1. Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study.
- Author
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Nygaard U, Petersen A, Larsen AR, Rytter MJH, Hartling U, Kirkby N, Hansen RN, Nielsen AB, Lundstrøm K, Holm M, and Vissing NH
- Subjects
- Adolescent, COVID-19 virology, Child, Child, Preschool, Coinfection, Comorbidity, Denmark epidemiology, Female, Humans, Infant, Male, Methicillin-Resistant Staphylococcus aureus genetics, Methicillin-Resistant Staphylococcus aureus metabolism, Public Health Surveillance, Severity of Illness Index, Staphylococcal Infections diagnosis, Staphylococcal Infections therapy, Staphylococcus aureus drug effects, Staphylococcus aureus metabolism, Bacteremia, Bacterial Toxins biosynthesis, COVID-19 complications, Exotoxins biosynthesis, Leukocidins biosynthesis, SARS-CoV-2, Staphylococcal Infections etiology, Staphylococcal Infections mortality, Staphylococcus aureus genetics
- Abstract
We reviewed all cases of Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) bacteremia in Danish children between 2016 and 2021. We found 2 fatal cases with preceding viral prodrome due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the usual benign course of SARS-CoV-2 infection in children, awareness of possible superinfection with PVL-SA in a child with rapid deterioration is crucial to ensure adequate treatment, including antimicrobial drugs with antitoxin effect., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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