156 results on '"Firth, Andrew"'
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2. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota).
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Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles, Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi, Kumar Chaturvedi, Krishna, Chooi, Kar, Crane, Anya, Dal Bó, Elena, Carlos de la Torre, Juan, de Souza, William, de Swart, Rik, Debat, Humberto, Dheilly, Nolwenn, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf, Digiaro, Michele, Drexler, J, Duprex, W, Dürrwald, Ralf, Easton, Andrew, Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew, Fooks, Anthony, Formenty, Pierre, Freitas-Astúa, Juliana, Gago-Zachert, Selma, Laura García, María, García-Sastre, Adolfo, Garrison, Aura, Gaskin, Thomas, Gong, Wenjie, Gonzalez, Jean-Paul, de Bellocq, JoëlleGoüy, Griffiths, Anthony, Groschup, Martin, Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen, Hongō, Seiji, Horie, Masayuki, Hughes, Holly, Hume, Adam, Hyndman, Timothy, Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda, Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kondō, Hideki, Koonin, Eugene, Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy, Lǐ, Jiànróng, Li, Jun-Min, Liu, Ran, Lukashevich, Igor, MacDiarmid, Robin, Maes, Piet, Marklewitz, Marco, Marshall, Sergio, Marzano, Shin-Yi, McCauley, John, Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José, Neriya, Yutaro, Netesov, Sergey, Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio, Ochoa-Corona, Francisco, Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin, Pauvolid-Corrêa, Alex, Pawęska, Janusz, Pérez, Daniel, and Pfaff, Florian
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Aliusviridae ,Arenaviridae ,Articulavirales ,Artoviridae ,Aspiviridae ,Bornaviridae ,Bunyavirales ,Crepuscuviridae ,Discoviridae ,Filoviridae ,Fimoviridae ,Goujianvirales ,Hantaviridae ,ICTV ,International Committee on Taxonomy of Viruses ,Jingchuvirales ,Lispiviridae ,Mononegavirales ,Muvirales ,Mymonaviridae ,Myriaviridae ,Nairoviridae ,Natareviridae ,Negarnaviricota ,Nyamiviridae ,Orthomyxoviridae ,Orthornavirae ,Paramyxoviridae ,Peribunyaviridae ,Phasmaviridae ,Phenuiviridae ,Pneumoviridae ,Rhabdoviridae ,Riboviria ,Serpentovirales ,Sunviridae ,Tenuivirus ,Tosoviridae ,Tospoviridae ,Tulasviridae ,articulaviral ,bunyaviral ,bunyavirus ,goujianviral ,megaclassification ,megataxonomy ,mononegaviral ,muviral ,negarnaviricot ,serpentoviral ,virus classification ,virus nomenclature ,virus taxonomy ,Negative-Sense RNA Viruses ,RNA Viruses ,RNA-Dependent RNA Polymerase - Abstract
In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
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- 2023
3. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.
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Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles, Candresse, Thierry, Carson, Jeremy, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi, Chiaki, Yuya, Crane, Anya, Crane, Mark, Dacheux, Laurent, Bó, Elena, de la Torre, Juan, de Lamballerie, Xavier, de Souza, William, de Swart, Rik, Dheilly, Nolwenn, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf, Digiaro, Michele, Drexler, J, Duprex, W, Dürrwald, Ralf, Easton, Andrew, Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Feuvrier, Claudette, Firth, Andrew, Fooks, Anthony, Formenty, Pierre, Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María, García-Sastre, Adolfo, Garrison, Aura, Godwin, Scott, Gonzalez, Jean-Paul, de Bellocq, Joëlle, Griffiths, Anthony, Groschup, Martin, Günther, Stephan, Hammond, John, Hepojoki, Jussi, Hierweger, Melanie, Hongō, Seiji, Horie, Masayuki, Horikawa, Hidenori, Hughes, Holly, Hume, Adam, Hyndman, Timothy, Jiāng, Dàohóng, Jonson, Gilda, Junglen, Sandra, Kadono, Fujio, Karlin, David, Klempa, Boris, Klingström, Jonas, Koch, Michel, Kondō, Hideki, Koonin, Eugene, Krásová, Jarmila, Krupovic, Mart, Kubota, Kenji, Kuzmin, Ivan, Laenen, Lies, Lambert, Amy, Lǐ, Jiànróng, Li, Jun-Min, Lieffrig, François, Lukashevich, Igor, Luo, Dongsheng, Maes, Piet, Marklewitz, Marco, Marshall, Sergio, Marzano, Shin-Yi, McCauley, John, Mirazimi, Ali, Mohr, Peter, Moody, Nick, Morita, Yasuaki, Morrison, Richard, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José, Neriya, Yutaro, Netesov, Sergey, Neumann, Gabriele, Nowotny, Norbert, Ochoa-Corona, Francisco, Palacios, Gustavo, Pallandre, Laurane, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, and Parrish, Colin
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Humans ,Mononegavirales ,Phylogeny ,Viruses - Abstract
In March 2022, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by two new families (bunyaviral Discoviridae and Tulasviridae), 41 new genera, and 98 new species. Three hundred forty-nine species were renamed and/or moved. The accidentally misspelled names of seven species were corrected. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
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- 2022
4. Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling
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Chandrabalan, Arundhasa, Firth, Andrew, Litchfield, Robert B., Appleton, C. Thomas, Getgood, Alan, and Ramachandran, Rithwik
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- 2023
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5. Multimodal analgesia did not improve post-operative pain scores, reduce opioid consumption or reduce length of stay following hip arthroscopy
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Degen, Ryan M., Firth, Andrew, Sehmbi, Herman, Martindale, Ashley, Wanlin, Stacey, Chen, Clara, Marsh, Jacqueline D., Willits, Kevin, and Bryant, Dianne
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- 2023
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6. Anterior Cruciate Ligament Reconstruction Plus Lateral Extra-articular Tenodesis Has a Similar Return-to-Sport Rate to Anterior Cruciate Ligament Reconstruction Alone but a Lower Failure Rate
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Getgood, Alan M.J., Bryant, Dianne M., Litchfield, Robert, Willits, Kevin, Birmingham, Trevor, Hewison, Chris, Firth, Andrew D., Pinto, Ryan, Martindale, Ashley, O’Neill, Lindsey, Jennings, Morgan, Daniluk, Michal, McCormack, Robert G., Boyer, Dory, Zomar, Mauri, Heard, Mark, Buchko, Gregory M., Hiemstra, Laurie A., Kerslake, Sarah, Tynedal, Jeremy, MacDonald, Peter B., Stranges, Greg, McRae, Sheila, Brown, Holly, Rezansoff, Alex, Mohtadi, Nick, Chan, Denise, Garven, Alexandra, Peterson, Devin, Simunovic, Nicole, Duong, Andrew, Skelly, Matt, Shanmugaraj, Ajaykumar, Bardana, Davide, Howells, Fiona, Spalding, Tim, Thompson, Pete, Metcalfe, Andrew, Verdonk, Peter C.M., and Declerq, Geert
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- 2024
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7. Extrusion After Meniscal Allograft Transplantation Is Lower or Equal With Bony Compared With Soft-Tissue Root Fixation: A Systematic Review
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Beel, Wouter, Firth, Andrew D., Tulloch, Scott, Abdelrehman, Taher, Olotu, Olumide, Bryant, Dianne, and Getgood, Alan
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- 2024
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8. Lateral Extra-articular Tenodesis Does Not Decrease Graft Failure in Revision Anterior Cruciate Ligament Reconstruction When Combined With Quadriceps or Patellar Tendon Grafts
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Vivacqua, Thiago Alberto, Winkler, Philipp W., Lucidi, Gian Andrea, Firth, Andrew D., Musahl, Volker, and Getgood, Alan
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- 2024
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9. The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
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Stewart, Hazel, Lu, Yongxu, O’Keefe, Sarah, Valpadashi, Anusha, Cruz-Zaragoza, Luis Daniel, Michel, Hendrik A., Nguyen, Samantha K., Carnell, George W., Lukhovitskaya, Nina, Milligan, Rachel, Adewusi, Yasmin, Jungreis, Irwin, Lulla, Valeria, Matthews, David A., High, Stephen, Rehling, Peter, Emmott, Edward, Heeney, Jonathan L., Davidson, Andrew D., Edgar, James R., Smith, Geoffrey L., and Firth, Andrew E.
