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2. Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study
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Podda, M, Di Martino, M, Pata, F, Nigri, G, Pisanu, A, Di Saverio, S, Pellino, G, Ielpo, B, Null, N, Tolla, A, Abdelkhalek, M, Emile, S, Dinagde, T, Bouzid, C, Mansour, A, Garzali, I, Aregawi, A, Zaghloul, T, Kchaou, A, Awad, S, Souadka, A, Ted, T, Saumtally, M, Ahmed, B, Bayileyegn, N, Nunziante, M, Shalaby, M, Debena, D, Zena, A, Adewunmi, O, Negasa, T, Bourguiba, M, Feituri, N, Kebede, K, Elfeki, H, Anas, A, Awad, A, Ermias, N, Hailemariam, D, Bejiga, G, Imana, R, Taffese, A, Feleke, T, Elghadban, H, Debela, B, Shiferaw, D, Tadesse, R, Chukwu, I, Mohammed, A, Hassen, K, Obiagwu, N, Tense, T, Taeme, M, Biniam, E, Tesfay, G, Tegegn, A, Teddy, T, Bekana, B, Nidaw, M, Ali, M, Gonfa, K, Kiros, S, Belay, T, Yallew, G, Wassie, C, Ayalew, A, Asfaw, F, Aimal, A, Casas, M, Madrid, F, Diaz-Elizondo, J, Merlo, I, De Campos, T, Schlottmann, F, Gomes, C, Hernández, E, Moncada-Ortega, A, Ramos-De la Medina, A, Vanerio, P, Morales, E, Stringfield, S, Gallardo, C, Fonseca, V, Muriel, M, Cantarino, F, Fichera, A, Rodriguez, A, Salinas, R, Crosbie, G, Menegozzo, C, Avellaneda, N, Briones, C, Varela, C, Lichliter, W, Koppel, D, Lenz, J, Pascual, F, Sibaja-Matamoros, D, Johnson, B, Mercado, O, Tita, A, Mukherjee, I, Lorenzo, I, Rueda, E, Rico, D, Terwes, N, Visag-Castillo, V, Escalante, K, Salvador, A, Pio, L, Rodas, E, Aguilar, J, Neri, I, Barzola, E, Barba, L, Zuchini, A, Acevedo, A, Gachabayov, M, Gonsaga, R, Bonilla, F, Knickerbocker, C, Tsouknidas, I, Salamea, J, Travers, L, Nari, G, Pachajoa, D, Valadez, M, Hale, L, Perez, G, Choudhry, A, Foreman, M, Brito, I, Ciro, M, Newton, C, Souza, H, Davis, D, Ferreira, R, Keller, D, Miguel, G, Singh-Ranger, G, Linares, N, Singares, E, Valdivieso, X, Teran, A, Vargas, L, Valinoti, A, Milne, D, Fleming, A, Quiroga-Garza, A, Espino, E, Bedros, N, Funk, G, Neves, F, Supit, T, Baba, A, Chalkoo, M, Kucuk, G, Sarmiento, R, Galeev, S, Korkoman, M, Yang, W, Medappil, N, Athar, R, Subramaniam, R, Chia, C, Alhazmi, A, Halder, S, Rusli, S, Rashid, A, Gülcü, B, Nagarajan, P, Rida, K, Jamiri, A, Batıkan, O, Khan, H, Mitul, A, Efetov, S, Junior, M, Gulcu, B, Farooqui, M, Mulpuri, V, Bagaria, D, Yusoff, A, Wani, R, Younis, M, Khobragade, K, Marwat, M, Bains, L, Kobe, Y, Koh, P, Tantravahi, U, Mohamad Mohamad, I, Abu-Arish, H, Yildirim, A, Ibrahim, A, Tan, J, Siagian, D, Bhattacharya, N, Chiu, J, Paramasvaran, G, Voon, K, Göktepe, B, Lee, L, Gupta, A, Rasheed, F, Al-Shehari, M, Syed, S, Bhat, P, Erdoğan, E, Roat, R, Nacion, A, Saraiya, S, Afolabi, A, Chai, F, Ghannam, W, Bhattacharya, K, Nl, H, Aloun, A, Bhatti, H, Koneti, A, Klib, M, Qureshi, A, Syn, N, Wani, A, Saeidi, S, Zeb, M, Bandaru, K, Menna, M, Morales-Conde, S, Gessa, E, Sánchez-Cabús, S, Spartalis, E, Antropoli, C, Manigrasso, M, Sica, G, Ercolani, G, Chitul, A, Bacchiocchi, G, Azevedo, J, Karamarkovic, A, Bonavina, L, Piozzi, G, Migueláñez, I, Merlini, D, Major, P, Grimaldi, L, Calu, V, Curro, G, Cotsoglou, C, Baldini, E, Delis, S, Kovacevic, B, Masetti, M, Selvaggi, F, Scabini, S, Reiti, A, Zullo, A, Giuliani, A, Alesina, P, Massey, L, Slesser, A, Neary, P, Sahnan, K, Colucci, G, Brady, R, Mihailescu, A, Adamina, M, Gerogiannis, I, van Ramshorst, G, Paradiso, G, Poto, G, Massaro, D, Nazir, F, Stubbs, B, Tasselli, F, Muñoz-Cruzado, V, Sabia, D, Vannelli, A, Marsella, V, Tomada, E, Giambusso, M, Davies, J, Uzzau, A, Balla, A, Scaringi, S, Lancellotti, F, Douka, E, Argenio, G, Cassese, G, Ammendola, M, Morelli, L, Francone, E, Bala, M, Thambi, P, Iacobone, M, Campisi, A, Tejedor, P, Spoletini, G, Mascherini, M, Belia, F, Idiz, U, Colak, E, Peters, P, Ros, E, Aytac, E, Vilallonga, R, Serrablo, A, Muttillo, E, Di Franco, G, Vanni, G, Isik, A, Sbacco, V, Tropeano, F, Porcellini, I, Butler, R, Fernandez, C, Papadopoulos, A, Salvans, S, Khan, J, Bellver, P, Mc Farlane, S, Apostolou, K, Tur-Martinez, J, Castellano, J, Santoliquido, M, Tallon-Aguilar, L, Celentano, V, Aliyev, V, al-Najami, I, Grama, F, Masior, Ł, Ciesielski, W, Luberto, A, Sparavigna, M, Klimczak, T, Negoi, I, Serradilla-Martín, M, Marinis, A, Cammarat, R, Bellido-luque, J, Manzo, C, Milana, F, Luglio, G, Zarnescu, N, Martínez, I, Olmi, S, Costea, R, Cerdán-Santacruz, C, Gica, N, Rompianesi, G, Gallo, G, Ridolfi, C, Sahid, S, Cc, T, López-Soler, G, Díaz, C, Mccawley, N, Luzzi, A, Abelló, D, Bonito, A, Ntomi, V, Gourgiotis, S, Pazos, N, Toscano, M, Zafra, D, Beisani, M, Oliva, A, Guler, M, Gómez, M, Oddis, L, Montcusí, B, Delgado, A, Lasarte, M, Antonacci, N, Sartori, A, Taylor, J, de Santos Iglesias, F, Mastronardi, M, Gunay, E, Yiu, A, Cano-Valderrama, O, Costantini, G, Digne-Malcolm, H, Petropoulou, T, Horesh, N, Kelly, M, Ahmed, N, Wyroslak-Najs, J, Naik, P, Vigorita, V, Michael, M, Castro, E, Paspala, A, D'Ambrosio, M, Pangeni, A, Dziakova, J, Terés, L, Lorente-Poch, L, Di Carlo, I, Spartalis, M, Moro-Valdezate, D, Davey, M, Turrado-Rodriguez, V, Tryliskyy, Y, Calussi, M, Farré, S, Labat, M, Marafante, C, Takkenberg, M, Brookes, C, Soares, A, Gialamas, E, Caputo, D, Corrons, L, Capitano, S, Charalabopoulos, A, Don, C, Marrano, E, Giuffrida, M, Tomasicchio, G, Bellato, V, Stijns, J, Creavin, B, Schizas, D, Blanco-Antona, F, Kykalos, S, Tartaglia, N, Pelegrina, A, Barranquero, A, Schena, C, Cremona, S, Baili, E, Cianci, P, Di Bella, A, Forcignanò, E, Fabbrizio, T, Salvetti, F, Inama, M, Campagnaro, T, Deerenberg, E, Reccia, I, Rocca, A, Fazio, F, Tampakis, A, Tepelenis, K, Di Meo, G, Konstantoudakis, G, Manatakis, D, Mineccia, M, Delvecchio, A, Faro, C, Rosso, E, Bandyopadhyay, S, Queffurus, M, Marin, J, Corvasce, A, Chillarge, G, Mohammed, M, Reid, R, Gherardi, D, Naeem, A, Pandanaboyana, S, Tayeh, S, Chevallay, M, Sergeant, G, Cuccomarino, S, Salimian, N, Kapsampelis, P, Ferretti, C, Glasbey, J, Harvitkar, R, Iqbal, M, de Oliveira, G, Pérez-Bertólez, S, Bergna, A, Brisinda, G, Rottoli, M, Roscio, F, Pedrazzani, C, Meyer, J, Marino, M, Brasset, C, Daniel, C, Devriendt, S, Soldini, G, Pennisi, D, Richards, C, Fiore, F, Bocchino, A, Au, S, Hernandez-Garcia, M, Frontali, A, Grossi, U, Lolis, E, Miotto, M, Di Filippo, G, Seretis, C, Barberis, A, De Luca, R, Levi Sandri, G, Reitano, E, Mattioli, M, Sciaudone, G, Fuschillo, G, Schiltz, B, Low, J, Bointas, G, Cozza, V, Delaune, V, Vescio, F, Curcio, S, Sevik, H, Santocchi, P, Stecca, T, Balaphas, A, Chessa, A, Leo, C, di Mola, F, Tarallo, M, Martini, F, Lisi, G, Khan, M, Nicolazzi, M, Pinotti, E, Morini, A, Esposito, G, Buonomo, O, Corallino, D, Demir, A, Roesel, R, De Lucia, C, Maruccia, M, Tekin, O, Pavone, G, Pradelle, I, Chrysikos, M, Farrukh, M, Baiocchi, G, Piras, C, Abellán, A, Olivieri, L, Materazzo, M, Carbone, L, Dulskas, A, Mulita, F, Corronca, F, Cappuccio, M, Smerieri, E, Sotiropoulu, M, Violante, T, Moletta, L, Rutegård, M, Brillantino, A, Landaluce-Olavarria, A, Ossola, P, Bono, D, Rosés, H, Perez-Sanchez, L, Sabbatini, S, Scotti, M, Cammarata, R, Ibáñez, N, Marano, A, Palmisano, S, Cascales-Sanchez, P, Mosca, V, Ballester, C, Iordache-Petrescu, M, Pozza, G, Akay, O, Bollino, R, Toti, J, Mascianà, G, Pach, R, Sensi, B, Natalia, S, Coppola, A, Altinel, Y, Brucchi, F, Guitart, M, Salido, A, Tamini, N, Garoufalia, Z, Mifsut, P, Wilkins, A, Navarro-Sánchez, A, Cestaro, G, Conti, L, Carvas, J, Gazia, C, Alonso, P, Spiezio, G, Maggi, G, Juloski, J, Braccio, B, Pañella, C, Freixa, C, Petrakis, G, Folliero, C, De Andrés-Asenjo, B, Iodice, A, Jansson, H, González, T, Ortega, I, Castro, M, Fernicola, A, Aparicio, A, Ortega, N, Chouliaras, C, Tura, M, Sidiropoulou, Z, Gonzalez, A, Augustin, G, Segura-Sampedro, J, Cuk, V, Piccolo, G, Ingallinella, S, Ortenzi, M, Uggeri, F, Carrabetta, S, Tolonen, M, Formisano, G, Manfredelli, S, Perra, T, Esposito, F, Perrone, G, Zacharis, G, Menéndez, J, Bottcher, S, Ioannidis, O, Borges, N, Sousa, X, Colombari, R, Tellez, C, Capolupo, G, Giuliani, G, Mastella, F, González, L, Merlini, I, Ghignone, F, de Sa, T, Mangana, O, Rodriguez-Lopez, M, Alvarez-Gallego, M, Chowdhury, A, Di Lascio, P, Carneros, V, Angrisani, M, Conte, L, Montiel, C, Ascari, F, Dajti, I, Lapolla, P, Sperotto, B, Mazzarella, G, Capuano, M, Lopez, M, Ferrario, L, Bulte, J, López, M, Guerci, C, Marra, A, Belkacem, A, Pérez, R, Panyko, A, Dimitrov, E, Luque, E, Manrique, M, Paranyak, M, Kaur, M, Barugola, G, Farazi-Chongouki, C, Estaire-Gómez, M, del Olmo, J, Nardo, B, Mutlu, A, Rubio, A, Marchegiani, F, Cereda, M, Vinci, D, Komaei, I, Petrucciani, N, Seyfried, S, Krsicka, P, Medas, F, Lesko, D, Murzi, V, Siragusa, L, Guerrero, M, Iranzo, M, Cestino, L, Pasculli, A, Smerieri, N, Benzoni, I, Festa, F, Jordão, D, Licardie, E, Nicolaescu, D, Balassone, V, La Vaccara, V, Romano, F, Adamovich, D, Papatheodorou, P, Maroni, N, Colás-Ruiz, E, Melberga, L, Chimenti, F, Ferrari, D, Arcudi, C, Police, A, De Simone, B, Sánchez-Guillén, L, Parreño-Manchado, F, Rachadell, J, Coletta, D, Saroglu, A, Pattacini, G, Antonelli, A, Anania, M, Litta, F, Lafranceschina, S, Bottari, A, Pavlovic, M, Rojas-Bonet, N, Tampaki, E, Kosir, J, Anelli, F, de las Casas, S, Kucukarslan, R, Pierobon, E, Milanesi, M, Drogouti, M, Sotiropoulou, M, Di Marco, F, Bannone, E, Sliwinski, S, Yildiz, I, Pellicciaro, M, Celotti, A, Malerba, M, Marino, F, Bourmpouteli, E, Bianco, G, Charitaki, E, Pascale, M, Ioannidis, A, Maraska, F, Petagna, L, Turri, G, Vailas, M, Romanzi, A, Pouwels, S, Rosa, F, Clocchiatti, L, Andreuccetti, J, Machairas, N, Frountzas, M, Lasithiotakis, K, Barone, M, Christodoulou, P, Potkonjak, D, Aiolfi, A, de Vries, H, Napetti, S, Castaldi, A, Botelho, P, Marziali, I, Uccelli, M, Pisano, M, Veroux, M, Locci, E, Romano, A, Cero, M, Cicerchia, P, Baldi, C, Russo, I, Tenconi, S, Saliu, F, Bondurri, A, Cardinali, L, Laracca, G, Martín-Pérez, B, Felsenreich, D, Cunha, M, Zerbo, D, Clementi, M, Delogu, D, Iossa, A, Bavikatte, A, Saracoglu, C, Pecorelli, N, Tufo, A, Biloslavo, A, Lianos, G, Carannante, F, Costanzo, A, Montuori, M, Cigognini, M, Silvestro, R, Atici, S, Milito, P, Ferronetti, A, Güngör, M, Di Venere, B, Puccioni, C, De Nobili, G, Selvaggi, L, Farolfi, T, Aeschbacher, P, Olivier, J, Frazzetta, G, Andriola, V, Giordano, A, De Luca, A, Ferrara, F, Casagranda, B, Sammartano, F, Russo, A, Rossi, S, Pacilli, M, Synekidou, E, Tutino, R, Ceresoli, M, De Rosa, M, Di Santo Albini, A, Vincenzi, P, Vellei, S, Benzoni, E, Murillo, G, Izzo, G, Scotto, B, Caruso, R, Colombo, F, D'Acapito, F, Lostoridis, E, Saladino, E, Poillucci, G, Moeckli, B, Manto, O, Kara, Y, Tatar, C, Cioffi, S, Mambrilla, S, Bianchi, V, Scopelliti, M, Agresta, F, Nava, A, Franchi, E, Fransvea, P, Prieto, M, Picardi, B, Rizzuto, A, Panaccio, P, Gussago, S, Marra, E, Addeo, P, Fernández Fernández, J, Gulmez, M, Pisaniello, D, Cannavo, M, López-López, V, Avella, P, Peloso, A, Bellanova, G, Candilio, G, Perotti, B, Granata, R, Florio, G, Ioia, G, Iannone, I, Ammerata, G, Zambon, M, Del Monte, S, Sasia, D, Fortuna, L, Litvin, A, Cannistra, M, De Padua, C, Sánchez, T, Paniagua-Garcia-Señorans, M, Guevara, J, Perfecto, A, Alconchel, F, Campanelli, M, Keci, L, Cricrì, M, Kampouroglou, G, Bagaglini, G, Farrarons, S, Greco, A, Walędziak, M, Serrano-Navidad, M, Van Doorn, B, Schiavo, C, Fabbri, N, Wani, I, Mondi, I, Anestiadou, E, Mendes, B, Verdi, D, Dorovinis, P, Cacciaguerra, A, Caldeira, B, Canonico, G, Dardanov, D, D'Ugo, S, Francis, F, Meneghini, S, Pesce, A, Puglisi, S, Bellini, M, Giordano, M, Fleres, F, Campus, F, Cillara, N, Moggia, E, Ciarleglio, F, Calini, G, Gravante, G, De Carlis, R, Altomare, M, Martines, G, Miggino, M, Marano, L, Stocco, A, Porcu, A, Pham, T, Gervasi, M, Pilia, T, Palomba, G, Picchetto, A, Spampinato, M, Tandoi, F, Piccoli, M, Gall, M, Santos, B, Agastra, E, Koëter, T, Samadov, E, Marsanic, P, Serena, D, Uzunoglu, M, Zanus, G, Braholli, E, Giovine, G, Galiffa, G, Lauricella, S, Lukmonov, S, Leventoglu, S, Chooklin, S, Dudi-Venkata, N, Gauci, C, Podda, Mauro, Di Martino, Marcello, Pata, Francesco, Nigri, Giuseppe, Pisanu, Adolfo, Di Saverio, Salomone, Pellino, Gianluca, Ielpo, Benedetto, null, null, Tolla, Ashenafi Negash, Abdelkhalek, Mohamed, Emile, Sameh, Dinagde, Tesfaye Aga, Bouzid, Chafik, Mansour, Ahmed Mohammed Farid Mahmoud, Garzali, Ibrahim Umar, Aregawi, Alazar Berhe, Zaghloul, Tarek M., Kchaou, Ali, Awad, Selmy S., Souadka, Amine, Ted, Tedla Gebretsadik, Saumtally, Mohammad Saad, Ahmed, Bensaad, Bayileyegn, Nebiyou Simegnew, Nunziante, Marco, Shalaby, Mostafa, Debena, Dawit Gebregiorgis, Zena, Alemayehu Shanko, Adewunmi, Olayinka Lukman, Negasa, Tolera A., Bourguiba, Mohamed Aboulkacem, Feituri, Nura, Kebede, Kirubel Abebe, Elfeki, Hossam, Anas, Abdelhmed, Awad, Ahmed K., Ermias, Nebiyou, Hailemariam, Dagnachew H., Bejiga, Gosa Hundie, Imana, Ruhama Yoseph, Taffese, Abebe, Feleke, Tsega Terefe, Elghadban, Hosam Mohamed, Debela, Bizuneh Sime, Shiferaw, Desta, Tadesse, Robel, Chukwu, Isaac Sunday, Mohammed, Abdullahi Ibrahim, Hassen, Khalid Arebo, Obiagwu, Ndubuisi K., Tense, Tadesse H., Taeme, Mulugeta, Biniam, Ewnte, Tesfay, Goytom Knfe, Tegegn, Ayenachew Getachew, Teddy, Tewodros Abule Bilata, Bekana, Bekana L., Nidaw, Melkamu Kibret, Ali, Mahmoud Ibrahim, Gonfa, Kebebe Bekele, Kiros, Samuel, Belay, Tatek, Yallew, Gebeyaw Mengist, Wassie, Chekol, Ayalew, Alem Mekete, Asfaw, Fitsum