188 results on '"E Michos"'
Search Results
2. Age-related Changes in Ventilation and Perfusion Ratio (V'/Q') Assessed With Dual-Energy CT: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study
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E.A. Hermann, E.A. Hoffman, A. Motahari, S.E. Gerard, P. Nagpal, A. Eskandari, J. Guo, N. Allen, E. Michos, K.D. Hinckley Stukovsky, D.W. Kaczka, K. Watson, and R.G. Barr
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- 2023
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3. Arousal Intensity Predicts Incident Dementia in Sleep Apnea: The Multiethnic Study of Atherosclerosis (MESA)
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G.P. Labarca, N. Esmaeili, L. Gell, W.-H. Hu, L. Messineo, D. Vena, J. Sumner, H.C. Yang, T.-Y. Wang, E. Michos, T. Sofer, Y. Kwon, K. Yaffe, K. Ensrud, K.L. Stone, S.A. Sands, D. White, A. Wellman, S.S. Redline, and A. Azarbarzin
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- 2023
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4. Ideal cardiovascular health and women's health characteristics in middle aged women free of diagnosed cardiovascular disease. The Polish Norwegian study
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G Vaidean, M Manczuk, and E Michos
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Cardiology and Cardiovascular Medicine - Abstract
Background Women's reproductive history has been recognized as a cardiovascular risk factor and risk enhancer. Purpose To compare ideal cardiovascular health (CVH) metrics across multiple women's health conditions: parity, breastfeeding, hormonal contraceptive use and menopause status. Methods Cross-sectional data were collected from 7034 women, age 45 to 64 years, free of CVD. Using the 7 American Heart Association criteria, we defined CVH as ideal, intermediate or poor if 6–7, 3–5 or 0–2 ideal metrics were met, respectively. We calculated the CVH score, ranging from 7 (all metrics poor) to 21 (all metrics ideal). Reproductive history was self-reported. We categorized parity in four categories (0, 1–2, 3–4 and 5 or more births). We used general linear models and proportional odds regression models to adjust for covariates and to assess mediation by age, education, income and urban/rural residence. Results Women had a mean age of 55.1 years (SD 5.3). The prevalence of nulliparity was 8.4%, menopause 75.49% and ever use of oral contraceptives, 12.8%. Among non-nulliparous, 88.9% breastfed for a median cumulative duration of 10 months. The prevalence of traditional CVD risk factors was high (obesity 27.6%, uncontrolled blood pressure 39.8%, poor diet 38%). The prevalence of ideal, intermediate and poor CVH was 0.1%, 41.7% and 58.2% respectively. None of the participants had all 7 cardiovascular health metrics at ideal level. Average CVH score was 14.1 (SD 1.9). The prevalence of intermediate CVH scores was highest among nulliparous (27.6%) and decreased with parity (26.72%, 19.87% and 11.42%). There was a statistically significant gradient in mean age-adjusted CVH score across the four parity categories, increasing from multiparous of 5 or more births (13.36, 95% CI 13.13–13.60) to nulliparous (14.24, 95% CI 14.08–14.39). Nulliparous women had 2.9 times greater odds (95% CI 1.91–4.54) of higher CVH scores than multiparous of 5 or more births, after adjusting for age, menopause and use of hormonal contraceptives. Similarly, for women who gave birth 1–2 times and 3–4 times, the adjusted relative odds were 2.65 (95% CI 1.78–3.94) and 1.80 (95% CI 1.2–2.71), respectively. Further adjustment for education, rural residence, personal and/or household finance status attenuated these relations, suggesting a mediating effect. Among non-nulliparous, neither ever breastfeeding or cumulative duration of breastfeeding were associated with CVH scores. Premenopausal women had 1.56 (95% CI 1.33–1.84) times higher odds of higher CVH scores then postmenopausal ones, after full adjustment. Conclusion Women's reproductive history, particularly parity is associated with middle-age cardiovascular health, and part of the association is explained by socio-economic status. These findings suggest the need for early screening and intensification of preventive cardiology interventions in women, especially among vulnerable subgroups. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): The Polish-Norwegian Research Fund (PNRF-228-AI-1/07)
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- 2022
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5. Quantitative CT emphysema subtypes and pulmonary blood volume on dual-energy CT: The MESA Lung Study
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E Hermann, A Motahari, E Hoffman, N Allen, E Angelini, A Bertoni, D Bluemke, A Eskandari, S Gerard, J Guo, D Kaczka, A Laine, E Michos, P Nagpal, J Pankow, S Shah, K Stukovsky, K Watson, and R G Barr
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- 2022
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6. Dysanapsis of the Upper and Lower Airways Among Older Adults: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung, Sleep and Atrial Fibrillation Studies
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B.M. Smith, A. Wiemken, E.A. Hoffman, B. Keenan, N. Allen, A. Bertoni, D. Jacobs, E. Michos, K. Watson, S.S. Redline, R.J. Schwab, R.G. Barr, and S.R. Heckbert
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- 2022
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7. Association of Central Airway Tree Caliber with Mortality Among Older Adults: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study
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M. Vameghestahbanati, C. Sack, E.A. Hoffman, N. Allen, A. Bertoni, J. Guo, D. Jacobs Jr, J.D. Kaufman, A. Laine, C.-L. Lin, D. Malinsky, E. Michos, E. Oelsner, S. Shea, K. Watson, A. Benedetti, R.G. Barr, and B.M. Smith
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- 2022
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8. Prognostic value of left atrioventricular coupling index (LACI) in pre- and post-menopausal women : from the multi-ethnic study of atherosclerosis (MESA)
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T Pezel, E Michos, V Varadarajan, M Shabani, B Ambale Venkatesh, D Vaidya, Y Kato, H De Vasconcellos, S Heckbert, C Wu, WENDY Post, D Bluemke, M Allison, and J Lima
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Radiology, Nuclear Medicine and imaging ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. BACKGROUND Although endogenous sex hormones influence both left atrial (LA) and left ventricular (LV) structure in peri-menopausal women, no study has ever evaluated the interaction between sex hormones levels and the left atrioventricular coupling. PURPOSE This study aimed to assess the prognostic value of a left atrioventricular coupling index (LACI) in pre- and post-menopausal women without history of CVD at baseline. METHODS In all women participating in the Multi-Ethnic Study of Atherosclerosis (MESA) with baseline cardiovascular magnetic resonance (CMR) study, LACI was measured as the ratio of the LA end-diastolic volume divided by the LV end-diastolic volume. Cox proportional hazard models were used to assess the association between LACI and the outcomes of atrial fibrillation (AF), heart failure (HF), coronary heart disease (CHD) death, and hard CVD defined by myocardial infarction, resuscitated cardiac arrest, stroke, or CHD death. In multivariable analyses, the associations between LACI and the time-to-event were evaluated, adjusting for demographics, traditional cardiovascular risk factors, menopausal status and sex hormone levels. RESULTS Among the 2,087 women (61.2 ± 10.1 years), 485 cardiovascular events were observed during mean follow-up period of 13.2 ± 3.3 years. Greater LACI was independently associated with AF (HR 1.70; 95% CI [1.51-1.90]), HF (HR 1.62; 95% CI [1.33-1.97]), CHD death (HR 1.36; 95% CI [1.10-1.68]), and hard CVD (1.30; 95% CI [1.13-1.51], all p CONCLUSIONS In a multi-ethnic population of pre- and post-menopausal women, LACI is an independent predictor of HF, AF, CHD death and hard CVD. In both pre- and post-menopausal women, LACI has an incremental prognostic value to predict cardiovascular events over traditional risk factors and sex hormone levels. ClinicalTrials.gov Identifier: NCT00005487 Abstract Figure. Kaplan-Meier curves by LACI terciles Abstract Figure. Kaplan-Meier curves by LACI and Menop.
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- 2022
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9. The association between perceived neighborhood safety and cardiovascular disease risk factors.
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Tomlinson, Madeline M., Kerstiens, Savanna, Smith, Courteney, Agbonlahor, Osayande, Clarke, Julianna, Vincent, Kolbie, Walker, Kandi L., McLeish, Alison C., Keith, Rachel J., Smith, Ted, Yeager, Ray A., Wood, Lindsey A., Bhatnagar, Aruni, and Hart, Joy L.
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CARDIOVASCULAR disease related mortality ,SAFETY ,RISK assessment ,STATISTICAL correlation ,SELF-evaluation ,PSYCHOLOGY of cardiac patients ,RESEARCH funding ,CARDIOVASCULAR diseases ,HYPERLIPIDEMIA ,HYPERTENSION ,RESIDENTIAL patterns ,CARDIOVASCULAR diseases risk factors ,DESCRIPTIVE statistics ,ODDS ratio ,RESEARCH ,TYPE 2 diabetes ,COMPARATIVE studies ,CONFIDENCE intervals ,NEIGHBORHOOD characteristics ,DISEASE complications - Abstract
Cardiovascular disease (CVD) remains the leading cause of mortality in the U.S. accounting for 1 in 4 deaths each year. Environmental factors, such as neighborhood safety, may increase the risk of CVD. Therefore, the current study assessed perceived neighborhood safety and its association with CVD risk factors (i.e. dyslipidemia, hypertension, type II diabetes) among 663 adults (mean age: 49.97 years, 61.24% female, 78.28% White). Participants completed self-report measures as part of a larger study of environmental influences on cardiac health. Results indicated that individuals reporting low perceived neighborhood safety had greater odds of having at least one CVD risk factor (OR = 2.76, 95% CI: 1.46, 5.22) compared to those with high perceived safety. There was a significant interaction between gender and the presence of at least one CVD risk factor in relation to perceived neighborhood safety. Low perceived neighborhood safety was associated with greater odds of having at least one CVD risk factor among males (OR = 5.48, 95% C.I: 1.82, 16.52) but not females. These findings suggest that low perceived safety is associated with CVD risk factors, especially among males. Future work should seek to better understand the interaction by gender in the relationship between perceived safety and CVD risk factors. [ABSTRACT FROM AUTHOR]
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- 2025
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10. The triglyceride-to-high-density lipoprotein cholesterol ratio is associated with an increased risk of peripartum cardiomyopathy.
