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Your search keyword '"Freeman, James"' showing total 409 results
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409 results on '"Freeman, James"'

2. Incorporating a cognitive model for evidence accumulation into deep reinforcement learning agents

Author

Mochizuki-Freeman, James, Kabir, Md Rysul, and Tiganj, Zoran

Subjects
Artificial Intelligence, Cognitive Neuroscience, Cognition of Time, Memory, Computational Modeling
Abstract

Recent neuroscience studies suggest that the hippocampus encodes a low-dimensional ordered representation of evidence through sequential neural activity. Cognitive modelers have proposed a mechanism by which such sequential activity could emerge through the modulation of the decay rate of neurons with exponentially decaying firing profiles. Through a linear transformation, this representation gives rise to neurons tuned to a specific magnitude of evidence, resembling neurons recorded in the hippocampus. Here we integrated this cognitive model inside reinforcement learning agents and trained the agents to perform an evidence accumulation task designed to mimic a task used in experiments on animals. We found that the agents were able to learn the task and exhibit sequential neural activity as a function of the amount of evidence, similar to the activity reported in the hippocampus.

Published
2024

4. In-hospital complications associated with pulmonary vein isolation with adjunctive lesions: the NCDR AFib Ablation Registry

Author

Darden, Douglas, Aldaas, Omar, Du, Chengan, Munir, Muhammad Bilal, Feld, Gregory K, Pothineni, Naga Venkata K, Gopinathannair, Rakesh, Lakkireddy, Dhanunjaya, Curtis, Jeptha P, Freeman, James V, Akar, Joseph G, and Hsu, Jonathan C

Subjects
Clinical Research, Cardiovascular, Heart Disease, Atrial fibrillation, Ablation, Pulmonary vein isolation, Adjunctive lesions, Paroxysmal, Persistent, Outcomes, Registry, Complications, Clinical Sciences, Cardiovascular System & Hematology
Abstract

AimsNo prior study has been adequately powered to evaluate real-world safety outcomes in those receiving adjunctive ablation lesions beyond pulmonary vein isolation (PVI). We sought to evaluate characteristics and in-hospital complications among patients undergoing PVI with and without adjunctive lesions.Methods and resultsPatients in the National Cardiovascular Data Registry AFib Ablation Registry undergoing first-time atrial fibrillation (AF) ablation between 2016 and 2020 were identified and stratified into paroxysmal (PAF) and persistent AF, and separated into PVI only, PVI + cavotricuspid isthmus (CTI) ablation, and PVI + adjunctive (superior vena cava isolation, coronary sinus, vein of Marshall, atypical atrial flutter lines, other). Adjusted odds of adverse events were calculated using multivariable logistic regression. A total of 50 937 patients [PAF: 30 551 (60%), persistent AF: 20 386 (40%)] were included. Among those with PAF, there were no differences in the adjusted odds of complications between PVI + CTI or PVI + adjunctive when compared with PVI only. Among persistent AF, PVI + adjunctive was associated with a higher risk of any complication [3.0 vs. 4.5%, odds ratio (OR) 1.30, 95% confidence interval (CI) 1.07-1.58] and major complication (0.8 vs. 1.4%, OR 1.56, 95% CI 1.10-2.21), while no differences were observed in PVI + CTI compared with PVI only. Overall, there was high heterogeneity in adjunctive lesion type, and those receiving adjunctive lesions had a higher comorbidity burden.ConclusionAdditional CTI ablation was common without an increased risk of complications. Adjunctive lesions other than CTI are commonly performed in those with more comorbidities and were associated with an increased risk of complications in persistent AF, although the current analysis is limited by high heterogeneity in adjunctive lesion set type.

