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3. External validation of a red cell-based blood prognostic score in patients with metastatic renal cell carcinoma treated with first-line immunotherapy combinations

Author

Maffezzoli, Michele, Santoni, Matteo, Mazzaschi, Giulia, Rodella, Sara, Lai, Eleonora, Maruzzo, Marco, Basso, Umberto, Bimbatti, Davide, Iacovelli, Roberto, Anghelone, Annunziato, Fiala, Ondřej, Rebuzzi, Sara Elena, Fornarini, Giuseppe, Lolli, Cristian, Massari, Francesco, Rosellini, Matteo, Mollica, Veronica, Nasso, Cecilia, Acunzo, Alessandro, Silini, Enrico Maria, Quaini, Federico, De Filippo, Massimo, Brunelli, Matteo, Banna, Giuseppe L., Rescigno, Pasquale, Signori, Alessio, and Buti, Sebastiano

Published
2024
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5. 18F-FDG

Author

Calabria, Ferdinando, Cimini, Andrea, Bagnato, Antonio, Gullà, Domenico, Cascini, Giuseppe L., Urbano, Nicoletta, Schillaci, Orazio, Calabria, Ferdinando, editor, and Schillaci, Orazio, editor

Published
2024
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8. Nature-Based Treatment Systems for Reclaimed Water Use in Agriculture in Mediterranean Countries

Author

Licciardello, Feliciana, Mahjoub, Olfa, Ventura, Delia, Kallali, Hamadi, Mohamed, Annabi, Barbagallo, Salvatore, Cirelli, Giuseppe L., Barceló, Damià, Series Editor, de Boer, Jacob, Editorial Board Member, Kostianoy, Andrey G., Series Editor, Garrigues, Philippe, Editorial Board Member, Hutzinger, Otto, Founding Editor, Gu, Ji-Dong, Editorial Board Member, Jones, Kevin C., Editorial Board Member, Knepper, Thomas P., Editorial Board Member, Negm, Abdelazim M., Editorial Board Member, Newton, Alice, Editorial Board Member, Nghiem, Duc Long, Editorial Board Member, Garcia-Segura, Sergi, Editorial Board Member, and Nasr, Mahmoud, editor

Published
2023
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9. Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis

Author

Anpalakhan, Shobana, Signori, Alessio, Cortellini, Alessio, Verzoni, Elena, Giusti, Raffaele, Aprile, Giuseppe, Ermacora, Paola, Catino, Annamaria, Pipitone, Stefania, Di Napoli, Marilena, Scotti, Vieri, Mazzoni, Francesca, Guglielmini, Pamela F., Veccia, Antonello, Maruzzo, Marco, Schinzari, Giovanni, Casadei, Chiara, Grossi, Francesco, Rizzo, Mimma, Montesarchio, Vincenzo, Verderame, Francesco, Mencoboni, Manlio, Zustovich, Fable, Fratino, Lucia, Accettura, Caterina, Cinieri, Saverio, Tondini, Carlo Alberto, Camerini, Andrea, Banzi, Maria Chiara, Sorarù, Mariella, Zucali, Paolo Andrea, Vignani, Francesca, Ricciardi, Serena, Russo, Antonio, Cosenza, Agnese, Di Maio, Massimo, De Giorgi, Ugo, Pignata, Sandro, Giannarelli, Diana, Pinto, Carmine, Buti, Sebastiano, Fornarini, Giuseppe, Rebuzzi, Sara Elena, Rescigno, Pasquale, Addeo, Alfredo, Banna, Giuseppe L., and Bersanelli, Melissa

Published
2023
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10. Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis

Author

Shobana Anpalakhan, Alessio Signori, Alessio Cortellini, Elena Verzoni, Raffaele Giusti, Giuseppe Aprile, Paola Ermacora, Annamaria Catino, Stefania Pipitone, Marilena Di Napoli, Vieri Scotti, Francesca Mazzoni, Pamela F. Guglielmini, Antonello Veccia, Marco Maruzzo, Giovanni Schinzari, Chiara Casadei, Francesco Grossi, Mimma Rizzo, Vincenzo Montesarchio, Francesco Verderame, Manlio Mencoboni, Fable Zustovich, Lucia Fratino, Caterina Accettura, Saverio Cinieri, Carlo Alberto Tondini, Andrea Camerini, Maria Chiara Banzi, Mariella Sorarù, Paolo Andrea Zucali, Francesca Vignani, Serena Ricciardi, Antonio Russo, Agnese Cosenza, Massimo Di Maio, Ugo De Giorgi, Sandro Pignata, Diana Giannarelli, Carmine Pinto, Sebastiano Buti, Giuseppe Fornarini, Sara Elena Rebuzzi, Pasquale Rescigno, Alfredo Addeo, Giuseppe L. Banna, and Melissa Bersanelli

Subjects
Immune response, Immunity, Immunology, Science
Abstract

Summary: The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been reported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and melanoma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of

Published
2023
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11. Cogging Torque Suppression of Modular Permanent Magnet Machines Using a Semi-Analytical Approach and Artificial Intelligence

Author

Elia Brescia, Marco Palmieri, Paolo R. Massenio, Giuseppe L. Cascella, and Francesco Cupertino

Subjects
Artificial neural networks, cogging torque, finite-element analysis, genetic algorithm, modular stators, permanent magnet synchronous motors, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The cogging torque of permanent magnet machines with a modular stator is affected by additional harmonic components due to the segmentation of the stator lamination. This paper proposes a novel approach based on the shaping of the stator tooth tips with sinusoidal profiles to minimize the cogging torque of such machines. A theoretical study and a design formula are proposed to determine the spatial frequency of the sinusoidal profiles, while an optimization procedure based on genetic algorithm and artificial neural networks is adopted to determine their amplitudes and phase shifts. The proposed method is validated through finite element analysis considering two different case studies. Also, a comparison with other approaches from the literature is presented to highlight the effectiveness of the proposed technique. Finally, an additional analysis is reported to demonstrate the effectiveness of the proposed method against manufacturing and assembling tolerances.

Published
2023
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12. 55 years of devoted service to medicine, morphology and pedagogy (on the 80th anniversary of the birth of Professor N.R. Karelina)

Author

Artyukh, Linard Y., primary, Gafiatulina, Ksenia A., additional, Gafiatullin, Marat R., additional, Oppedizano, Mikhail Giuseppe L., additional, Busorgina, Maria O., additional, Hakobyan, Arthur А., additional, Lupusharu, Anton, additional, Chernetsov, Roman A., additional, Yargunin, Vladimir S., additional, Sokolova, Irina N., additional, Mogilev, Irina I., additional, and Vasiliev, Andrei G., additional

Published
2024
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13. Efficacy outcomes and prognostic factors from real-world patients with advanced non-small-cell lung cancer treated with first-line chemoimmunotherapy: The Spinnaker retrospective study

Author

Banna, Giuseppe L., Cantale, Ornella, Muthuramalingam, Sethupathi, Cave, Judith, Comins, Charles, Cortellini, Alessio, Addeo, Alfredo, Signori, Alessio, McKenzie, Hayley, Escriu, Carles, Barone, Gloria, Chan, Samuel, Hicks, Alexander, Bainbridge, Hannah, Pinato, David J., Ottensmeier, Christian, and Gomes, Fabio

Published
2022
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14. Immunotherapy-related adverse events in real-world patients with advanced non-small cell lung cancer on chemoimmunotherapy: a Spinnaker study sub-analysis

Author

Shobana Anpalakhan, Prerana Huddar, Roya Behrouzi, Alessio Signori, Judith Cave, Charles Comins, Alessio Cortellini, Alfredo Addeo, Carles Escriu, Hayley McKenzie, Gloria Barone, Lisa Murray, David J. Pinato, Christian Ottensmeier, Sara Campos, Sethupathi Muthuramalingam, Samuel Chan, Fabio Gomes, and Giuseppe L. Banna