Terefe, Aimal, Aimal Khan, Casas, Maria Agustina, Madrid, Fausto A., Diaz-Elizondo, Jose Antonio, Merlo, Ignacio Guillermo, De Campos, Tercio, Schlottmann, Francisco, Gomes, Carlos Augusto, Hernández, Edgard Efrén Lozada, Moncada-Ortega, Augusto, Ramos-De la Medina, Antonio, Vanerio, Patricio, Morales, Emilio J., Stringfield, Sarah Beth, Gallardo, Cristian, Fonseca, Vinicius Cordeiro, Muriel, Maria Emilia, Cantarino, Frederico, Fichera, Alessandro, Rodriguez, Agustin E., Salinas, Roberto Paúl Andrade, Crosbie, Gonzalo Gabriel, Menegozzo, Carlos Augusto Metidieri, Avellaneda, Nicolas, Briones, Cristhian Gonzalo Aspiazu, Varela, Cristopher, Lichliter, Warren E., Varela, Cristopher L., Koppel, Darren, Lenz, Jorge Godoy, Pascual, Franco, Sibaja-Matamoros, Dauber A., Johnson, Benjamin E., Mercado, Octavio Avila, Tita, Agustín, Mukherjee, Indraneil, Lorenzo, Irving, Rueda, Erick, Rico, Douglas, Terwes, Natasha Loria, Visag-Castillo, Victor, Escalante, Karol S., Salvador, Alan Francisco Alfaro, Pio, Luca, Rodas, Edgar B., Aguilar, Juan Carlos Cardozo, Neri, Ignacio, Barzola, Ernesto J., Barba, Leonardo A., Zuchini, Andrés Mendoza, Acevedo, Ana Karen Radilla, Gachabayov, Mahir, Gonsaga, Ricardo Alessandro Teixeira, Bonilla, Fernando, Knickerbocker, Chase Barrett, Tsouknidas, Ioannis, Salamea, Juan C., Travers, Lawrence Albert Salter, Nari, Gustavo Adrian, Pachajoa, Diana Alejandra Pantoja, Valadez, Michel Hernandez, Hale, Lyman Lansing, Perez, Guillermo, Choudhry, Asad, Foreman, Michaael L., Brito, Ismael, Ciro, Mauricio Pedraza, Newton, Carla Joyce, Souza, Hamilton Petry, Davis, Daniel G., Ferreira, Rodrigo Vaz, Keller, Deborah S., Miguel, Gustavo Machain, Singh-Ranger, Gurpreet, Linares, Neiling Massiel Oviedo, Singares, Eduardo Smith, Valdivieso, Xavier HGarcía, Teran, Alfonso Ivan Sanchez, Vargas, Luis Felipe Cabrera, Valinoti, Agustín, Milne, David M., Fleming, Andrew Martin, Quiroga-Garza, Alejandro, Espino, Eduardo Morales, Bedros, Nicole Mary, Funk, Geoffrey A., Neves, Fernanda V. S., Supit, Tommy, Baba, Arshad Ahmed, Chalkoo, Mushtaq A., Kucuk, Gultekin Ozan, Sarmiento, Ray Inocencio, Galeev, Shamil I., Korkoman, Mohammed J., Yang, Wah, Medappil, Noushif, Athar, Rahmatullah, Subramaniam, Ravichandran, Chia, Chi Fung, Alhazmi, Ahmad, Halder, Subhadip, Rusli, Siti Mayuha, Rashid, Arshad, Gülcü, Barış, Nagarajan, Prasanth, Rida, Khaled, Jamiri, Al-Radjid, Batıkan, Oğuzkağan, Khan, Huma Ahmed, Mitul, Ashrarur Rahman, Efetov, Sergey, Junior, Marcelo A. F. Ribeiro, Gulcu, Baris, Farooqui, Marryam Riaz, Mulpuri, Venu Bhargava, Bagaria, Dinesh, Yusoff, Ahmad Ramzi, Wani, Rauf, Younis, Muhammad Umar, Khobragade, Krunal H., Marwat, Muhammad Ibrahim, Bains, Lovenish, Kobe, Yoshiro, Koh, Peng Soon, Tantravahi, Umasankar, Mohamad Mohamad, Ikhwan Sani, Abu-Arish, Hamdoon, Yildirim, Ali Cihat, Ibrahim, Aini Fahriza, Tan, Jih Huei, Siagian, Dumaria Ketty, Bhattacharya, Neela, Chiu, Jennifer H. F., Paramasvaran, Ganendra, Voon, Kelvin, Göktepe, Berk, Lee, Lee Yeong Sing, Gupta, Amit, Rasheed, Faaiz, Al-Shehari, Mohammed, Syed, Syed Muhammad Ali, Bhat, Pawan Singh, Erdoğan, Emre, Roat, Rajesh, Nacion, Aeris Jane D., Saraiya, Swapnil Mukesh, Afolabi, Akinwale Ibrahim, Chai, Feng Yih, Ghannam, Wagih, Bhattacharya, Kaushik, NL, Harish, Aloun, Ali, Bhatti, Hamza Waqar, Koneti, Akshadhar J., Klib, Mohamad, Qureshi, Ahmad Uzair, Syn, Nicholas L., Wani, Ajaz, Saeidi, Sara, Zeb, Muhammad, Bandaru, Kalyan Vijay Kumar, Menna, Maria Paola, Morales-Conde, Salvador, Gessa, Emanuela, Sánchez-Cabús, Santiago, Spartalis, Eleftherios, Antropoli, Carmine, Manigrasso, Michele, Sica, Giuseppe S., Ercolani, Giorgio, Chitul, Andrei, Bacchiocchi, Giulia, Azevedo, José, Karamarkovic, Aleksandar, Bonavina, Luigi, Piozzi, Guglielmo N., Migueláñez, Isabel Pascual, Merlini, David, Major, Piotr, Grimaldi, Luciano, Calu, Valentin, Curro, Giuseppe, Cotsoglou, Christian, Baldini, Edoardo, Delis, Spiros, Kovacevic, Bojan, Masetti, Michele, Selvaggi, Francesco, Scabini, Stefano, Reiti, Andrian, Zullo, Alessia, Giuliani, Antonio, Alesina, Pier Francesco, Massey, Lisa H., Slesser, Alistair A. P., Neary, Peter M., Sahnan, Kapil, Tan, Jessica J., Colucci, Gianluca, Brady, Richard R. W., Mihailescu, Andrei, Adamina, Michel, Gerogiannis, Ioannis, van Ramshorst, Gabrielle, Paradiso, Giulia, Poto, Gianmario Edoardo, Massaro, Daniele, Nazir, Fozia, Stubbs, Benjamin M., Tasselli, Francesco Menegon, Muñoz-Cruzado, Virginia Durán, Sabia, Domenico, Vannelli, Alberto, Marsella, Valentina Enrica, Tomada, Elisa Paoluzzi, Giambusso, Mauro, Davies, Justin, Uzzau, Alessandro, Balla, Andrea, Scaringi, Stefano, Lancellotti, Francesco, Douka, Eleftheria, Argenio, Giulio, Cassese, Gianluca, Ammendola, Michele, Morelli, Luca, Francone, Elisa, Bala, Miklosh, Thambi, Prem, Iacobone, Maurizio, Campisi, Andrea, Tejedor, Patricia, Spoletini, Gabriele, Mascherini, Matteo, Belia, Francesco, Idiz, Ufuk Oguz, Colak, Elif, Peters, Paul Adewunmi, Ros, Emilio Peña, Aytac, Erman, Vilallonga, Ramon, Serrablo, Alejandro, Muttillo, Edoardo Maria, Di Franco, Gregorio, Vanni, Gianluca, Isik, Arda, Sbacco, Valentina, Tropeano, Francesca Paola, Porcellini, Iride, Butler, Rebecca Jayne, Fernandez, Carmen Cagigas, Papadopoulos, Aristeidis, Salvans, Silvia, Khan, Jan Sher, Bellver, Pedro Palazón, Mc Farlane, Sebastian Jeri, Apostolou, Konstantinos, Tur-Martinez, Jaume, Castellano, Javier Rivera, Santoliquido, Matteo, Tallon-Aguilar, Luis, Celentano, Valerio, Aliyev, Vusal, al-Najami, Issam, Grama, Florin A., Masior, Łukasz, Ciesielski, Wojciech J., Luberto, Antonio, Sparavigna, Marco, Klimczak, Tomasz Jerzy, Negoi, Ionut, Serradilla-Martín, Mario, Marinis, Athanasios, Cammarat, Roberto, Bellido-luque, Juan, Manzo, Carlo Alberto, Milana, Flavio, Luglio, Gaetano, Zarnescu, Narcis Octavian, Martínez, Isidro, Olmi, Stefano, Costea, Radu V., Cerdán-Santacruz, Carlos, Gica, Nicolae, Rompianesi, Gianluca, Gallo, Gaetano, Ridolfi, Cristina, Sahid, Saidah, CC, Tommaso, López-Soler, Guillermo, Díaz, Carlos JGómez, Mccawley, Niamh, Luzzi, Andrea Pierre, Abelló, David, Bonito, Alba Correa, Ntomi, Vasileia, Gourgiotis, Stavros, Pazos, Natalia Suárez, Toscano, Marta Jiménez, Zafra, David Ambrona, Beisani, Marc, Oliva, Alba, Guler, Mert, Gómez, Marta Jiménez, Oddis, Lidia, Montcusí, Blanca, Delgado, Ander Timoteo, Lasarte, Mateusz PJęckowski Aingeru Sarriuga, Antonacci, Nicola, Sartori, Alberto, Taylor, John Vincent, de Santos Iglesias, Francisco Juan, Mastronardi, Manuela, Gunay, Emre, Yiu, Andrew, Cano-Valderrama, Oscar, Costantini, Giulia, Digne-Malcolm, Holly Jane, Petropoulou, Thalia, Horesh, Nir, Kelly, Michael E., Ahmed, Nauman, Wyroslak-Najs, Justyna, Naik, Prashant, Vigorita, Vincenzo, Michael, Michael, Castro, Ernest, Paspala, Anna, D'Ambrosio, Marco, Pangeni, Anang, Dziakova, Jana, Terés, Lara Blanco, Lorente-Poch, Leyre, Di Carlo, Isidoro, Spartalis, Michael, Moro-Valdezate, David, Davey, Matthew G., Turrado-Rodriguez, Victor, Tryliskyy, Yegor, Calussi, Marco, Farré, Silvia Pérez, Labat, Miriam Cazador, Marafante, Chiara, Takkenberg, Marijn, Brookes, Charlotte Elisabeth, Soares, Antonio S., Gialamas, Eleftherios, Caputo, Damiano, Corrons, Laia Codina, Capitano, Sante, Charalabopoulos, Alexandros, Don, Cristine Brooke Pathirannehalage, Marrano, Enrico, Giuffrida, Maria Carmela, Tomasicchio, Giovanni, Bellato, Vittoria, Stijns, Jasper, Creavin, Ben, Schizas, Dimitrios, Blanco-Antona, Francisco, Kykalos, Stylianos, Tartaglia, Nicola, Pelegrina, Amalia, Barranquero, Alberto G., Schena, Carlo Alberto, Cremona, Simone, Baili, Efstratia, Cianci, Pasquale, Di Bella, Annamaria, Forcignanò, Edoardo, Fabbrizio, Tiziana, Salvetti, Francesco, Inama, Marco, Campagnaro, Tommaso, Deerenberg, Eva B., Reccia, Isabella, Rocca, Aldo, Fazio, Federico, Tampakis, Athanasios, Tepelenis, Kostas, Di Meo, Giovanna, Konstantoudakis, Georgios, Manatakis, Dimitrios K., Mineccia, Michela, Delvecchio, Antonella, Faro, Carmelo Lo, Rosso, Edoardo, Bandyopadhyay, Samik K., Queffurus, Michael, Marin, Jacopo Nicolò, Corvasce, Arianna, Chillarge, Gauri, Mohammed, Mohammed Mustafa, Reid, Rebecca, Gherardi, Dario, Naeem, Awais, Pandanaboyana, Sanjay, Tayeh, Salim, Chevallay, Mickael, Sergeant, Gregory, Cuccomarino, Salvatore, Salimian, Nick, Kapsampelis, Panagiotis, Ferretti, Carlotta, Glasbey, James, Harvitkar, Rafique Umer, Iqbal, Muhammad Rafaih, de Oliveira, Gabriel Paiva, Pérez-Bertólez, Sonia, Bergna, Alessandro, Brisinda, Giuseppe, Rottoli, Matteo, Roscio, Francesco, Pedrazzani, Corrado, Meyer, Jeremy, Marino, Marco V., Brasset, Camille, Daniel, Clerc, Devriendt, Stefanie, Soldini, Gabriele, Pennisi, Damiano, Richards, Chris B., Fiore, Felicia, Bocchino, Antonio, Au, Stephanie, Hernandez-Garcia, Miguel, Frontali, Alice, Grossi, Ugo, Lolis, Evangelos, Miotto, Marco, Di Filippo, Giacomo, Seretis, Charalampos, Barberis, Andrea, De Luca, Raffaele, Levi Sandri, Giovanni Battista, Reitano, Elisa, Mattioli, Marco, Sciaudone, Guido, Fuschillo, Giacomo, Schiltz, Boris, Low, Juin, Bointas, Georgios, Cozza, Valerio, Delaune, Vaihere, Vescio, Francesca, Curcio, Silvia, Sevik, Husnu, Santocchi, Pietro, Stecca, Tommaso, Balaphas, Alexandre, Chessa, Antonella, Leo, Cosimo Alex, di Mola, Fabio F., Tarallo, Mariarita, Martini, Francesco, Lisi, Giorgio, Khan, Mansoor, Nicolazzi, Marco, Pinotti, Enrico, Morini, Andrea, Esposito, Giuseppe, Buonomo, Oreste Claudio, Corallino, Diletta, Demir, Anıl, Roesel, Raffaello, De Lucia, Chiara, Maruccia, Michele, Tekin, Oguzhan, Pavone, Giovanna, Gupta, Ashish, Pradelle, Irene, Chrysikos, Michael, Farrukh, Maira, Baiocchi, Gian Luca, Piras, Carla, Abellán, Antonio Melero, Olivieri, Laura, Materazzo, Marco, Carbone, Ludovico, Dulskas, Audrius, Mulita, Francesk, Corronca, Federico, Cappuccio, Micaela, Smerieri, Elia, Sotiropoulu, Maria, Violante, Tommaso, Moletta, Lucia, Rutegård, Martin, Brillantino, Antonio, Landaluce-Olavarria, Aitor, Ossola, Paolo, Bono, Dario, Rosés, Helena Salvador, Perez-Sanchez, Luis E., Sabbatini, Sonia, Scotti, Mauro Alessandro, Cammarata, Roberto, Ibáñez, Noelia, Marano, Alessandra, Palmisano, Silvia, Cascales-Sanchez, Pedro, Mosca, Vinicio, Ballester, Cristina, Iordache-Petrescu, Madalina Ionela, Pozza, Gioia, Akay, Omer, Bollino, Ruggero, Toti, Johannes M. A., Mascianà, Gianluca, Pach, Radoslaw, Sensi, Bruno, Natalia, Savvala N., Coppola, Alessandro, Altinel, Yuksel, Brucchi, Francesco, Guitart, Marc Pérez, Salido, Andrea Jiménez, Tamini, Nicolò, Garoufalia, Zoe, Mifsut, Patricia, Wilkins, Alex, Navarro-Sánchez, Antonio, Cestaro, Giovanni, Conti, Luigi, Carvas, João M. B., Gazia, Carlo, Alonso, Patricia, Spiezio, Giovanni, Maggi, Giulia, Juloski, Jovan, Braccio, Bartolomeo, Pañella, Clara, Freixa, Celia Caula, Petrakis, Georgios, Folliero, Cristina, De Andrés-Asenjo, Beatriz, Iodice, Alessandra, Jansson, Hannes, González, Tomas Elosua, Ortega, Irene, Castro, Maria J., Fernicola, Agostino, Aparicio, Antonio Carlos Maya, Ortega, Nuria, Chouliaras, Christos, Tura, Marina Vila, Sidiropoulou, Zacharoula, Gonzalez, Ana, Augustin, Goran, Segura-Sampedro, Juan J., Cuk, Vladica, Piccolo, Gaetano, Ingallinella, Sara, Ortenzi, Monica, Uggeri, Fabio, Carrabetta, Salvatore, Tolonen, Matti, Formisano, Giampaolo, Manfredelli, Simone, Perra, Teresa, Esposito, Francesco, Perrone, Gennaro, Zacharis, Georgios, Menéndez, Jaime Iturbe, Bottcher, Sofia Maria Jaume, Ioannidis, Orestis, Borges, Nuno, Sousa, Xavier, Colombari, Renan C., Tellez, Clara, Capolupo, Gabriella Teresa, Giuliani, Giuseppe, Mastella, Federica, González, Lluis García, Merlini, Ilenia, Ghignone, Federico, de Sa, Tiago Correia, Mangana, Orsalia, Rodriguez-Lopez, Mario, Alvarez-Gallego, Mario, Chowdhury, Ashim, Di Lascio, Pierpaolo, Carneros, Virginia Jiménez, Angrisani, Marco, Conte, Luigi E., Montiel, Carmen Galiana, Ascari, Francesca, Dajti, Irida, Lapolla, Pierfrancesco, Sperotto, Beatrice, Mazzarella, Gennaro, Capuano, Marianna, Lopez, Maria Martinez, Ferrario, Luca, Bulte, Joris P., López, María Martínez, Guerci, Claudio, Marra, Angelo Alessandro, Belkacem, Acidi, Pérez, Raquel Escalera, Panyko, Arpád, Dimitrov, Evgeni, Luque, Eduardo J., Manrique, Mario Montes, Paranyak, Mykola, Kaur, Mandeep, Barugola, Giuliano, Farazi-Chongouki, Christos, Estaire-Gómez, Mercedes, del Olmo, Juan Carlos Martín, Nardo, Bruno, Mutlu, Arda Ulaş, Rubio, Ainhoa Valle, Merlini, David A., Marchegiani, Francesco, Cereda, Marco Angelo, Vinci, Danilo, Komaei, Iman, Petrucciani, Niccolo, Seyfried, Steffen, Krsicka, Petr, Medas, Fabio, Lesko, Dusan, Murzi, Valentina, Siragusa, Leandro, Guerrero, María Alejandra, Iranzo, Marina Alarcón, Cestino, Luca, Pasculli, Alessandro, Smerieri, Nazareno, Benzoni, Ilaria, Festa, Federico, Jordão, Daniel Filipe Martins, Licardie, Eugenio, Nicolaescu, Diana C., Balassone, Valerio, La Vaccara, Vincenzo, Romano, Fabrizio, Adamovich, Dmitry Mikhailovich, Papatheodorou, Panayiotis, Maroni, Norvana, Colás-Ruiz, Enrique, Melberga, Liene, Chimenti, Federica, Ferrari, Davide, Arcudi, Claudio, Police, Andrea, De Simone, Belinda, Sánchez-Guillén, Luis, Parreño-Manchado, Felipe Carlos, Rachadell, Juan José, Coletta, Diego, Saroglu, Azize, Pattacini, Gianmaria Casoni, Antonelli, Amedeo, Anania, Marco, Litta, Francesco, Lafranceschina, Stefano, Bottari, Andrea, Pavlovic, Mladen, Rojas-Bonet, Noel, Tampaki, Ekaterini Christina, Kosir, Jurij A., Anelli, Ferdinando