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Chen, Naiyi, Xiao, Jie, Luo, Yijie, Fu, Kang, Sun, Ziru, Zhang, Xinyu, Liu, Yanan, Lu, Huixia, and Ji, Xiaoping
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HDL cholesterol ,RECEIVER operating characteristic curves ,PERIPARTUM cardiomyopathy ,LOGISTIC regression analysis ,CORONARY disease - Abstract
Background: Peripartum cardiomyopathy (PPCM) is a form of heart failure that severely affects women during the late stages of pregnancy and in the postpartum period. Currently, the diagnosis of PPCM is not fully understood and is likely multifactorial. Abnormal lipid metabolism plays an important role in the onset of cardiovascular diseases, especially in patients with heart failure. Moreover, animal experiments have confirmed a possible association between abnormal lipid metabolism and PPCM onset. However, clinical evidence is currently lacking, and reliable and effective indicators for predicting the onset of PPCM are insufficient. The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) is a novel metabolic marker that is associated with the risk of coronary heart disease. However, the relationship between the TG/HDL-C ratio and the risk of PPCM in parturients remains unknown. Therefore, this study aimed to explore the role of the TG/HDL-C ratio in predicting the risk of PPCM. Methods: This study included 600 parturients hospitalized at Qilu Hospital of Shandong University between January 2010 and August 2023 (150 patients with PPCM and 450 healthy parturients). The TG/HDL-C ratio was calculated as triglyceride levels (mmol/L)/high-density lipoprotein cholesterol levels (mmol/L). The relationship between the TG/HDL-C ratio and PPCM was analyzed using logistic regression analysis and receiver operating characteristic curve analysis. Results: Significant differences were observed in the TG/HDL-C ratio between patients with PPCM and healthy parturients. The TG/HDL-C ratio was higher in patients with PPCM than in healthy parturients (p < 0.001). Logistic regression analysis revealed that the TG/HDL-C ratio increased the risk of PPCM and had predictive accuracy for the onset of PPCM (odds ratio, 1.249; 95% confidence interval, 1.004–1.553; p = 0.046). Moreover, the TG/HDL-C ratio was positively correlated with the NT-proBNP levels at the onset of PPCM (R
2 = 0.081, p = 0.008). Conclusions: A higher TG/HDL-C ratio was significantly associated with the risk of PPCM. [ABSTRACT FROM AUTHOR]- Published
- 2024
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11. Associations Between Health-Related Social Needs and Cardiovascular Health Among US Adults.
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Zefeng Zhang, Jackson, Sandra L., Thompson-Paul, Angela M., Xiaoping Yin, Merritt, Robert K., and Coronado, Fatima
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- 2024
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12. African American Farmers' Attitudes and Perceptions Towards an Urban Agriculture Certificate Program.
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Nzaramyimana, Theoneste, Orvis, Kathryn, Shoaf, Nathan, Sarr, Sait, and Benjamin, Tamara
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AFRICAN American attitudes ,BUSINESS success ,AGRICULTURE ,FARM produce ,URBAN agriculture ,EXPERIENTIAL learning - Abstract
Farmers' training through experiential learning plays a crucial role in the success of their farming businesses. Aspiring farmers seek crucial skill sets, including financial management, marketing strategies, pricing, budgeting, whole-farm planning, and long-term decision-making. The objective of this study was to assess African American farmers' attitudes and perceptions towards an urban agriculture certificate program launched to equip them with farming skills to help them become more successful in an urban setting. A mixed-method (qualitative and quantitative) research approach was used to evaluate the impact of this certificate program. Pre- and post-survey questionnaires and interviews were administered to assess farmers' prior urban farming knowledge and skills and if there were any changes after the certificate program was launched. Eighteen participants (n = 18) who participated and completed the program were surveyed to measure knowledge and skills gained. Results showed that African American farmers participating in the Gary Urban Agriculture Certificate Program significantly (p < 0.03) increased their skill sets and knowledge about farming in comparison to their mean scores from pre- and post-certificate program. When participants were asked to summarize the impact of the course, several mentioned that it helped them develop a comprehensive approach to planning, planting, maintaining, and harvesting the produce of their farms. Narratives from interview discussions also support the survey results in which the majority expressed a positive impact of the certificate in helping them learn about the useful farming resources around them and gain skills in running a farm. Key findings support the concept that the urban agriculture certificate program administered by Purdue University impacted participant knowledge and provided a positive attitude towards farming. This study helped us understand the impact of the certificate program. Results provided greater awareness of creating programs to support the development of Gary urban farmers' ability to become more knowledgeable and successful in their farming endeavors. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Acetylation-Mediated Post-Translational Modification of Pyruvate Dehydrogenase Plays a Critical Role in the Regulation of the Cellular Acetylome During Metabolic Stress.
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Rajakumar, Aishwarya, Nguyen, Sarah, Ford, Nicole, Ogundipe, Gbenga, Lopez-Nowak, Ethan, Kondrachuk, Olena, and Gupta, Manish K
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PYRUVATE dehydrogenase complex ,KREBS cycle ,RYANODINE receptors ,CELL physiology ,CARDIOVASCULAR diseases ,POST-translational modification - Abstract
Background: Cardiac diseases remain one of the leading causes of death globally, often linked to ischemic conditions that can affect cellular homeostasis and metabolism, which can lead to the development of cardiovascular dysfunction. Considering the effect of ischemic cardiomyopathy on the global population, it is vital to understand the impact of ischemia on cardiac cells and how ischemic conditions change different cellular functions through post-translational modification of cellular proteins. Methods: To understand the cellular function and fine-tuning during stress, we established an ischemia model using neonatal rat ventricular cardiomyocytes. Further, the level of cellular acetylation was determined by Western blotting and affinity chromatography coupled with liquid chromatography–mass spectroscopy. Results: Our study found that the level of cellular acetylation significantly reduced during ischemic conditions compared to normoxic conditions. Further, in mass spectroscopy data, 179 acetylation sites were identified in the proteins in ischemic cardiomyocytes. Among them, acetylation at 121 proteins was downregulated, and 26 proteins were upregulated compared to the control groups. Differentially, acetylated proteins are mainly involved in cellular metabolism, sarcomere structure, and motor activity. Additionally, a protein enrichment study identified that the ischemic condition impacted two major biological pathways: the acetyl-CoA biosynthesis process from pyruvate and the tricarboxylic acid cycle by deacetylation of the associated proteins. Moreover, most differential acetylation was found in the protein pyruvate dehydrogenase complex. Conclusions: Understanding the differential acetylation of cellular protein during ischemia may help to protect against the harmful effect of ischemia on cellular metabolism and cytoskeleton organization. Additionally, our study can help to understand the fine-tuning of proteins at different sites during ischemia. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Evaluation of low-and middle-income countries according to cardiovascular disease risk factors by using pythagorean fuzzy AHP and TOPSIS methods.
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Aydın, Gizem Zevde and Özkan, Barış
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MULTIPLE criteria decision making ,FUZZY decision making ,DISEASE risk factors ,TOPSIS method ,MIDDLE-income countries - Abstract
Background: Cardiovascular disease risk factors play a crucial role in determining individuals' future health status and significantly affect health. This paper aimed to address cardiovascular disease risk factors in low- and middle-income countries using multi-criteria decision-making methods. Methods: In line with this objective, 22 evaluation criteria were identified. Due to the unequal importance levels of the criteria, the interval-valued Pythagorean Fuzzy AHP (PF-AHP) method was employed for weighting. The TOPSIS method was utilized to rank the countries. Results: The application of interval-valued PF-AHP revealed that metabolic, behavioral, and economic factors are more important in contributing to disease risk. Among adults, tobacco use prevalence was identified as the most significant risk factor. According to the TOPSIS method, Lebanon, Jordan, Solomon Islands, Serbia, and Bulgaria ranked highest, while Timor Leste, Benin, Ghana, Niger, and Ethiopia ranked lowest. Conclusions: Identifying disease risk factors and preventing or reducing risks are crucial in combating cardiovascular diseases. Therefore, it is recommended that countries ranking higher take remedial actions to reduce disease risk. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Tanshinone IIA Protects Ischemia/Reperfusion‐Induced Cardiomyocyte Injury by Inhibiting the HAS2/FGF9 Axis.
