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Your search keyword '"Ding, Hongxiang"' showing total 22 results
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22 results on '"Ding, Hongxiang"'

5. Contributors

Author

Advani, Mukti, primary, Amrit, Kumar, additional, Anable, Jillian, additional, Bhuyan, Prasanta Kumar, additional, Brown, Llinos, additional, Brunel, Julien, additional, Budd, Lucy, additional, Cavallaro, Federico, additional, Circella, Giovanni, additional, Ciriaco, Thayanne Gabryelle Medeiros, additional, Costa, Carolina Silva, additional, da Silva Correa, Leandro, additional, Dablanc, Laetitia, additional, Ding, Hongxiang, additional, Docherty, Iain, additional, Elbert, Ralf, additional, Fu, Daocheng, additional, Gao, Kun, additional, Goyal, Nitin, additional, Hanaoka, Tatsuya, additional, Hasegwa, Yu, additional, Hassan, Nurul, additional, Hayashi, Yoshitsugu, additional, Huscroft, Joseph R., additional, Ison, Stephen, additional, Jaya, Vidushi, additional, Kamnerdsap, Sudarat, additional, Kang, Jing, additional, Kanoshima, Hideyuki, additional, Kashima, Saori, additional, Khanganba Sanjram, Premjit, additional, Kobayashi, Yasuko Hassall, additional, Li, Shuangjin, additional, Li, Xiaopeng, additional, Lidasan, Hussein Sinsuat, additional, Liu, Feng, additional, Liu, Rui, additional, Ma, Shuang, additional, Marsden, Greg, additional, Morita, Hiroyoshi, additional, Nakamura, Shinichiro, additional, Nakanishi, Hitomi, additional, Ng, Wei-Shiuen, additional, Oguchi, Takashi, additional, Olczak, Magdalena, additional, Padma, S., additional, Patel, Chetan, additional, Pedreira Junior, Jorge Ubirajara, additional, Pedroso Moura, Melissa, additional, Perl, Anthony, additional, Pitombo, Cira Souza, additional, Qu, Xiaobo, additional, Regmi, Madan B., additional, Rodrigues da Silva, Antônio Nélson, additional, Roeper, Felix, additional, Rothengatter, Werner, additional, Sharma, Ritu, additional, Shibayama, Takeru, additional, Singhal, Ruchi, additional, Soni, Arti Roshan, additional, Soza-Parra, Jaime, additional, Sperling, Daniel, additional, Suda, Yoshihiro, additional, Sun, Fengzhi, additional, Takano, Tsuyoshi, additional, Unnikrishnan, Chithira, additional, Vanelslander, Thierry, additional, Veeneman, Wijnand, additional, Velmurugan, S., additional, Verhoeven, Patrick, additional, Vichiensan, Varameth, additional, Wang, Suixin, additional, Wang, Yacan, additional, Wu, Wenchao, additional, Yamamoto, Fuyo Jenny, additional, Zhang, Junyi, additional, Zhang, Linghan, additional, Zhang, Runsen, additional, Zhang, Zhao, additional, Zhou, Huiyu, additional, and Zhu, Taoxing, additional

Published
2023
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21. Pharmacokinetics-Derived Absorbed Components Responsible for Guizhi-Fuling Capsule Target PI3K/Akt-Erk to Exert Anti-Dysmenorrhea Effect

Author

Zhao, Qiulong, primary, Cheng, Jiaxin, additional, Bian, Xiaokun, additional, Wang, Chunxue, additional, Xu, Yi, additional, Ding, Hongxiang, additional, Ren, Hui, additional, Zhang, Yiying, additional, Xu, Min, additional, Shan, Chenxiao, additional, Qian, Dawei, additional, Duan, Jin-Ao, additional, Yan, Hui, additional, and Huang, Xi, additional

Published
2022
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22. [Phenotypic and genotypic analysis of a pedigree affected with hereditary protein C deficiency].

Author

Ding H, Li S, Zhu L, Xu X, Ni L, and Jiang M

Subjects
Aged, Female, Heterozygote, Humans, Male, Mutation, Pedigree, Phenotype, Phylogeny, Protein C Deficiency genetics
Abstract

Objective: To analyze the phenotype and genetic variant in a pedigree affected with inherited protein C (PC) deficiency., Methods: The proband and her family members (7 individuals from 3 generations) were tested for plasma protein C activity (PC:A), protein C antigen (PC:Ag) content and other coagulation indicators. All of the 9 exons and flanking sequences of the proband's PROC gene were amplified by PCR and sequenced. Suspected variants were verified by reverse sequencing of the proband and her family members. Bioinformatic software was used to analyze the pathogenicity and conservation of the variant site. Swiss-PdbViewer was used to analyze the three-dimensional model and the interaction with the mutant amino acid., Results: The PC:A and PC:Ag of the proband, her grandmother, father and elder brother were decreased to 55%, 52%, 48%, 51% and 53%, 55%, 50%, 56%, respectively. Genetic analysis showed that the four individuals have all carried heterozygous c.1318C>T (p.Arg398Cys) missense mutation in exon 9 of the PROC gene. The score of MutationTaster was 0.991, PROVEAN was -3.72, and FATHMM was -2.49, all predicted it to be a harmful mutation. Phylogenetic analysis also showed that Arg398 was weakly conservative among homologous species. Protein model analysis showed that, in the wild type, Arg398 can form a hydrogen bond with Glu341 and Lys395 respectively, when it was mutated to Cys398, the hydrogen bond with Glu341 disappears and an additional hydrogen bond was formed with Lys395, which has changed the spatial structure of the protein., Conclusion: The heterozygous missense mutation c.1318C>T (p.Arg398Cys) of the PROC gene probably underlay the decreased PC:A and PC:Ag in this pedigree.

Published
2021
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