M., de las Casas, Sara Gortázar, Kucukarslan, Rabia, Pierobon, Elisa Sefora, Milanesi, Maria, Drogouti, Maria, Sotiropoulou, Maria, Di Marco, Federica, Bannone, Elisa, Sliwinski, Svenja Christin, Yildiz, Ishak, Pellicciaro, Marco, Celotti, Andrea, Malerba, Michele, Marino, Fabio, Bourmpouteli, Eirini, Bianco, Giuseppe, Charitaki, Evgenia, Pascale, Marco Maria, Ioannidis, Argyrios, Maraska, Fatlum, Petagna, Lorenzo, Turri, Giulia, Vailas, Michail, Romanzi, Andrea, Pouwels, Sjaak, Rosa, Fausto, Clocchiatti, Lucrezia, Andreuccetti, Jacopo, Machairas, Nikolaos, Frountzas, Maximos, Lasithiotakis, Konstantinos, Barone, Mirko, Christodoulou, Prokopis, Potkonjak, Dario, Aiolfi, Alberto, de Vries, Hilbert S., Napetti, Sara, Castaldi, Antonio, Botelho, Pedro, Marziali, Irene, Uccelli, Matteo, Pisano, Michele, Veroux, Massimiliano, Locci, Eleonora, Romano, Angela, Cero, Mariagiulia Dal, Cicerchia, Pierfranco Maria, Baldi, Caterina, Russo, Iris Shari, Tenconi, Silvia Maria, Saliu, Fatmir, Bondurri, Andrea, Cardinali, Luca, Laracca, Giovanni Guglielmo, Martín-Pérez, Beatriz, Felsenreich, Daniel M., Cunha, Miguel, Zerbo, Domenico, Clementi, Marco, Delogu, Daniele, Iossa, Angelo, Bavikatte, Akshay Prasannakumar, Saracoglu, Can, Pecorelli, Nicolò, Tufo, Andrea, Biloslavo, Alan, Lianos, Georgios D., Carannante, Filippo, Costanzo, Antonio, Montuori, Mauro, Cigognini, Maria, Silvestro, Roberto, Atici, Semra Demirli, Milito, Pamela, Ferronetti, Antonio, Güngör, Mert, Di Venere, Beatrice, Puccioni, Caterina, De Nobili, Giovanni, Selvaggi, Lucio, Farolfi, Tommaso, Aeschbacher, Pauline, Olivier, James B., Frazzetta, Giuseppe, Andriola, Valeria, Giordano, Alessio, De Luca, Alessandro, Ferrara, Francesco, Casagranda, Biagio, Sammartano, Fabrizio, Russo, Alfio Alessandro, Rossi, Stefano, Pacilli, Mario, Synekidou, Eirini, Tutino, Roberta, Ceresoli, Marco, De Rosa, Michele, Di Santo Albini, Andrea G., Vincenzi, Paolo, Vellei, Samantha, Benzoni, Enrico, Murillo, Gabriela Aracelly Arroyo, Izzo, Giuliano, Scotto, Bruno, Caruso, Riccardo, Colombo, Francesco, D'Acapito, Fabrizio, Lostoridis, Eftychios, Saladino, Edoardo, Poillucci, Gaetano, Moeckli, Beat, Manto, Ottavia, Kara, Yasin, Tatar, Cihad, Cioffi, Stefano Piero Bernardo, Mambrilla, Sara, Bianchi, Valentina, Scopelliti, Michele, Agresta, Ferdinando, Nava, Andrea Kazemi, Franchi, Eloisa, Fransvea, Pietro, Prieto, Mikel, Picardi, Biagio, Rizzuto, Antonia, Panaccio, Paolo, Gussago, Stefano, Marra, Ester, Addeo, Pietro, Fernández Fernández, June, Gulmez, Mehmet, Pisaniello, Donatella, Cannavo, Maurizio, López-López, Victor, Avella, Pasquale, Peloso, Andrea, Bellanova, Giovanni, Candilio, Giuseppe, Perotti, Bruno, Granata, Roberta, Florio, Gaetano, Ioia, Giovanna, Iannone, Immacolata, Ammerata, Giorgio, Zambon, Martina, Romano, Francesco Maria, Del Monte, Simone Rossi, Sasia, Diego, Fortuna, Laura, Giuffrida, Mario, Litvin, Andrey, Cannistra, Marco, De Padua, Cristina, Sánchez, Tatiana Gómez, Paniagua-Garcia-Señorans, Marta, Guevara, Jenny, Perfecto, Arkaitz, Alconchel, Felipe, Campanelli, Michela, Keci, Laura, Cricrì, Michele, Kampouroglou, Georgios, Bagaglini, Giulia, Farrarons, Sara Sentí, Greco, Antonio, Walędziak, Maciej, Carvas, João M., Serrano-Navidad, Monica, Van Doorn, Berend, Schiavo, Ciro, Fabbri, Nicolò, Wani, Ishfaq Ahmad, Mondi, Isabella, Anestiadou, Elissavet, Mendes, Beatriz ISilva, Verdi, Daunia, Dorovinis, Panagiotis, Cacciaguerra, Andrea Benedetti, Caldeira, Beatriz, Canonico, Giuseppe, Dardanov, Dragomir, D'Ugo, Stefano, Francis, Fayez Maged, Meneghini, Simona, Pesce, Antonio, Puglisi, Silvana Bernadetta, Bellini, Maria Irene, Pisano, Marcello, Giordano, Marco, Fleres, Francesco, Campus, Federica, Cillara, Nicola, Moggia, Elisabetta, Ciarleglio, Francesco A., Calini, Giacomo, Gravante, Gianpiero, De Carlis, Riccardo, Altomare, Michele, Martines, Gennaro, Miggino, Marco, Marano, Luigi, Stocco, Alberto, Porcu, Alberto, Pham, Thuy Vy, Gervasi, Maria Clelia, Pilia, Tiziana, Palomba, Giuseppe, Picchetto, Andrea, Spampinato, Marcello Giuseppe, Tandoi, Francesco, Piccoli, Micaela, Gall, Malina ECaraiman, Santos, Bárbara Ribeiro, Agastra, Ervis, Koëter, Tijmen, Samadov, Elgun, Marsanic, Patrizia, Serena, De Fatico Gilda, Uzunoglu, Mustafa Yener, Zanus, Giacomo, Braholli, Eriol, Giovine, Gennaro, Galiffa, Giampaolo, Lauricella, Sara, Lukmonov, Saidrakhim, Leventoglu, Sezai, Chooklin, Serge, Dudi-Venkata, Nagendra N., Gauci, Chahaya M., Podda, M, Di Martino, M, Pata, F, Nigri, G, Pisanu, A, Di Saverio, S, Pellino, G, Ielpo, B, Null, N, Tolla, A, Abdelkhalek, M, Emile, S, Dinagde, T, Bouzid, C, Mansour, A, Garzali, I, Aregawi, A, Zaghloul, T, Kchaou, A, Awad, S, Souadka, A, Ted, T, Saumtally, M, Ahmed, B, Bayileyegn, N, Nunziante, M, Shalaby, M, Debena, D, Zena, A, Adewunmi, O, Negasa, T, Bourguiba, M, Feituri, N, Kebede, K, Elfeki, H, Anas, A, Awad, A, Ermias, N, Hailemariam, D, Bejiga, G, Imana, R, Taffese, A, Feleke, T, Elghadban, H, Debela, B, Shiferaw, D, Tadesse, R, Chukwu, I, Mohammed, A, Hassen, K, Obiagwu, N, Tense, T, Taeme, M, Biniam, E, Tesfay, G, Tegegn, A, Teddy, T, Bekana, B, Nidaw, M, Ali, M, Gonfa, K, Kiros, S, Belay, T, Yallew, G, Wassie, C, 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Giovine, G, Galiffa, G, Lauricella, S, Lukmonov, S, Leventoglu, S, Chooklin, S, Dudi-Venkata, N, Gauci, C, Podda, Mauro, Di Martino, Marcello, Pata, Francesco, Nigri, Giuseppe, Pisanu, Adolfo, Di Saverio, Salomone, Pellino, Gianluca, Ielpo, Benedetto, null, null, Tolla, Ashenafi Negash, Abdelkhalek, Mohamed, Emile, Sameh, Dinagde, Tesfaye Aga, Bouzid, Chafik, Mansour, Ahmed Mohammed Farid Mahmoud, Garzali, Ibrahim Umar, Aregawi, Alazar Berhe, Zaghloul, Tarek M., Kchaou, Ali, Awad, Selmy S., Souadka, Amine, Ted, Tedla Gebretsadik, Saumtally, Mohammad Saad, Ahmed, Bensaad, Bayileyegn, Nebiyou Simegnew, Nunziante, Marco, Shalaby, Mostafa, Debena, Dawit Gebregiorgis, Zena, Alemayehu Shanko, Adewunmi, Olayinka Lukman, Negasa, Tolera A., Bourguiba, Mohamed Aboulkacem, Feituri, Nura, Kebede, Kirubel Abebe, Elfeki, Hossam, Anas, Abdelhmed, Awad, Ahmed K., Ermias, Nebiyou, Hailemariam, Dagnachew H., Bejiga, Gosa Hundie, Imana, Ruhama Yoseph, Taffese, Abebe, Feleke, Tsega Terefe, Elghadban, Hosam Mohamed, Debela, Bizuneh Sime, Shiferaw, Desta, Tadesse, Robel, Chukwu, Isaac Sunday, Mohammed, Abdullahi Ibrahim, Hassen, Khalid Arebo, Obiagwu, Ndubuisi K., Tense, Tadesse H., Taeme, Mulugeta, Biniam, Ewnte, Tesfay, Goytom Knfe, Tegegn, Ayenachew Getachew, Teddy, Tewodros Abule Bilata, Bekana, Bekana L., Nidaw, Melkamu Kibret, Ali, Mahmoud Ibrahim, Gonfa, Kebebe Bekele, Kiros, Samuel, Belay, Tatek, Yallew, Gebeyaw Mengist, Wassie, Chekol, Ayalew, Alem Mekete, Asfaw, Fitsum Terefe, Aimal, Aimal Khan, Casas, Maria Agustina, Madrid, Fausto A., Diaz-Elizondo, Jose Antonio, Merlo, Ignacio Guillermo, De Campos, Tercio, Schlottmann, Francisco, Gomes, Carlos Augusto, Hernández, Edgard Efrén Lozada, Moncada-Ortega, Augusto, Ramos-De la Medina, Antonio, Vanerio, Patricio, Morales, Emilio J., Stringfield, Sarah Beth, Gallardo, Cristian, Fonseca, Vinicius Cordeiro, Muriel, Maria Emilia, Cantarino, Frederico, Fichera, Alessandro, Rodriguez, Agustin E., Salinas, Roberto Paúl Andrade, Crosbie, Gonzalo Gabriel, Menegozzo, Carlos Augusto Metidieri, Avellaneda, Nicolas, Briones, Cristhian Gonzalo Aspiazu, Varela, Cristopher, Lichliter, Warren E., Varela, Cristopher L., Koppel, Darren, Lenz, Jorge Godoy, Pascual, Franco, Sibaja-Matamoros, Dauber A., Johnson, Benjamin E., Mercado, Octavio Avila, Tita, Agustín, Mukherjee, Indraneil, Lorenzo, Irving, Rueda, Erick, Rico, Douglas, Terwes, Natasha Loria, Visag-Castillo, Victor, Escalante, Karol S., Salvador, Alan Francisco Alfaro, Pio, Luca, Rodas, Edgar B., Aguilar, Juan Carlos Cardozo, Neri, Ignacio, Barzola, Ernesto J., Barba, Leonardo A., Zuchini, Andrés Mendoza, Acevedo, Ana Karen Radilla, Gachabayov, Mahir, Gonsaga, Ricardo Alessandro Teixeira, Bonilla, Fernando, Knickerbocker, Chase Barrett, Tsouknidas, Ioannis, Salamea, Juan C., Travers, Lawrence Albert Salter, Nari, Gustavo Adrian, Pachajoa, Diana Alejandra Pantoja, Valadez, Michel Hernandez, Hale, Lyman Lansing, Perez, Guillermo, Choudhry, Asad, Foreman, Michaael L., Brito, Ismael, Ciro, Mauricio Pedraza, Newton, Carla Joyce, Souza, Hamilton Petry, Davis, Daniel G., Ferreira, Rodrigo Vaz, Keller, Deborah S., Miguel, Gustavo Machain, Singh-Ranger, Gurpreet, Linares, Neiling Massiel Oviedo, Singares, Eduardo Smith, Valdivieso, Xavier HGarcía, Teran, Alfonso Ivan Sanchez, Vargas, Luis Felipe Cabrera, Valinoti, Agustín, Milne, David M., Fleming, Andrew Martin, Quiroga-Garza, Alejandro, Espino, Eduardo Morales, Bedros, Nicole Mary, Funk, Geoffrey A., Neves, Fernanda V. S., Supit, Tommy, Baba, Arshad Ahmed, Chalkoo, Mushtaq A., Kucuk, Gultekin Ozan, Sarmiento, Ray Inocencio, Galeev, Shamil I., Korkoman, Mohammed J., Yang, Wah, Medappil, Noushif, Athar, Rahmatullah, Subramaniam, Ravichandran, Chia, Chi Fung, Alhazmi, Ahmad, Halder, Subhadip, Rusli, Siti Mayuha, Rashid, Arshad, Gülcü, Barış, Nagarajan, Prasanth, Rida, Khaled, Jamiri, Al-Radjid, Batıkan, Oğuzkağan, Khan, Huma Ahmed, Mitul, Ashrarur Rahman, Efetov, Sergey, Junior, Marcelo A. F. Ribeiro, Gulcu, Baris, Farooqui, Marryam Riaz, Mulpuri, Venu Bhargava, Bagaria, Dinesh, Yusoff, Ahmad Ramzi, Wani, Rauf, Younis, Muhammad Umar, Khobragade, Krunal H., Marwat, Muhammad Ibrahim, Bains, Lovenish, Kobe, Yoshiro, Koh, Peng Soon, Tantravahi, Umasankar, Mohamad Mohamad, Ikhwan Sani, Abu-Arish, Hamdoon, Yildirim, Ali Cihat, Ibrahim, Aini Fahriza, Tan, Jih Huei, Siagian, Dumaria Ketty, Bhattacharya, Neela, Chiu, Jennifer H. F., Paramasvaran, Ganendra, Voon, Kelvin, Göktepe, Berk, Lee, Lee Yeong Sing, Gupta, Amit, Rasheed, Faaiz, Al-Shehari, Mohammed, Syed, Syed Muhammad Ali, Bhat, Pawan Singh, Erdoğan, Emre, Roat, Rajesh, Nacion, Aeris Jane D., Saraiya, Swapnil Mukesh, Afolabi, Akinwale Ibrahim, Chai, Feng Yih, Ghannam, Wagih, Bhattacharya, Kaushik, NL, Harish, Aloun, Ali, Bhatti, Hamza Waqar, Koneti, Akshadhar J., Klib, Mohamad, Qureshi, Ahmad Uzair, Syn, Nicholas L., Wani, Ajaz, Saeidi, Sara, Zeb, Muhammad, Bandaru, Kalyan Vijay Kumar, Menna, Maria Paola, Morales-Conde, Salvador, Gessa, Emanuela, Sánchez-Cabús, Santiago, Spartalis, Eleftherios, Antropoli, Carmine, Manigrasso, Michele, Sica, Giuseppe S., Ercolani, Giorgio, Chitul, Andrei, Bacchiocchi, Giulia, Azevedo, José, Karamarkovic, Aleksandar, Bonavina, Luigi, Piozzi, Guglielmo N., Migueláñez, Isabel Pascual, Merlini, David, Major, Piotr, Grimaldi, Luciano, Calu, Valentin, Curro, Giuseppe, Cotsoglou, Christian, Baldini, Edoardo, Delis, Spiros, Kovacevic, Bojan, Masetti, Michele, Selvaggi, Francesco, Scabini, Stefano, Reiti, Andrian, Zullo, Alessia, Giuliani, Antonio, Alesina, Pier Francesco, Massey, Lisa H., Slesser, Alistair A. P., Neary, Peter M., Sahnan, Kapil, Tan, Jessica J., Colucci, Gianluca, Brady, Richard R. W., Mihailescu, Andrei, Adamina, Michel, Gerogiannis, Ioannis, van Ramshorst, Gabrielle, Paradiso, Giulia, Poto, Gianmario Edoardo, Massaro, Daniele, Nazir, Fozia, Stubbs, Benjamin M., Tasselli, Francesco Menegon, Muñoz-Cruzado, Virginia Durán, Sabia, Domenico, Vannelli, Alberto, Marsella, Valentina Enrica, Tomada, Elisa Paoluzzi, Giambusso, Mauro, Davies, Justin, Uzzau, Alessandro, Balla, Andrea, Scaringi, Stefano, Lancellotti, Francesco, Douka, Eleftheria, Argenio, Giulio, Cassese, Gianluca, Ammendola, Michele, Morelli, Luca, Francone, Elisa, Bala, Miklosh, Thambi, Prem, Iacobone, Maurizio, Campisi, Andrea, Tejedor, Patricia, Spoletini, Gabriele, Mascherini, Matteo, Belia, Francesco, Idiz, Ufuk Oguz, Colak, Elif, Peters, Paul Adewunmi, Ros, Emilio Peña, Aytac, Erman, Vilallonga, Ramon, Serrablo, Alejandro, Muttillo, Edoardo Maria, Di Franco, Gregorio, Vanni, Gianluca, Isik, Arda, Sbacco, Valentina, Tropeano, Francesca Paola, Porcellini, Iride, Butler, Rebecca Jayne, Fernandez, Carmen Cagigas, Papadopoulos, Aristeidis, Salvans, Silvia, Khan, Jan Sher, Bellver, Pedro Palazón, Mc Farlane, Sebastian Jeri, Apostolou, Konstantinos, Tur-Martinez, Jaume, Castellano, Javier Rivera, Santoliquido, Matteo, Tallon-Aguilar, Luis, Celentano, Valerio, Aliyev, Vusal, al-Najami, Issam, Grama, Florin A., Masior, Łukasz, Ciesielski, Wojciech J., Luberto, Antonio, Sparavigna, Marco, Klimczak, Tomasz Jerzy, Negoi, Ionut, Serradilla-Martín, Mario, Marinis, Athanasios, Cammarat, Roberto, Bellido-luque, Juan, Manzo, Carlo Alberto, Milana, Flavio, Luglio, Gaetano, Zarnescu, Narcis Octavian, Martínez, Isidro, Olmi, Stefano, Costea, Radu V., Cerdán-Santacruz, Carlos, Gica, Nicolae, Rompianesi, Gianluca, Gallo, Gaetano, Ridolfi, Cristina, Sahid, Saidah, CC, Tommaso, López-Soler, Guillermo, Díaz, Carlos JGómez, Mccawley, Niamh, Luzzi, Andrea Pierre, Abelló, David, Bonito, Alba Correa, Ntomi, Vasileia, Gourgiotis, Stavros, Pazos, Natalia Suárez, Toscano, Marta Jiménez, Zafra, David Ambrona, 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- Abstract
The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS (R) v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 +/- 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 +/- 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 +/- 4.9 and 7.8 +/- 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 +/- 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI.