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- 2023
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10. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
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Kuhn, Jens H., Adkins, Scott, Alkhovsky, Sergey V., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Bandte, Martina, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Bigarré, Laurent, Blair, Carol D., Blasdell, Kim R., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Bruggmann, Rémy, Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Candresse, Thierry, Carson, Jeremy, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chiaki, Yuya, Crane, Anya, Crane, Mark, Dacheux, Laurent, Bó, Elena Dal, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Souza, William M., de Swart, Rik L., Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J. Felix, Duprex, W. Paul, Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Feuvrier, Claudette, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B. H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Godwin, Scott E., Gonzalez, Jean-Paul J., de Bellocq, Joëlle Goüy, Griffiths, Anthony, Groschup, Martin H., Günther, Stephan, Hammond, John, Hepojoki, Jussi, Hierweger, Melanie M., Hongō, Seiji, Horie, Masayuki, Horikawa, Hidenori, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy H., Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Karlin, David G., Klempa, Boris, Klingström, Jonas, Koch, Michel C., Kondō, Hideki, Koonin, Eugene V., Krásová, Jarmila, Krupovic, Mart, Kubota, Kenji, Kuzmin, Ivan V., Laenen, Lies, Lambert, Amy J., Lǐ, Jiànróng, Li, Jun-Min, Lieffrig, François, Lukashevich, Igor S., Luo, Dongsheng, Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., McCauley, John W., Mirazimi, Ali, Mohr, Peter G., Moody, Nick J. G., Morita, Yasuaki, Morrison, Richard N., Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Ochoa-Corona, Francisco M., Palacios, Gustavo, Pallandre, Laurane, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Pozet, Françoise, Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Rumbou, Artemis, Runstadler, Jonathan A., Rupp, Melanie, Sabanadzovic, Sead, Sasaya, Takahide, Schmidt-Posthaus, Heike, Schwemmle, Martin, Seuberlich, Torsten, Sharpe, Stephen R., Shi, Mang, Sironi, Manuela, Smither, Sophie, Song, Jin-Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Tesh, Robert B., Těšíková, Jana, Thornburg, Natalie J., Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tsunekawa, Kenta, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Yamasaki, Junki, Yanagisawa, Hironobu, Ye, Gongyin, Zhang, Yong-Zhen, and Økland, Arnfinn Lodden
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- 2022
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11. Meniscal repair at the time of primary ACLR does not negatively influence short term knee stability, graft rupture rates, or patient-reported outcome measures: the STABILITY experience
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Marmura, Hana, Firth, Andrew, Batty, Lachlan, Bryant, Dianne M., and Getgood, Alan M. J.
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- 2022
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12. Molecular characterization of emerging variants of PRRSV in the United States: new features of the -2/-1 programmed ribosomal frameshifting signal in the nsp2 region
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Yan, Xingyu, Shang, Pengcheng, Yim-im, Wannarat, Sun, Yankuo, Zhang, Jianqiang, Firth, Andrew E., Lowe, James F., and Fang, Ying
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- 2022
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13. Evaluating ribosomal frameshifting in CCR5 mRNA decoding
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Khan, Yousuf A., Loughran, Gary, Steckelberg, Anna-Lena, Brown, Katherine, Kiniry, Stephen J., Stewart, Hazel, Baranov, Pavel V., Kieft, Jeffrey S., Firth, Andrew E., and Atkins, John F.
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- 2022
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14. Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections
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Parker, Matthew D., Stewart, Hazel, Shehata, Ola M., Lindsey, Benjamin B., Shah, Dhruv R., Hsu, Sharon, Keeley, Alexander J., Partridge, David G., Leary, Shay, Cope, Alison, State, Amy, Johnson, Katie, Ali, Nasar, Raghei, Rasha, Heffer, Joe, Smith, Nikki, Zhang, Peijun, Gallis, Marta, Louka, Stavroula F., Hornsby, Hailey R., Alamri, Hatoon, Whiteley, Max, Foulkes, Benjamin H., Christou, Stella, Wolverson, Paige, Pohare, Manoj, Hansford, Samantha E., Green, Luke R., Evans, Cariad, Raza, Mohammad, Wang, Dennis, Firth, Andrew E., Edgar, James R., Gaudieri, Silvana, Mallal, Simon, Collins, Mark O., Peden, Andrew A., and de Silva, Thushan I.
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- 2022
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15. A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit
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Rebelo-Guiomar, Pedro, Pellegrino, Simone, Dent, Kyle C., Sas-Chen, Aldema, Miller-Fleming, Leonor, Garone, Caterina, Van Haute, Lindsey, Rogan, Jack F., Dinan, Adam, Firth, Andrew E., Andrews, Byron, Whitworth, Alexander J., Schwartz, Schraga, Warren, Alan J., and Minczuk, Michal
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- 2022
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16. Osteochondroplasty Benefits the Pragmatic Patient With Femoroacetabular Impingement: Analysis From the Embedded Prospective Cohort of the Femoroacetabular Impingement RandomiSed Controlled Trial (FIRST)
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Ayeni, Olufemi R., Bhandari, Mohit, Bedi, Asheesh, Järvinen, Teppo, Musahl, Volker, Naudie, Douglas, Seppänen, Matti, Slobogean, Gerard, Thabane, Lehana, Simunovic, Nicole, Duong, Andrew, Skelly, Matthew, Shanmugaraj, Ajay, Crouch, Sarah, Sprague, Sheila, Heels-Ansdell, Diane, Buckingham, Lisa, Ramsay, Tim, Lee, John, Kousa, Petteri, Carsen, Sasha, Choudur, Hema, Sim, Yan, Johnston, Kelly, Wong, Ivan, Murphy, Ryland, Sparavalo, Sara, Whelan, Daniel, Khan, Ryan, Wood, Gavin C.A., Howells, Fiona, Grant, Heather, Zomar, Bryn, Pollock, Michael, Willits, Kevin, Firth, Andrew, Wanlin, Stacey, Remtulla, Alliya, Kaniki, Nicole, Belzile, Etienne L., Turmel, Sylvie, Jørgensen, Uffe, Gam-Pedersen, Annie, Hatanpää, Tays, Sihvonen, Raine, Raivio, Marko, Toivonen, Pirjo, Routapohja, Mari Pirjetta, Almasri, Mahmoud, and Ayenil, Olufemi R.
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- 2022
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17. A novel ilarvirus protein CP-RT is expressed via stop codon readthrough and suppresses RDR6-dependent RNA silencing
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Lukhovitskaya, Nina, primary, Brown, Katherine, additional, Hua, Lei, additional, Pate, Adrienne E., additional, Carr, John P., additional, and Firth, Andrew E., additional
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- 2024
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18. Establishing the Minimally Important Difference for the KOOS–Joint Replacement and PROMIS Global–10 in Patients After Total Knee Arthroplasty
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Spiering, Tyler J., primary, Firth, Andrew D., additional, Mousoulis, Christos, additional, Hallstrom, Brian R., additional, and Gagnier, Joel J., additional
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- 2024
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19. Low rates of serious complications but high rates of hardware removal after high tibial osteotomy with Tomofix locking plate
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Sidhu, Rajeshwar, Moatshe, Gilbert, Firth, Andrew, Litchfield, Robert, and Getgood, Alan
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- 2021
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20. Poster 311: Cost-effectiveness of Lateral Extra-Articular Tenodesis in ACL Reconstruction: An Economic Evaluation of the STABILITY Randomized Clinical Trial.
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Primeau, Codie, Getgood, Alan, Bryant, Dianne, Firth, Andrew, and Marsh, Jacquelyn
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- 2024
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21. Quantitative MRI Analysis of Patellofemoral Joint Cartilage Health 2 Years After Anterior Cruciate Ligament Reconstruction and Lateral Extra-Articular Tenodesis.
