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21 results on '"Endo, Motoyoshi"'

4. Caspase-4 has a role in cell division in epithelial cells through actin depolymerization

Author

Sumida, Kazuhiro, primary, Doi, Tomomitsu, additional, Obayashi, Kunie, additional, Chiba, Yosuke, additional, Nagasaka, Shohei, additional, Ogino, Noriyoshi, additional, Miyagawa, Koichiro, additional, Baba, Ryoko, additional, Morimoto, Hiroyuki, additional, Hara, Hideki, additional, Terabayashi, Takeshi, additional, Ishizaki, Toshimasa, additional, Harada, Masaru, additional, and Endo, Motoyoshi, additional

Published
2023
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5. Caspase-4 promotes both metastasis and interferon-γ-induced cell death in non-small cell lung cancer

Author

Endo, Motoyoshi, primary, Chiba, Yosuke, additional, Doi, Tomomitsu, additional, Obayashi, Kunie, additional, Sumida, Kazuhiro, additional, Nagasaka, Shohei, additional, Wang, Ke-Yong, additional, Yamasaki, Kei, additional, Masago, Katsuhiro, additional, Matsushita, Hirokazu, additional, Kuroda, Hiroaki, additional, and Yatera, Kazuhiro, additional

Published
2023
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6. Loss of Dja2 accompanies pH deviation in lysosomes and lysosome‐related organelles.

Author

Terada, Kazutoyo, Endo, Motoyoshi, Kiyonari, Hiroshi, Takeda, Naoki, and Oike, Yuichi

Subjects
*ORGANELLES, *ALVEOLAR macrophages, *PROTEIN C, *LYSOSOMES, *MECONIUM aspiration syndrome, *GLYCOLIPIDS, *AMILORIDE
Abstract

The Dja2 knockout (Dja2−/−) mice had respiratory distress, and >60% died within 2 days after birth. The surviving adult Dja2−/− mice were infertile and the lungs of Dja2−/− mice showed several abnormalities, including the processing defect of prosurfactant protein C in the alveolar epithelial type II cells and the accumulation of glycolipids in enlarged alveolar macrophages. The luminal pH of acidic organelles in Dja2−/− cells was shifted to pH 5.37–5.45. This deviated pH was immediately restored to control levels (pH 4.56–4.65) by the addition of a diuretic, ethyl isopropyl amiloride (EIPA). Although the role of DJA2 in maintaining the pH homeostasis of lysosome‐related organelles is currently obscure, this rapid and remarkable pH resilience is best explained by an EIPA‐sensitive proton efflux machinery that is disorganized and overactivated due to the loss of Dja2. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Supplementary Figure Legend from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Ogata, Aki, primary, Horiguchi, Haruki, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Fukushima, Satoshi, primary, Jinnin, Masatoshi, primary, Hirakawa, Satoshi, primary, Sawa, Tomohiro, primary, Akaike, Takaaki, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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9. Data from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Ogata, Aki, primary, Horiguchi, Haruki, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Fukushima, Satoshi, primary, Jinnin, Masatoshi, primary, Hirakawa, Satoshi, primary, Sawa, Tomohiro, primary, Akaike, Takaaki, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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10. Supplementary Figures 1 - 9 from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Ogata, Aki, primary, Horiguchi, Haruki, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Fukushima, Satoshi, primary, Jinnin, Masatoshi, primary, Hirakawa, Satoshi, primary, Sawa, Tomohiro, primary, Akaike, Takaaki, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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11. Data from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Nakano, Masahiro, primary, Horiguchi, Haruki, primary, Ogata, Aki, primary, Odagiri, Haruki, primary, Yano, Masato, primary, Araki, Kimi, primary, Jinnin, Masatoshi, primary, Ito, Takaaki, primary, Hirakawa, Satoshi, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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12. Data from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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13. Supplementary Video 3 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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14. Supplementary Video 2 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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15. Supplementary Figures 1-19, Methods from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