- Published
- 2024
3. How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons
- Author
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S., Giuliani G., Falcone F., Sebastiani S., Montuori M., Rossi S., Sagnotta A., Giuliani B., Imbriani G. C., Restaino S., Andreani L., Di Maria F., Lagana A. S., Vitiello L., Berton F., Virgilio E., Palisi M., Portigliotti L., Calussi M., Conti L., Mauriello C., Barone M., Saladino E., Giaquinta A., Zerb D., Frazzetta G., Merola G., Chierici A., Bini R., Centonze L., De Carlis R., Ferrario L., Giani A., Lauterio A., Tamini N., Corti S., Botteri E., Andreuccetti J., D'Alessio R., Cestaro G., Clarizia G., Spolini A., Carboni A. S., Benzoni E., Galiffa G., Perotti B., Veroux M., Randazzo V., Topa D., Pranteda C., Contini G., Iacusso C., Voglino V., Vita P., Carrano F. M., Ambrosio L., Cammarata R., Capolupo G. T., Caputo D., Carannante F., Cascone C., Esperto F., Farolfi T., Frasca L., Gallo I. F., Gibin G., Giurazza G., Improta L., La Vaccara V., Luffarelli P., Luvero D., Marangi G., Masciana G., Mazzola A., Mazzotta E., Miligi C. I., Montelione N., Nenna A., Orsaria P., Papalia R., Papalia G. F., Parisi F. R., Prata F., Salzillo R., Santini S., Sofo F., Zampoli A., Tanda C., Altieri G., Ardito F., Belia F., Bianchi V., Biondi A., Brisinda G., Chiappetta M., Ciolli G., Ciolli A., Ferracci F., Ferri L., Fico V., Fiorillo C., Fransvea P., Galiandro F., Giovinazzo F., La Greca A., Litta F., Mele C., Pafundi D. P., Panettieri E., Papa V., Patini R., Perrotta G., Puccioni C., Santocchi P., Armatura G., Olmi S., Casoni Pattacini G., Salgarello S., Trompetto M., Bombardini C., La Rocca R., Celentano G., Micalef A., Mazzella A., Settembrini A., Zoia C., Degrate L., Musumeci G., Palopoli C. A. M., Montori G., Bonati E., Dinuzzi V. P., Velluti F., Balla A., Bonasia D. E., Coletta D., Berardi G., Colasanti M., Ferretti S., Gasparoli C., Mariano G., Avenia S., Cianci P., Cestino L., Festa F., Fazio F., Ascari F., Desio M., Arroyo Murillo G. A., Cereda M., Galleano R., David G., Pansini A., Gazia C., Atzori G., Desideri L. F., Famularo S., Galvanin J., Giudici V. M., Mangiameli G., Mei S., Milana F., Pansa A., Sacchi M., Testori A., Di Carlo G., Paratore M., Perrone U., Vagge A., Vigano J., Torre B., Scotti M. A., Carbone G., Cerchione R., De Nardi P., Gozzini L., Ottaviani L., Senni C., Piccin O., Pio L., Colombo F., Avantifiori R., Baldassarri V., Caronna R., Cicerchia P. M., Corallino D., Crocetti D., Gallo G., Giovanardi F., Giovannetti F., Hassan R., Iossa A., Lai Q., Lancellotti F., Lucarini A., Lucchese S., Mazzarella G., Melandro F., Minervini A., Muttillo E. M., Palmieri L., Pasqua R., Rosiello F., Salina G., Sibio S., Sirignano P., Tarallo M., Usai S., Vanni C., Viglietta E., Zambon M., Conversano N. I., Epifani A. G., Milano V., Sacco L., Nava M., Maffioli A., Giuratrabocchetta S., Baracchi F., Zuolo M., Ceresoli M., Verdi D., Belli A., Pata F., Piovano E., Pastore G., Bernabei F., Deiana S., Arceri A., D'Agostino C., Marafante C., Moggia E., Parini S., Moretti M., Uggeri F., Pontarolo N., Fontana T., Palmisano G., Giuffrida M., Guaitoli E., Ferretti C., Iacopino G., Gioco R., Roscitano G., Montanelli P., Chiappetta M. F., Pinotti E., Monati E., Fazio G., Di Pietro F., Damarco F., Barberis A., Razzore A., Pascale A., Loi S., Ferrara F., Rossi M., Lisi G., Viel G., Sasia D., Bono D., Cordaro E. R., Giacomelli E., Giani I., Seriau L., Pellino G., Sparavigna M., Trigiante G., D'Ambrogio R. G., Cardella F., Guzzetti S., Luzzi A. -P., Carganico G., Drago B., Micheletto G., Orlandi R., Cutolo C., Gibello U., Mistrangelo M., Forcignano E., D'Ugo S., Losurdo P., Manitto M., Caroli G., Franco M., Tilocca P. L., Mendogni P., Sena G., Sambucci D., Luciani C., Atelli P., Guida A., Marino F., Morini A., Sibilla M. G., Longo F., Giaccari S., Vigorita V., Balduzzi A., Barra F., Delogu D., Milone E., Bencini L., Aprile V., Papini P., Montemurro N., Cavallo M., Picciariello A., Tomasicchio G., Fittipaldi A., Maruccia M., Gerardi S., Cillara N., Deidda S., Demarinis G., Peiretti E., Tatti F., Iovino C., Isola G., Progno V. C., Migliore M., Badessi G., Barilla C., Calleri G. S., Cianci S., Fama F., Fleres F., Mazzeo C., Visaloco M. G., Marchetto C., Bolognesi F., Benuzzi L., Bracchetti G., Brucchi F., Manzo C. A., Scaravilli L., Ferrari C., Rocca A., Napolitano P., Anoldo P., Caricato C., Manigrasso M., Milone M., Napolitano L., Palomba G., Schiavone V., Vetrella M., Grossi U., Moletta L., Annicchiarico A., Vella I., Talesa G., Boggi U., Aiello F., Anselmo A., Bacchiocchi G., Beati F., Bellato V., Billeci F., Blasi F., Buonomo O. C., Campanelli M., Coco G., Contadini A., Conte L. E., D'Ippolito G., Di Marcantonio A., Spicchiale C. F., Afflitto G. G., Gismondi A., Gorgolini G., Granai A. V., Grande S., Gravina A., Guida A. M., Ingallinella S., Keci L., Latini E., Marino D., Oddi F. M., Orecchia L., Don C. B. P., Pellicciaro M., Petagna L., Pirozzi B. M., Quaranta C., Rho M., Rosina A., Santicchia M. S., Saraceno F., Schiavone A., Sensi B., Spina A., Sullo L., Tacconi F., Taje R., Vanni G., Vinci D., Vita G., Alba G., Badalucco S., Carbone L., Samorani O. C., Chisci G., Cuomo R., Francia A., Fusario D., Gargiulo B., Pasqui E., Pasquetti L., Puoti P., Resca L., Cumbo J., Ganio S., Vizzielli G., Anastasi M., Guerra D., Romanzi A., Vannelli A., Baia M., Siragusa, L, Angelico, R, Angrisani, M, Zampogna, B, Materazzo, M, Sorge, R, Giordano, L, Meniconi, R, Coppola, A, Marino, A, Giraudo, G, Esposito, S, Urbani, A, De Pastena, M, Mastrapasqua, R, Garancini, M, Frontal, A, Pascal, G, Martellucc, J, Falb, F, Boscarelli, A, Bertoglio, P, Trecca, E, Galassi, L, Vento, V, Chiappini, A, Antonelli, A, Bennardo, F, Familiari, F, Giannaccare, G, Zappia, A, Giuliani, G, Falcone, F, Sebastiani, S, Montuori, M, Rossi, S, Sagnotta, A, Giuliani, B, Imbriani, G, Restaino, S, Andreani, L, Di Maria, F, Lagana, A, Vitiello, L, Berton, F, Virgilio, E, Palisi, M, Portigliotti, L, Calussi, M, Conti, L, Mauriello, C, Barone, M, Saladino, E, Giaquinta, A, Zerb, D, Frazzetta, G, Merola, G, Chierici, A, Bini, R, Centonze, L, De Carlis, R, Ferrario, L, Giani, A, Lauterio, A, Tamini, N, Corti, S, Botteri, E, Andreuccetti, J, D'Alessio, R, Cestaro, G, Clarizia, G, Spolini, A, Carboni, A, Benzoni, E, Galiffa, G, Perotti, B, Veroux, M, Randazzo, V, Topa, D, Pranteda, C, Contini, G, Iacusso, C, Voglino, V, Vita, P, Carrano, F, Ambrosio, L, Cammarata, R, Capolupo, G, Caputo, D, Carannante, F, Cascone, C, Esperto, F, Farolfi, T, Frasca, L, Gallo, I, Gibin, G, Giurazza, G, Improta, L, La Vaccara, V, Luffarelli, P, Luvero, D, Marangi, G, Masciana, G, Mazzola, A, Mazzotta, E, Miligi, C, Montelione, N, Nenna, A, Orsaria, P, Papalia, R, Papalia, G, Parisi, F, Prata, F, Salzillo, R, Santini, S, Sofo, F, Zampoli, A, Tanda, C, Altieri, G, Ardito, F, Belia, F, Bianchi, V, Biondi, A, Brisinda, G, Chiappetta, M, Ciolli, G, Ciolli, A, Ferracci, F, Ferri, L, Fico, V, Fiorillo, C, Fransvea, P, Galiandro, F, Giovinazzo, F, La Greca, A, Litta, F, Mele, C, Pafundi, D, Panettieri, E, Papa, V, Patini, R, Perrotta, G, Puccioni, C, Santocchi, P, Armatura, G, Olmi, S, Casoni Pattacini, G, Salgarello, S, Trompetto, M, Bombardini, C, La Rocca, R, Celentano, G, Micalef, A, Mazzella, A, Settembrini, A, Zoia, C, Degrate, L, Musumeci, G, Palopoli, C, Montori, G, Bonati, E, Dinuzzi, V, Velluti, F, Balla, A, Bonasia, D, Coletta, D, Berardi, G, Colasanti, M, Ferretti, S, Gasparoli, C, Mariano, G, Avenia, S, Cianci, P, Cestino, L, Festa, F, Fazio, F, Ascari, F, Desio, M, Arroyo Murillo, G, Cereda, M, Galleano, R, David, G, Pansini, A, Gazia, C, Atzori, G, Desideri, L, Famularo, S, Galvanin, J, Giudici, V, Mangiameli, G, Mei, S, Milana, F, Pansa, A, Sacchi, M, Testori, A, Di Carlo, G, Paratore, M, Perrone, U, Vagge, A, Vigano, J, Torre, B, Scotti, M, Carbone, G, Cerchione, R, De Nardi, P, Gozzini, L, Ottaviani, L, Senni, C, Piccin, O, Pio, L, Colombo, F, Avantifiori, R, Baldassarri, V, Caronna, R, Cicerchia, P, Corallino, D, Crocetti, D, Gallo, G, Giovanardi, F, Giovannetti, F, Hassan, R, Iossa, A, Lai, Q, Lancellotti, F, Lucarini, A, Lucchese, S, Mazzarella, G, Melandro, F, Minervini, A, Muttillo, E, Palmieri, L, Pasqua, R, Rosiello, F, Salina, G, Sibio, S, Sirignano, P, Tarallo, M, Usai, S, Vanni, C, Viglietta, E, Zambon, M, Conversano, N, Epifani, A, Milano, V, Sacco, L, Nava, M, Maffioli, A, Giuratrabocchetta, S, Baracchi, F, Zuolo, M, Ceresoli, M, Verdi, D, Belli, A, Pata, F, Piovano, E, Pastore, G, Bernabei, F, Deiana, S, Arceri, A, D'Agostino, C, Marafante, C, Moggia, E, Parini, S, Moretti, M, Uggeri, F, Pontarolo, N, Fontana, T, Palmisano, G, Giuffrida, M, Guaitoli, E, Ferretti, C, Iacopino, G, Gioco, R, Roscitano, G, Montanelli, P, Pinotti, E, Monati, E, Fazio, G, Di Pietro, F, Damarco, F, Barberis, A, Razzore, A, Pascale, A, Loi, S, Ferrara, F, Rossi, M, Lisi, G, Viel, G, Sasia, D, Bono, D, Cordaro, E, Giacomelli, E, Giani, I, Seriau, L, Pellino, G, Sparavigna, M, Trigiante, G, D'Ambrogio, R, Cardella, F, Guzzetti, S, Luzzi, A, Carganico, G, Drago, B, Micheletto, G, Orlandi, R, Cutolo, C, Gibello, U, Mistrangelo, M, Forcignano, E, D'Ugo, S, Losurdo, P, Manitto, M, Caroli, G, Franco, M, Tilocca, P, Mendogni, P, Sena, G, Sambucci, D, Luciani, C, Atelli, P, Guida, A, Marino, F, Morini, A, Sibilla, M, Longo, F, Giaccari, S, Vigorita, V, Balduzzi, A, Barra, F, Delogu, D, Milone, E, Bencini, L, Aprile, V, Papini, P, Montemurro, N, Cavallo, M, Picciariello, A, Tomasicchio, G, Fittipaldi, A, Maruccia, M, Gerardi, S, Cillara, N, Deidda, S, Demarinis, G, Peiretti, E, Tatti, F, Iovino, C, Isola, G, Progno, V, Migliore, M, Badessi, G, Barilla, C, Calleri, G, Cianci, S, Fama, F, Fleres, F, Mazzeo, C, Visaloco, M, Marchetto, C, Bolognesi, F, Benuzzi, L, Bracchetti, G, Brucchi, F, Manzo, C, Scaravilli, L, Ferrari, C, Rocca, A, Napolitano, P, Anoldo, P, Caricato, C, Manigrasso, M, Milone, M, Napolitano, L, Palomba, G, Schiavone, V, Vetrella, M, Grossi, U, Moletta, L, Annicchiarico, A, Vella, I, Talesa, G, Boggi, U, Aiello, F, Anselmo, A, Bacchiocchi, G, Beati, F, Bellato, V, Billeci, F, Blasi, F, Buonomo, O, Campanelli, M, Coco, G, Contadini, A, Conte, L, D'Ippolito, G, Di Marcantonio, A, Spicchiale, C, Afflitto, G, Gismondi, A, Gorgolini, G, Granai, A, Grande, S, Gravina, A, Ingallinella, S, Keci, L, Latini, E, Marino, D, Oddi, F, Orecchia, L, Don, C, Pellicciaro, M, Petagna, L, Pirozzi, B, Quaranta, C, Rho, M, Rosina, A, Santicchia, M, Saraceno, F, Schiavone, A, Sensi, B, Spina, A, Sullo, L, Tacconi, F, Taje, R, Vanni, G, Vinci, D, Vita, G, Alba, G, Badalucco, S, Carbone, L, Samorani, O, Chisci, G, Cuomo, R, Francia, A, Fusario, D, Gargiulo, B, Pasqui, E, Pasquetti, L, Puoti, P, Resca, L, Cumbo, J, Ganio, S, Vizzielli, G, Anastasi, M, Guerra, D, Romanzi, A, Vannelli, A, Baia, M, Siragusa L., Angelico R., Angrisani M., Zampogna B., Materazzo M., Sorge R., Giordano L., Meniconi R., Coppola A., Marino A., Giraudo G., Esposito S., Urbani A., De Pastena M., Mastrapasqua R., Garancini M., Frontal A., Pascal G., Martellucc J., Falb F., Boscarelli A., Bertoglio P., Trecca E., Galassi L., Vento V., Chiappini A., Antonelli A., Bennardo F., Familiari F., Giannaccare G., Zappia A. S., Giuliani G., Falcone F., Sebastiani S., Montuori M., Rossi S., Sagnotta A., Giuliani B., Imbriani G. C., Restaino S., Andreani L., Di Maria F., Lagana A. S., Vitiello L., Berton F., Virgilio E., Palisi M., Portigliotti L., Calussi M., Conti L., Mauriello C., Barone M., Saladino E., Giaquinta A., Zerb D., Frazzetta G., Merola G., Chierici A., Bini R., Centonze L., De Carlis R., Ferrario L., Giani A., Lauterio A., Tamini N., Corti S., Botteri E., Andreuccetti J., D'Alessio R., Cestaro G., Clarizia G., Spolini A., Carboni A. S., Benzoni E., Galiffa G., Perotti B., Veroux M., Randazzo V., Topa D., Pranteda C., Contini G., Iacusso C., Voglino V., Vita P., Carrano F. M., Ambrosio L., Cammarata R., Capolupo G. T., Caputo D., Carannante F., Cascone C., Esperto F., Farolfi T., Frasca L., Gallo I. F., Gibin G., Giurazza G., Improta L., La Vaccara V., Luffarelli P., Luvero D., Marangi G., Masciana G., Mazzola A., Mazzotta E., Miligi C. I., Montelione N., Nenna A., Orsaria P., Papalia R., Papalia G. F., Parisi F. R., Prata F., Salzillo R., Santini S., Sofo F., Zampoli A., Tanda C., Altieri G., Ardito F., Belia F., Bianchi V., Biondi A., Brisinda G., Chiappetta M., Ciolli G., Ciolli A., Ferracci F., Ferri L., Fico V., Fiorillo C., Fransvea P., Galiandro F., Giovinazzo F., La Greca A., Litta F., Mele C., Pafundi D. P., Panettieri E., Papa V., Patini R., Perrotta G., Puccioni C., Santocchi P., Armatura G., Olmi S., Casoni Pattacini G., Salgarello S., Trompetto M., Bombardini C., La Rocca R., Celentano G., Micalef A., Mazzella A., Settembrini A., Zoia C., Degrate L., Musumeci G., Palopoli C. A. M., Montori G., Bonati E., Dinuzzi V. P., Velluti F., Balla A., Bonasia D. E., Coletta D., Berardi G., Colasanti M., Ferretti S., Gasparoli C., Mariano G., Avenia S., Cianci P., Cestino L., Festa F., Fazio F., Ascari F., Desio M., Arroyo Murillo G. A., Cereda M., Galleano R., David G., Pansini A., Gazia C., Atzori G., Desideri L. F., Famularo S., Galvanin J., Giudici V. M., Mangiameli G., Mei S., Milana F., Pansa A., Sacchi M., Testori A., Di Carlo G., Paratore M., Perrone U., Vagge A., Vigano J., Torre B., Scotti M. A., Carbone G., Cerchione R., De Nardi P., Gozzini L., Ottaviani L., Senni C., Piccin O., Pio L., Colombo F., Avantifiori R., Baldassarri V., Caronna R., Cicerchia P. M., Corallino D., Crocetti D., Gallo G., Giovanardi F., Giovannetti F., Hassan R., Iossa A., Lai Q., Lancellotti F., Lucarini A., Lucchese S., Mazzarella G., Melandro F., Minervini A., Muttillo E. M., Palmieri L., Pasqua R., Rosiello F., Salina G., Sibio S., Sirignano P., Tarallo M., Usai S., Vanni C., Viglietta E., Zambon M., Conversano N. I., Epifani A. G., Milano V., Sacco L., Nava M., Maffioli A., Giuratrabocchetta S., Baracchi F., Zuolo M., Ceresoli M., Verdi D., Belli A., Pata F., Piovano E., Pastore G., Bernabei F., Deiana S., Arceri A., D'Agostino C., Marafante C., Moggia E., Parini S., Moretti M., Uggeri F., Pontarolo N., Fontana T., Palmisano G., Giuffrida M., Guaitoli E., Ferretti C., Iacopino G., Gioco R., Roscitano G., Montanelli P., Chiappetta M. F., Pinotti E., Monati E., Fazio G., Di Pietro F., Damarco F., Barberis A., Razzore A., Pascale A., Loi S., Ferrara F., Rossi M., Lisi G., Viel G., Sasia D., Bono D., Cordaro E. R., Giacomelli E., Giani I., Seriau L., Pellino G., Sparavigna M., Trigiante G., D'Ambrogio R. G., Cardella F., Guzzetti S., Luzzi A. -P., Carganico G., Drago B., Micheletto G., Orlandi R., Cutolo C., Gibello U., Mistrangelo M., Forcignano E., D'Ugo S., Losurdo P., Manitto M., Caroli G., Franco M., Tilocca P. L., Mendogni P., Sena G., Sambucci D., Luciani C., Atelli P., Guida A., Marino F., Morini A., Sibilla M. G., Longo F., Giaccari S., Vigorita V., Balduzzi A., Barra F., Delogu D., Milone E., Bencini L., Aprile V., Papini P., Montemurro N., Cavallo M., Picciariello A., Tomasicchio G., Fittipaldi A., Maruccia M., Gerardi S., Cillara N., Deidda S., Demarinis G., Peiretti E., Tatti F., Iovino C., Isola G., Progno V. C., Migliore M., Badessi G., Barilla C., Calleri G. S., Cianci S., Fama F., Fleres F., Mazzeo C., Visaloco M. G., Marchetto C., Bolognesi F., Benuzzi L., Bracchetti G., Brucchi F., Manzo C. A., Scaravilli L., Ferrari C., Rocca A., Napolitano P., Anoldo P., Caricato C., Manigrasso M., Milone M., Napolitano L., Palomba G., Schiavone V., Vetrella M., Grossi U., Moletta L., Annicchiarico A., Vella I., Talesa G., Boggi U., Aiello F., Anselmo A., Bacchiocchi G., Beati F., Bellato V., Billeci F., Blasi F., Buonomo O. C., Campanelli M., Coco G., Contadini A., Conte L. E., D'Ippolito G., Di Marcantonio A., Spicchiale C. F., Afflitto G. G., Gismondi A., Gorgolini G., Granai A. V., Grande S., Gravina A., Guida A. M., Ingallinella S., Keci L., Latini E., Marino D., Oddi F. M., Orecchia L., Don C. B. P., Pellicciaro M., Petagna L., Pirozzi B. M., Quaranta C., Rho M., Rosina A., Santicchia M. S., Saraceno F., Schiavone A., Sensi B., Spina A., Sullo L., Tacconi F., Taje R., Vanni G., Vinci D., Vita G., Alba G., Badalucco S., Carbone L., Samorani O. C., Chisci G., Cuomo R., Francia A., Fusario D., Gargiulo B., Pasqui E., Pasquetti L., Puoti P., Resca L., Cumbo J., Ganio S., Vizzielli G., Anastasi M., Guerra D., Romanzi A., Vannelli A., and Baia M.
