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Your search keyword '"Engele, Leo J."' showing total 7 results
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7 results on '"Engele, Leo J."'

1. Clinical Course of TGA After Arterial Switch Operation in the Current Era

Author

Engele, Leo J., van der Palen, Roel L.F., Joosen, Renée S., Sieswerda, Gertjan T., Schoof, Paul H., van Melle, Joost P., Berger, Rolf M.F., Accord, Ryan E., Rammeloo, Lukas A.J., Konings, Thelma C., Helbing, Wim A., Roos-Hesselink, Jolien W., van de Woestijne, Pieter C., Frerich, Stefan, van Dijk, Arie P.J., Kuipers, Irene M., Hazekamp, Mark G.H., Mulder, Barbara J.M., Breur, Johannes M.P.J., Blom, Nico, Jongbloed, Monique R.M., and Bouma, Berto J.

Published
2024
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4. Clinical Course of TGA After Arterial Switch Operation in the Current Era

Author

Cardiologie onderzoek 1, Cardiologie, Team Medisch, Circulatory Health, Cardiopulmonale Chirurgie pat. zorg, Child Health, Regenerative Medicine and Stem Cells, Engele, Leo J., van der Palen, Roel L.F., Joosen, Renée S., Sieswerda, Gertjan T., Schoof, Paul H., van Melle, Joost P., Berger, Rolf M.F., Accord, Ryan E., Rammeloo, Lukas A.J., Konings, Thelma C., Helbing, Wim A., Roos-Hesselink, Jolien W., van de Woestijne, Pieter C., Frerich, Stefan, van Dijk, Arie P.J., Kuipers, Irene M., Hazekamp, Mark G.H., Mulder, Barbara J.M., Breur, Johannes M.P.J., Blom, Nico, Jongbloed, Monique R.M., Bouma, Berto J., Cardiologie onderzoek 1, Cardiologie, Team Medisch, Circulatory Health, Cardiopulmonale Chirurgie pat. zorg, Child Health, Regenerative Medicine and Stem Cells, Engele, Leo J., van der Palen, Roel L.F., Joosen, Renée S., Sieswerda, Gertjan T., Schoof, Paul H., van Melle, Joost P., Berger, Rolf M.F., Accord, Ryan E., Rammeloo, Lukas A.J., Konings, Thelma C., Helbing, Wim A., Roos-Hesselink, Jolien W., van de Woestijne, Pieter C., Frerich, Stefan, van Dijk, Arie P.J., Kuipers, Irene M., Hazekamp, Mark G.H., Mulder, Barbara J.M., Breur, Johannes M.P.J., Blom, Nico, Jongbloed, Monique R.M., and Bouma, Berto J.

Published
2024

5. Decreased clinical performance in TGA-ASO patients after RVOT interventions; a multicenter European collaboration

Author

Engele, Leo J., González-Fernández, Víctor, Mulder, Barbara J.M., Ruperti-Repilado, Francisco Javier, Abia, Raquel Ladrón, van der Vlist, Kim, Buendía, Francisco, Rueda, Joaquin, Gabriel, Harald, Schrutka, Lore, Bouchardy, Judith, Schwerzmann, Markus, Possner, Mathias, Greutmann, Matthias, Gallego, Pastora, Ladouceur, Magalie, Jongbloed, Monique R.M., Tobler, Daniel, Dos, Laura, and Bouma, Berto J.

Published
2024
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6. Cardiac Fibrosis and Innervation State in Uncorrected and Corrected Transposition of the Great Arteries: A Postmortem Histological Analysis and Systematic Review

Author

Engele, Leo J., primary, van der Palen, Roel L. F., additional, Egorova, Anastasia D., additional, Bartelings, Margot M., additional, Wisse, Lambertus J., additional, Glashan, Claire A., additional, Kiès, Philippine, additional, Vliegen, Hubert W., additional, Hazekamp, Mark G., additional, Mulder, Barbara J. M., additional, Ruiter, Marco C. De, additional, Bouma, Berto J., additional, and Jongbloed, Monique R. M., additional

Published
2023
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7. Clinical Course of TGA After Arterial Switch Operation in the Current Era.

Author

Engele LJ, van der Palen RLF, Joosen RS, Sieswerda GT, Schoof PH, van Melle JP, Berger RMF, Accord RE, Rammeloo LAJ, Konings TC, Helbing WA, Roos-Hesselink JW, van de Woestijne PC, Frerich S, van Dijk APJ, Kuipers IM, Hazekamp MGH, Mulder BJM, Breur JMPJ, Blom N, Jongbloed MRM, and Bouma BJ

Abstract

Background: The number of patients with an arterial switch operation (ASO) for transposition of the great arteries (TGA) is steadily growing; limited information is available regarding the clinical course in the current era., Objectives: The purpose was to describe clinical outcome late after ASO in a national cohort, including survival, rates of (re-)interventions, and clinical events., Methods: A total of 1,061 TGA-ASO patients (median age 10.7 years [IQR: 2.0-18.2 years]) from a nationwide prospective registry with a median follow-up of 8.0 years (IQR: 5.4-8.8 years) were included. Using an analysis with age as the primary time scale, cumulative incidence of survival, (re)interventions, and clinical events were determined., Results: At the age of 35 years, late survival was 93% (95% CI: 88%-98%). The cumulative re-intervention rate at the right ventricular outflow tract and pulmonary branches was 36% (95% CI: 31%-41%). Other cumulative re-intervention rates at 35 years were on the left ventricular outflow tract (neo-aortic root and valve) 16% (95% CI: 10%-22%), aortic arch 9% (95% CI: 5%-13%), and coronary arteries 3% (95% CI: 1%-6%). Furthermore, 11% (95% CI: 6%-16%) of the patients required electrophysiological interventions. Clinical events, including heart failure, endocarditis, and myocardial infarction occurred in 8% (95% CI: 5%-11%). Independent risk factors for any (re-)intervention were TGA morphological subtype (Taussig-Bing double outlet right ventricle [HR: 4.9, 95% CI: 2.9-8.1]) and previous pulmonary artery banding (HR: 1.6, 95% CI: 1.0-2.2)., Conclusions: TGA-ASO patients have an excellent survival. However, their clinical course is characterized by an ongoing need for (re-)interventions, especially on the right ventricular outflow tract and the left ventricular outflow tract indicating a strict lifelong surveillance, also in adulthood., Competing Interests: Support was received from the Netherlands Cardiovascular Research lnitiative: An initiative with support of the Dutch Heart Foundation and Hartekind, CVON2019-002 OUTREACH. The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (© 2024 The Authors.)

Published
2023
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