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Advances in treatment have reduced mortality from Hodgkin Lymphoma and made it so greater attention can be focused on minimizing late effects. A variety of risk-adapted treatment regimens exist that prioritize disease presentation, but not patient-specific comorbidities. Herein we describe a patient with sickle cell disease diagnosed with Hodgkin Lymphoma and the considerations made in treatment planning to minimize therapy-related acute toxicity and late effects that overlap with the patient’s pre-existing sickle cell disease complications.