- Abstract
COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March–April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients’ management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons’ personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon–patient/family communication. From the Italian surgeons’ perspective, COVID-related measures will continue to influence
- Published
- 2023
4. How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons
- Author
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Siragusa, L., Angelico, R., Angrisani, M., Zampogna, B., Materazzo, M., Sorge, R., Giordano, Lucia, Meniconi, R., Coppola, A., Marino, A., Giraudo, G., Esposito, S., Urbani, A., De Pastena, M., Mastrapasqua, R., Garancini, M., Frontal, A., Pascal, G., Martellucc, J., Falb, F., Boscarelli, A., Bertoglio, P., Trecca, E., Galassi, L., Vento, V., Chiappini, A., Antonelli, A., Bennardo, F., Familiari, F., Giannaccare, G., Zappia, A. S., Giuliani, G., Falcone, F., Sebastiani, S., Montuori, M., Rossi, S., Sagnotta, A., Giuliani, B., Imbriani, G. C., Restaino, S., Andreani, L., Di Maria, F., Lagana, A. S., Vitiello, L., Berton, F., Virgilio, E., Palisi, M., Portigliotti, L., Calussi, M., Conti, L., Mauriello, C., Barone, Alessia Maria Addolorata, Saladino, E., Giaquinta, A., Zerb, D., Frazzetta, G., Merola, G., Chierici, A., Bini, R., Centonze, L., De Carlis, R., Ferrario, L., Giani, A., Lauterio, A., Tamini, N., Corti, Serafino, Botteri, E., Andreuccetti, J., D'Alessio, R., Cestaro, G., Clarizia, G., Spolini, A., Carboni, A. S., Benzoni, E., Galiffa, G., Perotti, B., Veroux, M., Randazzo, V., Topa, D., Pranteda, C., Contini, G., Iacusso, C., Voglino, V., Vita, P., Carrano, F. M., Ambrosio, L., Cammarata, R., Capolupo, G. T., Caputo, D., Carannante, F., Cascone, C., Esperto, F., Farolfi, T., Frasca, L., Gallo, I. F., Gibin, G., Giurazza, G., Improta, L., La Vaccara, V., Luffarelli, P., Luvero, D., Marangi, Giuseppe, Masciana, G., Mazzola, A., Mazzotta, E., Miligi, C. I., Montelione, N., Nenna, A., Orsaria, P., Papalia, R., Papalia, G. F., Parisi, F. R., Prata, F., Salzillo, R., Santini, Stefano Angelo, Sofo, F., Zampoli, A., Tanda, C., Altieri, G., Ardito, Francesco, Belia, Francesco, Bianchi, V., Biondi, Alberto, Brisinda, Giuseppe, Chiappetta, M., Ciolli, G., Ciolli, Alessandro, Ferracci, Federica, Ferri, L., Fico, V., Fiorillo, Claudio, Fransvea, Pietro, Galiandro, F., Giovinazzo, F., La Greca, Antonio, Litta, Francesco, Mele, C., Pafundi, D. P., Panettieri, Elena, Papa, Valerio, Patini, Romeo, Perrotta, Generoso, Puccioni, Caterina, Santocchi, P., Armatura, G., Olmi, S., Casoni Pattacini, G., Salgarello, S., Trompetto, M., Bombardini, C., La Rocca, R., Celentano, G., Micalef, A., Mazzella, A., Settembrini, A., Zoia, C., Degrate, L., Musumeci, Giampaolo, Palopoli, C. A. M., Montori, G., Bonati, E., Dinuzzi, V. P., Velluti, F., Balla, A., Bonasia, D. E., Coletta, D., Berardi, Giulia, Colasanti, M., Ferretti, Serena, Gasparoli, C., Mariano, Giuseppantonio, Avenia, S., Cianci, P., Cestino, L., Festa, F., Fazio, F., Ascari, F., Desio, M., Arroyo Murillo, G. A., Cereda, M., Galleano, R., David, G., Pansini, A., Gazia, C., Atzori, G., Desideri, L. F., Famularo, S., Galvanin, J., Giudici, V. M., Mangiameli, Gaetano, Mei, S., Milana, F., Pansa, A., Sacchi, Dario Marco, Testori, A., Di Carlo, Giampiero, Paratore, Mattia, Perrone, U., Vagge, A., Vigano, J., Torre, B., Scotti, M. A., Carbone, G., Cerchione, R., De Nardi, P., Gozzini, L., Ottaviani, Letizia, Senni, C., Piccin, O., Pio, L., Colombo, F., Avantifiori, R., Baldassarri, V., Caronna, R., Cicerchia, P. M., Corallino, D., Crocetti, D., Gallo, Giuseppe, Giovanardi, F., Giovannetti, F., Hassan, R., Iossa, A., Lai, Q., Lancellotti, F., Lucarini, A., Lucchese, S., Mazzarella, Giulio, Melandro, F., Minervini, A., Muttillo, E. M., Palmieri, L., Pasqua, R., Rosiello, F., Salina, Giulia, Sibio, S., Sirignano, P., Tarallo, M., Usai, S., Vanni, C., Viglietta, E., Zambon, M., Conversano, N. I., Epifani, A. G., Milano, Valentina, Sacco, L., Nava, Bruna Maria, Maffioli, A., Giuratrabocchetta, S., Baracchi, F., Zuolo, M., Ceresoli, M., Verdi, D., Belli, Andrea, Pata, F., Piovano, E., Pastore, G., Bernabei, F., Deiana, S., Arceri, A., D'Agostino, Cinzia, Marafante, C., Moggia, E., Parini, S., Moretti, M., Uggeri, F., Pontarolo, N., Fontana, T., Palmisano, Gerardo, Giuffrida, M., Guaitoli, E., Ferretti, C., Iacopino, G., Gioco, R., Roscitano, G., Montanelli, P., Chiappetta, M. F., Pinotti, E., Monati, E., Fazio, G., Di Pietro, F., Damarco, F., Barberis, A., Razzore, A., Pascale, A., Loi, S., Ferrara, F., Rossi, Marco, Lisi, G., Viel, G., Sasia, D., Bono, D., Cordaro, E. R., Giacomelli, E., Giani, I., Seriau, L., Pellino, Giuseppe, Sparavigna, M., Trigiante, G., D'Ambrogio, R. G., Cardella, F., Guzzetti, S., Luzzi, A. -P., Carganico, G., Drago, B., Micheletto, G., Orlandi, R., Cutolo, C., Gibello, U., Mistrangelo, M., Forcignano, E., D'Ugo, S., Losurdo, P., Manitto, M., Caroli, G., Franco, Manuela, Tilocca, P. L., Mendogni, P., Sena, G., Sambucci, D., Luciani, C., Atelli, P., Guida, Maria Antonietta, Marino, Filippo, Morini, A., Sibilla, M. G., Longo, Fabio, Giaccari, S., Vigorita, V., Balduzzi, A., Barra, F., Delogu, D., Milone, E., Bencini, L., Aprile, V., Papini, P., Montemurro, N., Cavallo, Michele, Picciariello, A., Tomasicchio, G., Fittipaldi, A., Maruccia, M., Gerardi, S., Cillara, N., Deidda, Silvia, Demarinis, G., Peiretti, E., Tatti, F., Iovino, C., Isola, G., Progno, V. C., Migliore, M., Badessi, G., Barilla, C., Calleri, G. S., Cianci, Stefano, Fama, F., Fleres, F., Mazzeo, C., Visaloco, M. G., Marchetto, C., Bolognesi, F., Benuzzi, L., Bracchetti, G., Brucchi, F., Manzo, C. A., Scaravilli, L., Ferrari, C., Rocca, A., Napolitano, Paola, Anoldo, P., Caricato, Chiara, Manigrasso, M., Milone, Maria, Napolitano, L., Palomba, G., Schiavone, V., Vetrella, M., Grossi, U., Moletta, L., Annicchiarico, A., Vella, I., Talesa, G., Boggi, U., Aiello, F., Anselmo, Anna, Bacchiocchi, G., Beati, F., Bellato, V., Billeci, F., Blasi, F., Buonomo, O. C., Campanelli, M., Coco, G., Contadini, A., Conte, L. E., D'Ippolito, G., Di Marcantonio, A., Spicchiale, C. F., Afflitto, G. G., Gismondi, A., Gorgolini, G., Granai, A. V., Grande, S., Gravina, A., Guida, A. M., Ingallinella, S., Keci, L., Latini, E., Marino, D., Oddi, F. M., Orecchia, L., Don, C. B. P., Pellicciaro, M., Petagna, L., Pirozzi, B. M., Quaranta, Caterina, Rho, M., Rosina, Alessandro, Santicchia, M. S., Saraceno, F., Schiavone, A., Sensi, B., Spina, A., Sullo, L., Tacconi, F., Taje, R., Vanni, G., Vinci, D., Vita, G., Alba, G., Badalucco, S., Carbone, Luigi, Samorani, O. C., Chisci, G., Cuomo, Rosa, Francia, A., Fusario, D., Gargiulo, B., Pasqui, E., Pasquetti, L., Puoti, P., Resca, L., Cumbo, J., Ganio, S., Vizzielli, Giuseppe, Anastasi, M., Guerra, D., Romanzi, A., Vannelli, A., Baia, M., Giordano L., Barone M., Corti S., Marangi G. (ORCID:0000-0002-6898-8882), Santini S. (ORCID:0000-0003-1956-5899), Ardito F. (ORCID:0000-0003-1596-2862), Belia F., Biondi A. (ORCID:0000-0002-2470-7858), Brisinda G. (ORCID:0000-0001-8820-9471), Ciolli A., Ferracci F., Fiorillo C. (ORCID:0000-0001-7681-3567), Fransvea P. (ORCID:0000-0003-4969-3373), La Greca A. (ORCID:0000-0002-7587-7427), Litta F., Panettieri E., Papa V. (ORCID:0000-0002-3709-8924), Patini R. (ORCID:0000-0001-7358-8763), Perrotta G., Puccioni C., Musumeci G., Berardi G., Ferretti S., Mariano G., Mangiameli G., Sacchi M. (ORCID:0000-0003-2826-8431), Di Carlo G., Paratore M., Ottaviani L. (ORCID:0009-0001-0967-8809), Gallo G., Mazzarella G., Salina G., Milano V., Nava M., Belli A., D'Agostino C., Palmisano G., Rossi M. (ORCID:0000-0002-4539-5670), Pellino G., Franco M., Guida A., Marino F., Longo F., Cavallo M., Deidda S., Cianci S., Napolitano P., Caricato C., Milone M., Anselmo A., Quaranta C., Rosina A. (ORCID:0000-0002-0158-0583), Carbone L., Cuomo R., Vizzielli G., Siragusa, L., Angelico, R., Angrisani, M., Zampogna, B., Materazzo, M., Sorge, R., Giordano, Lucia, Meniconi, R., Coppola, A., Marino, A., Giraudo, G., Esposito, S., Urbani, A., De Pastena, M., Mastrapasqua, R., Garancini, M., Frontal, A., Pascal, G., Martellucc, J., Falb, F., Boscarelli, A., Bertoglio, P., Trecca, E., Galassi, L., Vento, V., Chiappini, A., Antonelli, A., Bennardo, F., Familiari, F., Giannaccare, G., Zappia, A. S., Giuliani, G., Falcone, F., Sebastiani, S., Montuori, M., Rossi, S., Sagnotta, A., Giuliani, B., Imbriani, G. C., Restaino, S., Andreani, L., Di Maria, F., Lagana, A. S., Vitiello, L., Berton, F., Virgilio, E., Palisi, M., Portigliotti, L., Calussi, M., Conti, L., Mauriello, C., Barone, Alessia Maria Addolorata, Saladino, E., Giaquinta, A., Zerb, D., Frazzetta, G., Merola, G., Chierici, A., Bini, R., Centonze, L., De Carlis, R., Ferrario, L., Giani, A., Lauterio, A., Tamini, N., Corti, Serafino, Botteri, E., Andreuccetti, J., D'Alessio, R., Cestaro, G., Clarizia, G., Spolini, A., Carboni, A. S., Benzoni, E., Galiffa, G., Perotti, B., Veroux, M., Randazzo, V., Topa, D., Pranteda, C., Contini, G., Iacusso, C., Voglino, V., Vita, P., Carrano, F. M., Ambrosio, L., Cammarata, R., Capolupo, G. T., Caputo, D., Carannante, F., Cascone, C., Esperto, F., Farolfi, T., Frasca, L., Gallo, I. F., Gibin, G., Giurazza, G., Improta, L., La Vaccara, V., Luffarelli, P., Luvero, D., Marangi, Giuseppe, Masciana, G., Mazzola, A., Mazzotta, E., Miligi, C. I., Montelione, N., Nenna, A., Orsaria, P., Papalia, R., Papalia, G. F., Parisi, F. R., Prata, F., Salzillo, R., Santini, Stefano Angelo, Sofo, F., Zampoli, A., Tanda, C., Altieri, G., Ardito, Francesco, Belia, Francesco, Bianchi, V., Biondi, Alberto, Brisinda, Giuseppe, Chiappetta, M., Ciolli, G., Ciolli, Alessandro, Ferracci, Federica, Ferri, L., Fico, V., Fiorillo, Claudio, Fransvea, Pietro, Galiandro, F., Giovinazzo, F., La Greca, Antonio, Litta, Francesco, Mele, C., Pafundi, D. P., Panettieri, Elena, Papa, Valerio, Patini, Romeo, Perrotta, Generoso, Puccioni, Caterina, Santocchi, P., Armatura, G., Olmi, S., Casoni Pattacini, G., Salgarello, S., Trompetto, M., Bombardini, C., La Rocca, R., Celentano, G., Micalef, A., Mazzella, A., Settembrini, A., Zoia, C., Degrate, L., Musumeci, Giampaolo, Palopoli, C. A. M., Montori, G., Bonati, E., Dinuzzi, V. P., Velluti, F., Balla, A., Bonasia, D. E., Coletta, D., Berardi, Giulia, Colasanti, M., Ferretti, Serena, Gasparoli, C., Mariano, Giuseppantonio, Avenia, S., Cianci, P., Cestino, L., Festa, F., Fazio, F., Ascari, F., Desio, M., Arroyo Murillo, G. A., Cereda, M., Galleano, R., David, G., Pansini, A., Gazia, C., Atzori, G., Desideri, L. F., Famularo, S., Galvanin, J., Giudici, V. M., Mangiameli, Gaetano, Mei, S., Milana, F., Pansa, A., Sacchi, Dario Marco, Testori, A., Di Carlo, Giampiero, Paratore, Mattia, Perrone, U., Vagge, A., Vigano, J., Torre, B., Scotti, M. A., Carbone, G., Cerchione, R., De Nardi, P., Gozzini, L., Ottaviani, Letizia, Senni, C., Piccin, O., Pio, L., Colombo, F., Avantifiori, R., Baldassarri, V., Caronna, R., Cicerchia, P. M., Corallino, D., Crocetti, D., Gallo, Giuseppe, Giovanardi, F., Giovannetti, F., Hassan, R., Iossa, A., Lai, Q., Lancellotti, F., Lucarini, A., Lucchese, S., Mazzarella, Giulio, Melandro, F., Minervini, A., Muttillo, E. M., Palmieri, L., Pasqua, R., Rosiello, F., Salina, Giulia, Sibio, S., Sirignano, P., Tarallo, M., Usai, S., Vanni, C., Viglietta, E., Zambon, M., Conversano, N. I., Epifani, A. G., Milano, Valentina, Sacco, L., Nava, Bruna Maria, Maffioli, A., Giuratrabocchetta, S., Baracchi, F., Zuolo, M., Ceresoli, M., Verdi, D., Belli, Andrea, Pata, F., Piovano, E., Pastore, G., Bernabei, F., Deiana, S., Arceri, A., D'Agostino, Cinzia, Marafante, C., Moggia, E., Parini, S., Moretti, M., Uggeri, F., Pontarolo, N., Fontana, T., Palmisano, Gerardo, Giuffrida, M., Guaitoli, E., Ferretti, C., Iacopino, G., Gioco, R., Roscitano, G., Montanelli, P., Chiappetta, M. F., Pinotti, E., Monati, E., Fazio, G., Di Pietro, F., Damarco, F., Barberis, A., Razzore, A., Pascale, A., Loi, S., Ferrara, F., Rossi, Marco, Lisi, G., Viel, G., Sasia, D., Bono, D., Cordaro, E. R., Giacomelli, E., Giani, I., Seriau, L., Pellino, Giuseppe, Sparavigna, M., Trigiante, G., D'Ambrogio, R. G., Cardella, F., Guzzetti, S., Luzzi, A. -P., Carganico, G., Drago, B., Micheletto, G., Orlandi, R., Cutolo, C., Gibello, U., Mistrangelo, M., Forcignano, E., D'Ugo, S., Losurdo, P., Manitto, M., Caroli, G., Franco, Manuela, Tilocca, P. L., Mendogni, P., Sena, G., Sambucci, D., Luciani, C., Atelli, P., Guida, Maria Antonietta, Marino, Filippo, Morini, A., Sibilla, M. G., Longo, Fabio, Giaccari, S., Vigorita, V., Balduzzi, A., Barra, F., Delogu, D., Milone, E., Bencini, L., Aprile, V., Papini, P., Montemurro, N., Cavallo, Michele, Picciariello, A., Tomasicchio, G., Fittipaldi, A., Maruccia, M., Gerardi, S., Cillara, N., Deidda, Silvia, Demarinis, G., Peiretti, E., Tatti, F., Iovino, C., Isola, G., Progno, V. C., Migliore, M., Badessi, G., Barilla, C., Calleri, G. S., Cianci, Stefano, Fama, F., Fleres, F., Mazzeo, C., Visaloco, M. G., Marchetto, C., Bolognesi, F., Benuzzi, L., Bracchetti, G., Brucchi, F., Manzo, C. A., Scaravilli, L., Ferrari, C., Rocca, A., Napolitano, Paola, Anoldo, P., Caricato, Chiara, Manigrasso, M., Milone, Maria, Napolitano, L., Palomba, G., Schiavone, V., Vetrella, M., Grossi, U., Moletta, L., Annicchiarico, A., Vella, I., Talesa, G., Boggi, U., Aiello, F., Anselmo, Anna, Bacchiocchi, G., Beati, F., Bellato, V., Billeci, F., Blasi, F., Buonomo, O. C., Campanelli, M., Coco, G., Contadini, A., Conte, L. E., D'Ippolito, G., Di Marcantonio, A., Spicchiale, C. F., Afflitto, G. G., Gismondi, A., Gorgolini, G., Granai, A. V., Grande, S., Gravina, A., Guida, A. M., Ingallinella, S., Keci, L., Latini, E., Marino, D., Oddi, F. M., Orecchia, L., Don, C. B. P., Pellicciaro, M., Petagna, L., Pirozzi, B. M., Quaranta, Caterina, Rho, M., Rosina, Alessandro, Santicchia, M. S., Saraceno, F., Schiavone, A., Sensi, B., Spina, A., Sullo, L., Tacconi, F., Taje, R., Vanni, G., Vinci, D., Vita, G., Alba, G., Badalucco, S., Carbone, Luigi, Samorani, O. C., Chisci, G., Cuomo, Rosa, Francia, A., Fusario, D., Gargiulo, B., Pasqui, E., Pasquetti, L., Puoti, P., Resca, L., Cumbo, J., Ganio, S., Vizzielli, Giuseppe, Anastasi, M., Guerra, D., Romanzi, A., Vannelli, A., Baia, M., Giordano L., Barone M., Corti S., Marangi G. (ORCID:0000-0002-6898-8882), Santini S. (ORCID:0000-0003-1956-5899), Ardito F. (ORCID:0000-0003-1596-2862), Belia F., Biondi A. (ORCID:0000-0002-2470-7858), Brisinda G. (ORCID:0000-0001-8820-9471), Ciolli A., Ferracci F., Fiorillo C. (ORCID:0000-0001-7681-3567), Fransvea P. (ORCID:0000-0003-4969-3373), La Greca A. (ORCID:0000-0002-7587-7427), Litta F., Panettieri E., Papa V. (ORCID:0000-0002-3709-8924), Patini R. (ORCID:0000-0001-7358-8763), Perrotta G., Puccioni C., Musumeci G., Berardi G., Ferretti S., Mariano G., Mangiameli G., Sacchi M. (ORCID:0000-0003-2826-8431), Di Carlo G., Paratore M., Ottaviani L. (ORCID:0009-0001-0967-8809), Gallo G., Mazzarella G., Salina G., Milano V., Nava M., Belli A., D'Agostino C., Palmisano G., Rossi M. (ORCID:0000-0002-4539-5670), Pellino G., Franco M., Guida A., Marino F., Longo F., Cavallo M., Deidda S., Cianci S., Napolitano P., Caricato C., Milone M., Anselmo A., Quaranta C., Rosina A. (ORCID:0000-0002-0158-0583), Carbone L., Cuomo R., and Vizzielli G.
