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Roadway departure (RwD) crashes are significant safety concerns, especially at horizontal curves. The design of these curves plays a crucial role in mitigating RwD crashes. Thus, a thorough understanding of the interaction between driver behavior, vehicle automation, and geometric design is vital. Substantive safety, which emphasizes the inherent safety in a road's design and function, serves as the foundation of our approach. Building on this, the study employs a safe system approach to investigate the performance of horizontal curves under both non-automated and partially automated conditions, using a reliability-based analysis focusing on Stopping Sight Distance as the primary driver demand. Factors including Perception-Brake Time and Take-Over Time for automated vehicles are examined. The analysis covers horizontal curves, characterized by their geometric design and crash data. Our findings highlight a shift in the performance of horizontal curves under automation, emphasizing the need to consider automation in roadway design within the safe system approach. This study demonstrates how a reliability-based analysis can guide designers in making informed decisions regarding the geometric design of horizontal curves to reduce RwD crashes. To enhance transportation safety in the era of increasing automation, ongoing exploration of the relationships between driver behavior, automation, and road design is indispensable., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Stroke is one of the major causes of global death, which can occur due to blockage in a blood vessel by a clot. The immediate dissolving of the clot is essential to restore the blood flow and prevent tissue necrosis. Clot dissolution can be achieved via thrombolytic therapy using plasminogen activators. In this study, a clot dissolution model is developed for a three-dimensional patient-specific carotid artery that investigates the effect of different vessel wall models on clot dissolution. The lysis pattern of the clot and hemodynamics of blood flow are evaluated using three different models of the vessel wall, namely, rigid, linear elastic, and Mooney-Rivlin hyperelastic. The effect of flow condition is considered by solving the Navier-Stokes equations for the free flow domain and the Brinkman equation for the clot domain with the same pressure and velocity fields. This will result in continuous pressure and velocity over the interfaces of the free flow and clot domains. The blood inflow is assumed to be pulsatile. In addition, the species transport driven by diffusion and convection is considered to be different in the porous medium and plasma. The obtained results show that in all models, the starting time of clot volume decrease is almost the same and the clot starts dissolving from the inner curvature of the artery. However, in the hyperelastic model, dissolving the clot takes longer compared to the other two models. By monitoring the vessel wall deformation, the exact time of vessel recanalization is determined.