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Nakanishi, Yuta, Hegarty, Paul, Vivacqua, Thiago, Firth, Andrew, Milner, Jaques S., Pritchett, Stephany, Willits, Kevin, Litchfield, Robert, Bryant, Dianne, and Getgood, Alan M.J.
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TENODESIS ,SCALE analysis (Psychology) ,EFFECT sizes (Statistics) ,PEARSON correlation (Statistics) ,ARTICULAR cartilage ,ANTERIOR cruciate ligament surgery ,BODY mass index ,DATA analysis ,STATISTICAL significance ,FUNCTIONAL assessment ,HUMAN research subjects ,SEX distribution ,BODY weight ,REHABILITATION ,MAGNETIC resonance imaging ,AGE distribution ,TORQUE ,ANALYSIS of covariance ,DESCRIPTIVE statistics ,KNEE joint ,LONGITUDINAL method ,STATURE ,INFORMED consent (Medical law) ,QUALITY of life ,INTRACLASS correlation ,STATISTICS ,HEALTH outcome assessment ,COMPARATIVE studies ,EXERCISE tests ,DATA analysis software ,MUSCLE contraction ,ACTIVITIES of daily living - Abstract
Background: The addition of an iliotibial band–based lateral extra-articular tenodesis (LET) to anterior cruciate ligament (ACL) reconstruction (ACLR) has been shown to reduce failure rates. However, there are concerns as to the potential overconstraint of tibiofemoral kinematics that may increase the risk of cartilage degradation. To date, no clinical study has investigated the effect of LET on patellofemoral joint articular cartilage health. Hypothesis: It was hypothesized that at 2 years postoperatively, (1) the addition of LET at the time of ACLR would have no effect on cartilage health on magnetic resonance imaging (MRI), and (2) higher cartilage relaxation values would be associated with worse patient-reported and functional outcomes. Study Design: Cohort study; Level of evidence, 3. Methods: A subset of patients from the STABILITY 1 randomized controlled trial were included. All patients underwent primary ACLR with a hamstring autograft. Patients were randomized to either LET augmentation or not. Cartilage status in the patellofemoral joint between the ACLR group and ACLR+LET group was compared using 2-year postoperative quantitative MRI and the ACL osteoarthritis scores of both the surgical and the contralateral nonsurgical knees. Objective functional outcomes and patient-reported outcome measures (PROMs) were attained. Results: A total of 92 patients (43 patients in the ACLR group; mean age, 18.9 ± 3.2 years; 60.5% female; and 49 patients in the ACLR+LET group; mean age, 18.7 ± 3.2 years, 63.3% female) were included. No significant differences were seen in the mean values (ms) for adjusted T1ρ/T2 relaxation times in the medial patella (47.8/42.2 vs 47.3/43.2), central patella (45.5/42.5 vs 44.1/42.7), lateral patella (48.2/43.5 vs 47.3/43.0), medial trochlea (54.7/50.9 vs 56.4/50.9), central trochlea (53.3/51.1 vs 53.1/52.0), and lateral trochlea (54.9/52.1 vs 53.9/52.6) between the ACLR and ACLR+LET groups. No difference in overall ACL osteoarthritis scores was observed (P =.99). An increase in medial patellar T2 relaxation times was associated with a decreasing International Knee Documentation Committee score (P =.046), Knee injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale score (P =.01), and total KOOS (P =.01). Conclusion: There was no statistical difference in patellofemoral cartilage health between knees 2 years after primary ACLR with hamstring tendon autograft with or without LET. Statistically significant correlations were found between quantitative MRI relaxation times, functional outcome scores, and PROMs; however, the correlations were weak and the clinical significance is unknown. Registration: NCT02018354 (ClinicalTrials.gov identifier). [ABSTRACT FROM AUTHOR]
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- 2024
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22. A novel ilarvirus protein CP-RT is expressed via stop codon readthrough and suppresses RDR6-dependent RNA silencing.
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Lukhovitskaya, Nina, Brown, Katherine, Hua, Lei, Pate, Adrienne E., Carr, John P., and Firth, Andrew E.
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ZINC-finger proteins ,PLANT RNA ,PLANT viruses ,CHIMERIC proteins ,PEPTIDES ,MOLECULAR virology - Abstract
Ilarviruses are a relatively understudied but important group of plant RNA viruses that includes a number of crop pathogens. Their genomes comprise three RNA segments encoding two replicase subunits, movement protein, coat protein (CP), and (in some ilarvirus subgroups) a protein that suppresses RNA silencing. Here we report that, in many ilarviruses, RNA3 encodes an additional protein (termed CP-RT) as a result of ribosomal readthrough of the CP stop codon into a short downstream readthrough (RT) ORF. Using asparagus virus 2 as a model, we find that CP-RT is expressed in planta where it functions as a weak suppressor of RNA silencing. CP-RT expression is essential for persistent systemic infection in leaves and shoot apical meristem. CP-RT function is dependent on a putative zinc-finger motif within RT. Replacing the asparagus virus 2 RT with the RT of an ilarvirus from a different subgroup restored the ability to establish persistent infection. These findings open up a new avenue for research on ilarvirus silencing suppression, persistent meristem invasion and vertical transmission. Author summary: Ilarviruses comprise a group of plant-infecting RNA viruses. Until now, ilarvirus genomes were thought to only encode two components of the viral replicase, a movement protein, the capsid protein, and the 2b suppressor of RNA silencing. Interestingly, whereas most plant viruses encode one or more proteins that suppress the host antiviral RNA silencing pathway, the gene encoding 2b is only present in some ilarviruses. Here, we identify an additional ilarvirus protein that is expressed via low efficiency ribosomal readthrough of the capsid protein (CP) stop codon. Readthrough ribosomes translate a short downstream readthrough (RT) domain to produce the capsid-readthrough fusion protein, CP-RT. We show that CP-RT is a second ilarvirus suppressor of silencing protein and is required for the model ilarvirus asparagus virus 2 to maintain persistent infection in the model plant Nicotiana benthamiana. These findings advance our understanding of ilarvirus molecular virology and virus-host interaction. Interestingly, there are substantial differences in the RT peptide between divergent groups of ilarviruses and, in at least two cases, a separate RT peptide appears to have evolved independently. Thus it will be of future interest to investigate the function of CP-RT in different ilarvirus lineages. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch
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Hill, Chris H., Pekarek, Lukas, Napthine, Sawsan, Kibe, Anuja, Firth, Andrew E., Graham, Stephen C., Caliskan, Neva, and Brierley, Ian
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- 2021
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24. Clinical outcomes of contemporary lateral augmentation techniques in primary ACL reconstruction: a systematic review and meta-analysis
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Beckers, Lucas, Vivacqua, Thiago, Firth, Andrew D., and Getgood, Alan M. J.
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- 2021
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25. Predicting Patient Loss to Follow-up in the STABILITY 1 Study: A Multicenter, International, Randomized Controlled Trial of Young, Active Patients Undergoing ACL Reconstruction
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Firth, Andrew D., Bryant, Dianne M., Johnson, Andrew M., and Getgood, Alan M.J.
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- 2022
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26. Quantitative Magnetic Resonance Imaging of Lateral Compartment Articular Cartilage After Lateral Extra-articular Tenodesis.
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Firth, Andrew D., Pritchett, Stephany L., Milner, Jaques S., Atkinson, Hayden F., Bryant, Dianne M., Holdsworth, David W., and Getgood, Alan M.J.
