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Objective To compare the efficacy of olopatadine hydrochloride and desloratadine citrate disodium for the treatment of chronic urticaria. Methods A total of 184 patients with chronic urticaria were enrolled at the department of dermatology of Kaifeng People's Hospital from October 2020 to January 2024, and were randomly assigned into the study group (92 cases, olopatadine hydrochloride) and the controls (92 cases, desloratadine citrate disodium). Following one-month treatment, the clinical effective rate, symptom score, dermatology life quality index (DLQI) score and urticaria control test (UCT) score before and after the treatment, and adverse reactions were evaluated in both groups. Results After 1-month treatment, the total clinical effective rates were significantly higher in the study group than in the controls (95.65% vs. 86.96%, χ2=4.38, P=0.036). Moreover, the number and size of skin lesion, and itching severity were markedly lower in the study group (1.02±0.16 vs. 1.13±0.24 for lesion number; 0.88±0.18 vs. 0.96±0.13 for lesion size, and 0.88±0.21 vs. 0.97±0.25 for itching severity, P

Relatively high volumetric shrinkage induced by polymerization of photopolymer severely limits its applications in high-density holographic storage. In this paper, what we believe to be a novel organic-inorganic hybrid nanoparticles (NPs) of octaphenyl-polyhedral Oligomeric silsesquioxane (POSS) are employed into polyvinyl alcohol (PVA)/acrylamide photopolymer with 300µm thickness. By optimizing the concentration of octaphenyl-POSS, the volumetric shrinkage is successfully suppressed from 1.11% to 0.41%, and satisfies the requirements of commercial holographic data storage (HDS) material. Moreover, the introduction of POSS NPs does not sacrifice other holographic recording capacities. Contrarily, the diffraction efficiency of photopolymer after dispersing 2‰(w/v) POSS increases from 86% to 90%. The physical mechanism of enhanced capacities is discussed by using photopolymerization and NPs diffusion process. To our knowledge, this is the best results of PVA/acrylamide photopolymer with low volumetric shrinkage, high diffraction efficiency and angular selectivity. The POSS-dispersed photopolymer system is expected to have good application prospects in angular-multiplexing high-density 3-D holographic storage.