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The need to identify ammonia is necessary because of its harmful effects on the environment and humans. In this study, a colorimetric method was also developed for the detection of ammonia using silver nanoparticles (AgNPs) synthesized with the green approach. Biosynthesis of AgNPs was performed by silver nitrate as a silver precursor and Smyrnium cordifolium extract as a reducing and stabilizing agent. Plant extract was studied by FTIR and LC/Mass techniques. The optimization of the effective parameters was carried out with central composite design according to silver nitrate concentration, plant extract volume, pH, and temperature. Biosynthetic nano-silver was characterized with XRD, EDS/EDX, FE-SEM, FTIR, TGA, and DLS methods. The AgNPs was validated for ammonia colorimetric detection. Biosynthesis of AgNPs were increased in 20 mM AgNO 3 , 5 ml Smyrnium cordifolium extract, pH 10, and the temperature of 70 °C. Crystal form of AgNPs characterized with XRD at 2Ѳ value of 38.34°, 44.19°, 64.74°, and 77.59° and spherical shape highlighted in the range between 77.8 and 93 nm. Plant extract consisted of polyphenol (phenolic acid, flavonoid, and terpenoid), fatty acid, amino acid, sugar, purine, and organic acid. AgNPs were used for colorimetric detection of ammonia by shifting the λmax from 580 to 490 nm. A method for ammonia detection was set up, with linear range of 0.5-200 ppm, detection limit of 0.028 ppm and recovery level of 96.3 ± 6.5%. In conclusion, a new biosynthetic method by specified local plant was developed to propose a simple and sensitive colorimetric method for soluble ammonia detection., (© 2024. The Author(s).)

Background: Given the importance of achieving optimal therapeutical concentration in patients treated with antidepressants, this study investigates a novel technique for the simultaneous determination of trazodone (TRZ) and doxepin (DOX) in human plasma and serum samples for the first time., Results: To achieve simultaneous determination of two antidepressants, TRZ and DOX, a novel detection system was designed: a non-enzymatic voltammetric biosensor based on boron-reduced graphene oxide/manganese oxide nanoparticles (GCE/B-rGO/MnO NPs). The detection was accomplished after pre-concentration and extraction trace amounts of the analytes using the thin film-solid phase microextraction (TF-SPME) technique, which employed polyvinyl alcohol/polyvinyl acetate/copper oxide nanoparticles (PVA/PVAc/CuO NPs) electrospun nanofibers. The successful preparation of composite nanofibers and modified electrodes was confirmed using the evaluation of field emission-scanning electron microscopy (FE-SEM) and energy-dispersive X-ray spectroscopy (EDX). Also, the composite nanofibers were characterized with attenuated total reflectance-Fourier transform-infrared (ATR-FT-IR) and X-ray diffraction (XRD). In the solution of TRZ and DOX, under optimum experimental conditions, the linear dynamic ranges (LDRs) were 0.1-20.0 μmol L -1 and 0.5-27.0 μmol L -1 , respectively. Also, the limit of detection (LOD) values of TRZ and DOX were 0.032 and 0.150 μmol L -1 ., Significance: PVAc acts as a cross-linking agent for PVA, and their mixture is effective for sample preparation and pre-concentration of analytes in complex matrices. Also, adding CuO NPs to this polymeric mixture enhanced the adsorption efficiency. Taking advantage of the high surface area of MnO NPs and the high electrical conductivity of B-rGO, and considering the superiority of their simultaneous utilization, the constructed electrochemical biosensor is both cost-effective and rapid. It demonstrates excellent stability, repeatability, and sensitivity for the simultaneous determination of TRZ and DOX under optimal conditions. This biosensor, the first of its kind, is specifically designed for the simultaneous determination of TRZ and DOX in human plasma and serum samples, representing a significant advancement in biosensing technology., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Today, the