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TENODESIS , *MENISCUS injuries , *ANTERIOR cruciate ligament injuries , *ARTICULAR cartilage , *ANTERIOR cruciate ligament surgery , *RESEARCH funding , *STATISTICAL sampling , *MAGNETIC resonance imaging , *TREATMENT effectiveness , *DESCRIPTIVE statistics , *RANDOMIZED controlled trials , *ANALYSIS of variance , *RESEARCH , *POSTOPERATIVE period , *COMPARATIVE studies , *MUSCLE contraction - Abstract
Background: Concerns have arisen that anterior cruciate ligament reconstruction (ACLR) with lateral extra-articular tenodesis (LET) may accelerate the development of posttraumatic osteoarthritis in the lateral compartment of the knee. Purpose/Hypothesis: The purpose of this study was to evaluate whether the augmentation of ACLR with LET affects the quality of lateral compartment articular cartilage on magnetic resonance imaging (MRI) at 2 years postoperatively. We hypothesized that there would be no difference in T1rho and T2 relaxation times when comparing ACLR alone with ACLR + LET. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A consecutive subgroup of patients at the Fowler Kennedy Sport Medicine Clinic participating in the STABILITY 1 Study underwent bilateral 3-T MRI at 2 years after surgery. The primary outcome was T1rho and T2 relaxation times. Articular cartilage in the lateral compartment was manually segmented into 3 regions of the tibia (lateral tibia [LT]–1 to LT-3) and 5 regions of the femur (lateral femoral condyle [LFC]–1 to LFC-5). Analysis of covariance was used to compare relaxation times between groups, adjusted for lateral meniscal tears and treatment, cartilage and bone marrow lesions, contralateral relaxation times, and time since surgery. Semiquantitative MRI scores according to the Anterior Cruciate Ligament OsteoArthritis Score were compared between groups. Correlations were used to determine the association between secondary outcomes (including results of the International Knee Documentation Committee score, Knee injury and Osteoarthritis Outcome Score, Lower Extremity Functional Scale, 4-Item Pain Intensity Measure, hop tests, and isokinetic quadriceps and hamstring strength tests) and cartilage relaxation. Results: A total of 95 participants (44 ACLR alone, 51 ACLR + LET) with a mean age of 18.8 years (61.1% female [58/95]) underwent 2-year MRI (range, 20-36 months). T1rho relaxation times were significantly elevated for the ACLR + LET group in LT-1 (37.3 ± 0.7 ms vs 34.1 ± 0.8 ms, respectively; P =.005) and LFC-2 (43.9 ± 0.9 ms vs 40.2 ± 1.0 ms, respectively; P =.008) compared with the ACLR alone group. T2 relaxation times were significantly elevated for the ACLR + LET group in LFC-1 (51.2 ± 0.7 ms vs 49.1 ± 0.7 ms, respectively; P =.03) and LFC-4 (45.9 ± 0.5 ms vs 44.2 ± 0.6 ms, respectively; P =.04) compared with the ACLR alone group. All effect sizes were small to medium. There was no difference in Anterior Cruciate Ligament OsteoArthritis Scores between groups (P =.99). Weak negative associations (rs = –0.27 to –0.22; P <.05) were found between relaxation times and quadriceps and hamstring strength in the anterolateral knee, while all other correlations were nonsignificant (P >.05). Conclusion: Increased relaxation times demonstrating small to medium effect sizes suggested early biochemical changes in articular cartilage of the anterolateral compartment in the ACLR + LET group compared with the ACLR alone group. Further evidence and long-term follow-up are needed to better understand the association between these results and the potential risk of the development of osteoarthritis in our patient cohort. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Tetherin antagonism by SARS‐CoV‐2 ORF3a and spike protein enhances virus release
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Stewart, Hazel, primary, Palmulli, Roberta, additional, Johansen, Kristoffer H, additional, McGovern, Naomi, additional, Shehata, Ola M, additional, Carnell, George W, additional, Jackson, Hannah K, additional, Lee, Jin S, additional, Brown, Jonathan C, additional, Burgoyne, Thomas, additional, Heeney, Jonathan L, additional, Okkenhaug, Klaus, additional, Firth, Andrew E, additional, Peden, Andrew A, additional, and Edgar, James R, additional
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- 2023
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28. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
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Kuhn, Jens H., primary, Abe, Junya, additional, Adkins, Scott, additional, Alkhovsky, Sergey V., additional, Avšič-Županc, Tatjana, additional, Ayllón, María A., additional, Bahl, Justin, additional, Balkema-Buschmann, Anne, additional, Ballinger, Matthew J., additional, Kumar Baranwal, Virendra, additional, Beer, Martin, additional, Bejerman, Nicolas, additional, Bergeron, Éric, additional, Biedenkopf, Nadine, additional, Blair, Carol D., additional, Blasdell, Kim R., additional, Blouin, Arnaud G., additional, Bradfute, Steven B., additional, Briese, Thomas, additional, Brown, Paul A., additional, Buchholz, Ursula J., additional, Buchmeier, Michael J., additional, Bukreyev, Alexander, additional, Burt, Felicity, additional, Büttner, Carmen, additional, Calisher, Charles H., additional, Cao, Mengji, additional, Casas, Inmaculada, additional, Chandran, Kartik, additional, Charrel, Rémi N., additional, Kumar Chaturvedi, Krishna, additional, Chooi, Kar Mun, additional, Crane, Anya, additional, Dal Bó, Elena, additional, Carlos de la Torre, Juan, additional, de Souza, William M., additional, de Swart, Rik L., additional, Debat, Humberto, additional, Dheilly, Nolwenn M., additional, Di Paola, Nicholas, additional, Di Serio, Francesco, additional, Dietzgen, Ralf G., additional, Digiaro, Michele, additional, Drexler, J. Felix, additional, Duprex, W. Paul, additional, Dürrwald, Ralf, additional, Easton, Andrew J., additional, Elbeaino, Toufic, additional, Ergünay, Koray, additional, Feng, Guozhong, additional, Firth, Andrew E., additional, Fooks, Anthony R., additional, Formenty, Pierre B. H., additional, Freitas-Astúa, Juliana, additional, Gago-Zachert, Selma, additional, Laura García, María, additional, García-Sastre, Adolfo, additional, Garrison, Aura R., additional, Gaskin, Thomas R., additional, Gong, Wenjie, additional, Gonzalez, Jean-Paul J., additional, de Bellocq, JoëlleGoüy, additional, Griffiths, Anthony, additional, Groschup, Martin H., additional, Günther, Ines, additional, Günther, Stephan, additional, Hammond, John, additional, Hasegawa, Yusuke, additional, Hayashi, Kazusa, additional, Hepojoki, Jussi, additional, Higgins, Colleen M., additional, Hongō, Seiji, additional, Horie, Masayuki, additional, Hughes, Holly R., additional, Hume, Adam J., additional, Hyndman, Timothy H., additional, Ikeda, Kenichi, additional, Jiāng, Dàohóng, additional, Jonson, Gilda B., additional, Junglen, Sandra, additional, Klempa, Boris, additional, Klingström, Jonas, additional, Kondō, Hideki, additional, Koonin, Eugene V., additional, Krupovic, Mart, additional, Kubota, Kenji, additional, Kurath, Gael, additional, Laenen, Lies, additional, Lambert, Amy J., additional, Lǐ, Jiànróng, additional, Li, Jun-Min, additional, Liu, Ran, additional, Lukashevich, Igor S., additional, MacDiarmid, Robin M., additional, Maes, Piet, additional, Marklewitz, Marco, additional, Marshall, Sergio H., additional, Marzano, Shin-Yi L., additional, McCauley, John W., additional, Mirazimi, Ali, additional, Mühlberger, Elke, additional, Nabeshima, Tomoyuki, additional, Naidu, Rayapati, additional, Natsuaki, Tomohide, additional, Navarro, Beatriz, additional, Navarro, José A., additional, Neriya, Yutaro, additional, Netesov, Sergey V., additional, Neumann, Gabriele, additional, Nowotny, Norbert, additional, Nunes, Márcio R. T., additional, Ochoa-Corona, Francisco M., additional, Okada, Tomoyuki, additional, Palacios, Gustavo, additional, Pallás, Vicente, additional, Papa, Anna, additional, Paraskevopoulou, Sofia, additional, Parrish, Colin R., additional, Pauvolid-Corrêa, Alex, additional, Pawęska, Janusz T., additional, Pérez, Daniel R., additional, Pfaff, Florian, additional, Plemper, Richard K., additional, Postler, Thomas S., additional, Rabbidge, Lee O., additional, Radoshitzky, Sheli R., additional, Ramos-González, Pedro L., additional, Rehanek, Marius, additional, Resende, Renato O., additional, Reyes, Carina A., additional, Rodrigues, Thaís C. S., additional, Romanowski, Víctor, additional, Rubbenstroth, Dennis, additional, Rubino, Luisa, additional, Runstadler, Jonathan A., additional, Sabanadzovic, Sead, additional, Sadiq, Sabrina, additional, Salvato, Maria S., additional, Sasaya, Takahide, additional, Schwemmle, Martin, additional, Sharpe, Stephen R., additional, Shi, Mang, additional, Shimomoto, Yoshifumi, additional, Kavi Sidharthan, Venkidusamy, additional, Sironi, Manuela, additional, Smither, Sophie, additional, Song, Jin-Won, additional, Spann, Kirsten M., additional, Spengler, Jessica R., additional, Stenglein, Mark D., additional, Takada, Ayato, additional, Takeyama, Sawana, additional, Tatara, Akio, additional, Tesh, Robert B., additional, Thornburg, Natalie J., additional, Tian, Xin, additional, Tischler, Nicole D., additional, Tomitaka, Yasuhiro, additional, Tomonaga, Keizō, additional, Tordo, Noël, additional, Tu, Changchun, additional, Turina, Massimo, additional, Tzanetakis, Ioannis E., additional, Maria Vaira, Anna, additional, van den Hoogen, Bernadette, additional, Vanmechelen, Bert, additional, Vasilakis, Nikos, additional, Verbeek, Martin, additional, von Bargen, Susanne, additional, Wada, Jiro, additional, Wahl, Victoria, additional, Walker, Peter J., additional, Waltzek, Thomas B., additional, Whitfield, Anna E., additional, Wolf, Yuri I., additional, Xia, Han, additional, Xylogianni, Evanthia, additional, Yanagisawa, Hironobu, additional, Yano, Kazutaka, additional, Ye, Gongyin, additional, Yuan, Zhiming, additional, Zerbini, F. Murilo, additional, Zhang, Guilin, additional, Zhang, Song, additional, Zhang, Yong-Zhen, additional, Zhao, Lu, additional, and Økland, Arnfinn Lodden, additional
