Search

Your search keyword '"Eoghan P. McGrath"' showing total 1 results
Start Over Author "Eoghan P. McGrath" Publication Year Range Last 3 years
1 results on '"Eoghan P. McGrath"'

1. Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

Author

Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, and Afshin Samali

Subjects
Science
Abstract

IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lipid metabolism in cancer cells.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results