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Your search keyword '"Deng, Chu-Xia"' showing total 209 results
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209 results on '"Deng, Chu-Xia"'

6. Standard: Human intestinal cancer organoids

Author

Lin, Hanqing, Wang, Yalong, Cheng, Chunyan, Qian, Yuxin, Hao, Jie, Zhang, Zhen, Sheng, Weiqi, Song, Linhong, Deng, Chu-Xia, Zhao, Bing, Cao, Jiani, Wang, Lei, Wang, Liu, Liang, Lingmin, Chen, Wenli Kelly, Yu, Chunping, Sun, Zhijian, Yang, Yingying, Wang, Changlin, Zhang, Yong, Li, Qiyuan, Li, Ka, Ma, Aijin, Zhao, Tongbiao, Chen, Ye-Guang, and Hua, Guoqiang

Published
2023
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12. Carbon Dots Crosslinked Egg White Hydrogel for Tissue Engineering.

Author

Wu, Jun, Lei, Josh Haipeng, Li, Moxin, Zhang, Aiping, Li, Yuan, Liang, Xiao, de Souza, Senio Campos, Yuan, Zhen, Wang, Chunming, Chen, Guokai, Liu, Tzu‐Ming, Deng, Chu‐Xia, Tang, Zikang, and Qu, Songnan

Subjects
EGG whites, POROSITY, TISSUE engineering, AQUEOUS solutions, BIOMATERIALS, HAIR follicles
Abstract

Egg white (EW)‐derived hydrogels hold promise as biomaterials for in vitro cell culture due to their ability to mimic the extracellular matrix. However, their highly cross‐linked structures restrict their potential for in vivo applications, as they are unable to integrate dynamically with tissues before degradation. In this study, this limitation is addressed by introducing carbon dots (CDs) as cross‐linking agents for EW in a dilute aqueous solution. The resulting CDs‐crosslinked EW hydrogel (CEWH) exhibits tensile strength comparable to that of skin tissue and features a large pore structure that promotes cell infiltration. Subcutaneous implantation of CEWH demonstrated excellent integration with surrounding tissue and a degradation rate aligned with the hair follicles (HFs) regeneration cycle. This allows the long‐term regeneration and establishment of an M2 macrophage‐dominated immune microenvironment, which in turn promotes the re‐entry of HFs into the anagen phase from the telogen phase. Additionally, CEWH demonstrated potential as a wound dressing material. Overall, this study paves the way for utilizing EW as a versatile biomaterial for tissue engineering. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

Author

Ding, Ren-Bo, Chen, Ping, Rajendran, Barani Kumar, Lyu, Xueying, Wang, Haitao, Bao, Jiaolin, Zeng, Jianming, Hao, Wenhui, Sun, Heng, Wong, Ada Hang-Heng, Valecha, Monica Vishnu, Yang, Eun Ju, Su, Sek Man, Choi, Tak Kan, Liu, Shuiming, Chan, Kin Iong, Yang, Ling-Lin, Wu, Jingbo, Miao, Kai, Chen, Qiang, Shim, Joong Sup, Xu, Xiaoling, and Deng, Chu-Xia

Published
2021
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17. Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA.

Author

Yi, Ye, Qin, Guihui, Yang, Hongmei, Jia, Hao, Zeng, Qibing, Zheng, Dejin, Ye, Sen, Zhang, Zhiming, Liu, Tzu‐Ming, Luo, Kathy Qian, Deng, Chu‐Xia, and Xu, Ren‐He

Subjects
KILLER cells, HISTOCOMPATIBILITY class I antigens, STROMAL cells, NATURAL immunity, INTERFERON receptors
Abstract

Circulating tumor cells (CTCs) shed from primary tumors must overcome the cytotoxicity of immune cells, particularly natural killer (NK) cells, to cause metastasis. The tumor microenvironment (TME) protects tumor cells from the cytotoxicity of immune cells, which is partially executed by cancer‐associated mesenchymal stromal cells (MSCs). However, the mechanisms by which MSCs influence the NK resistance of CTCs remain poorly understood. This study demonstrates that MSCs enhance the NK resistance of cancer cells in a gap junction‐dependent manner, thereby promoting the survival and metastatic seeding of CTCs in immunocompromised mice. Tumor cells crosstalk with MSCs through an intercellular cGAS‐cGAMP‐STING signaling loop, leading to increased production of interferon‐β (IFNβ) by MSCs. IFNβ reversely enhances the type I IFN (IFN‐I) signaling in tumor cells and hence the expression of human leukocyte antigen class I (HLA‐I) on the cell surface, protecting the tumor cells from NK cytotoxicity. Disruption of this loop reverses NK sensitivity in tumor cells and decreases tumor metastasis. Moreover, there are positive correlations between IFN‐I signaling, HLA‐I expression, and NK tolerance in human tumor samples. Thus, the NK‐resistant signaling loop between tumor cells and MSCs may serve as a novel therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy

Author

Lei, Josh Haipeng, primary, Lee, Mi‐Hye, additional, Miao, Kai, additional, Huang, Zebin, additional, Yao, Zhicheng, additional, Zhang, Aiping, additional, Xu, Jun, additional, Zhao, Ming, additional, Huang, Zenan, additional, Zhang, Xin, additional, Chen, Si, additional, Jiaying, NG, additional, Feng, Yuzhao, additional, Xing, Fuqiang, additional, Chen, Ping, additional, Sun, Heng, additional, Chen, Qiang, additional, Xiang, Tingxiu, additional, Chen, Lin, additional, Xu, Xiaoling, additional, and Deng, Chu‐Xia, additional

Published
2023
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22. ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine

Author

Xu, Jun, Su, Sek Man, Zhang, Xin, Chan, Un In, Adhav, Ragini, Shu, Xiaodong, Liu, Jianlin, Li, Jianjie, Mo, Lihua, Wang, Yuqing, An, Tingting, Lei, Josh Haipeng, Miao, Kai, Deng, Chu-Xia, and Xu, Xiaoling

Subjects
Oncology, Experimental, Phospholipids -- Health aspects -- Genetic aspects, Metastasis -- Genetic aspects -- Care and treatment -- Models, Tumor suppressor genes -- Research, Breast cancer -- Genetic aspects -- Care and treatment -- Models, Cancer -- Research, Molecular targeted therapy -- Research, Health care industry
Abstract

Cancer metastasis is the cause of the majority of cancer-related deaths. In this study, we demonstrated that no expression or low expression of ATP11B in conjunction with high expression of PTDSS2, which was negatively regulated by BRCA1, markedly accelerates tumor metastasis. Further analysis revealed that cells with low ATP11B expression and high PTDSS2 expression ([ATP11B.sup.lo][PTDSS2.sup.hi] cells) were associated with poor prognosis and enhanced metastasis in breast cancer patients in general. Mechanistically, an [ATP11B.sup.lo][PTDSS2.sup.hi] phenotype was associated with increased levels of nonapoptotic phosphatidylserine (PS) on the outer leaflet of the cell membrane. This PS increase serves as a global immunosuppressive signal to promote breast cancer metastasis through an enriched tumor microenvironment with the accumulation of myeloid-derived suppressor cells and reduced activity of cytotoxic T cells. The metastatic processes associated with [ATP11B.sup.lo][PTDSS2.sup.hi] cancer cells can be effectively overcome by changing the expression phenotype to [ATP11B.sup.hi][PTDSS2.sup.lo] through a combination of anti-PS antibody with either paclitaxel or docetaxel. Thus, blocking the [ATP11B.sup.lo][PTDSS2.sup.hi] axis provides a new selective therapeutic strategy to prevent metastasis in breast cancer patients., Introduction Breast cancer is the most common type of cancer and the second leading cause of cancer mortality among women in the world (1, 2). While the majority of breast [...]

Published
2022
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24. Table S1-S9 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, primary, Chan, Un In, primary, Su, Sek Man, primary, Shi, Changxiang, primary, Zhang, Xin, primary, An, Tingting, primary, Xu, Jun, primary, Mo, Lihua, primary, Liu, Jianlin, primary, Wang, Yuqing, primary, Li, Xiaoling, primary, Deng, Min, primary, Lei, Josh Haipeng, primary, Wang, Chunfei, primary, Tian, Hao, primary, Heng, Sun, primary, Shim, Joong Sup, primary, Zhang, Xuanjun, primary, Dai, Yunlu, primary, Yao, Zhicheng, primary, Kuang, Xiaying, primary, Lin, Ying, primary, Deng, Chu-Xia, primary, and Xu, Xiaoling, primary

Published
2023
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25. Figure S6 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, primary, Chan, Un In, primary, Su, Sek Man, primary, Shi, Changxiang, primary, Zhang, Xin, primary, An, Tingting, primary, Xu, Jun, primary, Mo, Lihua, primary, Liu, Jianlin, primary, Wang, Yuqing, primary, Li, Xiaoling, primary, Deng, Min, primary, Lei, Josh Haipeng, primary, Wang, Chunfei, primary, Tian, Hao, primary, Heng, Sun, primary, Shim, Joong Sup, primary, Zhang, Xuanjun, primary, Dai, Yunlu, primary, Yao, Zhicheng, primary, Kuang, Xiaying, primary, Lin, Ying, primary, Deng, Chu-Xia, primary, and Xu, Xiaoling, primary

