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Hayelom Berhe,1 Wanzahun Godana,2 Negussie Boti Sidamo,2,3 Gebremaryam Temesgen Birgoda,4 Lielt Gebresillasie,5 Sultan Hussen,2 Selamawit Gebeyehu2 1Department of Nursing, Hossana College of Health Science, Hossana, Ethiopia; 2School of Public Health, College of Medicine and Health Science, Arba Minch University, Arba Minch, Ethiopia; 3Department of Public Health, PHARMA College, Wolaita Sodo Campus, Wolaita Sodo, Ethiopia; 4Departments of Midwifery, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia; 5Department of Nursing, College of Medicine and Health Sciences, Wolaita Sodo University, Wolaita, EthiopiaCorrespondence: Gebremaryam Temesgen Birgoda; Negussie Boti Sidamo, Email degnesh31@gmail.com; Hanehalid@gmail.comBackground: HIV/AIDS remains one of the world’s serious public health challenges. Patients with limited support from their family and community often experience social damage, poor adherence, compliance and are prone to additional psychosocial problems. This study aimed to assess the level of perceived social support and factors among adults living with HIV/AIDS.Methods: Facility-based mixed study (sequential explanatory) design was conducted among 423 adults living with HIV/AIDS attending chronic care follow-up at public hospitals in Gamo zone, southern Ethiopia. Respondents were selected by systematic sampling technique. The bivariable and multivariable ordinal logistic regression was used to determine associated factors. All assumptions applied to ordinal logistic regression including multicollinearity, proportional odds, model fitness and pseudo R2 were checked. Level of significance was declared at p-values < 0.05 and 95% CI.Results: Proportion of perceived social support of participants was 128 (30.7%), 197 (47.2%) and 92 (22.1%) with low, moderate and high levels of perceived social support, respectively. Females [(APOR = 2.42, 95% CI:(1.63– 3.58), P < 0.001)], no formal education [(AOR = 0.49, 95% CI: (0.30– 0.789), P = 0.004)], fair adherence [(APOR = 2.07, 95% CI: (1.17– 3.49), P = 0.006)], no comprehensive knowledge about HIV [(APOR = 0.40, 95% CI: (0.26– 0.62), P < 0.001)], and no disclosure status [(APOR = 0.64, 95% CI: (0.43– 0.95), P = 0.028] were significantly associated with perceived social support. Qualitative findings revealed that disclosure and adherences involving income generation activities are beneficial to perceived social support.Conclusion: This study showed that one from three of the participants had low perceived social support. Low perceived social support was associated with adherence, disclosure status of individual, educational status and knowledge about HIV/AIDS. Family, friends, health care providers and significant others should provide necessary support and inform people living with HIV/AIDS (PLWHA) about social support.Keywords: perceived social support, HIV/AIDS, adults, adherence

Objective The main objective of this study was to determine the prevalence and factors associated with unfavourable maternal outcomes among pregnant women with pre-eclampsia with severity features (PEWSF) at Abebech Gobena Maternal and Children’s Health and St. Peter’s Hospital, Addis Ababa, Ethiopia, 2023.Design A hospital-based cross-sectional study was conducted from 1 January 2023 to July 2023. The data was collected using a structured and pre-tested questionnaire through face-to-face interviews and a review clinical chart. Data was entered using EpiData V.4.6 and analysed using SPSS V.26.0 statistical software. Binary logistic regression analysis was run to identify predictors of maternal outcome.Setting Two hospitals in Addis Ababa, Ethiopia.Participants 348 pregnant women with PEWSF were included.Outcome measures Unfavourable maternal outcome was defined as mothers with PEWSF that develop at least one complication, that is, eclampsia, abruption placenta, Haemolysis, Elevated Liver Enzymes and Low Platelet Count (HELLP) syndrome, acute renal failure, disseminated intravascular coagulation, cardiac failure, stroke, postpartum haemorrhage, pulmonary oedema and death.Results The overall prevalence of unfavourable maternal outcomes was 33.9% (N=118) (95% CI=28.7 to 38.8). Abruptio placenta (17.2%), HELLP syndrome (15.5%) and postpartum haemorrhage (13.8%) were common complications that occurred among mothers with PEWSF. Age above 35 years (adjusted OR (AOR) (95% CI)=2.70 (1.31 to 5.59)), rural residence (AOR (95% CI)=1.94 (1.07 to 3.53)), unemployment (AOR (95% CI)=0.35 (0.20 to 0.62)), severe blood pressure on admission (AOR (95% CI)=2.32 (1.03 to 5.19)) and complain of severe headache (AOR (95% CI)=1.91 (1.16 to 3.16)) were significant associates of unfavourable maternal outcomes.Conclusions The prevalence of unfavourable maternal outcomes was high compared with other studies in Ethiopia. Maternal age, residence, occupation, blood pressure on admission and severe headache have shown a statistically significant association with unfavourable maternal outcomes. Socioeconomic development and early identification of severe signs and symptoms of pre-eclampsia are needed to reduce unfavourable outcomes.