Published
2023

13. Heart Watch Study: protocol for a pragmatic randomised controlled trial

Author

Dhruva, Sanket S, Shah, Nilay D, Vemulapalli, Sreekanth, Deshmukh, Abhishek, Beatty, Alexis L, Gamble, Ginger M, Freeman, James V, Hummel, James P, Piccini, Jonathan P, Akar, Joseph G, Ervin, Keondae, Arges, Kristine L, Emanuel, Lindsay, Noseworthy, Peter A, Hu, Tiffany, Bartlett, Victoria, and Ross, Joseph S

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Prevention, Clinical Trials and Supportive Activities, Patient Safety, Heart Disease, Cardiovascular, Clinical Research, Health Services, Management of diseases and conditions, 7.3 Management and decision making, Good Health and Well Being, Atrial Fibrillation, Atrial Flutter, Electric Countershock, Humans, Multicenter Studies as Topic, Pragmatic Clinical Trials as Topic, Prospective Studies, Quality of Life, Randomized Controlled Trials as Topic, adult cardiology, pacing & electrophysiology, telemedicine, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

IntroductionPersonal digital devices that provide health information, such as the Apple Watch, have developed an increasing array of cardiopulmonary tracking features which have received regulatory clearance and are directly marketed to consumers. Despite their widespread and increasing use, data about the impact of personal digital device use on patient-reported outcomes and healthcare utilisation are sparse. Among a population of patients with atrial fibrillation and/or atrial flutter undergoing cardioversion, our primary aim is to determine the impact of the heart rate measurement, irregular rhythm notification, and ECG features of the Apple Watch on quality of life and healthcare utilisation.Methods and analysisWe are conducting a prospective, open-label multicentre pragmatic randomised clinical trial, leveraging a unique patient-centred health data sharing platform for enrolment and follow-up. A total of 150 patients undergoing cardioversion for atrial fibrillation or atrial flutter will be randomised 1:1 to receive the Apple Watch Series 6 or Withings Move at the time of cardioversion. The primary outcome is the difference in the Atrial Fibrillation Effect on QualiTy-of-life global score at 6 months postcardioversion. Secondary outcomes include inpatient and outpatient healthcare utilisation. Additional secondary outcomes include a comparison of the Apple Watch ECG and pulse oximeter features with gold-standard data obtained in routine clinical care settings.Ethics and disseminationThe Institutional Review Boards at Yale University, Mayo Clinic, and Duke University Health System have approved the trial protocol. This trial will provide important data to policymakers, clinicians and patients about the impact of the heart rate, irregular rhythm notification, and ECG features of widely used personal digital devices on patient quality of life and healthcare utilisation. Findings will be disseminated to study participants, at professional society meetings and in peer-reviewed journals.Trial registration numberNCT04468321.

Published
2021

14. Demand-Side Response for Grid-Independent Islands Based on Flexible Energy Management Using Heat Pumps

Author

Freeman, James, Coakley, Daniel, Angelopoulos, Charalampos, Zheng, Zheng, Editor-in-Chief, Xi, Zhiyu, Associate Editor, Gong, Siqian, Series Editor, Hong, Wei-Chiang, Series Editor, Mellal, Mohamed Arezki, Series Editor, Narayanan, Ramadas, Series Editor, Nguyen, Quang Ngoc, Series Editor, Ong, Hwai Chyuan, Series Editor, Sun, Zaicheng, Series Editor, Ullah, Sharif, Series Editor, Wu, Junwei, Series Editor, Zhang, Baochang, Series Editor, Zhang, Wei, Series Editor, Zhu, Quanxin, Series Editor, Zheng, Wei, Series Editor, Schossig, Peter, editor, Droege, Peter, editor, Riemer, Antonia, editor, and Speer, Martin, editor

Published
2023
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21. Racial and Ethnic Disparities in the Utilization and Outcomes with WATCHMAN FLX: A SURPASS analysis of the NCDR LAAO Registry

Author

Alli, Seun, primary, Garg, Jalaj, additional, Boursiquot, Brian Charles, additional, Kapadia, Samir R., additional, Yeh, Robert W, additional, Price, Matthew J, additional, Piccini, Jonathan P. P, additional, Nair, Devi G, additional, Hsu, Jonathan C, additional, Gibson, Douglas N, additional, Allocco, Dominic J., additional, Christen, Thomas, additional, Sutton, Brad, additional, and Freeman, James V., additional

Published
2024
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30. Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation

Author

Carlisle, Matthew A., Shrader, Peter, Fudim, Marat, Pieper, Karen S., Blanco, Rosalia G., Fonarow, Gregg C., Naccarelli, Gerald V., Gersh, Bernard J., Reiffel, James A., Kowey, Peter R., Steinberg, Benjamin A., Freeman, James V., Ezekowitz, Michael D., Singer, Daniel E., Allen, Larry A., Chan, Paul S., Pokorney, Sean D., Peterson, Eric D., and Piccini, Jonathan P.