Published
2023
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26. Supplementary figure legends from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, primary, Chan, Un In, primary, Su, Sek Man, primary, Shi, Changxiang, primary, Zhang, Xin, primary, An, Tingting, primary, Xu, Jun, primary, Mo, Lihua, primary, Liu, Jianlin, primary, Wang, Yuqing, primary, Li, Xiaoling, primary, Deng, Min, primary, Lei, Josh Haipeng, primary, Wang, Chunfei, primary, Tian, Hao, primary, Heng, Sun, primary, Shim, Joong Sup, primary, Zhang, Xuanjun, primary, Dai, Yunlu, primary, Yao, Zhicheng, primary, Kuang, Xiaying, primary, Lin, Ying, primary, Deng, Chu-Xia, primary, and Xu, Xiaoling, primary

Published
2023
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27. Data from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, primary, Chan, Un In, primary, Su, Sek Man, primary, Shi, Changxiang, primary, Zhang, Xin, primary, An, Tingting, primary, Xu, Jun, primary, Mo, Lihua, primary, Liu, Jianlin, primary, Wang, Yuqing, primary, Li, Xiaoling, primary, Deng, Min, primary, Lei, Josh Haipeng, primary, Wang, Chunfei, primary, Tian, Hao, primary, Heng, Sun, primary, Shim, Joong Sup, primary, Zhang, Xuanjun, primary, Dai, Yunlu, primary, Yao, Zhicheng, primary, Kuang, Xiaying, primary, Lin, Ying, primary, Deng, Chu-Xia, primary, and Xu, Xiaoling, primary

Published
2023
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28. BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, additional, Chan, Un In, additional, Su, Sek Man, additional, Shi, Changxiang, additional, Zhang, Xin, additional, An, Tingting, additional, Xu, Jun, additional, Mo, Lihua, additional, Liu, Jianlin, additional, Wang, Yuqing, additional, Li, Xiaoling, additional, Deng, Min, additional, Lei, Josh Haipeng, additional, Wang, Chunfei, additional, Tian, Hao, additional, Heng, Sun, additional, Shim, Joong Sup, additional, Zhang, Xuanjun, additional, Dai, Yunlu, additional, Yao, Zhicheng, additional, Kuang, Xiaying, additional, Lin, Ying, additional, Deng, Chu-Xia, additional, and Xu, Xiaoling, additional

Published
2023
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36. Data from Frequent Met Oncogene Amplification in a Brca1/Trp53 Mouse Model of Mammary Tumorigenesis

Author

Smolen, Gromoslaw A., primary, Muir, Beth, primary, Mohapatra, Gayatry, primary, Barmettler, Anne, primary, Kim, Woo J., primary, Rivera, Miguel N., primary, Haserlat, Sara M., primary, Okimoto, Ross A., primary, Kwak, Eunice, primary, Dahiya, Sonika, primary, Garber, Judy E., primary, Bell, Daphne W., primary, Sgroi, Dennis C., primary, Chin, Lynda, primary, Deng, Chu-Xia, primary, and Haber, Daniel A., primary

Published
2023
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37. Supplementary Figure 1 from Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

Author

Deeb, Kristin K., primary, Michalowska, Aleksandra M., primary, Yoon, Cheol-yong, primary, Krummey, Scott M., primary, Hoenerhoff, Mark J., primary, Kavanaugh, Claudine, primary, Li, Ming-chung, primary, Demayo, Francesco J., primary, Linnoila, Ilona, primary, Deng, Chu-xia, primary, Lee, Eva Y-H.P., primary, Medina, Daniel, primary, Shih, Joanna H., primary, and Green, Jeffrey E., primary

Published
2023
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38. Supplementary Table 4 from Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

Author

Deeb, Kristin K., primary, Michalowska, Aleksandra M., primary, Yoon, Cheol-yong, primary, Krummey, Scott M., primary, Hoenerhoff, Mark J., primary, Kavanaugh, Claudine, primary, Li, Ming-chung, primary, Demayo, Francesco J., primary, Linnoila, Ilona, primary, Deng, Chu-xia, primary, Lee, Eva Y-H.P., primary, Medina, Daniel, primary, Shih, Joanna H., primary, and Green, Jeffrey E., primary

Published
2023
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39. Supplementary Methods from Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