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- 2023
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29. Identification of RNA virus-derived RdRp sequences in publicly available transcriptomic datasets
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Olendraite, Ingrida, Brown, Katherine, Firth, Andrew E, Olendraite, Ingrida [0000-0002-6209-2233], Brown, Katherine [0000-0002-8400-6922], Firth, Andrew E [0000-0002-7986-9520], and Apollo - University of Cambridge Repository
- Subjects
Infectious Diseases ,FOS: Biological sciences ,Genetics ,3 Good Health and Well Being ,FOS: Health sciences ,Infection - Abstract
RNA viruses are abundant, highly diverse, and infect all or most eukaryotic organisms. However, only a tiny fraction of the number and diversity of RNA virus species have been catalogued. To cost effectively expand the diversity of known RNA virus sequences we mined publicly available transcriptomic datasets. We developed 77 family-level Hidden Markov Model profiles for the viral RNA dependent RNA polymerase – the only universal “hall-mark” gene of RNA viruses. By using these to search the NCBI Transcriptome Shotgun Assembly database, we identified 5,867 contigs encoding RNA virus RdRps or fragments thereof and analysed their diversity, taxonomic classification, phylogeny and host associations. Our study expands the known diversity of RNA viruses, and the 77 curated RdRp pHMMs provide a useful resource for the virus discovery community.
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- 2023
30. Poster 248: Lateral extra-articular tenodesis augmentation of anterior cruciate ligament reconstruction does not impact cartilage health in the patellofemoral joint based on post-operative two year qualitative and quantitative MRI analysis
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Hegarty, Paul, primary, Vivacqua, Thiago, additional, Firth, Andrew, additional, Milner, Jaques, additional, Pritchett, Stephany, additional, Bryant, Dianne, additional, Getgood, Alan, additional, and Nakanishi, Yuta, additional
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- 2023
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31. Anterior Cruciate Ligament Reconstruction Plus Lateral Extra-articular Tenodesis Has a Similar Return-to-Sport Rate to Anterior Cruciate Ligament Reconstruction Alone but a Lower Failure Rate
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Rezansoff, Alex, primary, Firth, Andrew D., additional, Bryant, Dianne M., additional, Litchfield, Robert, additional, McCormack, Robert G., additional, Heard, Mark, additional, MacDonald, Peter B., additional, Spalding, Tim, additional, Verdonk, Peter C.M., additional, Peterson, Devin, additional, Bardana, Davide, additional, Getgood, Alan M.J., additional, Willits, Kevin, additional, Birmingham, Trevor, additional, Hewison, Chris, additional, Pinto, Ryan, additional, Martindale, Ashley, additional, O’Neill, Lindsey, additional, Jennings, Morgan, additional, Daniluk, Michal, additional, Boyer, Dory, additional, Zomar, Mauri, additional, Buchko, Gregory M., additional, Hiemstra, Laurie A., additional, Kerslake, Sarah, additional, Tynedal, Jeremy, additional, Stranges, Greg, additional, McRae, Sheila, additional, Brown, Holly, additional, Rezansoff, Alex, additional, Mohtadi, Nick, additional, Chan, Denise, additional, Garven, Alexandra, additional, Simunovic, Nicole, additional, Duong, Andrew, additional, Skelly, Matt, additional, Shanmugaraj, Ajaykumar, additional, Howells, Fiona, additional, Thompson, Pete, additional, Metcalfe, Andrew, additional, and Declerq, Geert, additional
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- 2023
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32. Identification of RNA Virus–Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets
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Olendraite, Ingrida, primary, Brown, Katherine, additional, and Firth, Andrew E, additional
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- 2023
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33. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
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Kuhn, Jens H., Abe, Junya, Adkins, Scott, Alkhovsky, Sergey V., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Baranwal, Virendra Kumar, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Blair, Carol D., Blasdell, Kim R., Blouin, Arnaud G., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chaturvedi, Krishna Kumar, Chooi, Kar Mun, Crane, Anya, Bó, Elena Dal, de la Torre, Juan Carlos, de Souza, William M., de Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J.F., Duprex, W.P., Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B.H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gong, Wenjie, Gonzalez, Jean Paul J., de Bellocq, Joëlle Goüy, Griffiths, Anthony, Groschup, Martin H., Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen M., Hongō, Seiji, Horie, Masayuki, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy H., Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Lǐ, Jiànróng, Li, Jun Min, Liu, Ran, Lukashevich, Igor S., MacDiarmid, Robin M., Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin Yi L., McCauley, John W., Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R.T., Ochoa-Corona, Francisco M., Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Rabbidge, Lee O., Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Rodrigues, Thaís C.S., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sadiq, Sabrina, Salvato, Maria S., Sasaya, Takahide, Schwemmle, Martin, Sharpe, Stephen R., Shi, Mang, Shimomoto, Yoshifumi, Sidharthan, Venkidusamy Kavi, Sironi, Manuela, Smither, Sophie, Song, Jin Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Takeyama, Sawana, Tatara, Akio, Tesh, Robert B., Thornburg, Natalie J., Tian, Xin, Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Waltzek, Thomas B., Whitfield, Anna E., Wolf, Yuri I., Xia, Han, Xylogianni, Evanthia, Yanagisawa, Hironobu, Yano, Kazutaka, Ye, Gongyin, Yuan, Zhiming, Zerbini, F.M., Zhang, Guilin, Zhang, Song, Zhang, Yong Zhen, Zhao, Lu, Økland, Arnfinn Lodden, Kuhn, Jens H., Abe, Junya, Adkins, Scott, Alkhovsky, Sergey V., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Baranwal, Virendra Kumar, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Blair, Carol D., Blasdell, Kim R., Blouin, Arnaud G., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chaturvedi, Krishna Kumar, Chooi, Kar Mun, Crane, Anya, Bó, Elena Dal, de la Torre, Juan Carlos, de Souza, William M., de Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J.F., Duprex, W.P., Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B.H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gong, Wenjie, Gonzalez, Jean Paul J., de Bellocq, Joëlle Goüy, Griffiths, Anthony, Groschup, Martin H., Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen M., Hongō, Seiji, Horie, Masayuki, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy H., Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Lǐ, Jiànróng, Li, Jun Min, Liu, Ran, Lukashevich, Igor S., MacDiarmid, Robin M., Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin Yi L., McCauley, John W., Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R.T., Ochoa-Corona, Francisco M., Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Rabbidge, Lee O., Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Rodrigues, Thaís C.S., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sadiq, Sabrina, Salvato, Maria S., Sasaya, Takahide, Schwemmle, Martin, Sharpe, Stephen R., Shi, Mang, Shimomoto, Yoshifumi, Sidharthan, Venkidusamy Kavi, Sironi, Manuela, Smither, Sophie, Song, Jin Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Takeyama, Sawana, Tatara, Akio, Tesh, Robert B., Thornburg, Natalie J., Tian, Xin, Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Waltzek, Thomas B., Whitfield, Anna E., Wolf, Yuri I., Xia, Han, Xylogianni, Evanthia, Yanagisawa, Hironobu, Yano, Kazutaka, Ye, Gongyin, Yuan, Zhiming, Zerbini, F.M., Zhang, Guilin, Zhang, Song, Zhang, Yong Zhen, Zhao, Lu, and Økland, Arnfinn Lodden
- Abstract
In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished.