wide utilization of triazole fungicides due to environmental damage and its side effects has raised global concern. Thus, in this investigation, polyacrylonitrile/MnCo-layered double hydroxides nanofiber was synthesized and applied as an effective and novel adsorbent at thin-film solid-phase micro-extraction technique for the quick and concurrent extraction of five triazole fungicides in fruit and vegetable samples before quantitative analysis by high-performance liquid chromatography-ultraviolet. The incorporation of MnCo-layered double hydroxides with porous structure and abundant functional groups in a polymer medium improves the extraction efficiency of nanofibers owing to hydrogen bonding and π-π interactions formed between analytes and synthesized nano-adsorbent. Various important elements that affect the extraction efficiency of the intended analytes were optimized using a time-variable approach. Under the optimum conditions, the limit of detection and quantification range from 0.1 to 0.15 and 0.3-0.5 ng mL -1 , respectively., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Today, the wide use of triazole fungicides due to environmental damage and its side effects has raised global concern. Hence, in this research, poly-vinyl alcohol/polyacrylic-acid/CoFe-PBA@GO electrospun nanofiber was synthesized and applied as effective, degradable, and novel adsorbent at pipette-tip microextraction (PT-μSPE) method for the rapid and concurrent extraction of five of triazole fungicides in fruit and vegetable samples prior to quantitative analysis by high-performance liquid chromatography-ultraviolet. The incorporation of CoFe-PBA@GO with superporous structure and abundant functional groups in a polymer medium improves the extraction efficiency of nanofibers due to hydrogen bonding and π-π interactions formed between analytes and synthesized nano-adsorbent. Various important elements that affect the extraction yield of the target analytes were optimized utilizing a time-variable approach. Under the optimum conditions, dynamic range was attained in the range of 0.3-900.0 ng/mL with correlation coefficients ≥ 0.999. The identification limit of the PT-μSPE-HPLC-UV method ranged from 0.1 to 0.3 ng/mL., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

This study introduces an innovative needle trap device (NTD) featuring a molecularly imprinted polymer (MIP) surface-modified Zeolite Y. The developed NTD was integrated with gas chromatography-flame ionization detector (GC-FID) and employed for analysis of fuel ether oxygenates (methyl tert‑butyl ether, MTBE, ethyl tert‑butyl ether, ETBE, and tert‑butyl formate, TBF) in urine samples. To optimize the key experimental variables including extraction temperature, extraction time, salt concentration, and stirring speed, a central composite design-response surface methodology (CCD-RSM) was employed. The optimal values for extraction in the study were found to be 51.2 °C extraction temperature, 46.2 min extraction time, 27 % salt concentration, and 620 rpm stirring speed. Under the optimized conditions, the calibration curves demonstrated excellent linearity within the range of 0.1-100 μg L -1 , with correlation coefficients (R 2 ) exceeding 0.99. The limits of detection (LODs) for MTBE, ETBE, and TBF were obtained 0.06, 0.08, and 0.09 μg L -1 , respectively. Moreover, the limits of quantification (LOQs) for MTBE, ETBE, and TBF were obtained 0.18, 0.24, and 0.27 μg L -1 , respectively. The enrichment factor was also found to be in the range of 98-129.The NTD-GC-FID procedure demonstrated a high extraction efficiency, making it a promising tool for urinary biomonitoring of fuel ether oxygenates with improved sensitivity and selectivity compared to current methods., Competing Interests: Declaration of competing interest The authors affirm that they do not have any known conflicts of interest or personal relationships that could have potentially affected the findings presented in this paper., (Copyright © 2024. Published by Elsevier B.V.)