- Abstract
COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March–April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients’ management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons’ personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon–patient/family communication. From the Italian surgeons’ perspective, COVID-related measures will continue to influence
- Published
- 2023
5. First detection of West Caucasian Bat Lyssavirus infection in a domestic cat, Italy, 2020: ecological and sanitary implications
- Author
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Leopardi, S., primary, Barneschi, E., additional, Manna, G., additional, Zecchin, B., additional, Priori, P., additional, Drzewnioková, P., additional, Festa, F., additional, Lombardo, A., additional, Parca, F., additional, Scaravelli, D., additional, Ponti, A. Maroni, additional, and De Benedictis, P., additional
- Published
- 2022
- Full Text
- View/download PDF
6. Augmented reality (AR) in minimally invasive surgery (MIS) training: where are we now in Italy? The Italian Society of Endoscopic Surgery (SICE) ARMIS survey
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Balla, Andrea, Sartori, Alberto, Botteri, Emanuele, Podda, Mauro, Ortenzi, Monica, Silecchia, Gianfranco, Guerrieri, Mario, Agresta, Ferdinando, Antonino, Agrusa, Daniele, Aguzzi, Mariantonietta, Alagia, Laura, Alberici, Marco Ettore Allaix, Luisa, Ambrosio, Alfonso, Amendola, Michele, Ammendola, Pietro Maria Amodio, Gabriele, Anania, Jacopo, Andreuccetti, Alfredo, Annichiarico, Pietro, Anoldo, Alessandro, Anselmo, Giovanni, Aprea, Giacomo, Arcuri, Alberto, Arezzo, Giulia, Armatura, Giulia, Bagaglini, Francesco, Bagolini, Beatrice, Bailetti, Gianluca, Baiocchi, Edoardo, Baldini, Elisa, Bannone, Mirko, Barone, Gianluca, Baronio, Raffaele, Basile, Bellucci, Marco, Andrea Benedetti Cacciaguerra, Ilaria, Benzoni, Francesco, Bianco, Giuseppe, Boccia, Cristina, Bombardini, Luigi, Boni, Dario, Bono, Luca Domenico Bonomo, Giulia, Bonventre, Andrea, Bottari, Claudio, Botti, Giacomo, Brentegani, Mattia, Buonomo, Umberto, Bracale, Cosimo, Callari, Luca, Calligaris, Pietro Giorgio Calò, Angelo, Cangiano, Lorenzo, Capezzuoli, Gabriella Teresa Capolupo, Marianna, Capuano, Filippo, Carannante, Eugenia, Cardamone, Teresa, Carfora, Chiara, Caricato, Pietro, Carnevali, Francesco Maria Carrano, Lorenzo, Casali, Gianmaria Casoni Pataccini, Gianluca, Cassese, Simone, Castiglioni, Flavia, Cavicchi, Ceccarelli, Graziano, Giovanni, Cestaro, Pasquale, Cianci, Claudio, Cimmino, Marco, Clementi, Coletta, Diego, Riccardo, Conventi, Corallino, Diletta, Maurizio, Costantini, Lorenzo, Crepaz, Diego, Cuccurullo, Curci, FABIO PIO, Giuseppe, Currò, Giorgio, Dalmonte, Giovanni, D'Alterio, Michele, D'Ambra, D'Ambrosio, Giancarlo, Anna, D'Amore, Michele De Capua, Simona, Deidda, Daniele, Delogu, Maurizio De Luca, Nicolò De Manzini, DE STEFANI, Elena, Giuseppe Di Buono, Marcello Di Martino, DI TOMASO, Anna, Ugo, Elmore, CORDOVA HERENCIA, INGRID ELVA, Giovanni, Emiliani, Sofia, Esposito, Fazio, Federico, Federico, Festa, Marcello, Filotico, Fiocca, Fausto, Irene, Fiume, Francesco, Fleres, Giulia, Fontana, Tommaso, Fontana, Edoardo, Forcignanò, Giampaolo, Formisano, Laura, Fortuna, Uberto Fumagalli Romario, Andrea, Galderisi, Raffaele, Galleano, Carlo, Gazia, Alessio, Giordano, Giorgio, Giraudo, Maria Carmela Giuffrida, Simona, Giura, Anna, Guida, Antonio Maria Iannello, Marco, Inama, Sara, Ingallinella, Iossa, Angelo, Livio, Iudici, Laracca, GIOVANNI GUGLIELMO, LARGHI LAUREIRO, Zoe, Saverio, Latteri, Luca, Leonardi, Pasquale, Lepiane, Edelweiss, Licitra, Paolo, Locurto, Sarah Lo Faso, Nicola, Luciani, Luzza, Luigi, Magaletti, Sara, Michele, Manigrasso, Alessandra, Marano, Francesco, Marchetti, Alessandra, Marello, Nicolò, Mariani, Jacopo Nicolò Marin, Gennaro, Martines, Laura, Mastrangelo, Antonio, Matarangolo, Marco, Materazzo, Mazzarella, Gennaro, Giorgio, Mazzarolo, Maria Paola Menna, Meoli, Francesca, Marco, Milone, Elisabetta, Moggia, Davide, Moioli, Sarah, Molfino, Vitantonio, Mongelli, Roberto, Montalti, Giulia, Montori, Luca, Morelli, Gianluigi, Moretto, Muttillo, EDOARDO MARIA, Irnerio, Muttillo, Francesca, Notte, Alessandro, M Paganini, Gianluca, Pagano, Palmieri, Livia, Giuseppe, Palomba, Valentina, Palumbo, Panetta, Cristina, Giulia, Paradiso, Beniamino, Pascotto, Passannanti, Daniele, Renato, Patrone, Francesca, Pecchini, Francesca, Pego, Fabio, Pelle, Perrotta, Nicola, Wanda, Petz, Biagio, Picardi, Picchetto, Andrea, Chiara, Piceni, Pietricola, Giulia, Enrico, Pinotti, Felice, Pirozzi, Paolo, Pizzini, Poillucci, Gaetano, Ilaria, Puccica, Lorenzo, Ramaci, Rapanotti, Eleonora, Daniela, Rega, Angelica, Reggiani, Giorgio, Romano, Gregorio, Romeo, Luigi, Romeo, Gianluca, Rompianesi, Stefano, Rossi, Edoardo, Saladino, Roberto, Santambrogio, Federica, Saraceno, Giuliano, Sarro, Diego, Sasia, Grazia, Savino, Rosa, Scaramuzzo, Antonio, Sciuto, Michela, Scollica, Giovanni, Scudo, Ardit, Seitaj, Carlo, Serra, Francesco, Serra, Pierpaolo, Sileri, Leandro, Siragusa, Carmen, Sorrentino, Giuseppe, Surfaro, Ernesto, Tartaglia, Beatrice, Torre, Andrea, Tufo, Matteo, Uccelli, Alessandro, Ussia, Vaccari, Samuele, Marina, Valente, Sara, Vertaldi, Alessandro, Vitali, Luca, Zaccherini, Luigi, Zorcolo, Noemi, Zorzetti, Balla, A., Sartori, A., Botteri, E., Podda, M., Ortenzi, M., Silecchia, G., Guerrieri, M., Agresta, F., Agrusa, A., Aguzzi, D., Alagia, M., Alberici, L., Allaix, M. E., Ambrosio, L., Amendola, A., Ammendola, M., Amodio, P. M., Anania, G., Andreuccetti, J., Annichiarico, A., Anoldo, P., Anselmo, A., Aprea, G., Arcuri, G., Arezzo, A., Armatura, G., Bagaglini, G., Bagolini, F., Bailetti, B., Baiocchi, G., Baldini, E., Bannone, E., Barone, M., Baronio, G., Basile, R., Bellucci, M., Cacciaguerra, A. B., Benzoni, I., Bianco, F., Boccia, G., Bombardini, C., Boni, L., Bono, D., Bonomo, L. D., Bonventre, G., Bottari, A., Botti, C., Brentegani, G., Buonomo, M., Bracale, U., Callari, C., Calligaris, L., Calo, P. G., Cangiano, A., Capezzuoli, L., Capolupo, G. T., Capuano, M., Carannante, F., Cardamone, E., Carfora, T., Caricato, C., Carnevali, P., Carrano, F. M., Casali, L., Pataccini, G. C., Cassese, G., Castiglioni, S., Cavicchi, F., Ceccarelli, G., Cestaro, G., Cianci, P., Cimmino, C., Clementi, M., Coletta, D., Conventi, R., Corallino, D., Costantini, M., Crepaz, L., Cuccurullo, D., Curci, F. P., Curro, G., Dalmonte, G., D'Alterio, G., D'Ambra, M., D'Ambrosio, G., D'Amore, A., De Capua, M., Deidda, S., Delogu, D., De Luca, M., De Manzini, N., De Stefani, E., Di Buono, G., Di Martino, M., Di Tomaso, A., Elmore, U., Herencia, I. E. C., Emiliani, G., Esposito, S., Fazio, F., Festa, F., Filotico, M., Fiocca, F., Fiume, I., Fleres, F., Fontana, G., Fontana, T., Forcignano, E., Formisano, G., Fortuna, L., Romario, U. F., Galderisi, A., Galleano, R., Gazia, C., Giordano, A., Giraudo, G., Giuffrida, M. C., Giura, S., Guida, A., Iannello, A. M., Inama, M., Ingallinella, S., Iossa, A., Iudici, L., Laracca, G. G., Laureiro, Z. L., Latteri, S., Leonardi, L., Lepiane, P., Licitra, E., Locurto, P., Faso, S. L., Luciani, N., Luzza, L., Magaletti, S., Manigrasso, M., Marano, A., Marchetti, F., Marello, A., Mariani, N., Marin, J. N., Martines, G., Mastrangelo, L., Matarangolo, A., Materazzo, M., Mazzarella, G., Mazzarolo, G., Menna, M. P., Meoli, F., Milone, M., Moggia, E., Moioli, D., Molfino, S., Mongelli, V., Montalti, R., Montori, G., Morelli, L., Moretto, G., Muttillo, E. M., Muttillo, I., Notte, F., Paganini, A. M., Pagano, G., Palmieri, L., Palomba, G., Palumbo, V., Panetta, C., Paradiso, G., Pascotto, B., Passannanti, D., Patrone, R., Pecchini, F., Pego, F., Pelle, F., Perrotta, N., Petz, W., Picardi, B., Picchetto, A., Piceni, C., Pietricola, G., Pinotti, E., Pirozzi, F., Pizzini, P., Poillucci, G., Puccica, I., Ramaci, L., Rapanotti, E., Rega, D., Reggiani, A., Romano, G., Romeo, G., Romeo, L., Rompianesi, G., Rossi, S., Saladino, E., Santambrogio, R., Saraceno, F., Sarro, G., Sasia, D., Savino, G., Scaramuzzo, R., Sciuto, A., Scollica, M., Scudo, G., Seitaj, A., Serra, C., Serra, F., Sileri, P., Siragusa, L., Sorrentino, C., Surfaro, G., Tartaglia, E., Torre, B., Tufo, A., Uccelli, M., Ussia, A., Vaccari, S., Valente, M., Vertaldi, S., Vitali, A., Zaccherini, L., Zorcolo, L., Zorzetti, N., Balla, Andrea, Sartori, Alberto, Botteri, Emanuele, Podda, Mauro, Ortenzi, Monica, Silecchia, Gianfranco, Guerrieri, Mario, Agresta, Ferdinando, de Manzini, Nicolo, and ARMIS (Augmented Reality in Minimally Invasive Surgery) Collaborative, Group
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Virtual reality (VR) ,minimally invasive surgery (MIS) ,Augmented reality (AR) ,Minimally invasive surgery (MIS) ,Mixed reality (MR) ,Survey ,Training ,training ,augmented reality (AR) ,mixed reality (MR) ,survey ,virtual reality (VR) ,Settore MED/18 - Chirurgia Generale ,Surgery - Abstract
Minimally invasive surgery (MIS) is a widespread approach in general surgery. Computer guiding software, such as the augmented reality (AR), the virtual reality (VR) and mixed reality (MR), has been proposed to help surgeons during MIS. This study aims to report these technologies' current knowledge and diffusion during surgical training in Italy. A web-based survey was developed under the aegis of the Italian Society of Endoscopic Surgery (SICE). Two hundred and seventeen medical doctors' answers were analyzed. Participants were surgeons (138, 63.6%) and residents in surgery (79, 36.4%). The mean knowledge of the role of the VR, AR and MR in surgery was 4.9 ± 2.4 (range 1-10). Most of the participants (122, 56.2%) did not have experience with any proposed technologies. However, although the lack of experience in this field, the answers about the functioning of the technologies were correct in most cases. Most of the participants answered that VR, AR and MR should be used more frequently for the teaching and training and during the clinical activity (170, 80.3%) and that such technologies would make a significant contribution, especially in training (183, 84.3%) and didactic (156, 71.9%). Finally, the main limitations to the diffusion of these technologies were the insufficient knowledge (182, 83.9%) and costs (175, 80.6%). Based on the present study, in Italy, the knowledge and dissemination of these technologies are still limited. Further studies are required to establish the usefulness of AR, VR and MR in surgical training.
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- 2023
7. Towards Sustainable Orthodontics: Environmental Implications and Strategies for Clear Aligner Therapy.
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Macrì M, D'Albis V, Marciani R, Nardella M, and Festa F
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The increasing concern over environmental sustainability has prompted various industries to reassess their practices and explore greener alternatives. Dentistry, as a significant contributor to waste generation, is actively seeking methods to minimize its environmental footprint. This paper examines the environmental implications of clear aligner therapy (CAT) in orthodontics and explores strategies to prioritize sustainability in aligner manufacturing and usage. CAT has gained popularity as a viable alternative to traditional fixed appliances due to advancements in biomaterials and computer-aided design (CAD) and manufacturing (CAM) technologies. The global market for clear aligners is expanding rapidly, with significant growth projected in the coming years. To address these challenges, this paper proposes adopting the principles of reduce, reuse, recycle, and rethink (4Rs) in orthodontic practices. Strategies such as minimizing resource consumption, incorporating recycled materials, and promoting proper aligner disposal and recycling can significantly reduce environmental harm. This paper explores emerging technologies and materials to mitigate the environmental impacts of CAT. Additionally, initiatives promoting aligner recycling and repurposing offer promising avenues for reducing plastic waste and fostering a circular economy. In conclusion, while CAT offers numerous benefits in orthodontic treatment, its environmental impact cannot be overlooked. By implementing sustainable practices and embracing innovative solutions, the orthodontic community can contribute to a more environmentally conscious future while continuing to provide quality care to patients.
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- 2024
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8. Midpalatal Suture Maturation in Relation to Age, Sex, and Facial Skeletal Growth Patterns: A CBCT Study.
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Festa F, Festa M, Medori S, Perrella G, Valentini P, Bolino G, and Macrì M
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Background: The evaluation of midpalatal suture maturation is essential to undertake the most predictable maxillary expansion approach. Several factors, such as age, gender, and facial growth patterns, seem to be involved in midpalatal suture staging and, consequently, in its opening; however, the link between these variables and the stages of midpalatal suture development remains poorly understood. Our study aimed to analyse the midpalatal suture maturation in relation to age, sex, and skeletal growth patterns by CBCT., Methods: We enrolled 263 patients (119 males and 144 females) aged from 8 to 20 years. The midpalatal suture maturation was defined according to Angelieri et al.'s classification using a low-dose CBCT. The chi-square test and linear regression were applied to investigate the suture stages by age, sex, and vertical and sagittal growth patterns., Results: Stage A was present in 8- and 9-year-olds with a larger prevalence in boys, while the prevalence of stage E increased progressively with age. Stage D was the most prevalent in our sample. The statistical analysis described that stage A was more likely in the youngest subjects, and stage E in the oldest participants. The males tended to have lower maturation stages. Moreover, the hypodivergent and normodivergent subjects tended to have higher maturation stages, while Class III was more likely in subjects in stages D or E., Conclusions: A total of 127 patients were in stages A, B, and C, showing an unfused suture. In young individuals, the opening of the midpalatal suture leads to a proper facial growth development by correcting the transverse superior hypoplasia. The midpalatal sutural maturation classification was related to age, sex, and divergence.
