1. Site-directed placement of three-dimensional DNA origami.
- Author
-
Martynenko IV, Erber E, Ruider V, Dass M, Posnjak G, Yin X, Altpeter P, and Liedl T
- Subjects
- Nanotechnology methods, Gold chemistry, DNA chemistry, Silicon Dioxide chemistry, Nucleic Acid Conformation, Metal Nanoparticles chemistry, Nanostructures chemistry
- Abstract
The combination of lithographic methods with two-dimensional DNA origami self-assembly has led, among others, to the development of photonic crystal cavity arrays and the exploration of sensing nanoarrays where molecular devices are patterned on the sub-micrometre scale. Here we extend this concept to the third dimension by mounting three-dimensional DNA origami onto nanopatterned substrates, followed by silicification to provide hybrid DNA-silica structures exhibiting mechanical and chemical stability and achieving feature sizes in the sub-10-nm regime. Our versatile and scalable method relying on self-assembly at ambient temperatures offers the potential to three-dimensionally position any inorganic and organic components compatible with DNA origami nanoarchitecture, demonstrated here with gold nanoparticles. This way of nanotexturing could provide a route for the low-cost production of complex and three-dimensionally patterned surfaces and integrated devices designed on the molecular level and reaching macroscopic dimensions., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
- Published
- 2023
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