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Wang, Yanzhe, Sun, Weixin, Shen, Le, Yu, Peng, Shen, Qiusheng, Zhou, Yaozhong, Yao, Lu, Chen, Xiaohu, and Luo, Zhiwen
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IN vitro studies ,CORONARY disease ,MYOCARDIAL reperfusion complications ,RESEARCH funding ,TERPENES ,APOPTOSIS ,CARDIOTONIC agents ,OXIDATIVE stress ,GENE expression ,GENES ,MYOCARDIUM ,FIBROBLAST growth factors ,GROWTH factors ,TRANSFERASES ,CELL survival ,CYTOKINES ,HEART cells ,BIOMARKERS ,HYPOXEMIA ,PHARMACODYNAMICS ,DISEASE complications - Abstract
Purpose. This study aimed to investigate the impacts of tanshinone IIA (Tan IIA) on ischemia/reperfusion (I/R)‐induced cardiomyocyte injury in coronary heart disease (CHD), and to determine whether Tan IIA regulates myocardial cell injury induced by I/R through the Hyaluronan Synthase 2/fibroblast growth factor 9 (HAS2/FGF9) axis. Methods. Weighted gene co‐expression network analysis (WGCNA) of the GSE23561 microarray dataset determined gene modules linked to CHD. The key genes were further explored through differential expression and protein‐protein interaction (PPI) network analyses. Human AC16 cardiomyocytes were treated with Tan IIA, HAS2 knockdown, and FGF9 overexpression and they were exposed to normoxic, hypoxic, and I/R environments. Cell viability, apoptosis, gene/protein expression, and markers of oxidative stress were evaluated in vitro. Results. The turquoise module was significantly correlated with CHD and HAS2 was identified as a hub gene. Under hypoxic conditions, Tan IIA exhibited a dose‐dependent cardioprotective effect. Tan IIA ameliorated I/R‐induced cellular injury, as evidenced by increased cell viability, decreased apoptosis, and regulation of key proteins (PCNA, Bax). After I/R conditions, knockdown of HAS2 increased cell viability and reduced apoptosis, whereas overexpression of FGF9 reversed these effects. Notably, HAS2 knockdown also ameliorated I/R‐induced increases in inflammatory cytokines and oxidative stress, and synergistic protection was provided by combined treatment with FGF9 and Tan IIA. Conclusion. Taken together, our findings confirm that Tan IIA protects cardiomyocytes from I/R‐induced injury by controlling the HAS2/FGF9 axis. These findings reveal the potential therapeutic significance of Tan IIA in alleviating CHD‐related myocardial dysfunction. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Spline Estimator in Nonparametric Ordinal Logistic Regression Model for Predicting Heart Attack Risk.
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Chamidah, Nur, Lestari, Budi, Susilo, Hendri, Alsagaff, Mochamad Yusuf, Budiantara, I Nyoman, and Aydin, Dursun
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MYOCARDIAL infarction ,DISTRIBUTION (Probability theory) ,HYPERTENSION risk factors ,MULTINOMIAL distribution ,NON-communicable diseases - Abstract
In Indonesia, one of the main causes of death for both young and elderly people is heart attacks, and the main cause of heart attacks is non-communicable diseases such as hypertension. Deaths due to heart attacks caused by non-communicable diseases, namely hypertension, rank first in Indonesia. Therefore, predictions of the risk of having a heart attack caused by hypertension need serious attention. Further, for determining whether a patient is experiencing a heart attack, an effective method of prediction is required. One efficient approach is to use statistical models. This study discusses predicting risk of heart attack via modeling and classifying hypertension risk based on factors that influence it, namely, age, cholesterol levels, and triglyceride levels by using the spline estimator of the Nonparametric Ordinal Logistic Regression (NOLR) model. In this study, we assume an ordinal scale response variable with q categories to have an asymmetric distribution, namely, a multinomial distribution. The data used in this study are secondary data from medical records of cardiac poly patients at the Haji General Hospital in Surabaya, Indonesia. The results show that the proposed model approach has the greatest classification accuracy and sensitivity values compared to NOLR model approach using GAM, and the classical model approach, namely the Parametric Ordinal Logistic Regression (POLR) model. This means that the NOLR model approach is suitable for predicting hypertension and heart attack risks. Also, the NOLR model estimated using the LS-Spline estimator obtained is valid for predicting the risk of heart attack with accuracy value of 85% and sensitivity value of 100%. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Clinical insights into the immunomodulatory effects of food‐derived peptides.
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Chen, Kangkai, Ma, Dongwei, Yang, Xin, Liu, Ping, Wang, Jin, and Liao, Wang
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- 2024
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18. Assessing the relative importance of vitamin D deficiency in cardiovascular health.
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Rubab, Maira and Kelleher, John D.
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- 2024
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19. A Comprehensive Review on Potential In Silico Screened Herbal Bioactive Compounds and Host Targets in the Cardiovascular Disease Therapy.
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Zarenezhad, Elham, Hadi, Ali Tareq, Nournia, Ensieh, Rostamnia, Sadegh, Ghasemian, Abdolmajid, and Cherstvy, Andrey
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THERAPEUTIC use of antioxidants ,PHYTOTHERAPY ,CARDIOVASCULAR disease treatment ,COMPUTER-assisted molecular modeling ,HERBAL medicine ,PHYTOCHEMICALS ,BIOLOGICAL products ,PLANT extracts ,DRUG efficacy ,MOLECULAR structure ,MEDICINAL plants ,ORGANIC compounds ,EVALUATION - Abstract
Herbal medicines (HMs) have deciphered indispensable therapeutic effects against cardiovascular disease (CVD) (the predominant cause of death worldwide). The conventional CVD therapy approaches have not been efficient and need alternative medicines. The objective of this study was a review of herbal bioactive compound efficacy for CVD therapy based on computational and in silico studies. HM bioactive compounds with potential anti‐CVD traits include campesterol, naringenin, quercetin, stigmasterol, tanshinaldehyde, Bryophyllin A, Bryophyllin B, beta‐sitosterol, punicalagin, butein, eriodyctiol, butin, luteolin, and kaempferol discovered using computational studies. Some of the bioactive compounds have exhibited therapeutic effects, as followed by in vitro (tanshinaldehyde, punicalagin, butein, eriodyctiol, and butin), in vivo (gallogen, luteolin, chebulic acid, butein, eriodyctiol, and butin), and clinical trials (quercetin, campesterol, and naringenin). The main mechanisms of action of bioactive compounds for CVD healing include cell signaling and inhibition of inflammation and oxidative stress, decrease of lipid accumulation, and regulation of metabolism and immune cells. Further experimental studies are required to verify the anti‐CVD effects of herbal bioactive compounds and their pharmacokinetic/pharmacodynamic features. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Effects of Aerobic Exercise on Vascular Wall Thickness: A Meta-Analysis of Pre-Clinical Trials on Rat Model.
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Hamza, Fatima, Nawaid Shah, Syed Nudrat, Khan, Amna Aamir, Farooqui, Sumaira Imran, and Jerome Borges, Kevin Joseph
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- 2024
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21. Evaluation of the efficacy after Total Knee Arthroplasty by Gait analysis in patients with Knee Osteoarthritis: a meta-analysis.
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Yu, Xinfeng, Zhuang, Rujie, and Jin, Peng
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KNEE osteoarthritis ,MEDICAL information storage & retrieval systems ,DIAGNOSIS ,GAIT in humans ,TREATMENT effectiveness ,META-analysis ,DESCRIPTIVE statistics ,CHI-squared test ,SYSTEMATIC reviews ,MEDLINE ,TOTAL knee replacement ,MEDICAL databases ,ONLINE information services ,DATA analysis software ,CONFIDENCE intervals ,WALKING speed ,RANGE of motion of joints - Abstract
Background: Total knee replacement (TKA) is a frequent modality performed in patients with knee osteoarthritis (OA). The aim of this study was to perform a meta-analysis and systematic review to evaluate the efficacy after TKA by gait analysis in patients with OA. Methods: PubMed, EMBASE, the Cochrane library, and Web of Science were searched for relevant studies from inception to July 2024. STATA SE 14.0 software was used for statistical analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guideline. Results: A total of 2525 reports were identified with 24 studies meeting pre-designed inclusion criteria. Several gait parameters were investigated. In patients with knee OA after TKA, there existed an increase in the Max knee flexion (WMD, 3.12; 95% CI, 0.93 to 5.32; I
2 = 73.9%, P < 0.001), the Cadence (WMD, 4.05; 95% CI, 2.28 to 5.82; I2 = 48.9%, P = 0.068), the stride length (WMD, 0.05; 95% CI, 0.01 to 0.09; I2 = 77.1%, P < 0.001), the walking speed (WMD, 0.08; 95% CI, 0.02 to 0.14; I2 = 93.3%, P < 0.001), and the step length (WMD, 0.04; 95% CI, 0.00 to 0.07; I2 = 89.3%, P < 0.001) while a decrease in the double support time (WMD, -0.04; 95% CI, − 0.08 to -0.01; I2 = 0.0%, P = 0.585). Besides, no statistically significant differences were observed in the Knee range of motion (ROM), the Max knee rotation at stance phase, the Max knee extension, the step width, the stride time and the step time. Sensitivity analysis showed that all the results were robust. Conclusions: In summary, the study found that, in patients with knee OA undergoing TKA may have great effects on improving gait parameters. If there are more high-quality studies in the future, we should make a more comprehensive evaluation of walking function by gait analysis together with other evaluation systems such as muscle strength and proprioception measurement. [ABSTRACT FROM AUTHOR]- Published
- 2024
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22. Intelligent cardiovascular disease diagnosis using deep learning enhanced neural network with ant colony optimization.
