no córtex pré-frontal medial, reduziu os níveis de AQP4 no córtex pré-frontal medial e aumentou AQP4 na área somatossensorial primária (com prevenção pelo RSV), além de aumentar o número de astrócitos e a imunomarcação de GFAP na área somatossensorial primária e no córtex pré-frontal medial, com melhora funcional promovida pelo RSV. No Capítulo II, fizemos uma extensa revisão da literatura e observamos a translacionalidade das alterações imunológicas entre pacientes com TEA e o modelo de TEA por exposição ao VPA. As alterações neuroimunológicas são uma marca registrada no TEA; nesse sentido, hipotetizamos que a indução do modelo de TEA pelo VPA possivelmente envolve mecanismos de ativação imunitária materna e que as alterações neuroimunológicas podem estar por trás das alterações observadas no Capítulo I, uma vez que são relacionadas com disfunções de BHE. Finalmente, no Capítulo III, revisamos a contribuição das alterações no metabolismo das purinas na fisiopatologia do TEA, pois, apesar da etiologia desse transtorno permanecer desconhecida, algumas rotas biológicas já foram associadas ao desencadeamento e/ou progressão do TEA, como a sinalização purinérgica. Em resumo, demonstramos a importante contribuição do modelo VPA também nos estudos de disfunções de barreiras neurais – ampliando os conhecimentos e a aplicabilidade desse modelo –, bem como reforçamos o caráter neuroprotetor preventivo do RSV nas disfunções da BHE devido ao seu papel tanto na manutenção da integridade da BHE quanto na prevenção de alterações subjacentes observadas. Finalmente, a partir de investigações translacionais, postulamos que as disfunções neuroimunológicas podem promover as alterações tanto em barreiras neurais quanto em vias biológicas associadas ao TEA, como a sinalização purinérgica, o que pode contribuir, não só na fisiopatologia, mas também na manutenção das características associadas a esse transtorno. Autism Spectrum Disorder (ASD) can present a plethora of associated clinical conditions, such as increased brain volume in the first years of life in a portion of patients; therefore, we proposed to evaluate, in an animal model of autism, processes possibly associated with the formation of macrocephaly, as well as to review, in the literature, the possible mechanisms underlying this dynamic. In Chapter I, we evaluated brain water content, blood-brain barrier (BBB) permeability, aquaporin (AQP) 1 and 4, and glial fibrillary acidic protein (GFAP, a marker of astrocytes) expression in the animal model of ASD by exposure to valproic acid (VPA), and the potential effect of resveratrol (RSV). Treatment with RSV prevented the increased permeability of the BBB and the brain edema present in the VPA group. Exposure to VPA decreased AQP1 levels in the choroid plexus, primary somatosensory area, amygdala region, and medial prefrontal cortex, reduced AQP4 levels in the medial prefrontal cortex, and increased AQP4 in the primary somatosensory area (with prevention by RSV), in addition to an increase in the number of astrocytes and GFAP immunostaining in the primary somatosensory area and in the medial prefrontal cortex, with functional improvement promoted by RSV. In Chapter II, we revised the literature and looked at the translationality of immunological changes between ASD patients and the VPA exposure model of ASD. Neuroimmunological changes are a hallmark of ASD; in this sense, we hypothesized that the induction of the ASD model by the VPA possibly involves mechanisms of maternal immune activation and that neuroimmunological alterations may be behind the alterations observed in Chapter I, since they are related to BBB dysfunctions. Finally, in Chapter III, we also reviewed the contribution of changes in purine metabolism to the pathophysiology of ASD, because, although the etiology of this disorder remains unknown, some biological pathways have already been associated with the triggering and/or progression of ASD, such as purinergic signaling. In summary, we demonstrated the important contribution of the VPA model also in the studies of neural barriers dysfunctions – expanding the knowledge and applicability of this model –, as well as reinforcing the preventive neuroprotective character of RSV in BBB dysfunctions due to its role both in maintaining the BBB integrity and prevention of underlying changes observed. Finally, from translational investigations, we postulated that neuroimmunological dysfunctions could promote changes both in neural barriers and in biological pathways associated with ASD, such as purinergic signaling, which can contribute not only to the pathophysiology but also to the maintenance of the characteristics associated with this disorder.
