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In order to realize the rational utilization of low-grade polymetallic symbiotic mineral resources with low input, typical copper–nickel symbiotic low-grade ores were used as the test object. After careful process mineralogy research on the ore, it was learned that the main valuable elements of the ore were Cu and Ni, and the content of these two elements was 0.16 wt.% and 0.39 wt.%, respectively. The main copper-bearing mineral in the ore was chalcopyrite, and the main nickel-bearing mineral was pentlandite Useful minerals were finely distributed in ores. Based on the properties of ore, a beneficiation process of one stage grinding copper/nickel mixed flotation copper/nickel separation was proposed. A copper concentrate with a Cu grade of 17.08 wt.% and a nickel concentrate with a Ni grade of 4.63 wt.% were obtained by separation. This study provides a lowinvestment technical solution for the rational utilization of polymetallic paragenetic mineral resources. [ABSTRACT FROM AUTHOR]