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Xia, Biao, Innab, Nisreen, Kandasamy, Venkatachalam, Ahmadian, Ali, and Ferrara, Massimiliano
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To identify patterns in big medical datasets and use Deep Learning and Machine Learning (ML) to reliably diagnose Cardio Vascular Disease (CVD), researchers are currently delving deeply into these fields. Training on large datasets and producing highly accurate validation results is exceedingly difficult. Furthermore, early and precise diagnosis is necessary due to the increased global prevalence of cardiovascular disease (CVD). However, the increasing complexity of healthcare datasets makes it challenging to detect feature connections and produce precise predictions. To address these issues, the Intelligent Cardiovascular Disease Diagnosis based on Ant Colony Optimisation with Enhanced Deep Learning (ICVD-ACOEDL) model was developed. This model employs feature selection (FS) and hyperparameter optimization to diagnose CVD. Applying a min–max scaler, medical data is first consistently prepared. The key feature that sets ICVD-ACOEDL apart is the use of Ant Colony Optimisation (ACO) to select an optimal feature subset, which in turn helps to upgrade the performance of the ensuring deep learning enhanced neural network (DLENN) classifier. The model reforms the hyperparameters of DLENN for CVD classification using Bayesian optimization. Comprehensive evaluations on benchmark medical datasets show that ICVD-ACOEDL exceeds existing techniques, indicating that it could have a significant impact on CVD diagnosis. The model furnishes a workable way to increase CVD classification efficiency and accuracy in real-world medical situations by incorporating ACO for feature selection, min–max scaling for data pre-processing, and Bayesian optimization for hyperparameter tweaking. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Systemic Health Effects of Oleuropein and Hydroxytyrosol Supplementation: A Systematic Review of Randomized Controlled Trials.
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Frumuzachi, Oleg, Gavrilaș, Laura Ioana, Vodnar, Dan Cristian, Rohn, Sascha, and Mocan, Andrei
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MEDITERRANEAN diet ,OLIVE leaves ,ENRICHED foods ,OLIVE oil ,BONE health - Abstract
Non-communicable diseases (NCDs) cause 41 million deaths annually, accounting for 74% of global fatalities. The so-called Mediterranean diet, with its especially significant consumption of olive oil, has shown promising results in reducing the risk of developing NCDs, such as cardiovascular, liver, or bone diseases. In the context of the nutritional health benefits of foods, phenolic compounds such as olive oil's main components, oleuropein (OLE) and hydroxytyrosol (HT), have been shown to possess different beneficial effects. However, no systematic review has evaluated the health-promoting effects of OLE and HT until now. Consequently, this systematic review analyzed 12 human randomized controlled trials (RCTs), involving 683 participants, to assess the effects of supplements, pure compounds, or enriched foods containing OLE and HT regarding systemic health outcomes, including CVD risk factors, liver parameters, and bone, joint, and cognitive health. The review found contrasting but encouraging results, with some studies reporting significant modulation of body weight, lipid profile, and glucose metabolism, and improvements in bone, joint, and cognitive functions. The studies described different dosages and forms of supplementation, ranging from 5 mg/d HT to 990 mL/d olive leaf infusion (320.8 mg OLE and 11.9 mg HT), highlighting the need for further research to determine the optimal dosing and duration. Despite the mixed outcomes, OLE and HT supplementation show potential for improving some of the cardiometabolic health outcomes and bone, joint, and cognitive health. However, further studies are necessary to understand their benefits better and address existing limitations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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24. Active Commuting as a Factor of Cardiovascular Disease Prevention: A Systematic Review with Meta-Analysis.
- Author
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Baran, Claudia, Belgacem, Shanice, Paillet, Mathilde, de Abreu, Raphael Martins, de Araujo, Francisco Xavier, Meroni, Roberto, and Corbellini, Camilo
- Subjects
MYOCARDIAL ischemia ,HEMORRHAGIC stroke ,CORONARY disease ,ISCHEMIC stroke ,CARDIOVASCULAR diseases - Abstract
Active commuting (AC) may have the potential to prevent the incidence of cardiovascular disease (CVD). However, the evidence for a correlation between AC and the risk of CVD remains uncertain. The current study thoroughly and qualitatively summarized research on the relationship between AC and the risk of CVD disease. From conception through December 2022, researchers explored four databases (PubMed, PEDro, Cochrane, and Bibliothèque Nationale of Luxembourg [BnL]) for observational studies. The initial findings of the search yielded 1042 references. This systematic review includes five papers with 491,352 participants between 16 and 85 years old, with 5 to 20 years of follow-up period. The exposure variable was the mode of transportation used to commute on a typical day (walking, cycling, mixed mode, driving, or taking public transportation). The primary outcome measures were incident CVD, fatal and non-fatal (e.g., ischemic heart disease (IHD), ischemic stroke (IS), hemorrhagic stroke (HS) events, and coronary heart disease (CHD). Despite methodological variability, the current evidence supports AC as a preventive measure for the development of CVD. Future research is needed to standardize methodologies and promote policies for public health and environmental sustainability. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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25. Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being.
- Author
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Ibrahim, Zeinab, Khan, Naveed A, Siddiqui, Ruqaiyyah, Qaisar, Rizwan, Marzook, Hezlin, Soares, Nelson C., and Elmoselhi, Adel B
- Subjects
REDUCED gravity environments ,GUT microbiome ,METABOLITES ,CARDIOVASCULAR system physiology ,LIPOPOLYSACCHARIDES ,MUSCULOSKELETAL system physiology ,CARDIOVASCULAR fitness - Abstract
The gut microbiota and its secreted metabolites play a significant role in cardiovascular and musculoskeletal health and diseases. The dysregulation of the intestinal microbiota poses a significant threat to cardiovascular and skeletal muscle well-being. Nonetheless, the precise molecular mechanisms underlying these changes remain unclear. Furthermore, microgravity presents several challenges to cardiovascular and musculoskeletal health compromising muscle strength, endothelial dysfunction, and metabolic changes. The purpose of this review is to critically examine the role of gut microbiota metabolites on cardiovascular and skeletal muscle functions and dysfunctions. It also explores the molecular mechanisms that drive microgravity-induced deconditioning in both cardiovascular and skeletal muscle. Key findings in this review highlight that several alterations in gut microbiota and secreted metabolites in microgravity mirror characteristics seen in cardiovascular and skeletal muscle diseases. Those alterations include increased levels of Firmicutes/Bacteroidetes (F/B) ratio, elevated lipopolysaccharide levels (LPS), increased in para-cresol (p-cresol) and secondary metabolites, along with reduction in bile acids and Akkermansia muciniphila bacteria. Highlighting the potential, modulating gut microbiota in microgravity conditions could play a significant role in mitigating cardiovascular and skeletal muscle diseases not only during space flight but also in prolonged bed rest scenarios here on Earth. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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26. Charting the Unseen: How Non-Invasive Imaging Could Redefine Cardiovascular Prevention.
- Author
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Trimarchi, Giancarlo, Pizzino, Fausto, Paradossi, Umberto, Gueli, Ignazio Alessio, Palazzini, Matteo, Gentile, Piero, Di Spigno, Francesco, Ammirati, Enrico, Garascia, Andrea, Tedeschi, Andrea, and Aschieri, Daniela
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- 2024
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27. A roadmap for empowering cardiovascular disease patients: a 5P-Medicine approach and technological integration.
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Denysyuk, Hanna V., Pires, Ivan Miguel, and Garcia, Nuno M.
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PATIENT participation ,LITERATURE reviews ,SELF-efficacy ,RESEARCH questions ,WORLD health ,INDIVIDUALIZED medicine ,HEALTH literacy - Abstract
This article explores the multifaceted concept of cardiovascular disease (CVD) patients' empowerment, emphasizing a shift from compliance-oriented models to active patient participation. In recognizing that cardiovascular disease is a paramount global health challenge, this study illuminates the pressing need for empowering patients, underscoring their role as active participants in their healthcare journey. Grounded in 5P-Medicine principles—Predictive, Preventive, Participatory, Personalized, and Precision Medicine—the importance of empowering CVD patients through analytics, prevention, participatory decision making, and personalized treatments is highlighted. Incorporating a comprehensive overview of patient empowerment strategies, including self-management, health literacy, patient involvement, and shared decision making, the article advocates for tailored approaches aligned with individual needs, cultural contexts, and healthcare systems. Technological integration is examined to enhance patient engagement and personalized healthcare experiences. The critical role of patient-centered design in integrating digital tools for CVD management is emphasized, ensuring successful adoption and meaningful impact on healthcare outcomes. The conclusion proposes vital research questions addressing challenges and opportunities in CVD patient empowerment. These questions stress the importance of medical community research, understanding user expectations, evaluating existing technologies, defining ideal empowerment scenarios, and conducting a literature review for informed advancements. This article lays the foundation for future research, contributing to ongoing patient-centered healthcare evolution, especially in empowering individuals with a 5P-Medicine approach to cardiovascular diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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28. Cardioprotective Effects of Aloysia polystachya Essential Oil on a Rat Model with Multiple Cardiovascular Risk Factors.
