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4 results on '"Feijen, E. A. M. Lieke"'

1. Treatments affecting splenic function as a risk factor for valvular heart disease in Childhood Cancer Survivors: A DCCSS‐LATER study.

Author

Houtman, Bente M., Walraven, Iris, Kapusta, Livia, Teske, Arco J., van Dulmen‐den Broeder, Eline, Tissing, Wim J. E., van den Heuvel‐Eibrink, Marry M., Versluys, A. B. Birgitta, Bresters, Dorine, van der Heiden‐van der Loo, Margriet, Ronckers, Cécile, Kok, Wouter E. M., van der Pal, Helena J. H., Pluijm, Saskia M. F., Janssens, Geert O., Blijlevens, Nicole M. A., Kremer, Leontien C. M., Loonen, Jacqueline J., and Feijen, E. A. M. Lieke

Published
2024
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2. Treatments affecting splenic function as a risk factor for valvular heart disease in Childhood Cancer Survivors:A DCCSS-LATER study

Author

Houtman, Bente M., Walraven, Iris, Kapusta, Livia, Teske, Arco J., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., van den Heuvel-Eibrink, Marry M., Versluys, A. B. Birgitta, Bresters, Dorine, van der Heiden-vander Loo, Margriet, Ronckers, Cecile, Kok, Wouter E. M., van der Pal, Helena J. H., Pluijm, Saskia M. F., Janssens, Geert O., Blijlevens, Nicole M. A., Kremer, Leontien C. M., Loonen, Jacqueline J., Feijen, E. A. M. Lieke, Houtman, Bente M., Walraven, Iris, Kapusta, Livia, Teske, Arco J., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., van den Heuvel-Eibrink, Marry M., Versluys, A. B. Birgitta, Bresters, Dorine, van der Heiden-vander Loo, Margriet, Ronckers, Cecile, Kok, Wouter E. M., van der Pal, Helena J. H., Pluijm, Saskia M. F., Janssens, Geert O., Blijlevens, Nicole M. A., Kremer, Leontien C. M., Loonen, Jacqueline J., and Feijen, E. A. M. Lieke

Abstract

PurposeSplenectomy might be a risk factor for valvular heart disease (VHD) in adult Hodgkin lymphoma survivors. As this risk is still unclear for childhood cancer survivors (CCS), the aim of this study is to evaluate the association between treatments affecting splenic function (splenectomy and radiotherapy involving the spleen) and VHD in CCS.MethodsCCS were enrolled from the DCCSS-LATER cohort, consisting of 6,165 five-year CCS diagnosed between 1963 and 2002. Symptomatic VHD, defined as symptoms combined with a diagnostic test indicating VHD, was assessed from questionnaires and validated using medical records. Differences in the cumulative incidence of VHD between CCS who received treatments affecting splenic function and CCS who did not were assessed using the Gray test. Risk factors were analyzed in a multivariable Cox proportional hazards model.ResultsThe study population consisted of 5,286 CCS, with a median follow-up of 22 years (5-50 years), of whom 59 (1.1%) had a splenectomy and 489 (9.2%) radiotherapy involving the spleen. VHD was present in 21 CCS (0.4%). The cumulative incidence of VHD at the age of 40 years was significantly higher in CCS who received treatments affecting splenic function (2.7%, 95% confidence interval (CI) 0.4%-4.9%) compared with CCS without (0.4%, 95% CI 0.1%-0.7%) (Gray's test, p = 0.003). Splenectomy was significantly associated with VHD in a multivariable analysis (hazard ratio 8.6, 95% CI 3.1-24.1).Conclusions and implicationsSplenectomy was associated with VHD. Future research is needed to determine if CCS who had a splenectomy as part of cancer treatment might benefit from screening for VHD.

Published
2024

3. Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study.

Author

Maas A, Maurice-Stam H, Feijen EAML, Teepen JC, van der Aa-van Delden AM, Streefkerk N, van Dulmen-den Broeder E, Tissing WJE, Loonen JJ, van der Pal HJH, de Vries ACH, van den Heuvel-Eibrink MM, Ronckers C, Neggers S, Bresters D, Louwerens M, Versluys BAB, van der Heiden-van der Loo M, Kremer LCM, and Grootenhuis M

Subjects
Humans, Female, Male, Adult, Adolescent, Child, Surveys and Questionnaires, Risk Factors, Netherlands, Young Adult, Depression psychology, Stress Disorders, Post-Traumatic psychology, Anxiety psychology, Middle Aged, Cancer Survivors psychology, Self Concept, Social Support, Protective Factors, Neoplasms psychology, Quality of Life psychology, Psychosocial Functioning
Abstract

Objective: This study examines the association between psychosocial risk and protective factors and a wide range of psychosocial outcomes including emotional, social, cognitive, and physical domains in childhood cancer survivors (CCS)., Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963-2001) part 2 (age ≥ 18 years, diagnosed < 18 years, ≥ 5 years since diagnosis) completed questionnaires on psychosocial risk and protective factors (Benefit and Burden Scale, Illness Cognition Questionnaire, Rosenberg Self-Esteem Scale, and Impact of Cancer Scale), and psychosocial outcomes (Hospital Anxiety and Depression Scale, Self-Rating Scale for Post-Traumatic Stress Disorder, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and Short Form-36). Associations were assessed with regression analysis, adjusting for attained age, sex, number of health conditions, and time since diagnosis, while correcting for multiple testing (p < 0.004)., Results: A total of 1382 CCS participated, all diagnosed ≥ 15 years ago. The mean age of participating CCS was 36 years, and 51% were female. Perceived benefit and burden, acceptance, and helplessness, self-esteem and social support were associated with the psychosocial outcomes. In the models including all psychosocial factors, most associations with psychosocial outcomes were seen for self-esteem (10×), and perceived burden (9×). Self-esteem (all β ≤ 0.47) and perceived burden (all β ≤ 0.38) demonstrated strongest associations of medium/large size., Conclusions: Perceptions of childhood cancer, illness cognitions, self-esteem, and social support play a role in explaining psychosocial functioning in CCS, outweighing the influence of socio-demographic and medical variables. Addressing negative perceptions and reducing feelings of helplessness, while promoting acceptance, self-esteem, and social support, could provide intervention targets for CCS who encounter psychosocial challenges., (© 2024 The Author(s). Psycho‐Oncology published by John Wiley & Sons Ltd.)

Published
2024
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