Author

Aoi, Jun, primary, Endo, Motoyoshi, primary, Kadomatsu, Tsuyoshi, primary, Miyata, Keishi, primary, Nakano, Masahiro, primary, Horiguchi, Haruki, primary, Ogata, Aki, primary, Odagiri, Haruki, primary, Yano, Masato, primary, Araki, Kimi, primary, Jinnin, Masatoshi, primary, Ito, Takaaki, primary, Hirakawa, Satoshi, primary, Ihn, Hironobu, primary, and Oike, Yuichi, primary

Published
2023
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16. Supplementary Video 4 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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17. Supplementary Methods, Figures 1-18, Movie Legends 1-4, Tables 1-4 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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18. Supplementary Video 1 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis

Author

Endo, Motoyoshi, primary, Nakano, Masahiro, primary, Kadomatsu, Tsuyoshi, primary, Fukuhara, Shigetomo, primary, Kuroda, Hiroaki, primary, Mikami, Shuji, primary, Hato, Tai, primary, Aoi, Jun, primary, Horiguchi, Haruki, primary, Miyata, Keishi, primary, Odagiri, Haruki, primary, Masuda, Tetsuro, primary, Harada, Masahiko, primary, Horio, Hirotoshi, primary, Hishima, Tsunekazu, primary, Nomori, Hiroaki, primary, Ito, Takaaki, primary, Yamamoto, Yutaka, primary, Minami, Takashi, primary, Okada, Seiji, primary, Takahashi, Takashi, primary, Mochizuki, Naoki, primary, Iwase, Hirotaka, primary, and Oike, Yuichi, primary

Published
2023
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20. Plasma Angiopoietin-Like Protein 2 Levels and Mortality Risk Among Younger-Old Japanese People: A Population-Based Case–Cohort Study

Author

Zhao, Wenjing, primary, Morinaga, Jun, additional, Ukawa, Shigekazu, additional, Endo, Motoyoshi, additional, Yamada, Hiroya, additional, Kawamura, Takashi, additional, Wakai, Kenji, additional, Tsushita, Kazuyo, additional, Ando, Masahiko, additional, Suzuki, Koji, additional, Oike, Yuichi, additional, and Tamakoshi, Akiko, additional

Published
2022
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21. A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells.

Author

Hikasa H, Kawahara K, Inui M, Yasuki Y, Yamashita K, Otsubo K, Kitajima S, Nishio M, Arima K, Endo M, Taira M, and Suzuki A

Abstract

The activation of yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ) has been implicated in both regeneration and tumorigenesis, thus representing a double-edged sword in tissue homeostasis. However, how the activity of YAP1/TAZ is regulated or what leads to its dysregulation in these processes remains unknown. To explore the upstream stimuli modulating the cellular activity of YAP1/TAZ, we developed a highly sensitive YAP1/TAZ/TEAD-responsive DNA element (YRE) and incorporated it into a lentivirus-based reporter cell system to allow for sensitive and specific monitoring of the endogenous activity of YAP1/TAZ in terms of luciferase activity in vitro and Venus fluorescence in vivo. Furthermore, by replacing YRE with TCF- and NF-κB-binding DNA elements, we demonstrated the applicability of this reporter system to other pathways such as Wnt/β-catenin/TCF- and IL-1β/NF-κB-mediated signaling, respectively. The practicality of this system was evaluated by performing cell-based reporter screening of a chemical compound library consisting of 364 known inhibitors, using reporter-introduced cells capable of quantifying YAP1/TAZ- and β-catenin-mediated transcription activities, which led to the identification of multiple inhibitors, including previously known as well as novel modulators of these signaling pathways. We further confirmed that novel YAP1/TAZ modulators, such as potassium ionophores, Janus kinase inhibitors, platelet-derived growth factor receptor inhibitors, and genotoxic stress inducers, alter the protein level or phosphorylation of endogenous YAP1/TAZ and the expression of their target genes. Thus, this reporter system provides a powerful tool to monitor endogenous signaling activities of interest (even in living cells) and search for modulators in various cellular contexts., (© 2024 The Author(s). Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.)

Published
2024
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