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The molybdenum oxide nanoparticles (MoO3 NPs) have been successfully synthesized via green combustion method using Centella asiatica plant powder. The powder x-ray diffraction (PXRD), Fourier transform infrared spectroscopic (FTIR), scanning electron microscopic (SEM) and diffuse reflectance spectroscopic (DRS) techniques were used to characterize the MoO3 nanoparticles. The PXRD patterns of the sample revealed pure hexagonal phase. The Scherrer's method was employed to find the crystallite size of the synthesized material and the result obtained was confirmed by the TEM analysis. The optical energy band gap value (Eg) of the sample was calculated using the Tauc relation, and it was found to be around 3.41 eV. The photocatalytic degradation of MoO3 NPs on Direct Green (DG) and Navy Blue (NB) dye was evaluated under UV light irradiation. The electrochemical study of prepared electrode with graphite powder in 0.1 M KOH electrolyte solution displayed superior redox potential output as intended by cyclic voltammetric and amperometric studies, where the material was employed for its sensing abilities such as a highly toxic metal like lead. [ABSTRACT FROM AUTHOR]

Ayurveda the ancient science well known for its potential therapeutic effects with unique metallic, herbal juices/fruits in the treatment of chronic ailments. A well- known ayurvedic potent preparation, Bhasma is also known as ash which is a metallic base prepared by sophisticated pharmaceutical processes also plays a major role in acute, sub-acute, and chronic diseases. In order to determine its quality and purity to make sure the acceptability, the safety of the formulation standardization is very necessary. In this short review, an attempt has been made to present ancient methods to standardize physical characterstics like Verna, Nisvadutam, Nishchandratvam, Varitara, Unama, Rekhapurmatvam, Slakshmatvam..etc.,and chemical characterstics of bhasmas like Apurnabhavta, Niruttha, Amla Pariksha with advanced methods like SEM, TEM, and NPST, along with other natural and ancient analytical techniques. [ABSTRACT FROM AUTHOR]

In connection with our continuous efforts in the synthesis of derivatives from major compounds isolated from traditional medicinal plants, in the present study we have attempted to synthesize the furan-conjugated aloe-emodin derivatives ( 5a-j ) using a three-component reaction. The synthesized derivatives were assessed for anticancer activity against five different cancer cell lines using the in vitro MTT assay and the results showed that most of the derivatives are potent against cancer cells comparing with the control. Compounds 5a and 5e showed excellent activity against all the cancer cells with less than 12.5 µM and arrested the cell cycle at the G0/G1 phase in both CAL27 and SCC9 cells. Compound 5e induces the early apoptosis in CAL27 cells and compounds 5a and 5e induce early and late apoptosis, respectively, in SCC9 cells. Moreover, compounds 5b , 5c , 5i , and 5j showed excellent anti-inflammatory activity in LPS-stimulated RAW 264.7 cells by inhibiting IL-6 production. The molecular docking studies revealed that compound 5e has strong interaction with the CLK kinase and protein kinase II through hydrogen binding Asp325 and Lys290.

Cancer is a disease that continues to plague our modern society. Among all types of cancer, breast cancer is now the most common type of cancer occurring in women worldwide. Various factors, including genetics, lifestyle, and the environment, have contributed to the rise in the prevalence of breast cancer among women of all socioeconomic strata. Therefore, proper screening for early diagnosis and treatment becomes a major factor when fighting the disease. Artificial intelligence (AI) continues to revolutionize various spheres of our lives with its numerous applications. Using AI in the existing screening process makes obtaining results even easier and more convenient. Faster, more accurate results are some of the benefits of AI methods in breast cancer screening. Nonetheless, there are many challenges in the process of the integration of AI that needs to be addressed systematically. The following is a review of the application of AI in breast cancer screening., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Dileep et al.)

Removal of the hazardous and endocrine-disrupting 2,4-dichlorophenol (2,4-DCP) from water bodies is crucial to maintain the sanctity of the ecosystem. As a low bandgap material (1.37 eV), NaBiS 2 was hydrothermally prepared and used as a potential photocatalyst to degrade 2,4-DCP under visible light irradiation. NaBiS 2 appeared to be highly stable and remained structurally undeterred despite thermal variations. With a surface area of 6.69 m 2 /g, NaBiS 2 has enough surface-active sites to adsorb the reactive molecules and exhibit a significant photocatalytic activity. In alkaline pH, the adsorption of 2,4-DCP on NaBiS 2 appeared to decrease whereas, the acidic and neutral environments favoured the degradation. An increase in the photocatalyst dosage enhanced the degradation efficiency from 81 to 86 %, because of higher vacant adsorbent sites and the electrostatic attraction between NaBiS 2 and 2,4-DCP. The dominant scavengers degraded 2,4-DCP by forming a coordination bond between chlorine's lone pair of electrons and the vacant orbitals of bismuth, following the order hole> OH > singlet oxygen. Being non-toxic to both natural and aquatic systems, NaBiS 2 exhibits antifungal properties at higher concentrations. Finally, the electron-rich NaBiS 2 is an excellent electrocatalyst that effectively degrades organic pollutants and is a promising material for industrial and environmental applications., (Copyright © 2021 Elsevier Ltd. All rights reserved.)