Author

Deeb, Kristin K., primary, Michalowska, Aleksandra M., primary, Yoon, Cheol-yong, primary, Krummey, Scott M., primary, Hoenerhoff, Mark J., primary, Kavanaugh, Claudine, primary, Li, Ming-chung, primary, Demayo, Francesco J., primary, Linnoila, Ilona, primary, Deng, Chu-xia, primary, Lee, Eva Y-H.P., primary, Medina, Daniel, primary, Shih, Joanna H., primary, and Green, Jeffrey E., primary

Published
2023
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42. Supplementary Methods and Table from Frequent Met Oncogene Amplification in a Brca1/Trp53 Mouse Model of Mammary Tumorigenesis

Author

Smolen, Gromoslaw A., primary, Muir, Beth, primary, Mohapatra, Gayatry, primary, Barmettler, Anne, primary, Kim, Woo J., primary, Rivera, Miguel N., primary, Haserlat, Sara M., primary, Okimoto, Ross A., primary, Kwak, Eunice, primary, Dahiya, Sonika, primary, Garber, Judy E., primary, Bell, Daphne W., primary, Sgroi, Dennis C., primary, Chin, Lynda, primary, Deng, Chu-Xia, primary, and Haber, Daniel A., primary

Published
2023
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44. Supplementary Table 1 from Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

Author

Deeb, Kristin K., primary, Michalowska, Aleksandra M., primary, Yoon, Cheol-yong, primary, Krummey, Scott M., primary, Hoenerhoff, Mark J., primary, Kavanaugh, Claudine, primary, Li, Ming-chung, primary, Demayo, Francesco J., primary, Linnoila, Ilona, primary, Deng, Chu-xia, primary, Lee, Eva Y-H.P., primary, Medina, Daniel, primary, Shih, Joanna H., primary, and Green, Jeffrey E., primary

Published
2023
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45. Supplementary Table 3 from Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

Author

Deeb, Kristin K., primary, Michalowska, Aleksandra M., primary, Yoon, Cheol-yong, primary, Krummey, Scott M., primary, Hoenerhoff, Mark J., primary, Kavanaugh, Claudine, primary, Li, Ming-chung, primary, Demayo, Francesco J., primary, Linnoila, Ilona, primary, Deng, Chu-xia, primary, Lee, Eva Y-H.P., primary, Medina, Daniel, primary, Shih, Joanna H., primary, and Green, Jeffrey E., primary

Published
2023
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46. Supplementary Figure 3 from Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

Author

Deeb, Kristin K., primary, Michalowska, Aleksandra M., primary, Yoon, Cheol-yong, primary, Krummey, Scott M., primary, Hoenerhoff, Mark J., primary, Kavanaugh, Claudine, primary, Li, Ming-chung, primary, Demayo, Francesco J., primary, Linnoila, Ilona, primary, Deng, Chu-xia, primary, Lee, Eva Y-H.P., primary, Medina, Daniel, primary, Shih, Joanna H., primary, and Green, Jeffrey E., primary

Published
2023
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48. Supplementary Table 2 from Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

Author

Deeb, Kristin K., primary, Michalowska, Aleksandra M., primary, Yoon, Cheol-yong, primary, Krummey, Scott M., primary, Hoenerhoff, Mark J., primary, Kavanaugh, Claudine, primary, Li, Ming-chung, primary, Demayo, Francesco J., primary, Linnoila, Ilona, primary, Deng, Chu-xia, primary, Lee, Eva Y-H.P., primary, Medina, Daniel, primary, Shih, Joanna H., primary, and Green, Jeffrey E., primary

Published
2023
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49. Supplementary Figure 2 from Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

Author

Deeb, Kristin K., primary, Michalowska, Aleksandra M., primary, Yoon, Cheol-yong, primary, Krummey, Scott M., primary, Hoenerhoff, Mark J., primary, Kavanaugh, Claudine, primary, Li, Ming-chung, primary, Demayo, Francesco J., primary, Linnoila, Ilona, primary, Deng, Chu-xia, primary, Lee, Eva Y-H.P., primary, Medina, Daniel, primary, Shih, Joanna H., primary, and Green, Jeffrey E., primary

Published
2023
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50. Fluorescence intensity and lifetime imaging of lipofuscin-like autofluorescence for label-free predicting clinical drug response in cancer

Author

Yan, Yinghan, primary, Xing, Fuqiang, additional, Cao, Jiayue, additional, Hu, Yiling, additional, Li, Ling, additional, Gao, Zhengyin, additional, Jia, Hao, additional, Miao, Kai, additional, Shao, Fangyuan, additional, Deng, Chu-Xia, additional, Luo, Kathy Qian, additional, Lee, Leo Tsz on, additional, and Liu, Tzu-Ming, additional

Published
2023
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