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- 2024
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9. Three-Dimensional Analysis of the Maxillary Sinuses in Ancient Crania Dated to the V-VI Centuries BCE from Opi (Italy): Volumetric Measurements in Ancient Skulls from the Necropolis of Opi, Abruzzi, Italy.
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Festa F, D'Anastasio R, Benazzi S, and Macrì M
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Cone beam computed tomography (CBCT) can provide precise information about complex anatomical structures as it is characterised by rapid volumetric image acquisition with high resolution. The aim of this study was to provide measurements for 20 ancient skulls of the Samnite people found in the necropolis of Opi, a small and isolated mountain village in Abruzzo, a region in central Italy. All the images (left and right) of the 20 ancient skulls from Opi were acquired. All the data are the property of the Department of Innovative Technologies in Medicine and Dentistry of G. D'Annunzio University, Chieti, and different parameters (area and volume) were measured and evaluated. The mean and standard deviation of the facial measurements were also calculated. All the data were subjected to statistical analysis. CBCT scan data of 20 fossil skulls did not show significant values regarding the MS area and the volume between the right and left sides. In the ancient skulls, no difference was found between the right and left sides.
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- 2024
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10. The Role and Applications of Artificial Intelligence in Dental Implant Planning: A Systematic Review.
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Macrì M, D'Albis V, D'Albis G, Forte M, Capodiferro S, Favia G, Alrashadah AO, García VD, and Festa F
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Artificial intelligence (AI) is revolutionizing dentistry, offering new opportunities to improve the precision and efficiency of implantology. This literature review aims to evaluate the current evidence on the use of AI in implant planning assessment. The analysis was conducted through PubMed and Scopus search engines, using a combination of relevant keywords, including "artificial intelligence implantology", "AI implant planning", "AI dental implant", and "implantology artificial intelligence". Selected articles were carefully reviewed to identify studies reporting data on the effectiveness of AI in implant planning. The results of the literature review indicate a growing interest in the application of AI in implant planning, with evidence suggesting an improvement in precision and predictability compared to traditional methods. The summary of the obtained findings by the included studies represents the latest AI developments in implant planning, demonstrating its application for the automated detection of bones, the maxillary sinus, neuronal structure, and teeth. However, some disadvantages were also identified, including the need for high-quality training data and the lack of standardization in protocols. In conclusion, the use of AI in implant planning presents promising prospects for improving clinical outcomes and optimizing patient management. However, further research is needed to fully understand its potential and address the challenges associated with its implementation in clinical practice.
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- 2024
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11. Periodontal Health and Its Relationship with Psychological Stress: A Cross-Sectional Study.
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Macrì M, D'Albis G, D'Albis V, Antonacci A, Abbinante A, Stefanelli R, Pegreffi F, and Festa F
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Background : Studies suggest that chronic psychological stress can lead to oral health deterioration, alter the immune response, and possibly contribute to increased inflammation, which can impact the physiological healing of periodontal tissues. This cross-sectional study seeks to assess and improve clinical understanding regarding the relationship between perceived stress, mindfulness, and periodontal health. Methods : A total of 203 people were analyzed from December 2022 to June 2023. The Periodontal Screening and Recording (PSR) score and Gingival Bleeding Index (GBI), and Plaque Control Record (PCR) of every patient were registered. Subsequently, participants completed the Sheldon Cohen Perceived Stress Scale (PSS) and the Mindfulness Awareness Attention Scale (MAAS) questionnaires. The collected data underwent statistical analysis, encompassing the evaluation of correlations and dependencies. Applying Welch's t -test to assess the relationship between MAAS and the variable indicating the presence or absence of periodontitis, a noteworthy p -value of 0.004265 was obtained. Results : This underscores a significant distinction in MAAS scores between patients affected by periodontitis and those unaffected by the condition. Additionally, Pearson correlations were computed for GBI and perceived stress, PCR and perceived stress, PCR and MAAS. The resulting p -values of 2.2-16, 3.925-8, and 2.468-8, respectively, indicate a statistically significant correlation in each instance. Conclusions : These findings contribute valuable insights into the interconnectedness of these variables, emphasizing the significance of their associations in the study context. Despite the limitations, the findings of this study suggest a significant relationship between psychological stress, mindfulness, and periodontal tissue health. Clinical trials are necessary to incorporate the assessment of a patient's psychological status as a new valuable tool in the management of periodontal health.
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- 2024
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12. Non-Pharmacological Pain Treatment of Patients with Myofascial Pain Syndrome of the Masticatory Muscles-Case Series.
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Macrì M, Rotelli C, Pegreffi F, and Festa F
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Myofascial pain is the most common cause of chronic pain in the masticatory region and can be assessed through clinical analysis and muscle palpation. Generally, it appears with headache and orofacial pain associated with sensitive points (trigger points) due to the excessive contraction of the masticatory muscle fibers. The study aims to evaluate how a correct treatment of myofascial pain can improve the life quality of affected patients. In this case series, 300 patients with myofascial pain were divided into two groups: 150 with intra- and extra-articular disorders and 150 with only extra-articular disorder. Each group included 75 males and 75 females. All the patients were treated with gnathological therapy through passive aligners and biofeedback exercises for four months. They underwent pain assessment (through a visual analogue scale and muscular palpation test) before, during, and after the treatment, as well as nuclear magnetic resonance of the temporomandibular joint before and after the gnathological treatment. The treatment considerably reduced the pain in all patients, without drugs, in four months according to the visual analogue scales and the palpation test. The temporomandibular magnetic resonance in each patient was similar before and after the gnathological treatment. The improvement in pain did not depend on a change in the relationship between the articular condyle and the disc.
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- 2023
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13. Impact of frailty on clinical outcomes and resource utilization of hospitalizations for renal stone surgery.
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Uwumiro F, Okpujie V, Madu F, Abesin O, Chigbu N, Isuekebhor C, Ezennaya L, Olaomi O, Bojerenu M, and Aderehinwo B
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- Adult, Humans, Cohort Studies, Postoperative Complications epidemiology, Postoperative Complications etiology, Hospitalization, Length of Stay, Risk Factors, Retrospective Studies, Frailty epidemiology, Frailty complications, Kidney Calculi complications
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Purpose: Frailty is reportedly associated with poorer outcomes among surgical patients. Using a coding-based frailty tool, we investigated the impact of frailty on clinical outcomes and resource utilization for urolithiasis hospitalizations., Methods: A cohort study using the 2018 National Inpatient Sample database. All adult elective hospitalizations for urolithiasis were included in the study. The study population was categorized into FRAIL and non-frail (nFRAIL) cohorts using the Johns Hopkins Adjusted Clinical Groups frailty clusters. The association between frailty and clinical and financial outcomes was evaluated using multivariate regression models., Results: About 1028 (14.9%) out of 6900 total hospitalizations were frail. Frailty was not associated with a significant increase in the odds of in-hospital mortality (adjusted odds ratio (aOR) 1.73, 95% CI 0.15-20.02) or length of hospital stay, but was associated with a lower chance of surgery within 24 h of admission (aOR 0.65, 95% CI 0.48-0.90, P = 0.008). A higher Charlson index was independently associated with an over 100% increase in the odds of in-hospital mortality (aOR 2.091, 95% CI 1.53-2.86, P < 0.001). Frail patients paid $15,993 higher in total hospital costs and had a higher likelihood of non-home discharges (aOR 4.29, 95% CI 2.74-6.71, P < 0.001) and peri-operative complications (aOR 1.77, 95% CI 1.14-2.73, P = 0.01)., Conclusion: Frailty was correlated with unfavorable outcomes, except mortality and prolonged hospital stay. Incorporating frailty evaluation into risk models has the potential to enhance patient selection and preparation for urolithiasis intervention., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2023
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14. One health surveillance strategy for coronaviruses in Italian wildlife - CORRIGENDUM.
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Leopardi S, Desiato R, Mazzucato M, Orusa R, Obber F, Averaimo D, Berjaoui S, Canziani S, Capucchio MT, Conti R, di Bella S, Festa F, Garofalo L, Lelli D, Madrau MP, Mandola ML, Martin AMM, Peletto S, Pirani S, Robetto S, Torresi C, Varotto M, Citterio C, and Terregino C
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- 2023
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15. Move Your Body, Boost Your Brain: The Positive Impact of Physical Activity on Cognition across All Age Groups.
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Festa F, Medori S, and Macrì M
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While the physical improvements from exercise have been well documented over the years, the impact of physical activity on mental health has recently become an object of interest. Physical exercise improves cognition, particularly attention, memory, and executive functions. However, the mechanisms underlying these effects have yet to be fully understood. Consequently, we conducted a narrative literature review concerning the association between acute and chronic physical activity and cognition to provide an overview of exercise-induced benefits during the lifetime of a person. Most previous papers mainly reported exercise-related greater expression of neurotransmitter and neurotrophic factors. Recently, structural and functional magnetic resonance imaging techniques allowed for the detection of increased grey matter volumes for specific brain regions and substantial modifications in the default mode, frontoparietal, and dorsal attention networks following exercise. Here, we highlighted that physical activity induced significant changes in functional brain activation and cognitive performance in every age group and could counteract psychological disorders and neural decline. No particular age group gained better benefits from exercise, and a specific exercise type could generate better cognitive improvements for a selected target subject. Further research should develop appropriate intervention programs concerning age and comorbidity to achieve the most significant cognitive outcomes.
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- 2023
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16. Transmission dynamics of lyssavirus in Myotis myotis : mechanistic modelling study based on longitudinal seroprevalence data.
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Kim Y, Leopardi S, Scaravelli D, Zecchin B, Priori P, Festa F, Drzewnioková P, De Benedictis P, and Nouvellet P
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- Humans, Pregnancy, Animals, Female, Seroepidemiologic Studies, Antibodies, Viral, RNA, Viral analysis, Rhabdoviridae Infections epidemiology, Rhabdoviridae Infections veterinary, Chiroptera
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We investigated the transmission dynamics of lyssavirus in Myotis myotis and Myotis blythii , using serological, virological, demographic and ecological data collected between 2015 and 2022 from two maternity colonies in northern Italian churches. Despite no lyssavirus detection in 556 bats sampled over 11 events by reverse transcription-polymerase chain reaction (RT-PCR), 36.3% of 837 bats sampled over 27 events showed neutralizing antibodies to European bat lyssavirus 1 , with a significant increase in summers. By fitting sets of mechanistic models to seroprevalence data, we investigated factors that influenced lyssavirus transmission within and between years. Five models were selected as a group of final models: in one model, a proportion of exposed bats (median model estimate: 5.8%) became infectious and died while the other exposed bats recovered with immunity without becoming infectious; in the other four models, all exposed bats became infectious and recovered with immunity. The final models supported that the two colonies experienced seasonal outbreaks driven by: (i) immunity loss particularly during hibernation, (ii) density-dependent transmission, and (iii) a high transmission rate after synchronous birthing. These findings highlight the importance of understanding ecological factors, including colony size and synchronous birthing timing, and potential infection heterogeneities to enable more robust assessments of lyssavirus spillover risk.
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- 2023
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17. Discovery of a coronavirus in the Eurasian badger (Meles meles) belonging to a putative new genus.
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Zamperin G, Festa F, Palumbo E, Quaranta E, Monne I, Terregino C, De Benedictis P, and Leopardi S
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- Animals, Phylogeny, Animals, Wild, Mustelidae, COVID-19
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In the aftermath of COVID-19, coronaviruses gained renewed attention by the scientific community. The study reports the identification and genetic characterization of a novel coronavirus in the European badger (Meles meles) obtained in the framework of passive surveillance implemented in Italian wildlife in response to the pandemic. Positive samples were characterized using next generation sequencing as well as genetic and phylogenetic analyses, aiming for taxonomic placement under ICTV guidelines of the viruses contained in each sample. Results obtained for six conserved domains within the polyprotein showed that the virus clustered as outgroup and shared <46% amino acid identity with other coronaviruses, supporting the assumption that it belongs to a new putative genus Epsiloncoronavirus. This finding highlights that mammals still hide diverse coronaviruses whose zoonotic and epizootic potential remains unknown., Competing Interests: Declaration of Competing Interest None., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2023
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18. Prevalence of Ponticulus Posticus and Migraine in 220 Orthodontic Patients: A Cross-Sectional Study.
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Macrì M, Rendina F, Feragalli B, Pegreffi F, and Festa F
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Background: Ponticulus posticus (PP) is a medical term that describes an anomaly of the atlas (C1), which has a complete or partial bone bridge over the vertebral artery (VA) groove. The purpose of the study is to estimate the prevalence of PP in patients with a diagnosis of migraine., Methods: Cone beam CT (CBCT) scans (n = 220) were reviewed for the detection of PP in the University "G. D'Annunzio" of Chieti in the Department of Medical, Oral and Biotechnological Sciences. The sample included 220 Italian patients between 18 and 87 years. Pearson chi-square analysis ( p < 0.05 and 95% CI) was used to establish an association between migraine and PP., Results: The present study found a prevalence of PP of 20.9% and a prevalence of migraine of 12.272%. The association between migraine and PP was confirmed by the chi-square statistic, since the p -value was 0.008065 (significant at p < 0.05). PP was more frequent in the migraine without aura group, without a statistical difference relative to the migraine with aura group., Conclusions: The study concluded that PP is positively associated with migraine.
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- 2023
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19. Pediatric thyroid surgery: Retrospective analysis on the first 25 pediatric thyroidectomies performed in a reference center for adult thyroid diseases.
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Quaglino F, Bellocchia AB, Tuli G, Munarin J, Matarazzo P, Cestino L, Festa F, Carbonaro G, Oleandri S, Manini C, Vergano R, and De Sanctis L
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- Adult, Child, Humans, Retrospective Studies, Thyroidectomy, Graves Disease etiology, Hypoparathyroidism etiology, Thyroid Neoplasms surgery, Thyroid Neoplasms etiology, Thyroid Nodule surgery, Thyroid Nodule etiology
- Abstract
Introduction: Pediatric thyroid carcinoma represents about 4-5% of all pediatric carcinoma with an incidence of 0.5 cases/100,000, compared to 2-10/100000 cases in the adult population. The aim of this study is to present the experience of a reference adult endocrine surgery unit in charge of the treatment of pediatric thyroid diseases., Materials and Methods: From January 2019 to September 2022, 25 patients, aged 5-17, underwent thyroid surgery. We analysed indications for surgery, use of intraoperative nerve monitoring (IONM), definitive histological examination, postoperative outcomes and risk factors related., Results: Surgical indication was performed for Graves' disease (27%) and for nodular pathology (73%): of these, four were malignant lesions (TIR4/TIR5), eight with indeterminate characteristics (TIR3A/TIR3B) and four characterized as benign (TIR1/TIR2). Total thyroidectomy (TT) was performed in 76% of cases, three of which were prophylactic for the activation of the RET gene mutation in MEN 2A. IONM was used in eight cases (32%), all patients aged 11 years or less. FNA's accuracy was 100% for lesions typified as benign and malignant (TIR1/TIR2 and TIR4/TIR5). The overall malignancy rate achieved was 40% and in the final histological examination 75% of the TIR 3B lesions were malignant. Six patients (24%) developed hypoparathyroidism in the first postoperative day, with normalization of calcium values within thirty days in 5 patients., Conclusions: Pediatric thyroid nodules are rare and distinguished from adult thyroid disease by a worse prognosis and higher malignancy rates. Our work reports a much higher malignancy rate among indeterminate TIR 3B lesions than observed in the adult population and the three patients who underwent prophylactic total thyroidectomy for activating RET gene mutation had all a definitive histological diagnosis of medullary carcinoma. Post-surgical hypoparathyroidism is a common finding in these patients: in most cases the condition is transient and it benefits from supportive therapy. Intraoperative finding of a thinner recurrent laryngeal nerve in younger patients makes nerve isolation more difficult than in adult surgery: IONM is recommended in patients under 12. Pediatric thyroid surgery is challenging, we sustain it requires referral thyroid Centers for thyroid disease with highly skilled general endocrine surgeons., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Quaglino, Bellocchia, Tuli, Munarin, Matarazzo, Cestino, Festa, Carbonaro, Oleandri, Manini, Vergano and De Sanctis.)
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- 2023
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20. Interpreting the prevalence of musculoskeletal pain impacting Italian and Peruvian dentists likewise: A cross-sectional study.
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Macrì M, Flores NVG, Stefanelli R, Pegreffi F, and Festa F
- Subjects
- Humans, Male, Female, Cross-Sectional Studies, Dentists, Peru epidemiology, Prevalence, Professional Role, Musculoskeletal Pain epidemiology
- Abstract
Background: Musculoskeletal pain is a frequent condition among dental practitioners due to working in prolonged static isometric/eccentric contraction. The study aimed to describe musculoskeletal pain prevalence and the interplay between environmental conditions, lifestyle, and drugs consumed among Italian and Peruvian dentists., Methods: A 18 multiple choice questionnaire was administered to Peruvian and Italian dental care practitioners. A total of 187 questionnaires were submitted. One hundred sixty-seven questionnaires were selected for the analysis, including 86 questionnaires from Italy, and 81 from Perú. The study examined musculoskeletal pain presence in dental practitioners. The prevalence of musculoskeletal pain presence was analyzed considering different parameters: gender, age, type of dental practitioners, specialization in dentistry, hours of work per day, years of work, physical activity, localization of musculoskeletal pain and the influence of musculoskeletal pain on the performance on work., Results: The selected questionnaires for analysis were 167 (67 from Italy and 81 from Perú). Male and female participants were numerically equal. Most of the dental practitioners were dentists. The percentage of dentists who present musculoskeletal pain is 87.2% in Italy and 91.4% in Perú ( p < 0.05)., Conclusion: Musculoskeletal pain represents a very diffused condition in dental practitioners. The results about the prevalence of musculoskeletal pain show how the two populations (Italian and Peruvian) are very similar despite the geographical distance. Nevertheless, the high percentages of musculoskeletal pain in dental practitioners translate into the need to use solutions to reduce its onsets, such as improving ergonomics and physical activity., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Macrì, Flores, Stefanelli, Pegreffi and Festa.)
- Published
- 2023
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21. Bat responses to climate change: a systematic review.