The study was performed in two phases. First, the polymerization was carried out upon three magnetized surfaces of silica aerogel, zeolite Y, and MIL-101(Cr). Then, optimal molecularly imprinted polymer and optimal extraction conditions were determined by the central composite design-response surface method. Subsequently, the validation parameters of dispersive solid-phase extraction based optimal molecularly imprinted polymer were examined for the extraction of the fuel ether oxygenates. The optimal conditions include the type of adsorbent: Zeolite-magnetic molecularly imprinted polymer, the amount of adsorbent: 40 mg, pH: 7.7, and absorption time: 24.8 min which was selected with desirability equal to 0.996. The calibration graphs were linear between 1 and 100 μg L -1 , with good correlation coefficients. The limits of detection were found to be 0.64, 0. 4, and 0.34 μg L -1 for methyl tert-butyl ether, ethyl tert-butyl ether, and tert butyl formate, respectively. The method proved reliable for analyzing fuel ether oxygenates in drinking water., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: Although NSAIDs possess notable therapeutic and pharmaceutical qualities, it's essential to acknowledge that excessive doses can result in toxicity within the human body. Moreover, the importance lies in identifying and measuring their trace amounts. Due to their existence within intricate matrices, the creation of novel electrospun nanofibers as sorbents for electrically-assisted solidphase microextraction (EA-SPME) becomes vital. This innovation caters to the requirement for the effective pre-treatment of NSAID samples, providing a strategic approach to managing the complexities associated with trace quantities found in various matrices., Results: First, polyvinylalcohol/casein/tannic acid/polyaniline/titanium dioxide nanoparticles (PVA/CAS/TA/PANI/TiO 2 NPs) electrospun nanofibers were prepared for EA-SPME on pewter rode and then, trace amounts of six NSAIDs (Acetaminophen, Caffeine, Naproxen, Celecoxib, Ibuprofen and mefenamic acid) were adsorbed chemically on these nanofibers. In the next step, the desorption of six NSAIDs was electrochemically done from prepared electrospun nanofibers on a pewter rod which was as working electrode at three electrodes system. Finally, these drugs were quantified from different human plasma samples with HPLC-UV. The synthesis of electrospun nanofibers was confirmed through a series of analytical techniques including field emission-scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy with elemental mapping analysis (EDX-Mapping), X-ray diffraction (XRD), and Fourier transform-infrared (FT-IR). The optimal percentage of additive compounds to PVA/CAS for electrospinning, as well as the factors influencing adsorption and desorption processes, were determined through both of Design Expert software and MATLAB programming language., Significance: Under optimum conditions, the wide linear range was 27-8000 ng mL -1 with R 2 ≥ 0.9897, low detection limits were ranged from 8 to 27.3 ng mL -1 based on S/N = 3 and significant enrichment factors were acquired. The intra-day and inter-day RSDs% were obtained within the 4.51% - 5.68% and 4.28%-5.45%, respectively. Finally, The effectiveness of the EA-SPME-HPLC-UV method was assessed for determining NSAIDs in plasma samples, demonstrating good recoveries ranging from 90.2% to 105.2%., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Today, the widespread use of opioid and analgesic drugs (OAs) has caused global concern due to their addictive properties and side effects. Therefore, in this study, polyvinyl alcohol (PVA)/poly acrylic acid (PAA)/MOF NiCoZn-LDH@graphene oxide (GO) electrospun nanofiber was synthesized and employed as an effective and novel sorbent at thin-film microextraction (TF-μSPE) method for the fast and simultaneous extraction of seven opioid and analgesic drugs in human biological fluids (plasma, urine) before performing quantitative analysis by high-pressure liquid chromatography (HPLC-UV) device. This new nano-absorbent was characterized by energy dispersive X-ray spectrometer (EDX), X-ray photoelectron spectroscope (XPS), Fourier transforms infrared spectrometer (FT-IR), field emission scanning electron microscopy (FE-SEM), X-ray diffraction analysis (XRD), and nitrogen absorption-desorption analysis (BET). The combination of MOF NiCoZn-LDH@GO with a highly porous structure and rich functional groups in the PVA/PAA substrate casing significantly improves the absorption properties of the nanofibers. In other words, the existence, of MOF NiCoZn-LDH@GO composite in the polymer network PVA/PAA causes an increase in the extraction efficiency of the electrospinning adsorbent due to the creation of hydrogen bonds and π-π interactions with the intended analytes. Various effective factors in the extraction efficiency of the desired analytes were optimized using a one-variable-at-a-time method. Under the optimum conditions, the linearity dynamic range was achieved in the range of 0.3-1000.0 for caffeine, naloxone, noscapine, and celecoxib, and 0.5-1000.0 μg L -1 for tramadol, codeine, and hydrocodone with correlation coefficients ≥0.999. The lowest detection limit (LODs) and