BackgroundPreeclampsia is a new onset of hypertension and either proteinuria or end-organ failure after 20 weeks of gestation. It is a prevalent cause of perinatal mortality, morbidity, and neonatal complications in developing nations including Ethiopia. Thus, the aimed to assess the prevalence and determinants of adverse perinatal outcomes among women with preeclampsia with severity features (PEWSF) at two selected public hospitals in Addis Ababa, Ethiopia, 2023.MethodA cross-sectional study was carried out among 348 mothers between January 1, 2023, and July 1, 2023. A structured, pre-tested questionnaire was used to gather data from in-person interviews and a review of the patient's medical record. The statistical program Epi-Data version 4.6 was used to enter the data, and SPSS version 26.0 was used for analysis. Binary logistic regression analysis was used to find factors that were associated with unfavorable perinatal outcomes. A p-value of less than 0.05 was used to declare the significance level.ResultThe overall prevalence of unfavorable perinatal outcomes was 59.2% (95% CI: 54.0–63.8). Among the complications, low birth weight, prematurity, NICU admission, and a low fifth-minute APGAR score, encompass 48.9%, 39.4%, 20.4%, and 14.7%, respectively. No formal education [OR = 5.14, 95% CI: (1.93–13.63)], unemployment [OR = 0.42, 95% CI: (0.24–0.73)], referral cases [OR = 2.03, 95% CI: (1.08–4.06), inadequate antenatal care (ANC) contact [OR = 3.63, 95% CI: (1.22–10.71)], and family history of hypertension [OR = 1.99, 95% CI: (1.03–3.85)] have shown a statistically significant association with unfavorable perinatal outcomes.ConclusionIn this study, the prevalence of unfavorable perinatal outcomes was high compared to other studies in Ethiopia. Level of education, occupation, mode of admission, ANC contact, and family history of hypertension were significant predictors of unfavorable perinatal outcomes. Socio-economic development, improving referral systems, and adequate antenatal care contact are needed to improve unfavorable outcomes. Additionally, antenatal screening and specialized care for high-risk mothers, e.g., those with a family history of hypertension are recommended.

In eastern Ethiopia, sweet potato is a vital food and nutrition security crop; moreover, orange-fleshed sweet potato (OFSP) varieties are rich in beta-carotene content and have the potential to alleviate chronic Vitamin A malnutrition in the region. However, the unavailability of adaptable varieties and lack of information on production and post-harvest handling practices have limited its production and utilization in eastern Ethiopia. The research was conducted to identify the proper harvesting stage of OFSP varieties for optimum yield and nutritional compositions at Rare and Babile research stations of Haramaya University during the main rainy season of 2022. Three varieties ( Alamura, Kabode, and Bakule ) and four harvesting periods (120, 150, 180, and 210 days after planting (DAP) in factorial combinations were evaluated in randomized complete block design with three replications. Data were collected for growth, yield, and physicochemical composition-related parameters. Combined analysis of variance revealed the interaction effect of harvesting time and varieties had a significant (p < 0.05) effect on yield, yield-related parameters, and physicochemical components. Alamura variety produced comparable above-ground biomass (28.99 t ha -1 ) and the highest marketable root yield of 36.40 t ha -1 at 150 DAP, with dry matter content of 33.01 and 30.58 % at 150 and 120 DAP, respectively. Harvesting Alamura at 150 DAP also had the highest ꞵ-carotene, zinc, and iron contents of 11809 μg/100 g, 3.79, and 14.47 mg/100 g, respectively. It was concluded that growing the Alamura variety and harvesting at 150 DAP was better for obtaining higher root yield with good nutritional compositions in the study area., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier Ltd.)