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Moreno, Karyne Garcia Tafarelo, Marques, Aline Aparecida Macedo, da Silva, Gabriela Pereira, Bertoncelo, Luana Ale, Pessoal, Luciane Barbosa, Gonçalves, Larissa Dantas, dos Santos, Ariany Carvalho, Souza, Roosevelt Isaías Carvalho, Silva, Denise Brentan, and Gasparotto Junior, Arquimedes
- Subjects
BIOLOGICAL models ,KIDNEY function tests ,RESEARCH funding ,CREATININE ,DATA analysis ,ESSENTIAL oils ,CARDIOTONIC agents ,LIPIDS ,ASPARTATE aminotransferase ,BLOOD collection ,CARDIOVASCULAR diseases risk factors ,HEMODYNAMICS ,PHYTOCHEMICALS ,OXIDATIVE stress ,DESCRIPTIVE statistics ,RATS ,GAS chromatography ,SERUM ,HEART beat ,ELECTROLYTES ,PLANT extracts ,ELECTROCARDIOGRAPHY ,MEDICINAL plants ,ANIMAL experimentation ,MASS spectrometry ,SODIUM ,DIASTOLIC blood pressure ,ALANINE aminotransferase ,ONE-way analysis of variance ,ANALYSIS of variance ,STATISTICS ,INFLAMMATION ,SYSTOLIC blood pressure ,CYTOKINES ,DATA analysis software ,BIOMARKERS ,BLOOD pressure measurement ,ROSUVASTATIN ,CHLORIDES ,MALONDIALDEHYDE ,INTERLEUKINS ,PHARMACODYNAMICS - Abstract
Traditional medicine is a frequently utilized method to treat cardiovascular disease and its primary risk factors, including hypertension and dyslipidemia. Aloysia polystachya is a species that is commonly employed to treat various pathological conditions, and it has already been identified as having some cardioprotective effects. This study aimed to investigate the protective effects of the essential oil extracted from the leaves of A. polystachya in a rat model that simulates multiple cardiovascular risk factors. We evaluate the acute toxicity, as well as the cardioprotective effects, by giving different doses of A. polystachya essential oil (1.47 mg/kg, 4.40 mg/kg, and 13.20 mg/kg) over a period of 42 days. The control group was treated with rosuvastatin (5 mg/kg). At the end of the treatments, the renal function, electrocardiography, blood pressure, vascular reactivity, serum biochemical profile, and organ histopathology were evaluated. The main compounds identified in the essential oil of A. polystachya using gas chromatography coupled with mass spectrometry were beta-myrcene (1.08%), limonene (40.13%), and carvone (56.47%). The essential oil of A. polystachya not only lacks acute toxicity but also mitigates the reduction in the excretion of sodium, chloride, and creatinine in urine. Furthermore, it reduces electrocardiographic abnormalities and decreases blood pressure levels. Moreover, this treatment prevents an elevation in markers of inflammation and oxidative stress in the bloodstream. Our findings indicate significant cardioprotective effects of the essential oil of A. polystachya against multiple risk factors for cardiovascular diseases in hypertensive rats. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Curcumin Equipped Nanozyme‐Like Metal−Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability.
- Author
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Lv, Fanzhen, Fang, Huaqiang, Huang, Li, Wang, Qingqing, Cao, Shuangyuan, Zhao, Wenpeng, Zhou, Zhibin, Zhou, Weimin, and Wang, Xiaolei
- Subjects
MAGNETIC resonance imaging ,METAL-organic frameworks ,FOAM cells ,CURCUMIN ,ATHEROSCLEROSIS - Abstract
Atherosclerotic cardiovascular disease (ASCVD) has become the leading cause of death worldwide, and early diagnosis and treatment of atherosclerosis (AS) are crucial for reducing the occurrence of acute cardiovascular events. However, early diagnosis of AS is challenging, and oral anti‐AS drugs suffer from limitations like imprecise targeting and low bioavailability. To overcome the aforementioned shortcomings, Cur/MOF@DS is developed, a nanoplatform integrating diagnosis and treatment by loading curcumin (Cur) into metal−organic frameworks with nanozymes and magnetic resonance imaging (MRI) properties. In addition, the surface‐modification of dextran sulfate (DS) enables PCN‐222(Mn) effectively target scavenger receptor class A in macrophages or foam cells within the plaque region. This nanoplatform employs mechanisms that effectively scavenge excessive reactive oxygen species in the plaque microenvironment, promote macrophage autophagy and regulate macrophage polarization to realize lipid regulation. In vivo and in vitro experiments confirm that this nanoplatform has outstanding MRI performance and anti‐AS effects, which may provide a new option for early diagnosis and treatment of AS. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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30. Genotyping and Molecular Characterization of VP6 and NSP4 Genes of Unusual Rotavirus Group A Isolated from Children with Acute Gastroenteritis.
- Author
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Dellis, Charilaos, Tatsi, Elizabeth-Barbara, Koukou, Dimitra-Maria, Filippatos, Filippos, Vetouli, Evangelia-Eirini, Zoumakis, Emmanouil, Michos, Athanasios, Syriopoulou, Vasiliki, and Jose, Leny
- Subjects
GENETIC variation ,GENOTYPES ,GASTROENTERITIS ,IMMUNE response ,ROTAVIRUSES - Abstract
Group A rotavirus (RVA), which causes acute gastroenteritis (AGE) in children worldwide, is categorized mainly based on VP7 (genotype G) and VP4 (genotype P) genes. Genotypes that circulate at <1% are considered unusual. Important genes also include VP6 (genotype I) and NSP4 (genotype E). VP6 establishes the group and affects immunogenicity, while NSP4, as an enterotoxin, is responsible for the clinical symptoms. The aim of this study was to genotype the VP6 and NSP4 genes and molecularly characterize the NSP4 and VP6 genes of unusual RVA. Unusual RVA strains extracted from fecal samples of children ≤16 years with AGE were genotyped in VP6 and NSP4 genes with Sanger sequencing. In a 15‐year period (2007–2021), 54.8% (34/62) of unusual RVA were successfully I and E genotyped. Three different I and E genotypes were identified; I2 (73.5%, 25/34) and E2 (35.3%, 12/34) were the most common. E3 genotype was detected from 2017 onwards. The uncommon combination of I2‐E3 was found in 26.5% (9/34) of the strains and G3‐P[9]‐I2‐E3 remained the most frequent G‐P‐I‐E combination (20.6%, 7/34). Children infected with RVA E2 strains had a statistically higher frequency of dehydration (50%) than those infected with RVA E3 strains (p = 0.019). Multiple substitutions were detected in NSP4, but their functional effect remains unknown. The result indicates the genetic diversity of RVA strains. Continuous surveillance of the RVA based on the whole genome will provide better knowledge of its evolution. [ABSTRACT FROM AUTHOR]
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- 2024
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31. The efficacy of 3D gait analysis to evaluate surgical (and rehabilitation) outcome after degenerative lumbar surgery.
- Author
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Zhou, Chao, Zhou, Ning, Zheng, Yanping, Si, Haipeng, Wang, Yanguo, and Yin, Jun
- Subjects
MOTION capture (Human mechanics) ,BODY-weight-supported treadmill training ,GAIT in humans ,PEARSON correlation (Statistics) ,WALKING speed ,KNEE osteoarthritis - Abstract
Background: Lumbar degenerative conditions are a major cause of back pain and disability in individuals aged 45 and above. Gait analysis utilizes sensor technology to collect movement data, aiding in the evaluation of various gait aspects like spatiotemporal parameters, joint angles, neuromuscular activity, and joint forces. It is widely used in conditions such as cerebral palsy and knee osteoarthritis. This research aims to assess the effectiveness of 3D gait analysis in evaluating surgical outcomes and postoperative rehabilitation for lumbar degenerative disorders. Methods: A prospective self-controlled before-after study (n = 85) carried out at our Hospital (Sep 2018 - Dec 2021) utilized a 3D motion analysis system to analyze gait in patients with lumbar degenerative diseases. The study focused on the multifidus muscle, a crucial spinal muscle, during a minimally invasive lumbar interbody fusion surgery conducted by Shandong Weigao Pharmaceutical Co., Ltd. Pre- and postoperative assessments included time-distance parameters (gait speed, stride frequency, stride length, stance phase), hip flexion angle, and stride angle. Changes in 3D gait parameters post-surgery and during rehabilitation were examined. Pearson correlation coefficient was employed to assess relationships with the visual analog pain scale (VAS), Oswestry Disability Index (ODI), and Japanese Orthopedic Association (JOA) scores. Patient sagittal alignment was evaluated using "Surgimap" software from two types of lateral radiographs to obtain parameters like pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumbar lordosis (LL), intervertebral space height (DH), posterior height of the intervertebral space (PDH) at the operative segment, and anterior height of the intervertebral space (ADH). Results: By the 6th week post-operation, significant improvements were observed in the VAS score, JOA score, and ODI score of the patients compared to preoperative values (P < 0.05), along with notable enhancements in 3D gait quantification parameters (P < 0.05). Pearson correlation analysis revealed a significant positive correlation between improvements in 3D gait quantification parameters and VAS score, JOA score, and ODI value (all P < 0.001). Conclusion: 3D gait analysis is a valuable tool for evaluating the efficacy of surgery and rehabilitation training in patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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32. Predictors of cognitive change in cognitively healthy older women in Panama: the PARI-HD study.
- Author
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Oviedo, Diana C., Tratner, Adam E., Rodríguez-Araña, Sofía, Villarreal, Alcibiades E., Rangel, Giselle, Carreira, María B., and Britton, Gabrielle B.
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- 2024
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33. Propolis Reduces Inflammation and Dyslipidemia Caused by High-Cholesterol Diet in Mice by Lowering ADAM10/17 Activities.