the lowest quantitative limit (LOQs) of the TF-μSPE method were obtained in the range of (0.1-0.15) and (0.3-0.5), respectively., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Background: Here, it has been discussed about creating a specific and sustainable analytical technique for monitoring anti-diabetic drugs in order to accurately determine the dosage in patients and reduce side effects, remove them from wastewater (as emerging contaminants), and ultimately abate pharmaceutical pollutants in the environment., Results: In this research, a green and reproducible Quick Easy Cheap Effective Rugged Safe (QuEChERS) method based on syringe filter based micro-solid phase extraction (SF-μSPE) coupled with HPLC-UV using a green sorbent was developed and optimized for the extraction of five anti-diabetic drugs from wastewater, serum, and plasma real samples. A novel green sorbent composed of a liquid mixture of thymol: menthol ([Thy]:[Men], 1:1) hydrophobic natural deep eutectic solvent (HNADES) and curcumin (Cur) immobilized into the non-toxic and biodegradable polyvinyl alcohol (PVA) electrospun nanofibers' mat was synthesized simply via cheap equipment. Cur was added to enhance the hydrophobicity and functionality of the sorbent. The immobilization process was performed by soaking the mat in the liquid mixture for a specific duration. The correct synthesis and experimental molar ratio of the HNADES components were confirmed by ATR-FTIR and NMR ( 1 H and 13 C) spectroscopy. The prepared green sorbent (Cur-HNADES/PVA) was characterized using ATR-FTIR, FE-SEM, EDX/EDX mapping analysis, and water contact angle (WCA) measurement, and it exhibited satisfactory adsorption capacity for the target analytes., Significance: Under optimal conditions (pH = 6.0, adsorption cycle = 3, sample volume = 5.0 mL, desorption cycle = 1, type and volume of elution = 80:20 %v/v MeOH/ACN and 500.0 μL), the method was validated in terms of specificity, linear dynamic ranges (LDRs = 0.1-2000.0 μg L -1 and 0.1-1800.0 μg L -1 ), limits of detection (LODs = 0.03-0.09 μg L -1 ), and precision (within-day RSDs% = 0.32-1.45% and between-day RSDs% = 0.59-2.03%). Evaluation of the greenness aspects of the proposed method was accomplished using the Green Analytical Procedure Index (GAPI) and Analytical GREEnness (AGREE) approaches. It is noteworthy that the conducted research represents the first report of the synthesis and application of this novel and green sorbent for the determination of anti-diabetic drugs in the mentioned real samples., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Herein, a composite of polyacrylonitrile (PAN)/agar/silver nanoparticles (AgNPs) electrospun nanofibers was fabricated and applied as an efficient sorbent for thin-film micro-extraction (TFME) of five metal ions followed by inductively coupled plasma optical emission spectroscopy (ICP-OES). Incorporating agar into the nanofibers followed by in situ photo-reductive reaction under UV-lamp resulted in highly uniform dispersion of AgNPs in the nanofibers. Under the optimized conditions, agreeable linearity was acquired in the range of 0.5-250.0 ng mL -1 (R 2  ≥ 0.9985). The LODs (based on S/N = 3) were attained in the range of 0.2 to 0.5 ng mL -1 . The relative standard deviations (RSDs) were between 4.5% and 5.6% (intra-day, n = 5) and 5.3%-5.9% (inter-day, n = 3) for three sequential days. The developed method was investigated with water and rice samples, and recoveries (93.9-98.0%) indicated that the PAN/agar/AgNPs could be a promising film for the adsorption of heavy metal ions in varied samples., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Today, antidepressants are widely used and it is important to determine their trace amounts due to harmful consequences. Here, a new nano sorbent was reported for the simultaneous extraction and determination of three types of antidepressant drugs (Clomipramine (CLO), Clozapine (CLZ), and Trimipramine (TRP) by the thin-film solid-phase micro-extraction (TFME-μSPE) method followed by the Gas Chromatography-flame ionization detector (GC-FID) analysis. So, the compound poly (vinyl alcohol) (PVA)/citric acid(CA)/β-cyclodextrin/Bi 2 S 3 @g-C 3 N 4 nano sorbent was constructed by electrospinning technique. Then, nano sorbent was studied to optimize the many parameters impacting the extraction performance. Electrospun nanofiber has a large surface area, high porosity, and homogeneous morphology with a uniform bead-free structure. In optimal conditions, the limits of detection and quantification were calculated to be 0.15-0.03 ng mL -1 and 0.5-0.1 ng mL -1 , respectively. The dynamic linear range (DLR) was in the range of 0.1 to 1000 ng mL -1 for CLO and CLZ, and 0.5 to 1000 ng mL -1 for TRP with correlation coefficients (R 2 ) of 0.999. The relative standard deviations (RSDs) were achieved in the range of 4.9-6.8% (intra-day, n = 4) and 5.4-7.9% (inter-day, n = 3) in the period of 3 days. Finally, the capability of the method was evaluated to simultaneously measure trace amounts of antidepressants aqueous sample with desirable extraction efficiency (78 to 95%)., Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests., (Copyright © 2023. Published by Elsevier B.V.)

