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Auch Zellen und Gewebe außerhalb des Mundraumes verfügen über Chemorezeptoren, die normalerweise mit bitter, süß oder scharf schmeckenden Lebensmittelinhaltsstoffen interagieren. Da wir aber weder mit Organen wie dem Magen oder Darm im eigentlichen Sinne „schmecken“, stellt sich die Frage, welche Aufgaben Chemorezeptoren dort erfüllen.

Clarifying the function of sensory active TRP channels in non-sensory tissue is of growing interest, especially with regard to food ingredients in nutritionally relevant concentrations. The study hypothesized the TRPV1 agonist [6]-gingerol to facilitate cellular immune responses of primary human neutrophils, after treatment with 50 nM, a concentration that can be reached in the circulation after habitual dietary intake.qRT-PCR analyses revealed a high abundancy of TRP channel RNA expression in the types of primary leukocytes investigated, namely neutrophils, monocytes, NK cells, T cells, and B cells. Incubation of neutrophils with 50 nM of the known TRPV1 ligand [6]-gingerol led to increased surface expression of CD11b, CD66b, and the fMLF receptor FPR1, as shown by flow cytometry. Upon subsequent stimulation with fMLF, the neutrophils displayed an about 30 % (p0.05) increase in CXCL8 secretion as well as in ROS production. Pharmacological inhibition of TRPV1 by trans-tert-butylcyclohexanol abolished the [6]-gingerol induced effects.The TRPV1 channel is functionally expressed in human neutrophils. Activation of the channel with [6]-gingerol as a food-derived ligand in nutritionally relevant concentrations leads to an enhanced responsiveness in the cells towards activating stimuli, thereby facilitating a canonical cellular immune response in human neutrophils. This article is protected by copyright. All rights reserved.