- Author
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Yigit, Ertugrul, Deger, Orhan, Korkmaz, Katip, Huner Yigit, Merve, Uydu, Huseyin Avni, Mercantepe, Tolga, and Demir, Selim
- Abstract
Atherosclerosis is one of the most important causes of cardiovascular diseases. A disintegrin and metalloprotease (ADAM)10 and ADAM17 have been identified as important regulators of inflammation in recent years. Our study investigated the effect of inhibiting these enzymes with selective inhibitor and propolis on atherosclerosis. In our study, C57BL/6J mice (n = 16) were used in the control and sham groups. In contrast, ApoE
-/- mice (n = 48) were used in the case, water extract of propolis (WEP), ethanolic extract of propolis (EEP), GW280264X (GW-synthetic inhibitor), and solvent (DMSO and ethanol) groups. The control group was fed a control diet, and all other groups were fed a high-cholesterol diet for 16 weeks. WEP (400 mg/kg/day), EEP (200 mg/kg/day), and GW (100 µg/kg/day) were administered intraperitoneally for the last four weeks. Animals were sacrificed, and blood, liver, aortic arch, and aortic root tissues were collected. In serum, total cholesterol (TC), triglycerides (TGs), and glucose (Glu) were measured by enzymatic colorimetric method, while interleukin-1β (IL-1β), paraoxonase-1 (PON-1), and lipoprotein-associated phospholipase-A2 (Lp-PLA2) were measured by ELISA. Tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), myeloperoxidase (MPO), interleukin-6 (IL-6), interleukin-10 (IL-10), and interleukin-12 (IL-12) levels were measured in aortic arch by ELISA and ADAM10/17 activities were measured fluorometrically. In addition, aortic root and liver tissues were examined histopathologically and immunohistochemically (ADAM10 and sortilin primary antibody). In the WEP, EEP, and GW groups compared to the case group, TC, TG, TNF-α, IL-1β, IL-6, IL-12, PLA2, MPO, ADAM10/17 activities, plaque burden, lipid accumulation, ADAM10, and sortilin levels decreased, while IL-10 and PON-1 levels increased (p < 0.003). Our study results show that propolis can effectively reduce atherosclerosis-related inflammation and dyslipidemia through ADAM10/17 inhibition. [ABSTRACT FROM AUTHOR]- Published
- 2024
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34. Tackling Shift Work: Cardiovascular Health in the Auto Industry.
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Bunescu, Marius Gabriel, Gheorman, Veronica, Marcu, Iulia Rahela, Lungulescu, Cristian Virgil, and Dinescu, Venera Cristina
- Subjects
RISK assessment ,BODY mass index ,CARDIOVASCULAR diseases ,STATISTICAL significance ,RESEARCH funding ,HUMAN research subjects ,LIPIDS ,SEX distribution ,EMPLOYEE assistance programs ,CARDIOVASCULAR diseases risk factors ,AGE distribution ,WORK experience (Employment) ,DESCRIPTIVE statistics ,LONGITUDINAL method ,BLOOD sugar ,ODDS ratio ,MANUFACTURING industries ,INFORMED consent (Medical law) ,MEDICAL records ,OCCUPATIONAL exposure ,HEALTH promotion ,CONFIDENCE intervals ,DATA analysis software ,SHIFT systems ,SLEEP disorders ,INDUSTRIAL hygiene ,MOTOR vehicles ,EMPLOYEE attitudes ,SLEEP hygiene - Abstract
Shift work, particularly in the auto industry, presents significant health challenges, notably in how it impacts cardiovascular health due to irregular work schedules and associated sleep disruptions. This prospective study evaluated 4683 workers from a single Romanian automotive enterprise to investigate the relationship between fixed shift work schedules and cardiovascular health outcomes. Our analysis focused on fixed-shift workers, excluding those on rotating shifts to reduce variability and enhance the clarity of the findings. The findings reveal that night shift workers are at a heightened risk of cardiovascular diseases (CVDs) compared to their day shift counterparts. Night shift workers demonstrated a higher CVD incidence (4.3%) compared to day shift workers (2.6%), with an odds ratio (OR) of 1.68 (95% CI: 1.08 to 2.62, p = 0.021). This association remained significant after adjusting for potential confounders, with an adjusted OR of 1.74 (95% CI: 1.09 to 2.75, p = 0.019). Male night shift workers exhibited a significantly higher CVD incidence (4.5%) compared to male day shift workers (3.0%), with an OR of 1.75 (95% CI: 1.07 to 2.89, p = 0.026). Female night shift workers also showed a higher CVD incidence (3.4%) compared to female day shift workers (1.3%), although this was not statistically significant. These findings underscore the urgent need for targeted interventions and effective strategies to mitigate these risks and promote the cardiovascular health and overall well-being of shift workers in the auto industry. This research contributes to a deeper understanding of how non-traditional work schedules affect health and provides a basis for implementing protective measures in occupational settings. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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35. Enhancing Security and Privacy in Distributed Face Recognition Systems through Blockchain and GAN Technologies.
- Author
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Nawaz Ul Ghani, Muhammad Ahmad, Kun She, Rauf, Muhammad Arslan, Khan, Shumaila, Khan, Javed Ali, Aldakheel, Eman Abdullah, and Khafaga, Doaa Sami
- Abstract
The use of privacy-enhanced facial recognition has increased in response to growing concerns about data security and privacy in the digital age. This trend is spurred by rising demand for face recognition technology in a variety of industries, including access control, law enforcement, surveillance, and internet communication. However, the growing usage of face recognition technology has created serious concerns about data monitoring and user privacy preferences, especially in context-aware systems. In response to these problems, this study provides a novel framework that integrates sophisticated approaches such as Generative Adversarial Networks (GANs), Blockchain, and distributed computing to solve privacy concerns while maintaining exact face recognition. The framework's painstaking design and execution strive to strike a compromise between precise face recognition and protecting personal data integrity in an increasingly interconnected environment. Using cutting-edge tools like Dlib for face analysis,Ray Cluster for distributed computing, and Blockchain for decentralized identity verification, the proposed system provides scalable and secure facial analysis while protecting user privacy. The study's contributions include the creation of a sustainable and scalable solution for privacy-aware face recognition, the implementation of flexible privacy computing approaches based on Blockchain networks, and the demonstration of higher performance over previous methods. Specifically, the proposed StyleGAN model has an outstanding accuracy rate of 93.84% while processing high-resolution images from the CelebA-HQ dataset, beating other evaluated models such as Progressive GAN 90.27%, CycleGAN 89.80%, and MGAN 80.80%. With improvements in accuracy, speed, and privacy protection, the framework has great promise for practical use in a variety of fields that need face recognition technology. This study paves the way for future research in privacy-enhanced face recognition systems, emphasizing the significance of using cutting-edge technology to meet rising privacy issues in digital identity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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36. Ateroskleroz Gelişim Sürecinde Kinürenin Yolağının Rolü: Geleneksel Derleme.
- Author
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KARADUMAN, Abdullah Burak and ILGIN, Sinem
- Abstract
Copyright of Journal of Literature Pharmacy Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
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37. Dyslipidaemia management in pregnant patients: a 2024 update.
- Author
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Lewek, Joanna, Bielecka-Dąbrowa, Agata, Toth, Peter P, and Banach, Maciej
- Subjects
PREGNANT women ,BEHAVIOR modification ,DYSLIPIDEMIA ,BILE acids - Abstract
Over several decades, the approach to treating dyslipidaemias during pregnancy remains essentially unchanged. The lack of advancement in this field is mostly related to the fact that we lack clinical trials of pregnant patients both with available as well as new therapies. While there are numerous novel therapies developed for non-pregnant patients, there are still many limitations in dyslipidaemia treatment during pregnancy. Besides pharmacotherapy and careful clinical assessment, the initiation of behavioural modifications as well as pre-conception management is very important. Among the various lipid-lowering medications, bile acid sequestrants are the only ones officially approved for treating dyslipidaemia in pregnancy. Ezetimibe and fenofibrate can be considered if their benefits outweigh potential risks. Statins are still considered contraindicated, primarily due to animal studies and human case reports. However, recent systematic reviews and meta-analyses as well as data on familial hypercholesterolaemia (FH) in pregnant patients have indicated that their use may not be harmful and could even be beneficial in certain selected cases. This is especially relevant for pregnant patients at very high cardiovascular risk, such as those who have already experienced an acute cardiovascular event or have homozygous or severe forms of heterozygous FH. In these cases, the decision to continue therapy during pregnancy should weigh the potential risks of discontinuation. Bempedoic acid, olezarsen, evinacumab, evolocumab and alirocumab, and inclisiran are options to consider just before and after pregnancy is completed. In conclusion, decisions regarding lipid-lowering therapy for pregnant patients should be personalized. Despite the challenges in designing and conducting studies in pregnant women, there is a strong need to establish the safety and efficacy of dyslipidaemia treatment during pregnancy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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38. Leisure-time and occupational physical activity and risk of cardiovascular disease incidence: a systematic-review and dose-response meta-analysis of prospective cohort studies.