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- 2023
34. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
- Author
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National Institute of Allergy and Infectious Diseases (US), Antiviral Countermeasures Development Center (US), Department of Agriculture (US), Department of the Army (US), Department of Health and Human Services (US), US Department of Homeland Security, Federal Government of the United States, Kuhn, Jens H. [0000-0002-7800-6045], Abe, Junya [0000-0003-3627-7071], Adkins, Scott [0000-0003-0095-8414], Alkhovsky, Sergey V. [0000-0001-6913-5841], Avsic-Zupanc, Tatjana [0000-0001-6243-0688], Ayllón, María A. [0000-0001-7893-6106], Bahl, Justin [0000-0001-7572-4300], Balkema-Buschmann, A. [0000-0001-7613-9592], Ballinger, Matthew J. [0000-0001-7453-8725], Bejerman, Nicolas [0000-0002-7851-3506], Biedenkopf, Nadine [0000-0002-6061-8019], Blair, Carol D.[0000-0002-2803-0354], Blasdell, Kim R.[0000-0003-2121-0376], Bradfute, Steven B.[0000-0002-1985-751X], Briese, Thomas [0000-0002-4819-8963], Buchholz, Ursula J. [0000-0002-2329-3198], Buchmeier, Michael J.[0000-0002-2387-9287], Bukreyev, Alexander [0000-0002-0342-4824], Burt, Felicity [0000-0002-7238-7799], Büttner, Carmen [0000-0002-2086-2594], Calisher, Charles H. [0000-0003-0213-294X], Cao, Mengji [0000-0003-0396-262X], Casas, Inmaculada [0000-0003-1840-1198], Chandran, Kartik [0000-0003-0232-7077], Charrel, Rémi N.[0000-0002-7675-8251], Chaturvedi, Krishna Kumar [0000-0002-6529-5466], Crane, Anya [0000-0002-2060-2469], De Swart, Rik L.[0000-0003-3599-8969], Debat, Humberto [0000-0003-3056-3739], Dheilly, Nolwenn M.[0000-0002-3675-5013], Di Paola, Nicholas [0000-0002-9694-3913], Di Serio, Francesco [0000-0003-2822-704X], Dietzgen, Ralf G.[0000-0002-7772-2250], Digiaro, Michele [0009-0006-3089-3606], Drexler, J. Felix [0000-0002-3509-0232], Duprex, W. Paul [0000-0003-1716-6376], Elbeaino, Toufic [0000-0003-2211-7907], Ergünay, Koray [0000-0001-5422-1982], Feng, Guozhong [0000-0002-9489-9322], Fooks, Anthony R.[0000-0002-3243-6154], Formenty, Pierre B.H.[0000-0002-9482-5411], Freitas-Astúa, Juliana [0000-0002-0506-6880], Gago-Zachert, Selma [0000-0002-1084-2119], García, María Laura [0000-0001-6468-6943], Garrison, Aura R.[0000-0003-3034-6400], Gaskin, Thomas R. [0000-0002-5644-4431], Gouy de Bellocq, Joelle [0000-0001-5831-6284], Griffiths, Anthony [0000-0001-5435-8364], Groschup, M. H.[0000-0003-0215-185X], Günther, Stephan [0000-0002-6562-0230], Hayashi, Kazusa [0009-0002-9395-0066], Hepojoki, Jussi [0000-0001-5699-214X], Higgins, Colleen M. [0000-0001-9016-2940], Horie, Masayuki [0000-0003-4682-7698], Hughes, Holly R.[0000-0003-1380-8263], Hyndman, Timothy [0000-0002-7047-5023], Jiāng, Dàohóng [0000-0002-3862-7461], Jonson, Gilda B.[0000-0003-0097-8634], Junglen, Sandra [0000-0002-3799-6011], Klempa, B.[0000-0002-6931-1224], Klingström, Jonas [0000-0001-9076-1441], Kondō, Hideki [0000-0001-9220-5350], Koonin, Eugene V. [0000-0003-3943-8299], Krupovic, Mart [0000-0001-5486-0098], Kurath, Gael [0000-0003-3294-560X], Laenen, Lies [0000-0001-9118-8608], Li, Jianrong [0000-0002-7130-1084], Lukashevich, Igor S.[0000-0001-6523-5116], MacDiarmid, Robin M.[0000-0002-7057-2018], Maes, Piet [0000-0002-4571-5232], Marklewitz, Marco [0000-0003-1828-8770], Marshall, Sergio H.[0000-0003-0438-8252], Marzano, Shin-Yi L. [0000-0003-0548-3761], Mühlberger, Elke [0000-0003-3547-9376], Nabeshima, Tomoyuki [0000-0002-6570-096X], Naidu, Rayapati [0000-0002-7273-5116], Natsuaki, Tomohide [0000-0003-1823-7308], Navarro, José A. [0000-0002-0536-6074], Neriya, Yutaro [0000-0002-1385-0050], Netesov, Sergey V. [0000-0002-7786-2464], Neumann, Gabriele [0000-0001-7054-1775], Nowotny, N. [0000-0002-3548-571X], Ochoa-Corona, Francisco M. [0000-0002-4112-8209], Pallás, Vicente [0000-0003-4954-989X], Papa, Anna [0000-0002-6643-3322], Paraskevopoulou, Sofia [0000-0003-2608-2596], Parrish, Colin R. [0000-0002-1836-6655], Pauvolid-Corrêa, Alex [0000-0002-6924-157X], Pawęska, Janusz T. [0000-0001-8776-7519], Pérez, Daniel R. [0000-0002-6569-5689], Pfaff, Florian [0000-0003-0178-6183], Plemper, Richard K. [0000-0003-2034-2107], Postler, Thomas S. [0000-0002-3558-9084], Rabbidge, Lee O. [0009-0001-7962-4881], Radoshitzky, Sheli R. [0000-0001-8976-8056], Ramos-González, Pedro L. [0000-0002-9640-6587], Rehanek, Marius [0000-0002-5710-5060], Resende, Renato O. [0000-0003-3852-1576], Romanowski, Víctor [0000-0001-6378-7929], Rubbenstroth, Dennis [0000-0002-8209-6274], Rubino, Luisa [0000-0002-2073-2415], Runstadler, Jonathan A. 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Murilo [0000-0001-8617-0200], Okland, Arnfinn Lodden [0000-0003-3062-4386], Kuhn, Jens H., Abe, Junya, Adkins, Scott, Alkhovsky, Sergey V., Avsic-Zupanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, A., Ballinger, Matthew J., Kumar Baranwal, Virendra, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Blair, Carol D., Blasdell, Kim R., Blouin, Arnaud G., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chaturvedi, Krishna Kumar, Chooi, Kar Mun, Crane, Anya, Dal Bó, Elena, de la Torre, J. C., de Souza, William Marciel, De Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J. Felix, Duprex, W. 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Murilo, Zhang, Guilin, Zhang, Song, Zhang, Yong-Zhen, Zhao, Lu, Okland, Arnfinn Lodden, National Institute of Allergy and Infectious Diseases (US), Antiviral Countermeasures Development Center (US), Department of Agriculture (US), Department of the Army (US), Department of Health and Human Services (US), US Department of Homeland Security, Federal Government of the United States, Kuhn, Jens H. [0000-0002-7800-6045], Abe, Junya [0000-0003-3627-7071], Adkins, Scott [0000-0003-0095-8414], Alkhovsky, Sergey V. [0000-0001-6913-5841], Avsic-Zupanc, Tatjana [0000-0001-6243-0688], Ayllón, María A. [0000-0001-7893-6106], Bahl, Justin [0000-0001-7572-4300], Balkema-Buschmann, A. [0000-0001-7613-9592], Ballinger, Matthew J. 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Murilo [0000-0001-8617-0200], Okland, Arnfinn Lodden [0000-0003-3062-4386], Kuhn, Jens H., Abe, Junya, Adkins, Scott, Alkhovsky, Sergey V., Avsic-Zupanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, A., Ballinger, Matthew J., Kumar Baranwal, Virendra, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Blair, Carol D., Blasdell, Kim R., Blouin, Arnaud G., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chaturvedi, Krishna Kumar, Chooi, Kar Mun, Crane, Anya, Dal Bó, Elena, de la Torre, J. C., de Souza, William Marciel, De Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J. Felix, Duprex, W. Paul, Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B.H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gong, Wenjie, Gonzalez, Jean-Paul J., Gouy de Bellocq, Joelle, Griffiths, Anthony, Groschup, M. H., Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen M., Hongo, Seiji, Horie, Masayuki, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy, Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Klempa, B., Klingström, Jonas, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Li, Jianrong, Li, Jun-Min, Liu, Ran, Lukashevich, Igor S., MacDiarmid, Robin M, Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., McCauley, John W., Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, N., Nunes, Márcio R.T., Ochoa-Corona, Francisco M., Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Rabbidge, Lee O., Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Rodrigues, Thaís C.S., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sadiq, Sabrina, Salvato, Maria S., Sasaya, Takahide, Schwemmle, Martin, Sharpe, Stephen R., Shi, Mang, Shimomoto, Yoshifumi, Kavi Sidharthan, Venkidusamy, Sironi, Manuela, Smither, Sophie, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Takeyama, Sawana, Tatara, Akio, Tesh, Robert B., Thornburg, Natalie J., Tian, Xin, Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, Van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, Von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Waltzek, Thomas B., Whitfield, Anna E., Wolf, Yuri I., Xia, Han, Xylogianni, Evanthia, Yanagisawa, Hironobu, Yano, Kazutaka, Ye, Gongyin, Yuan, Zhiming, Zerbini, F. Murilo, Zhang, Guilin, Zhang, Song, Zhang, Yong-Zhen, Zhao, Lu, and Okland, Arnfinn Lodden