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Festa F, Ancillotto L, Santini L, Pacifici M, Rocha R, Toshkova N, Amorim F, Benítez-López A, Domer A, Hamidović D, Kramer-Schadt S, Mathews F, Radchuk V, Rebelo H, Ruczynski I, Solem E, Tsoar A, Russo D, and Razgour O
- Subjects
- Animals, Biodiversity, Climate Change, Ecosystem, Population Dynamics, Chiroptera
- Abstract
Understanding how species respond to climate change is key to informing vulnerability assessments and designing effective conservation strategies, yet research efforts on wildlife responses to climate change fail to deliver a representative overview due to inherent biases. Bats are a species-rich, globally distributed group of organisms that are thought to be particularly sensitive to the effects of climate change because of their high surface-to-volume ratios and low reproductive rates. We systematically reviewed the literature on bat responses to climate change to provide an overview of the current state of knowledge, identify research gaps and biases and highlight future research needs. We found that studies are geographically biased towards Europe, North America and Australia, and temperate and Mediterranean biomes, thus missing a substantial proportion of bat diversity and thermal responses. Less than half of the published studies provide concrete evidence for bat responses to climate change. For over a third of studied bat species, response evidence is only based on predictive species distribution models. Consequently, the most frequently reported responses involve range shifts (57% of species) and changes in patterns of species diversity (26%). Bats showed a variety of responses, including both positive (e.g. range expansion and population increase) and negative responses (range contraction and population decrease), although responses to extreme events were always negative or neutral. Spatial responses varied in their outcome and across families, with almost all taxonomic groups featuring both range expansions and contractions, while demographic responses were strongly biased towards negative outcomes, particularly among Pteropodidae and Molossidae. The commonly used correlative modelling approaches can be applied to many species, but do not provide mechanistic insight into behavioural, physiological, phenological or genetic responses. There was a paucity of experimental studies (26%), and only a small proportion of the 396 bat species covered in the examined studies were studied using long-term and/or experimental approaches (11%), even though they are more informative about the effects of climate change. We emphasise the need for more empirical studies to unravel the multifaceted nature of bats' responses to climate change and the need for standardised study designs that will enable synthesis and meta-analysis of the literature. Finally, we stress the importance of overcoming geographic and taxonomic disparities through strengthening research capacity in the Global South to provide a more comprehensive view of terrestrial biodiversity responses to climate change., (© 2022 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.)
- Published
- 2023
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22. The human ion channel TRPM2 modulates migration and invasion in neuroblastoma through regulation of integrin expression.
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Bao L, Festa F, Hirschler-Laszkiewicz I, Keefer K, Wang HG, Cheung JY, and Miller BA
- Subjects
- Humans, Cell Survival, Integrin alpha1, Integrins genetics, Neoplasms, Second Primary, Neuroblastoma genetics, TRPM Cation Channels genetics
- Abstract
Transient receptor potential channel TRPM2 is highly expressed in many cancers and involved in regulation of key physiological processes including mitochondrial function, bioenergetics, and oxidative stress. In Stage 4 non-MYCN amplified neuroblastoma patients, high TRPM2 expression is associated with worse outcome. Here, neuroblastoma cells with high TRPM2 expression demonstrated increased migration and invasion capability. RNA sequencing, RT-qPCR, and Western blotting demonstrated that the mechanism involved significantly greater expression of integrins α1, αv, β1, and β5 in cells with high TRPM2 expression. Transcription factors HIF-1α, E2F1, and FOXM1, which bind promoter/enhancer regions of these integrins, were increased in cells with high TRPM2 expression. Subcellular fractionation confirmed high levels of α1, αv, and β1 membrane localization and co-immunoprecipitation confirmed the presence of α1β1, αvβ1, and αvβ5 complexes. Inhibitors of α1β1, αvβ1, and αvβ5 complexes significantly reduced migration and invasion in cells highly expressing TRPM2, confirming their functional role. Increased pAkt
Ser473 and pERKThr202/Tyr204 , which promote migration through mechanisms including integrin activation, were found in cells highly expressing TRPM2. TRPM2 promotes migration and invasion in neuroblastoma cells with high TRPM2 expression through modulation of integrins together with enhancing cell survival, negatively affecting patient outcome and providing rationale for TRPM2 inhibition in anti-neoplastic therapy., (© 2022. The Author(s).)- Published
- 2022
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23. Carnivore protoparvovirus 1 (CPV-2 and FPV) Circulating in Wild Carnivores and in Puppies Illegally Imported into North-Eastern Italy.
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Leopardi S, Milani A, Cocchi M, Bregoli M, Schivo A, Leardini S, Festa F, Pastori A, de Zan G, Gobbo F, Beato MS, Palei M, Bremini A, Rossmann MC, Zucca P, Monne I, and De Benedictis P
- Subjects
- Cats, Animals, Dogs, Feline Panleukopenia Virus genetics, Animals, Wild, Italy epidemiology, Phylogeny, Parvovirus, Canine genetics, Wolves, Parvoviridae Infections epidemiology, Parvoviridae Infections veterinary, Parvovirus genetics, Carnivora
- Abstract
The illegal trade of animals poses several health issues to the global community, among which are the underestimated risk for spillover infection and the potential for an epizootic in both wildlife and domestic naïve populations. We herein describe the genetic and antigenic characterization of viruses of the specie Carnivore protoparvovirus 1 detected at high prevalence in puppies illegally introduced in North Eastern Italy and compared them with those circulating in wild carnivores from the same area. We found evidence of a wide diversity of canine parvoviruses (CPV-2) belonging to different antigenic types in illegally imported pups. In wildlife, we found a high circulation of feline parvovirus (FPV) in golden jackals and badgers, whereas CPV-2 was observed in one wolf only. Although supporting a possible spillover event, the low representation of wolf samples in the present study prevented us from inferring the origin, prevalence and viral diversity of the viruses circulating in this species. Therefore, we suggest performing more thorough investigations before excluding endemic CPV-2 circulation in this species.
- Published
- 2022
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24. Three-dimensional evaluation using CBCT of the mandibular asymmetry and the compensation mechanism in a growing patient: A case report.
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Macrì M and Festa F
- Subjects
- Male, Humans, Mandible diagnostic imaging, Cephalometry methods, Cone-Beam Computed Tomography methods, Facial Asymmetry diagnostic imaging, Spiral Cone-Beam Computed Tomography
- Abstract
Background: This case report aims to evaluate the development and the compensation mechanisms of the mandibular asymmetry in a growing male patient using cone beam computed tomography (CBCT). In this case, the menton deviated on the right, a sporadic condition, which may be the consequence of a disorder in the mandibular growth., Case Presentation: The young male patient was treated with rapid palatal expander (RPE) and Fränkel functional regulator III (FR-3). The initial CBCT was acquired at the beginning of therapy when the patient was 8 years old, and the final CBCT was developed at the end of the treatment when the patient was 12 years old. The patient's CBCT was performed with the head oriented according to the Natural Head Position (NHP); the NHP is a physiological and reproducible posture defined for morphological analysis. The 3D image of the cranium was oriented in the Dolphin software according to NHP posture, and cephalometric measurements were taken in the software's frontal, laterolateral right and left, posteroanterior, and submentovertex views. The therapy lasted 3.8 years and ended with significant regression of the mandibular asymmetry from moderate grade (4.2 mm) to slight grade (1.3 mm)., Conclusion: The literature shows that the left hemi-mandible has grown more than the right side, which affirms that in case of deviation of the menton >4 mm, the bone volume increases on the non-deviated side., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Macrì and Festa.)
- Published
- 2022
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25. Prevalence of temporomandibular disorders and its association with malocclusion in children: A transversal study.
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Macrì M, Murmura G, Scarano A, and Festa F
- Subjects
- Adolescent, Child, Humans, Prevalence, Risk Factors, Bruxism complications, Bruxism epidemiology, Malocclusion complications, Malocclusion epidemiology, Malocclusion therapy, Temporomandibular Joint Disorders complications, Temporomandibular Joint Disorders epidemiology
- Abstract
This study investigated the prevalence of temporomandibular disorders (TMDs) in a sample of children and adolescents and evaluated the correlation with occlusal variables. TMD signs and symptoms were recorded in 411 subjects (age range 7-15 years), divided into two groups: 214 subjects treated in Chieti (Italy) CG group and 197 in Murcia (Spain) MG group. Once the Angle dental class was identified, it was recorded if there were signs and symptoms of temporomandibular disorders (TMDs) and occlusal interferences. The percentages of signs and symptoms were compared to determine the differences among the groups for TMDs, bruxism, joint sounds, deviation during the opening, reduced opening/lateral/protrusive movements, malocclusions, and myofascial pain. There is no statistically significant difference between the two groups (χ
2 = 1.057, p > 0.05). Subjects with Angle Class I (37.37%), deep bite (43.43%), and increased overjet (41.41%) showed a higher prevalence of TMD symptoms., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Macrì, Murmura, Scarano and Festa.)- Published
- 2022
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26. Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement.
- Author
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Centofanti A, Vermiglio G, Cutroneo G, Favaloro A, Picciolo G, Festa F, and Anastasi GP
- Abstract
The dystrophin-glycoprotein complex is a multimeric system made up of the sarcoglycan sub-complex, the sarcomplasmatic complex and the dystroglycans complex. The sarcoglycan sub-complex stabilizes the sarcolemma during muscle activity and plays a role in force transduction. This protein system is also expressed in the muscle of non-human primates such as chimpanzees and baboons, and its expression changes depending on social ranking. In fact, previous data have shown that all muscle fibers of masseter and sternocleidomastoid muscles of chimpanzees and high- ranking baboons always express sarcoglycans, while middle- and low-ranking baboons are characterized by fibers that are negative for the sarcoglycan sub-complex. Given this information, the aim of the present work was to evaluate the expression of other proteins such as laminin, beta dystroglycan and dystrophin in the sternocleidomastoid muscle of high- and low-ranking baboons. The samples were processed by immunohistochemistry; results show that in high-ranking baboons, all tested proteins were always expressed while in low-ranking baboons, fibers that were negative for sarcoglycans and beta dystroglycan have been observed. No negative fibers for laminin and dystrophin have been found in low-ranking baboons suggesting that only the transmembrane proteins of the dystrophin glycoprotein complex change in their expression and that could be correlated to a phylogenetic arrangement.
- Published
- 2022
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27. Axonal architecture of the mouse inner retina revealed by second harmonic generation.
- Author
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Meah A, Boodram V, Bucinca-Cupallari F, and Lim H
- Abstract
We describe a novel method for visualizing the network of axons in the unlabeled fresh wholemount retina. The intrinsic radiation of second harmonic generation (SHG) was utilized to visualize single axons of all major retinal neurons, i.e., photoreceptors, horizontal cells, bipolar cells, amacrine cells, and the retinal ganglion cells. The cell types of SHG+ axons were determined using transgenic GFP/YFP mice. New findings were obtained with retinal SHG imaging: Müller cells do not maintain uniformly polarized microtubules in the processes; SHG+ axons of bipolar cells terminate in the inner plexiform layer (IPL) in a subtype-specific manner; a subset of amacrine cells, presumably the axon-bearing types, emits SHG; and the axon-like neurites of amacrine cells provide a cytoskeletal scaffolding for the IPL stratification. To demonstrate the utility, retinal SHG imaging was applied to testing whether the inner retina is preserved in glaucoma, using DBA/2 mice as a model of glaucoma and DBA/2- Gpnmb+ as the nonglaucomatous control. It was found that the morphology of the inner retina was largely intact in glaucoma and the presynaptic compartments to the retinal ganglion cells were uncompromised. It proves retinal SHG imaging as a promising technology for studying the physiological and diseased retinas in 3D., (© The Author(s) 2022. Published by Oxford University Press on behalf of the National Academy of Sciences.)
- Published
- 2022
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28. Gliptin-associated bullous pemphigoid shows peculiar features of anti-BP180 and -BP230 humoral response: Results of a multicenter study.
- Author
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Salemme A, Fania L, Scarabello A, Caproni M, Marzano AV, Cozzani E, Feliciani C, De Simone C, Papini M, Satta RR, Parodi A, Mariotti F, Lechiancole S, Genovese G, Passarelli F, Festa F, Bellei B, Provini A, Sordi D, Pallotta S, Abeni D, Mazzanti C, Didona B, and Di Zenzo G
- Subjects
- Autoantibodies, Autoantigens, Humans, Immunoglobulin G, Non-Fibrillar Collagens, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors adverse effects, Pemphigoid, Bullous
- Abstract
Background: Recently, several case-control studies demonstrated an association between gliptins and bullous pemphigoid (BP) occurrence. However, data on the clinical and immunologic features of gliptin-associated bullous pemphigoid (GABP) are controversial., Objective: This study aimed to clinically and immunologically characterize a large cohort of GABP patients to get an insight into the pathophysiology of this emerging drug-induced variant of BP., Methods: Seventy-four GABP patients were prospectively enrolled and characterized from 9 different Italian dermatology units between 2013 and 2020., Results: Our findings demonstrated the following in the GABP patients: (1) a noninflammatory phenotype, which is characterized by low amounts of circulating and skin-infiltrating eosinophils, is frequently found; (2) immunoglobulin (Ig)G, IgE, and IgA humoral responses to BP180 and BP230 antigens are reduced in frequency and titers compared with those in patients with idiopathic BP; (3) IgG reactivity targets multiple BP180 epitopes other than noncollagenous region 16A., Limitations: A limitation of the study is that the control group did not comprise only type 2 diabetes mellitus patients with BP., Conclusion: GABP patients show peculiar features of anti-BP180 and -BP230 humoral responses, laying the foundation for diagnostic improvements and getting novel insights into understanding the mechanism of BP onset., Competing Interests: Conflicts of interest None disclosed., (Copyright © 2022 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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29. Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality.
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Leopardi S, Drzewnioková P, Baggieri M, Marchi A, Bucci P, Bregoli M, De Benedictis P, Gobbo F, Bellinati L, Citterio C, Monne I, Pastori A, Zamperin G, Palumbo E, Festa F, Castellan M, Zorzan M, D'Ugo E, Zucca P, Terregino C, and Magurano F
- Subjects
- Animals, Austria, Italy epidemiology, Mice, Murinae, Phylogeny, Orthohantavirus, Hantavirus Infections
- Abstract
Hantaviruses include several zoonotic pathogens that cause different syndromes in humans, with mortality rates ranging from 12 to 40%. Most commonly, humans get infected through the inhalation of aerosols or dust particles contaminated with virus-containing rodent excreta. Hantaviruses are specifically associated with the host species, and human cases depend on the presence and the dynamics of reservoir hosts. In this letter, we report the identification of Dobrava-Belgrade virus (DOBV) in the yellow-necked mouse ( Apodemus flavicollis ) from Italy. The virus was detected in the mountainous area of the province of Udine, bordering Austria and Slovenia, during an event of enhanced mortality in wild mice and voles. Despite serological evidence in rodents and humans that suggested the circulation of hantaviruses in Italy since 2000, this is the first virological confirmation of the infection. Phylogenetic analyses across the whole genome of the two detected viruses confirmed the host-specificity of DOBV sub-species and showed the highest identity with viruses identified in Slovenia and Croatia from both A. flavicollis and humans, with no signs of reassortment. These findings highlight the need for ecologists, veterinarians and medical doctors to come together in a coordinated approach in full compliance with the One Health concept.
- Published
- 2022
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30. Pudendal nerve block: a safe, simple and effective approach in surgical proctological patients.
- Author
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Bonatti L, Soncini S, Bellocchia AB, Selivanov D, Cestino L, Festa F, Natta F, and Quaglino F
- Subjects
- Humans, Pain, Postoperative prevention & control, Retrospective Studies, Nerve Block methods, Pudendal Nerve surgery, Pudendal Neuralgia surgery
- Abstract
Background: Pudendal nerve block (PNB) is commonly used in pudendal neuralgia (PN) and, as anesthesiological technique, in obstetrical and urological procedures. The purpose of this retrospective study was to compare the efficacy of PNB with other anesthesiolocal techniques in proctological surgery., Methods: A total of 362 patients were seen from a 22-month-time interval. Surgical indication was placed after a conservative therapy. Seventy-eight patients underwent surgery: 42 with spinal anesthesia with PNB and 36 with PNB alone according to their anatomical characteristics. All the patients underwent PNB in lithotomy position and with a perirectal approach. The success rate of PNB was evaluated in postoperative pain control with the VAS score, after the first and the second evacuation. The follow-up also included a third check on the seventh day after surgery., Results: In postoperative period, the mean VAS score found after the first evacuation in patients undergoing PNB was 2.66, after the second evacuation was 1.55, while the VAS score on the seventh day was 0.38. The mean VAS score in the group who underwent spinal anesthesia and PNB were respectively 3.71 and 1.80 after the first and second evacuation. The VAS score calculated on the seventh day was 0.50. There were no statistically significant differences in the VAS score between the 2 groups (P>0.05)., Conclusions: PNB may be a valid alternative to spinal anesthesia in proctological patients. PNB has proven to be both safe and effective technique.
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- 2022
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31. The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1.
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Hirschler-Laszkiewicz I, Festa F, Huang S, Moldovan GL, Nicolae C, Dhoonmoon A, Bao L, Keefer K, Chen SJ, Wang HG, Cheung JY, and Miller BA
- Subjects
- Cell Line, Tumor, Cell Survival drug effects, Cell Survival genetics, Doxorubicin pharmacology, Humans, E2F1 Transcription Factor metabolism, Forkhead Box Protein M1 genetics, Forkhead Box Protein M1 metabolism, Neuroblastoma drug therapy, Neuroblastoma metabolism, Neuroblastoma pathology, TRPM Cation Channels metabolism
- Abstract
Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer and has an essential function in preserving viability through maintenance of mitochondrial function and antioxidant response. Here, the role of TRPM2 in cell survival was examined in neuroblastoma cells with TRPM2 deletion with CRISPR technology. Viability was significantly decreased in TRPM2 knockout after doxorubicin treatment. RNA sequence analysis and RT-qPCR revealed reduced RNAs encoding master transcription regulators FOXM1 and E2F1/2 and downstream cell cycle targets including Cyclin B1, CDK1, PLK1, and CKS1. CHIP analysis demonstrated decreased FOXM1 binding to their promoters. Western blotting confirmed decreased expression, and increased expression of CDK inhibitor p21, a CKS1 target. In cells with TRPM2 deletion, cell cycle progression to S and G2/M phases was reduced after treatment with doxorubicin. RNA sequencing also identified decreased DNA repair proteins in cells with TRPM2 deletion after doxorubicin treatment, and DNA damage was increased. Wild type TRPM2, but not Ca
2+ -impermeable mutant E960D, restored live cell number and reconstituted expression of E2F1, FOXM1, and cell cycle/DNA repair proteins. FOXM1 expression alone restored viability. TRPM2 is a potential therapeutic target to reduce tumor proliferation and increase doxorubicin sensitivity through modulation of FOXM1, E2F1, and cell cycle/DNA repair proteins., (© 2022. The Author(s).)- Published
- 2022
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32. Evaluation of a new antibacterial coating of the internal chamber of an implant via real time measurement of Volatile Organic Compounds (VOCs).
- Author
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Scarano A, de Oliveira PS, Leo L, Festa F, Carinci F, and Lorusso F
- Subjects
- Anti-Bacterial Agents pharmacology, Humans, Volatile Organic Compounds
- Abstract
The aim of the present investigation was to evaluate the efficacy of an antibacterial coating of implant-abutment prosthetic junctions by real time measurement of Volatile Organic Compounds (VOCs). A total of 20 patients and 40 internal prosthetic junction implants were evaluated in the present investigation: 20 fixtures with antibacterial internal coating (Test) and 20 without treatment (Control). The VOCs measurements were evaluated at the baseline (T
0 ) after the cover unit unscrewing, after 7 days (T1 ) and at 14 days (T2 ). No significant difference were detected at T0 (baseline), as Test and Control groups showed a VOCs max peak mean respectively of 2.15 ± 0.71 and 2.21 ± 0.69 ( p > 0.05). At T1 and T2 as significant difference between the Test and Control Groups was detected ( p < 0.01). At T2 the Test max peak was 2.29 ± 0.73 and the Control was 3.65 ± 0.91 ( p < 0.01). The antibacterial internal coating demonstrated the capacity to prevent microbial VOCS activity at the level of the implant internal chamber and could be useful for long-term peri-implant tissue health., (© 2021 The Author(s). Published by BRI.)- Published
- 2021
- Full Text
- View/download PDF
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