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- 2022
10. Resveratrol prevents cytoarchitectural and interneuronal alterations in the valproic acid rat model of autism
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Machado, Júlio Santos Terra, Deckmann, Iohanna, Collar, Giovanna Carello, Nunes, Gustavo Della Flora, Negrini, Guilherme Bauer, Schwingel, Gustavo Brum, Silva, Mellanie Fontes Dutra da, Riesgo, Rudimar dos Santos, and Gottfried, Carmem Juracy Silveira
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Efeitos tardios da exposição pré-natal ,Interneuron ,Interneurônios ,Ácido valpróico ,Transtorno do espectro autista ,GABA receptor ,Resveratrol ,Modelos animais de doenças ,Valproic acid ,Autism spectrum disorder ,Synapse - Abstract
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by several alterations, including disorganized brain cytoarchitecture and excitatory/inhibitory (E/I) imbalance. We aimed to analyze aspects associated with the inhibitory components in ASD, using bioinformatics to develop notions about embryonic life and tissue analysis for postnatal life. We analyzed microarray and RNAseq datasets of embryos from different ASD models, demonstrating that regions involved in neuronal development are affected. We evaluated the effect of prenatal treatment with resveratrol (RSV) on the neuronal organization and quantity of parvalbumin-positive (PV+), somatostatin-positive (SOM+), and calbindin-positive (CB+) GABAergic interneurons, besides the levels of synaptic proteins and GABA receptors in the medial prefrontal cortex (mPFC) and hippocampus (HC) of the ASD model induced by valproic acid (VPA). VPA increased the total number of neurons in the mPFC, while it reduced the number of SOM+ neurons, as well as the proportion of SOM+, PV+, and CB+ neurons (subregion-specific manner), with preventive effects of RSV. In summary, metabolic alterations or gene expression impairments could be induced by VPA, leading to extensive damage in the late developmental stages. By contrast, due to its antioxidant, neuroprotective, and opposite action on histone properties, RSV may avoid damages induced by VPA.
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- 2022
11. Resveratrol prevents long-term structural hippocampal alterations and modulates interneuron organization in an animal model of ASD
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Santos-Terra, Júlio, primary, Deckmann, Iohanna, additional, Schwingel, Gustavo Brum, additional, Paz, André Vinicius Contri, additional, Gama, Clarissa S., additional, Bambini-Junior, Victorio, additional, Fontes-Dutra, Mellanie, additional, and Gottfried, Carmem, additional
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- 2021
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12. Resveratrol prevents brain edema, blood–brain barrier permeability, and altered aquaporin profile in autism animal model.
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Deckmann, Iohanna, Santos‐Terra, Júlio, Fontes‐Dutra, Mellanie, Körbes‐Rockenbach, Marília, Bauer‐Negrini, Guilherme, Schwingel, Gustavo Brum, Riesgo, Rudimar, Bambini‐Junior, Victorio, and Gottfried, Carmem
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BLOOD-brain barrier , *AQUAPORINS , *CEREBRAL edema , *AUTISM spectrum disorders , *RESVERATROL , *SOMATOSENSORY cortex - Abstract
Autism spectrum disorder can present a plethora of clinical conditions associated with the disorder, such as greater brain volume in the first years of life in a significant percentage of patients. We aimed to evaluate the brain water content, the blood–brain barrier permeability, and the expression of aquaporin 1 and 4, and GFAP in a valproic acid‐animal model, assessing the effect of resveratrol. On postnatal day 30, Wistar rats of the valproic acid group showed greater permeability of the blood–brain barrier to the Evans blue dye and a higher proportion of brain water volume, prevented both by resveratrol. Prenatal exposition to valproic acid diminished aquaporin 1 in the choroid plexus, in the primary somatosensory area, in the amygdala region, and in the medial prefrontal cortex, reduced aquaporin 4 in medial prefrontal cortex and increased aquaporin 4 levels in primary somatosensory area (with resveratrol prevention). Valproic acid exposition also increased the number of astrocytes and GFAP fluorescence in both primary somatosensory area and medial prefrontal cortex. In medial prefrontal cortex, resveratrol prevented the increased fluorescence. Finally, there was an effect of resveratrol per se on the number of astrocytes and GFAP fluorescence in the amygdala region and in the hippocampus. Thus, this work demonstrates significant changes in blood–brain barrier permeability, edema formation, distribution of aquaporin 1 and 4, in addition to astrocytes profile in the animal model of autism, as well as the use of resveratrol as a tool to investigate the mechanisms involved in the pathophysiology of autism spectrum disorder. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors.
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Santos‐Terra, Júlio, Deckmann, Iohanna, Fontes‐Dutra, Mellanie, Schwingel, Gustavo Brum, Bambini‐Junior, Victorio, and Gottfried, Carmem
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TRANSCRIPTION factors , *NEURAL development , *MENTAL illness , *RNA synthesis , *BLOOD-brain barrier , *NERVOUS system - Abstract
Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of psychiatric conditions marked by impairments in the nervous system. Their onset occurs during gestation, and the alterations are observed throughout the postnatal life. Although many genetic and environmental risk factors have been described in this context, the interactions between them challenge the understanding of the pathways associated with NDDs. Transcription factors (TFs)—a group of over 1,600 proteins that can interact with DNA, regulating gene expression through modulation of RNA synthesis—represent a point of convergence for different risk factors. In addition, TFs organize critical processes like angiogenesis, blood‐brain barrier formation, myelination, neuronal migration, immune activation, and many others in a time and location‐dependent way. In this review, we summarize important TF alterations in NDD and associated disorders, along with specific impairments observed in animal models, and, finally, establish hypotheses to explain how these proteins may be critical mediators in the context of genome‐environment interactions. [ABSTRACT FROM AUTHOR]
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- 2021
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