- Abstract
In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
- Published
- 2023
35. Identification of RNA Virus-Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets
- Author
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Olendraite, Ingrida, Brown, Katherine, and Firth, Andrew E
- Subjects
RdRp ,splicing ,virus discovery ,RNA virus ,pHMM ,RNA Viruses ,RNA, Viral ,Genome, Viral ,Orthomyxoviridae ,Transcriptome ,RNA-Dependent RNA Polymerase ,Phylogeny - Abstract
RNA viruses are abundant and highly diverse and infect all or most eukaryotic organisms. However, only a tiny fraction of the number and diversity of RNA virus species have been catalogued. To cost-effectively expand the diversity of known RNA virus sequences, we mined publicly available transcriptomic data sets. We developed 77 family-level Hidden Markov Model profiles for the viral RNA-dependent RNA polymerase (RdRp)-the only universal "hallmark" gene of RNA viruses. By using these to search the National Center for Biotechnology Information Transcriptome Shotgun Assembly database, we identified 5,867 contigs encoding RNA virus RdRps or fragments thereof and analyzed their diversity, taxonomic classification, phylogeny, and host associations. Our study expands the known diversity of RNA viruses, and the 77 curated RdRp Profile Hidden Markov Models provide a useful resource for the virus discovery community.
- Published
- 2023
- Full Text
- View/download PDF
36. Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria
- Author
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Remes, Cristina, primary, Khawaja, Anas, additional, Pearce, Sarah F, additional, Dinan, Adam M, additional, Gopalakrishna, Shreekara, additional, Cipullo, Miriam, additional, Kyriakidis, Vasileios, additional, Zhang, Jingdian, additional, Dopico, Xaquin Castro, additional, Yukhnovets, Olessya, additional, Atanassov, Ilian, additional, Firth, Andrew E, additional, Cooperman, Barry, additional, and Rorbach, Joanna, additional
- Published
- 2023
- Full Text
- View/download PDF
37. Closing-Wedge Posterior Tibial Slope–Reducing Osteotomy in Complex Revision ACL Reconstruction
- Author
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Vivacqua, Thiago, primary, Thomassen, Stephan, additional, Winkler, Philipp W., additional, Lucidi, Gian A., additional, Rousseau-Saine, Alexis, additional, Firth, Andrew D., additional, Heard, Mark, additional, Musahl, Volker, additional, and Getgood, Alan M.J., additional
- Published
- 2023
- Full Text
- View/download PDF
38. The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
- Author
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Stewart, Hazel, primary, Lu, Yongxu, additional, O'Keefe, Sarah, additional, Valpadashi, Anusha, additional, Cruz-Zaragoza, Luis Daniel, additional, Michel, Hendrik A, additional, Nguyen, Samantha K, additional, Carnell, George W, additional, Lukhovitskaya, Nina, additional, Milligan, Rachel, additional, Jungreis, Irwin, additional, Lulla, Valeria, additional, Davidson, Andrew D, additional, Matthews, David A, additional, High, Stephen, additional, Rehling, Peter, additional, Emmott, Edward, additional, Heeney, Jonathan Luke, additional, Edgar, James R, additional, Smith, Geoffrey L., additional, and Firth, Andrew E, additional
- Published
- 2022
- Full Text
- View/download PDF
39. Identification of RNA virus-derived RdRp sequences in publicly available transcriptomic datasets
- Author
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Olendraite, Ingrida, primary, Brown, Katherine, additional, and Firth, Andrew E., additional
- Published
- 2022
- Full Text
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40. Turnip Mosaic Virus Transcriptional Slippage Dynamics and Distribution in RNA Subpopulations
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Kärblane, Kairi, primary, Firth, Andrew E., additional, and Olspert, Allan, additional
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- 2022
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41. Poster 214: Posterior Tibial Slope Reducing Osteotomy in Complex Revision Anterior Cruciate Ligament Reconstruction
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Thomassen, Stephan, primary, Winkler, Philipp, additional, Lucidi, Gian Andrea, additional, Firth, Andrew, additional, Musahl, Volker, additional, Getgood, Alan, additional, and Vivacqua, Thiago, additional
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- 2022
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42. Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency
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Ivanov, Ivaylo P, Saba, James A, Fan, Chen-Ming, Wang, Ji, Firth, Andrew E, Cao, Chune, Green, Rachel, Dever, Thomas E, Ivanov, Ivaylo P [0000-0002-6008-3261], Saba, James A [0000-0003-3453-8151], Fan, Chen-Ming [0000-0003-3211-6617], Green, Rachel [0000-0001-9337-2003], and Apollo - University of Cambridge Repository
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Evolution, Molecular ,Hox genes ,Mice ,Open Reading Frames ,Protein Biosynthesis ,start codon selection stringency ,Genes, Homeobox ,Animals ,Codon, Initiator ,eIF1 ,RNA, Messenger ,eIF5 ,uORF - Abstract
Translation start site selection in eukaryotes is influenced by context nucleotides flanking the AUG codon and by levels of the eukaryotic translation initiation factors eIF1 and eIF5. In a search of mammalian genes, we identified five homeobox (Hox) gene paralogs initiated by AUG codons in conserved suboptimal context as well as 13 Hox genes that contain evolutionarily conserved upstream open reading frames (uORFs) that initiate at AUG codons in poor sequence context. An analysis of published cap analysis of gene expression sequencing (CAGE-seq) data and generated CAGE-seq data for messenger RNAs (mRNAs) from mouse somites revealed that the 5' leaders of Hox mRNAs of interest contain conserved uORFs, are generally much shorter than reported, and lack previously proposed internal ribosome entry site elements. We show that the conserved uORFs inhibit Hox reporter expression and that altering the stringency of start codon selection by overexpressing eIF1 or eIF5 modulates the expression of Hox reporters. We also show that modifying ribosome homeostasis by depleting a large ribosomal subunit protein or treating cells with sublethal concentrations of puromycin leads to lower stringency of start codon selection. Thus, altering global translation can confer gene-specific effects through altered start codon selection stringency.