The Przewalski's horse (Equus ferus przewalskii) is an endangered equid native to the steppes of central Asia. After becoming extinct in the wild multiple conservation efforts convened to preserve the species, including captive breeding programs, reintroduction and monitoring systems, protected lands, and cloning. Availability of a highly contiguous reference genome is essential to support these continued efforts. We used Oxford Nanopore sequencing to produce a scaffold-level 2.5 Gb nuclear assembly and 16,002 bp mitogenome from a captive Przewalski's mare. All assembly drafts were generated from 111 Gb of sequence from a single PromethION R10.4.1 flow cell. The mitogenome contained 37 genes in the standard mammalian configuration and was 99.63% identical to the domestic horse (Equus caballus). The nuclear assembly, EquPr2, contained 2,146 scaffolds with an N50 of 85.1 Mb, 43X mean depth, and BUSCO quality score of 98.92%. EquPr2 successfully improves upon the existing Przewalski's horse reference genome (Burgud), with 25-fold fewer scaffolds, a 166-fold larger N50, and phased pseudohaplotypes. Modified basecalls revealed 79.5% DNA methylation and 2.1% hydroxymethylation globally. Allele-specific methylation analysis between pseudohaplotypes revealed 226 differentially methylated regions in known imprinted genes and loci not previously reported as imprinted. The heterozygosity rate of 0.165% matches previous estimates for the species and compares favorably to other endangered animals. This improved Przewalski's horse assembly will serve as a valuable resource for conservation efforts and comparative genomics investigations., Competing Interests: Conflicts of interest The author(s) declare no conflicts of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America.)

Background: There are few studies that have evaluated the provision of compassionate care in Ethiopian contexts. One probable factor could be a lack of validated tools for assessing compassionate care in Ethiopia., Objective: To adapt the Compassionate Care Assessment Tool into the Amharic version and to assess its reliability and validity for application in obstetric services of the Ethiopian context., Method: Four hundred ten mothers who gave birth at the four referral hospitals in North West Amhara participated in this study. Using SPSS version 23.0 and SPSS Amos 26 and by applying principal axial factoring, the Compassionate Care Assessment Tool was assessed for structural reliability and validity. Cronbach's alpha was used to evaluate internal consistency and reliability. Factor loadings, composite reliability, average variance extracted and square root of the average variance extracted were used to test convergent and discriminant validity., Results: Three factors with thirteen items were identified that explained 69.87% of the variation in the Compassionate Care Assessment Tool. Cronbach's alpha was 0.917. In the confirmatory factor analysis, all items had factor loadings more than 0.6, and the average variance extracted was greater than 0.5. Composite reliability values were above 0.7, and the square root of the average variance extracted for each element was greater than the correlation of each factor with other factors in the model., Conclusion: The three factors and the thirteen items of the tool have shown internal consistency in the exploratory factor analysis. The factor loadings and the average variance extracted confirmed the convergent validity of the tool, while composite reliability and the square root of the average variance extracted values confirmed discriminant validity. Thus, the Amharic version of the Compassionate Care Assessment Tool was found to have excellent internal consistency as well as adequate structural, convergent, and discriminant validity among obstetric service users in Ethiopia., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2024.)

Background: The Ethiopian government implemented a national community health program, the Health Extension Program (HEP), to provide community-based health services to address persisting access-related barriers to care using health extension workers (HEWs). We used implementation research to understand how Ethiopia leveraged the HEP to widely implement evidence-based interventions (EBIs) known to reduce under-5 mortality (U5M) and address health inequities., Methods: This study was part of a six-country case study series using implementation research to understand how countries implemented EBIs between 2000-2015. Our mixed-methods research was informed by a hybrid implementation science framework using desk review of published and gray literature, analysis of existing data sources, and 11 key informant interviews. We used implementation of pneumococcal conjugate vaccine (PCV-10) and integrated community case management (iCCM) to illustrate Ethiopia's ability to rapidly integrate interventions into existing systems at a national level through leveraging the HEP and other implementation strategies and contextual factors which influenced implementation outcomes., Results: Ethiopia implemented numerous EBIs known to address leading causes of U5M, leveraging the HEP as a platform for delivery to successfully introduce and scale new EBIs nationally. By 2014/15, estimated coverage of three doses of PCV-10 was at 76%, with high acceptability (nearly 100%) of vaccines in the community. Between 2000 and 2015, we found evidence of improved care-seeking; coverage of oral rehydration solution for treatment of diarrhea, a service included in iCCM, doubled over this period. HEWs made health services more accessible to rural and pastoralist communities, which account for over 80% of the population, with previously low access, a contextual factor that had been a barrier to high coverage of interventions., Conclusions: Leveraging the HEP as a platform for service delivery allowed Ethiopia to successfully introduce and scale existing and new EBIs nationally, improving feasibility and reach of introduction and scale-up of interventions. Additional efforts are required to reduce the equity gap in coverage of EBIs including PCV-10 and iCCM among pastoralist and rural communities. As other countries continue to work towards reducing U5M, Ethiopia's experience provides important lessons in effectively delivering key EBIs in the presence of challenging contextual factors., (© 2023. The Author(s).)