Composite nanofibers, namely, polyvinyl alcohol (PVA), citric acid (CA), β-cyclodextrin (β-CD), and copper oxide nanoparticles (PVA/CA/β-cyclodextrin/CuO NPs), were developed as a novel, green, and efficient adsorbent in the pipette tip-micro-solid-phase extraction method (PT-µSPE), for the simultaneous extraction of three antidepressants drugs namely imipramine (IMP), citalopram (CIT), and clozapine (CLZ) in biological fluids before quantification by gas chromatography (GC-FID). Based on the obtained results from field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD), the successful synthesis of composite nanofibers was approved. Due to the presence of β-cyclodextrins and CuO NPs rich of functional groups on their surface, the nanofibers have high extraction efficiency. Under the optimal conditions, the linear range for imipramine, citalopram, and clozapine was 0.1 to 1000.0 ng mL -1 with a determination coefficient ≥ 0.99. The limits of detection (LODs) were in the range 0.03 to 0.15 ng mL -1 . The relative standard deviation was 4.8 to 8.7% (within-day, n = 4) and 5.1 to 9.2% (between-day, n = 3) for 3 consecutive days. In addition, excellent clean-up was achieved which is a great advantage over other sample preparation methods. Finally, the ability of the developed method to extract the target analytes from the biological samples was evaluated., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)

Herein, the composite of polylactic acid (PLA)/ Iron-based metal-organic framework (r-MIL-88A)/ Cellulose electrospun nanofibers was fabricated; and then, applied as a novel sorbent for thin-film micro-extraction (TFME) of four selected pesticides followed by GC-FID analysis. From the evaluation of scanning electron microscopy, Fourier transform infrared spectroscopy energy dispersive X-ray spectroscopy and X-ray diffraction, the successful fabrication of composite nanaofibers was approved. The presence of r-MIL-88A/Cellulose with large surface area and plenty of OH-functional groups results in improving PLA extraction efficiency. The effect of various main parameters on extraction efficiency was evaluated. The LODs (based on S/N = 3) were in the range of 1.0 to 1.5 ng mL -1 . Intra-day and inter-day relative standard deviations (RSDs) were in the range of 4.8% - 5.6% and 5.2%-6.4%, respectively. In addition, the fiber to fiber relative standard deviations were observed in the range of 5.2%-12.3%. By using the optimized factors, acceptable linearity ranges were obtained in the range of 3.0-1900.0 ng mL -1 for metribuzin and ethofumasate, and 5.0-2000.0 for atrazine and ametryn (R 2  = 0.9913-0.9967). The developed method was investigated in fruit juice, vegetables, milk and honey samples, and recoveries (79.3-95.6%) indicate that the PLA/r-MIL-88A/Cellulose can be a prominent composite film for the extraction of the target analytes in various samples., Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests., (Copyright © 2022. Published by Elsevier B.V.)

Herein, an electrospun composite from poly(vinyl alcohol) (PVA) and Stevia extract as a cross-linked nanofibrous was prepared with incorporating Fe-metal organic framework@Au nanoparticles (MIL-88A@AuNPs). The final composite was characterized, and then used as an efficient sorbent in pipette-tip micro solid-phase extraction (PT-µSPE) of eight selected pesticides in food samples followed by HPLC-UV analysis. Under the opted conditions, the linearity was in the range of 1.0-1000.0 ng mL -1 for atrazine and ametryn, 3.0-1500.0 ng mL -1 for tribenuron-methyl, metribuzin, profenofos and chlorpyrifos, 5.0 to 1500.0 ng mL -1 for phosalone, and 5.0-2000.0 ng mL -1 for malation with coefficient of determination (r 2 ) ≥ 0.9943. The LODs (based on S/N = 3) ranged from 0.3 to 1.5 ng m L -1 . The relative standard deviations (RSDs) were between 5.2% and 6.6% (intra-day, n = 5) and 5.9%-7.4% (inter-day, n = 3) for three consecutive days. Ultimately, the capability of the method in various food samples was appraised with good recoveries (79.3 to 97.6%)., (Copyright © 2022. Published by Elsevier Ltd.)