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- 2022
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43. CIAlign: A highly customisable command line tool to clean, interpret and visualise multiple sequence alignments
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Tumescheit, Charlotte, primary, Firth, Andrew E., additional, and Brown, Katherine, additional
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- 2022
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44. Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
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Cook, Georgia M, primary, Brown, Katherine, additional, Shang, Pengcheng, additional, Li, Yanhua, additional, Soday, Lior, additional, Dinan, Adam M, additional, Tumescheit, Charlotte, additional, Mockett, AP Adrian, additional, Fang, Ying, additional, Firth, Andrew E, additional, and Brierley, Ian, additional
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- 2022
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45. Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency
- Author
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Ivanov, Ivaylo P., primary, Saba, James A., additional, Fan, Chen-Ming, additional, Wang, Ji, additional, Firth, Andrew E., additional, Cao, Chune, additional, Green, Rachel, additional, and Dever, Thomas E., additional
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- 2022
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46. Author response: Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
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Cook, Georgia M, primary, Brown, Katherine, additional, Shang, Pengcheng, additional, Li, Yanhua, additional, Soday, Lior, additional, Dinan, Adam M, additional, Tumescheit, Charlotte, additional, Mockett, AP Adrian, additional, Fang, Ying, additional, Firth, Andrew E, additional, and Brierley, Ian, additional
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- 2022
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47. sj-pdf-1-ajs-10.1177_03635465211061150 ��� Supplemental material for Predictors of Graft Failure in Young Active Patients Undergoing Hamstring Autograft Anterior Cruciate Ligament Reconstruction With or Without a Lateral Extra-articular Tenodesis: The Stability Experience
- Author
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Firth, Andrew D., Bryant, Dianne M., Litchfield, Robert, McCormack, Robert G., Heard, Mark, MacDonald, Peter B., Spalding, Tim, Verdonk, Peter C.M., Peterson, Devin, Bardana, Davide, Rezansoff, Alex, Getgood, Alan M.J., Willits, Kevin, Birmingham, Trevor, Hewison, Chris, Wanlin, Stacey, Pinto, Ryan, Martindale, Ashley, O���Neill, Lindsey, Jennings, Morgan, Daniluk, Michal, Boyer, Dory, Zomar, Mauri, Moon, Karyn, Moon, Raely, Fan, Brenda, Mohan, Bindu, Buchko, Gregory M., Hiemstra, Laurie A., Kerslake, Sarah, Tynedal, Jeremy, Stranges, Greg, Mcrae, Sheila, Gullett, LeeAnne, Brown, Holly, Legary, Alexandra, Longo, Alison, Christian, Mat, Ferguson, Celeste, Mohtadi, Nick, Barber, Rhamona, Chan, Denise, Campbell, Caitlin, Garven, Alexandra, Pulsifer, Karen, Mayer, Michelle, Simunovic, Nicole, Duong, Andrew, Robinson, David, Levy, David, Skelly, Matt, Shanmugaraj, Ajaykumar, Howells, Fiona, Tough, Murray, Thompson, Pete, Metcalfe, Andrew, Asplin, Laura, Dube, Alisen, Clarkson, Louise, Brown, Jaclyn, Bolsover, Alison, Bradshaw, Carolyn, Belgrove, Larissa, Milan, Francis, Turner, Sylvia, Verdugo, Sarah, Lowe, Janet, Dunne, Debra, McGowan, Kerri, Suddens, Charlie-Marie, Declerq, Geert, Vuylsteke, Kristien, and Van Haver, Mieke
- Subjects
FOS: Clinical medicine ,110323 Surgery ,110604 Sports Medicine ,FOS: Health sciences ,110314 Orthopaedics - Abstract
Supplemental material, sj-pdf-1-ajs-10.1177_03635465211061150 for Predictors of Graft Failure in Young Active Patients Undergoing Hamstring Autograft Anterior Cruciate Ligament Reconstruction With or Without a Lateral Extra-articular Tenodesis: The Stability Experience by Andrew D. Firth, Dianne M. Bryant, Robert Litchfield, Robert G. McCormack, Mark Heard, Peter B. MacDonald, Tim Spalding, Peter C.M. Verdonk, Devin Peterson, Davide Bardana, Alex Rezansoff, STABILITY Study Group, Alan M.J. Getgood, Kevin Willits, Trevor Birmingham, Chris Hewison, Stacey Wanlin, Ryan Pinto, Ashley Martindale, Lindsey O���Neill, Morgan Jennings, Michal Daniluk, Dory Boyer, Mauri Zomar, Karyn Moon, Raely Moon, Brenda Fan, Bindu Mohan, Gregory M. Buchko, Laurie A. Hiemstra, Sarah Kerslake, Jeremy Tynedal, Greg Stranges, Sheila Mcrae, LeeAnne Gullett, Holly Brown, Alexandra Legary, Alison Longo, Mat Christian, Celeste Ferguson, Nick Mohtadi, Rhamona Barber, Denise Chan, Caitlin Campbell, Alexandra Garven, Karen Pulsifer, Michelle Mayer, Nicole Simunovic, Andrew Duong, David Robinson, David Levy, Matt Skelly, Ajaykumar Shanmugaraj, Fiona Howells, Murray Tough, Pete Thompson, Andrew Metcalfe, Laura Asplin, Alisen Dube, Louise Clarkson, Jaclyn Brown, Alison Bolsover, Carolyn Bradshaw, Larissa Belgrove, Francis Milan, Sylvia Turner, Sarah Verdugo, Janet Lowe, Debra Dunne, Kerri McGowan, Charlie-Marie Suddens, Geert Declerq, Kristien Vuylsteke and Mieke Van Haver in The American Journal of Sports Medicine
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- 2022
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48. Correction: pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread
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Benedyk, Tomasz H., primary, Muenzner, Julia, additional, Connor, Viv, additional, Han, Yue, additional, Brown, Katherine, additional, Wijesinghe, Kaveesha J., additional, Zhuang, Yunhui, additional, Colaco, Susanna, additional, Stoll, Guido A., additional, Tutt, Owen S., additional, Svobodova, Stanislava, additional, Svergun, Dmitri I., additional, Bryant, Neil A., additional, Deane, Janet E., additional, Firth, Andrew E., additional, Jeffries, Cy M., additional, Crump, Colin M., additional, and Graham, Stephen C., additional
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- 2022
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49. Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
- Author
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Cook, Georgia M., primary, Brown, Katherine, additional, Shang, Pengcheng, additional, Li, Yanhua, additional, Soday, Lior, additional, Dinan, Adam M., additional, Tumescheit, Charlotte, additional, Adrian Mockett, A. P., additional, Fang, Ying, additional, Firth, Andrew E., additional, and Brierley, Ian, additional
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- 2021
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50. Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus
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Hill, Chris H, primary, Cook, Georgia M, additional, Napthine, Sawsan, additional, Kibe, Anuja, additional, Brown, Katherine, additional, Caliskan, Neva, additional, Firth, Andrew E, additional, Graham, Stephen C, additional, and Brierley, Ian, additional
- Published
- 2021
- Full Text
- View/download PDF
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