- Author
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Kazemi, Asma, Soltani, Sepideh, Aune, Dagfinn, Hosseini, Elham, Mokhtari, Zeinab, Hassanzadeh, Zahra, Jayedi, Ahmad, Pitanga, Francisco, and Akhlaghi, Masoumeh
- Subjects
CARDIOVASCULAR disease treatment ,CARDIOVASCULAR disease prevention ,CORONARY heart disease risk factors ,ATRIAL fibrillation risk factors ,STATISTICAL models ,CARDIOVASCULAR diseases ,RUNNING ,CARDIOVASCULAR diseases risk factors ,META-analysis ,EXERCISE intensity ,SYSTEMATIC reviews ,DOSE-response relationship in biochemistry ,MEDLINE ,LONGITUDINAL method ,LEISURE ,RESEARCH bias ,ONLINE information services ,HEALTH outcome assessment ,OXYGEN consumption ,CONFIDENCE intervals ,STROKE ,PHYSICAL activity ,DISEASE risk factors - Abstract
Background and objective: Physical activity has benefits for the cardiovascular system, however, what levels and types of activity provide optimal cardiovascular health is unclear. We aimed to determine the level of physical activity that has the most benefits against cardiovascular diseases (CVD). Methods: PubMed, Scopus, and Web of Science were searched for prospective cohort studies on leisure-time (LTPA) or occupational physical activity (OPA) as the exposure and major types of CVD (total CVD, coronary heart disease [CHD], stroke, and atrial fibrillation [AF]) incidence as the outcome. Risk of bias of studies was evaluated using the ROBINS-I tool. Summary hazard ratios (HR) were calculated using random-effects pairwise model. Results: A total of 103 studies were included in the analysis. The highest versus the lowest LTPA was associated with a lower risk of overall CVD (HR = 0.81; 95% CI: 0.77–0.86), CHD (HR = 0.83; 0.79–0.88), and stroke (HR = 0.83; 0.79–0.88), but not AF (HR = 0.98; 0.92–1.05). Linear dose-response analyses showed a 10%, 12%, 9%, and 8% risk reduction in CVD, CHD, stroke, and AF incidence, respectively, for every 20 MET-hours/week increase in LTPA. In nonlinear dose-response analyses, there were inverse associations up to 20 MET-hours/week with 19% and 20% reduction in CVD and CHD risk, and up to 25 MET-hours/week with 22% reduction in stroke, with no further risk reduction at higher LTPA levels. For AF, there was a U-shaped nonlinear association with the maximum 8% risk reduction at 10 MET-hours/week of LTPA. Higher levels of OPA were not associated with risk of CVD, CHD, stroke, or AF. Conclusions: Overall, results showed an inverse dose-response relationship between LTPA and risk of CVD, CHD, stroke, and AF. Running was the most beneficial LTPA but the risk was similar among various LTPA intensities. OPA showed no benefits in total or any type of CVD. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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39. Nutritional value of clariid catfish in the conditions of aquaculture in Ukraine.
- Author
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Bal, Іvan
- Subjects
CATFISHES ,AQUACULTURE ,FATTY acids ,ATOMIC absorption spectroscopy - Abstract
The nutritional value of raw materials is determined by a set of indicators that define the biological value of protein, lipids, mineral composition, and safety. Therefore, their investigation in the meat of one of Ukraine's aquaculture species - the clariid catfish - is relevant. The purpose of the study was to investigate the biological value of protein, lipids, mineral composition, and safety of catfish meat when grown in Ukraine and evaluate these indicators in accordance with the recommendations of FAO/WHO. The amino acid composition of the protein was determined by ion exchange liquid-column chromatography on an automatic analyser T 339 (Czech Republic); the fatty acid composition of lipids was determined on a gas chromatograph HRGC 5300 ("Carlo Erba", Italy). The mineral composition of meat was investigated by atomic emission spectrometry with inductively coupled plasma; the content of heavy metals was determined by atomic absorption spectrometry. The study of the amino acid composition of the protein established the presence of all essential amino acids in an amount significantly exceeded in the ideal protein in accordance with FAO/WHO recommendations, which indicates a high biological value. The fatty acid composition of lipids is typical for freshwater fish and catfish lipids from other aquacultures. The biological value of catfish lipids is determined by the ratio of fatty acids of the ω-6/ω-3 families as 1.8:1.0 at the recommended value of 10:5, which indicates the possibility of using lipids of this fish as a source of especially deficient ω-3 fatty acids in the human diet. The low level of polyunsaturated fatty acids and the absence of essential fatty acids eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids gives the basis for developing the design of biologically valuable catfish meat products by enriching it with lipids from marine aquatic organisms. The practical significance of the findings is to obtain original data on the nutritional value of meat from one of the aquaculture species in Ukraine, determine the degree of satisfaction of the daily human need for its consumption, and develop recommendations for rational use. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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40. Measles in paediatric patients in Poland - a 3-year retrospective single-centre study.
- Author
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Stępień, Maciej, Cholewik, Martyna, Eksmond, Magdalena, Piotrowska, Agata, Sokołowska, Małgorzata, Bieńkowski, Carlo, and Pokorska-Śpiewak, Maria
- Subjects
MEASLES complications ,MEASLES prevention ,RISK factors of pneumonia ,OTITIS media ,ANTIBIOTICS ,ERYTHEMA ,ACUTE diseases ,VISION disorders ,MEASLES ,SCIENTIFIC observation ,CHILDREN'S hospitals ,AGE distribution ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,FEVER ,HEPATOMEGALY ,MEDICAL records ,ACQUISITION of data ,MEASLES vaccines ,LYMPHATIC diseases ,SPLEEN diseases ,VACCINATION status ,DISEASE risk factors ,SYMPTOMS - Abstract
Introduction: Measles is a highly contagious viral disease. In recent years, there has been an alarming increase in measles cases in Europe. Most patients were not vaccinated. The aim of this study was to analyse the clinical manifestation of measles in paediatric patients, considering the differences between infants and older children. Material and methods: This was a retrospective observational study, for which data were collected from the medical records of paediatric patients hospitalised due to measles January 2017 - December 2019. Stratification was based on age. In the younger group (infants), children under 13 months of age were included. Results: In total 84 children were enrolled in the study, including 26 infants (30.95%) and 58 older children (69.5%). In 67/84 (79.76%) participants no history of measles vaccination was reported. Among those not vaccinated, there were 28/67 (41.79%) children too young for vaccination. Fever and erythema occurred in all patients. The disease was complicated by pneumonia in 39/84 (46.43%) and acute otitis media in 19/84 (22.62%) children. Antibiotics were administered in 45/84 (69.05%) cases, of which 10/58 (17.24%) had 2 or more. The infants had significantly less frequent photophobia (p = 0.041693), lymphadenopathy (p = 0.005229), hepatomegaly (p = 0.030619), and splenomegaly (p = 0.019469), Instead, they were significantly more likely to have acute otitis media (p = 0.020141). Conclusions: Measles is a serious disease that most commonly affects unvaccinated children. The most common symptoms include fever and rash. Otitis media and pneumonia were the most common measles complications. The variations in symptoms and complications of measles differ significantly between infants and older children. [ABSTRACT FROM AUTHOR]
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- 2024
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41. Comparative Discrimination of Life’s Simple 7 and Life’s Essential 8 to Stratify Cardiovascular Risk: Is the Added Complexity Worth It?
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Howard, George, Cushman, Mary, Blair, Jessica, Wilson, Nicole R., Ya Yuan, Safford, Monika M., Levitan, Emily B., Judd, Suzanne E., and Howard, Virginia J.
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- 2024
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42. Association of Achievement of the American Heart Association's Life's Essential 8 Goals With Incident Cardiovascular Diseases in the SHFS.
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Paing, Pyone Yadanar, Littman, Alyson J., Reese, Jessica A., Sitlani, Colleen M., Umans, Jason G., Cole, Shelley A., Ying Zhang, Ali, Tauqeer, and Fretts, Amanda M.
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- 2024
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43. Emotional Eating and Cardiovascular Risk Factors in the Police Force: The Carolina Blue Project.
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Wu, Ya-Ke, Pacchioni, Tany G., Gehi, Anil K., Fitzgerald, Katherine E., and Tailor, Divya V.
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- 2024
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44. Management of cardiac emergencies in women: a clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), the European Association of Percutaneous Cardiovascular Interventions (EAPCI), the Heart Failure Association (HFA), and the European Heart Rhythm Association (EHRA) of the ESC, and the ESC Working Group on Cardiovascular Pharmacotherapy
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Sambola, Antonia, Halvorsen, Sigrun, Adlam, David, Hassager, Christian, Price, Susanna, Rosano, Giuseppe, Schiele, Francois, Holmvang, Lene, de Riva, Marta, Rakisheva, Amina, Sulzgruber, Patrick, and Swahn, Eva
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HEART failure ,EMERGENCY management ,PERIPARTUM cardiomyopathy ,MYOCARDIAL infarction ,ACUTE coronary syndrome ,EVIDENCE gaps ,CARDIAC arrest - Abstract
Cardiac emergencies in women, such as acute coronary syndromes, acute heart failure, and cardiac arrest, are associated with a high risk of adverse outcomes and mortality. Although women historically have been significantly underrepresented in clinical studies of these diseases, the guideline-recommended treatment for these emergencies is generally the same for both sexes. Still, women are less likely to receive evidence-based treatment compared to men. Furthermore, specific diseases affecting predominantly or exclusively women, such as spontaneous coronary dissection, myocardial infarction with non-obstructive coronary arteries, takotsubo cardiomyopathy, and peripartum cardiomyopathy, require specialized attention in terms of both diagnosis and management. In this clinical consensus statement, we summarize current knowledge on therapeutic management of these emergencies in women. Key statements and specific quality indicators are suggested to achieve equal and specific care for both sexes. Finally, we discuss several gaps in evidence and encourage further studies designed and powered with adequate attention for sex-specific analysis. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Photodynamic Therapy and Cardiovascular Diseases.