This study was conducted to assess the psychometric properties of the Barkin Index of Maternal Functioning (BIMF) in an Ethiopian context. Data were obtained from 202 women with a child less than 1 year of age. Narrow standard deviations characterized responses to most BIMF items, but a handful of items had wider standard deviations associated with bimodality. Most interitem correlations were < |.15|, and 13 of the 20 BIMF items did not load satisfactorily on any factor in exploratory factor analyses. Two factors emerged from the remaining items, one with three items and the other with four. Although poor reliability results relating to internal (interitem) and temporal consistency could be attributed to limited variability in the data, a number of concerns are raised about the BIMF itself, including its content validity, instructions, response options, and usefulness in healthcare settings. Suggestions are made for improving the assessment of maternal functioning in Ethiopia and other contexts. More generally, this research demonstrates that researchers should not assume that the psychometric properties and appropriateness of scales will remain robust when those scales are used in contexts that differ from the contexts in which they were created.

A cross-sectional study was conducted to explore the prevalence of Trypanosome infections in cattle and within the tsetse flies from December 2020 to May 2021 in Dabo Hana district, Buno Bedelle Zone, Southwest Ethiopia. A total of 415 blood samples were examined utilizing Buffy coat and Giemsa-stained thin blood smear techniques. Vector distribution and tsetse fly infection rate were studied by deploying 60 traps in four purposively chosen villages of the district. The prevalence of Trypanosomes was 10.6% and 6.5% in cattle and in tsetse flies, respectively. Trypanosoma congolense (59.1%) in cattle and T. vivax (62.5%) in tsetse flies, were the foremost common species distinguished in the area. A significant difference (P ≤ 0.05) was observed in the prevalence of bovine Trypanosomosis between body condition scores of cattle. However, differences were not significant between coat color, sex, and age categories (P > 0.05). The mean PCV values of Trypanosome-infected cattle (22.6 ± 0.6) were significantly (P < 0.05) lower than those of non-infected cattle (25.6 ± 0.3). Out of 1441 flies caught, 1242 (86.2%) were Glossina, 113 (7.84%) were Stomoxys, and 86 (5.97%) were Tabanus. Of 1242 Glossina, 85% were G. tachinoides and the remaining 15% were G. m. sub-morsitans. This finding revealed that, three Trypanosoma species are circulating in cattle as well as in tsetse flies. It is recommended that, sustainable and integrated tsetse and Trypanosomosis control practices should be implemented to foster live stock health and agricultural development in the district. Other sensitive methods should be employed to determine the true picture of infection in the area., Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The prevalence of hypertension in diabetic patients is nearly twice that of non-diabetic patients. The presence of both hypertension and diabetes accelerates complications and raises the risk of death. Thus, identifying determinants of hypertension in diabetic patients is critical for preventing the development of devastating acute and chronic complications, as well as diabetes-related death., Methods and Materials: A case-control study was carried out in public hospitals of Gamo Zone, Southern Ethiopia. To select study participants, a systematic random sampling technique was used. The KOBO toolbox was used to collect data, which was then exported to the IBM SPSS version 25 software package for analysis. Bivariate and multivariable logistic regression analyses were performed to identify factors associated with hypertension in diabetes patients, and variables in the multivariable logistic regression analysis with a P value less than 0.05 were declared significantly associated at a 95% CI., Results: In this study, age greater than or equal to 50 years [adjusted odd ratio (AOR)=4.08, 95% CI (1.41, 11.82)], higher body mass index [AOR=3.23, 95% CI (1.40, 7.66)], and higher waist to hip ratio [AOR=2.15, 95% CI (1.12, 4.13)] were significantly associated with hypertension in diabetic patients., Conclusions: This study found that factors associated with hypertension among diabetic patients included older age (>50 years), a high waait to st#to#hip ratio, and a higher body mass index. The concerned health authorities and healthcare providers in the study area should focus on those identified factors to prevent hypertension among diabetic patients., Competing Interests: All author declares that they have no competing interests., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)