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Your search keyword '"Füzik, Tibor"' showing total 13 results
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13 results on '"Füzik, Tibor"'

7. Structure and replication cycle of a virus infecting climate-modulating alga Emiliania huxleyi

Author

Homola, Miroslav, primary, Büttner, Carina R., additional, Füzik, Tibor, additional, Křepelka, Pavel, additional, Holbová, Radka, additional, Nováček, Jiří, additional, Chaillet, Marten L., additional, Žák, Jakub, additional, Grybchuk, Danyil, additional, Förster, Friedrich, additional, Wilson, William H., additional, Schroeder, Declan C., additional, and Plevka, Pavel, additional

Published
2024
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8. Structure and replication cycle of a virus infecting climate-modulating alga Emiliania huxleyi

Author

Structural Biochemistry, Sub Structural Biochemistry, Homola, Miroslav, Büttner, Carina R., Füzik, Tibor, Křepelka, Pavel, Holbová, Radka, Nováček, Jiří, Chaillet, Marten L., Žák, Jakub, Grybchuk, Danyil, Förster, Friedrich, Wilson, William H., Schroeder, Declan C., Plevka, Pavel, Structural Biochemistry, Sub Structural Biochemistry, Homola, Miroslav, Büttner, Carina R., Füzik, Tibor, Křepelka, Pavel, Holbová, Radka, Nováček, Jiří, Chaillet, Marten L., Žák, Jakub, Grybchuk, Danyil, Förster, Friedrich, Wilson, William H., Schroeder, Declan C., and Plevka, Pavel

Published
2024

9. The structure of immature tick-borne encephalitis virus supports the collapse model of flavivirus maturation.

Author

Anastasina, Maria, Füzik, Tibor, Domanska, Aušra, Pulkkinen, Lauri Ilmari Aurelius, Šmerdová, Lenka, Formanová, Petra Pokorná, Straková, Petra, Nováček, Jiří, Růžek, Daniel, Plevka, Pavel, and Butcher, Sarah Jane

Subjects
*TICK-borne encephalitis viruses, *FLAVIVIRUSES, *ATOMIC models
Abstract

We present structures of three immature tick-borne encephalitis virus (TBEV) isolates. Our atomic models of the major viral components, the E and prM proteins, indicate that the pr domains of prM have a critical role in holding the heterohexameric prM3E3 spikes in a metastable conformation. Destabilization of the prM furin-sensitive loop at acidic pH facilitates its processing. The prM topology and domain assignment in TBEV is similar to the mosquito-borne Binjari virus, but is in contrast to other immature flavivirus models. These results support that prM cleavage, the collapse of E protein ectodomains onto the virion surface, the large movement of the membrane domains of both E and M, and the release of the pr fragment from the particle render the virus mature and infectious. Our work favors the collapse model of flavivirus maturation warranting further studies of immature flaviviruses to determine the sequence of events and mechanistic details driving flavivirus maturation. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Structure and replication cycle of a virus infecting climate-modulating algaEmiliania huxleyi

Author

Sub Structural Biochemistry, Structural Biochemistry, Homola, Miroslav, Büttner, Carina R., Füzik, Tibor, Křepelka, Pavel, Holbová, Radka, Nováček, Jiří, Chaillet, Marten, Förster, Friedrich, Wilson, William H., Schroeder, Declan C., Plevka, Pavel, Sub Structural Biochemistry, Structural Biochemistry, Homola, Miroslav, Büttner, Carina R., Füzik, Tibor, Křepelka, Pavel, Holbová, Radka, Nováček, Jiří, Chaillet, Marten, Förster, Friedrich, Wilson, William H., Schroeder, Declan C., and Plevka, Pavel

Published
2023

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