Published
2022
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33. First Experience With Amulet in the United States

Author

Alkhouli, Mohamad, primary, Freeman, James V., additional, Ellis, Christopher R., additional, Shah, Atman P., additional, Gada, Hemal, additional, Coylewright, Megan, additional, Lo, Monica, additional, Makkar, Akash, additional, Agarwal, Himanshu, additional, and Lakkireddy, Dhanunjaya, additional

Published
2024
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41. Research Opportunities in Stroke Prevention for Atrial Fibrillation: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop

Author

Go, Alan S., Al-Khatib, Sana M., Desvigne-Nickens, Patrice, Bansal, Nisha, Bushnell, Cheryl D., Fang, Margaret C., Freeman, James V., Gage, Brian F., Hanke, Thorsten, Hylek, Elaine M., Lopes, Renato D., Noseworthy, Peter A., Reddy, Vivek Y., Singer, Daniel E., Thomas, Kevin L., True Hills, Mellanie, Turakhia, Mintu P., Zieman, Susan J., Cooper, Lawton S., and Benjamin, Emelia J.

Published
2023
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47. Assessment of serum total 25-hydroxyvitamin D assays for Vitamin D External Quality Assessment Scheme (DEQAS) materials distributed at ambient and frozen conditions

Author

Sempos, Christopher T., Williams, Emma L., Carter, Graham D., Jones, Julia, Camara, Johanna E., Burdette, Carolyn Q., Hahm, Grace, Nalin, Federica, Duewer, David L., Kuszak, Adam J., Merkel, Joyce, Hoofnagle, Andrew N., Lukas, Pierre, Cavalier, Étienne, Durazo-Arvizu, Ramón A., Crump, Peter M., Popp, Christian, Beckert, Christian, Schultess, Jan, Van Slooten, Glen, Tourneur, Carole, Pease, Camille, Kaul, Ravi, Villarreal, Alfredo, Ivison, Fiona, Fischer, Ralf, van den Ouweland, Jody M. W., Ho, Chung S., Law, Emmett W. K., Simard, Jean-Nicolas, Gonthier, Renaud, Holmquist, Brett, Batista, Marcelo Cidade, Meadows, Sarah, Cox, Lorna, Jansen, Eugene, Khan, Dilshad Ahmed, Robyak, Kimberly, Creer, Michael H., Kilbane, Mark, Twomey, Patrick J., Freeman, James, Parker, Neil, Yuan, Jinyun, Fitzgerald, Robert, Mushtaq, Sohail, Clarke, Michael W., Breen, Norma, Simpson, Christine, and Wise, Stephen A.

Published
2022
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48. Interlaboratory comparison of 25-hydroxyvitamin D assays: Vitamin D Standardization Program (VDSP) Intercomparison Study 2 — Part 2 ligand binding assays — impact of 25-hydroxyvitamin D2 and 24R,25-dihydroxyvitamin D3 on assay performance

Author

Wise, Stephen A., Camara, Johanna E., Burdette, Carolyn Q., Hahm, Grace, Nalin, Federica, Kuszak, Adam J., Merkel, Joyce, Durazo-Arvizu, Ramón A., Williams, Emma L., Popp, Christian, Beckert, Christian, Schultess, Jan, Van Slooten, Glen, Tourneur, Carole, Pease, Camille, Kaul, Ravi, Villarreal, Alfredo, Batista, Marcelo Cidade, Pham, Heather, Bennett, Alex, Jansen, Eugene, Khan, Dilshad Ahmed, Kilbane, Mark, Twomey, Patrick J., Freeman, James, Parker, Neil, Mushtaq, Sohail, Simpson, Christine, Lukas, Pierre, Cavalier, Étienne, and Sempos, Christopher T.

Published
2022
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