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Oskroba, Aleksander, Bartusik-Aebisher, Dorota, Myśliwiec, Angelika, Dynarowicz, Klaudia, Cieślar, Grzegorz, Kawczyk-Krupka, Aleksandra, and Aebisher, David
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PHOTODYNAMIC therapy ,CARDIOVASCULAR diseases ,MYOCARDIAL infarction ,THERAPEUTICS ,DISEASE management - Abstract
Cardiovascular diseases are the third most common cause of death in the world. The most common are heart attacks and stroke. Cardiovascular diseases are a global problem monitored by many centers, including the World Health Organization (WHO). Atherosclerosis is one aspect that significantly influences the development and management of cardiovascular diseases. Photodynamic therapy (PDT) is one of the therapeutic methods used for various types of inflammatory, cancerous and non-cancer diseases. Currently, it is not practiced very often in the field of cardiology. It is most often practiced and tested experimentally under in vitro experimental conditions. In clinical practice, the use of PDT is still rare. The aim of this review was to characterize the effectiveness of PDT in the treatment of cardiovascular diseases. Additionally, the most frequently used photosensitizers in cardiology are summarized. [ABSTRACT FROM AUTHOR]
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- 2024
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46. Association between the trajectory of ideal cardiovascular health metrics and incident chronic kidney disease among 27,635 older adults in northern China–a prospective cohort study.
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Bai, Pufei, Shao, Xian, Ning, Xiaoqun, Jiang, Xi, Liu, Hongyan, Lin, Yao, Hou, Fang, Zhang, Yourui, Zhou, Saijun, and Yu, Pei
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CHRONIC kidney failure ,OLDER people ,COHORT analysis ,LIKELIHOOD ratio tests ,LONGITUDINAL method - Abstract
Background: There is a lack of relevant studies evaluating the long-term impact of cardiovascular health factor (CVH) metrics on chronic kidney disease (CKD). Objective: This study investigates the long-term change in CVH metrics in older people and explores the relationship between CVH metrics trajectory and CKD. Methods: In total, 27,635 older people aged over 60 from the community-based Tianjin Chronic Kidney Disease Cohort study were enrolled. The participants completed five annual physical examinations between January 01, 2014, and December 31, 2018, and a subsequent follow-up between January 01, 2019, and December 31, 2021. CVH metrics trajectories were established by the group-based trajectory model to predict CKD risk. The relationships between baseline CVH, CVH change (ΔCVH), and CKD risk were also explored by logistic regression and restricted cubic spline regression model. In addition, likelihood ratio tests were used to compare the goodness of fit of the different models. Results: Six distinct CVH metrics trajectories were identified among the participants: low-stable (11.19%), low-medium-stable (30.58%), medium-stable (30.54%), medium-high-decreased (5.46%), medium-high-stable (18.93%), and high-stable (3.25%). After adjustment for potential confounders, higher CVH metrics trajectory was associated with decreased risk of CKD (P for trend < 0.001). Comparing the high-stable with the low-stable group, the risk of CKD decreased by 46%. All sensitivity analyses, including adjusting for baseline CVH and removing each CVH component from the total CVH, produced consistent results. Furthermore, the likelihood ratio test revealed that the model established by the CVH trajectory fit better than the baseline CVH and Δ CVH. Conclusion: The higher CVH metrics trajectory and improvement of CVH metrics were associated with decreased risk of CKD. This study emphasized the importance of improving CVH to achieve primary prevention of CKD in older people. [ABSTRACT FROM AUTHOR]
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- 2024
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47. Physical activity and odds of coronary heart disease among Lebanese women.
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Ghaddar, Fatima, Zeidan, Rouba K, Salameh, Pascale, and Maupas-Schwalm, Françoise
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Background: It is known that physical activity (PA) is protective against cardiovascular morbidity and mortality. However, few studies have examined the association between PA, sedentary lifestyle and coronary heart disease (CHD) in women. This case–control study investigates the relationship between PA and sedentary behavior on CHD odds in Lebanese women over forty. Methods: One thousand five hundred selected Lebanese women (300 cases and 1200 controls) were included between 2018–2019. Cases were hospitalized women newly diagnosed with CHD, whereas the control groups were free of any heart diseases. Data on socio-demographic, lifestyle, cardiovascular factors, PA and sedentary lifestyle were collected. Multivariate logistic regressions, adjusted for covariates, were performed to investigate the association of PA domains and sedentary behavior with CHD. Results: A sedentary lifestyle combined with low activity levels increased the odds of CHD. Among cases, 46.7% participated in moderate or vigorous PA against almost 60.3% of controls. 36.3% of coronary patients had more than 10 h/day of sedentary time, with a positive correlation with CHD (adjusted OR: 1.533, 95%CI: 1.046–2.247). Conversely, moderate and high levels (respectively 600–3000 and ≥ 3000 metabolic equivalents [MET]-minutes/week) of domestic/garden PA revealed lower CHD odds (OR: 0.566, 95%CI: 0.396–0.808 and 0.193, 0.065–0.578 respectively). The detrimental influence of sedentary lifestyle appeared to be significantly reversed by weekly moderate PA, especially as weekly sedentary time was less (OR: 0.616, 95%CI: 0.427–0.888/ 6 to10h of sedentary time and OR: 0.537, 95% CI: 0.37–0.779/ ≤ 6 h), and except sedentary time exceeding 10 h daily. Two PA patterns revealed lower CHD odds: transport-related and domestic/garden PA, as early as low amount, even after adjustment for possible confounders. Conclusion: The current study highlights the importance of combating sedentary behaviors and engaging in regular, easily accessible PA to reduce the odds of coronary disease among aging women. Therefore, better information regarding the benefits of physical activities such as transportation-related activities or gardening would be helpful in enhancing the prevention of CHD in aging women. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Xanthorrhizol: Its bioactivities and health benefits.
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Simamora, Adelina, Timotius, Kris Herawan, Setiawan, Heri, Yerer, Mukerrem Betul, Ningrum, Ratih Asmana, and Mun'im, Abdul
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- 2024
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49. Coatings for Cardiovascular Stents—An Up-to-Date Review.
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Udriște, Alexandru Scafa, Burdușel, Alexandra Cristina, Niculescu, Adelina-Gabriela, Rădulescu, Marius, and Grumezescu, Alexandru Mihai
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NONMETALLIC materials ,ALLOYS ,CARDIOVASCULAR development ,ENDOTHELIAL cells ,DRUG coatings ,SURFACE coatings - Abstract
Cardiovascular diseases (CVDs) increasingly burden health systems and patients worldwide, necessitating the improved awareness of current treatment possibilities and the development of more efficient therapeutic strategies. When plaque deposits narrow the arteries, the standard of care implies the insertion of a stent at the lesion site. The most promising development in cardiovascular stents has been the release of medications from these stents. However, the use of drug-eluting stents (DESs) is still challenged by in-stent restenosis occurrence. DESs' long-term clinical success depends on several parameters, including the degradability of the polymers, drug release profiles, stent platforms, coating polymers, and the metals and their alloys that are employed as metal frames in the stents. Thus, it is critical to investigate new approaches to optimize the most suitable DESs to solve problems with the inflammatory response, delayed endothelialization, and sub-acute stent thrombosis. As certain advancements have been reported in the literature, this review aims to present the latest updates in the coatings field for cardiovascular stents. Specifically, there are described various organic (e.g., synthetic and natural polymer-based coatings, stents coated directly with drugs, and coatings containing endothelial cells) and inorganic (e.g., metallic and nonmetallic materials) stent coating options, aiming to create an updated framework that would serve as an inception point for future research. [ABSTRACT FROM AUTHOR]
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- 2024
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50. Association of parathyroid hormone with risk of hypertension and type 2 diabetes: a dose-response meta-analysis.
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Feng, Mingming, Xu, Mengqi, Wang, Qing, Xia, Shicui, Yu, Cheng, Li, Min, and Liu, Yafeng
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TYPE 2 diabetes ,PARATHYROID hormone ,HYPERTENSION - Abstract
Background: Despite an increase in parathyroid hormone (PTH) has been reported to be associated with a higher risk of hypertension and type 2 diabetes (T2D), the comprehensive evaluation of the dose-response relationship between PTH and hypertension and T2D remains ambiguous. Therefore, a dose-response meta-analysis was performed to quantitatively investigate this association. Methods: PubMed, Web of Science, and Embase were systematically searched up to May 2023. Random-effect models were used to estimate the summary odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were used to model the dose-response association. Results: Ten articles (including 13 studies) were identified, with a total of 11,878 cases and 51,234 participants in the meta-analysis. Of these studies, eight (five cohort and three cross-sectional) studies investigated the association of PTH with hypertension; five (two cohort and three cross-sectional) studies assessed the association of PTH with T2D. The results showed a positive relationship between PTH and the risk of hypertension (OR,1.24, 95% CI: 1.16–1.33). We found a linear association between PTH and hypertension (P
non−linearity = 0.222). In the dose-response analysis, the risk of hypertension increased 5% for every 10 pg/ml increase in PTH (OR,1.05, 95% CI: 1.02–1.08). The pooled OR of T2D risk for a 10 pg/ml increase in PTH was 1.00 (95% CI: 0.98–1.02). Conclusions: Elevated PTH is associated with an increased risk of hypertension. However, the evidence of the association between PTH and T2D is limited, and more well-designed studies need to be explored. [ABSTRACT FROM AUTHOR]- Published
- 2024
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