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Objective: Solved the problems of poor motion stability and accuracy in the food sorting process of parallel robots. Methods: Based on the analysis of the three degree of freedom food sorting robot system, a method proposed which combined polynomial interpolation and improve multi-objective particle swarm optimization algorithm for Delta robot trajectory optimization. As a parallel robot, the optimization of the shortest operation time, lowest energy consumption, and minimal motion impact were taken as multiple objectives. The improved multi-objective particle swarm optimization algorithm was applied to optimize the polynomial interpolation method, and its performance was validated. Results: The planning trajectory of the proposed planning method in the experiment was smoother and more efficient compared to conventional methods. In the actual selection of Camellia oleifera fruits, the accuracy was ＞99.00%, and the average screening time was 0.620 s. Conclusion: The trajectory planning optimization method proposed in the experiment has improved the sorting efficiency, accuracy, and stability of the Camellia oleifera fruit sorting robot.

Dementia is a devastating disorder characterized by progressive and persistent cognitive decline, imposing a heavy public health burden on the individual and society. Despite numerous efforts by researchers in the field of dementia, pharmacological treatments are limited to relieving symptoms and fail to prevent disease progression. Therefore, studies exploring novel therapeutics or repurposing classical drugs indicated for other diseases are urgently needed. Metformin, a first-line antihyperglycemic drug used to treat type 2 diabetes, has been shown to be beneficial in neurodegenerative diseases including dementia. This review discusses and evaluates the neuroprotective role of metformin in dementia, from the perspective of basic and clinical studies. Mechanistically, metformin has been shown to improve insulin resistance, reduce neuronal apoptosis, and decrease oxidative stress and neuroinflammation in the brain. Collectively, the current data presented here support the future potential of metformin as a potential therapeutic strategy for dementia. This study also inspires a new field for future translational studies and clinical research to discover novel therapeutic targets for dementia., Competing Interests: Author CL was employed by Hangzhou Simo Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Cui, Lv, Geng, Fu, Zhou, Xiong and Li.)