Subjects
lung cancer, immunotherapy, immune-related adverse effects, neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), overall survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundThe Spinnaker study evaluated survival outcomes and prognostic factors in patients with advanced non-small-cell lung cancer receiving first-line chemoimmunotherapy in the real world. This sub-analysis assessed the immunotherapy-related adverse effects (irAEs) seen in this cohort, their impact on overall survival (OS) and progression-free survival (PFS), and related clinical factors.MethodsThe Spinnaker study was a retrospective multicentre observational cohort study of patients treated with first-line pembrolizumab plus platinum-based chemotherapy in six United Kingdom and one Swiss oncology centres. Data were collected on patient characteristics, survival outcomes, frequency and severity of irAEs, and peripheral immune-inflammatory blood markers, including the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII).ResultsA total of 308 patients were included; 132 (43%) experienced any grade irAE, 100 (32%) Grade 1–2, and 49 (16%) Grade 3–4 irAEs. The median OS in patients with any grade irAES was significantly longer (17.5 months [95% CI, 13.4–21.6 months]) than those without (10.1 months [95% CI, 8.3–12.0 months]) (p

Published
2023
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15. High familial burden of cancer correlates with improved outcome from immunotherapy in patients with NSCLC independent of somatic DNA damage response gene status

Author

Cortellini, Alessio, Giusti, Raffaele, Filetti, Marco, Citarella, Fabrizio, Adamo, Vincenzo, Santini, Daniele, Buti, Sebastiano, Nigro, Olga, Cantini, Luca, Di Maio, Massimo, Aerts, Joachim G. J. V., Bria, Emilio, Bertolini, Federica, Ferrara, Miriam Grazia, Ghidini, Michele, Grossi, Francesco, Guida, Annalisa, Berardi, Rossana, Morabito, Alessandro, Genova, Carlo, Mazzoni, Francesca, Antonuzzo, Lorenzo, Gelibter, Alain, Marchetti, Paolo, Chiari, Rita, Macerelli, Marianna, Rastelli, Francesca, Della Gravara, Luigi, Gori, Stefania, Tuzi, Alessandro, De Tursi, Michele, Di Marino, Pietro, Mansueto, Giovanni, Pecci, Federica, Zoratto, Federica, Ricciardi, Serena, Migliorino, Maria Rita, Passiglia, Francesco, Metro, Giulio, Spinelli, Gian Paolo, Banna, Giuseppe L., Friedlaender, Alex, Addeo, Alfredo, Ficorella, Corrado, Porzio, Giampiero, Tiseo, Marcello, Russano, Marco, Russo, Alessandro, and Pinato, David James

Published
2022
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17. Role of Bone Metastases in Patients Receiving Immunotherapy for Pre-Treated Urothelial Carcinoma: The Multicentre, Retrospective Meet-URO-1 Bone Study

Author

Raggi, Daniele, Giannatempo, Patrizia, Marandino, Laura, Pierantoni, Francesco, Maruzzo, Marco, Lipari, Helga, Banna, Giuseppe L., De Giorgi, Ugo, Casadei, Chiara, Naglieri, Emanuele, Buti, Sebastiano, Bersanelli, Melissa, Stellato, Marco, Santini, Daniele, Vignani, Francesca, Roviello, Giandomenico, Veccia, Antonello, Caffo, Orazio, Losanno, Tania, Calabrò, Fabrizio, Mucciarini, Claudia, Pignata, Sandro, Necchi, Andrea, and Di Maio, Massimo

Published
2022
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18. Enhancing Conversion Efficiency of Direct Ink Write Printed Copper (I) Sulfide Thermoelectrics via Sulfur Infusion Process

Author

Raden Gustinvil, William Jordan Wright, Giuseppe L. Di Benedetto, Donald Skelton, Samuel Stuart, John W. Drazin, and Emrah Celik

Subjects
thermoelectricity, copper (I) sulfide, 3D printing, sulfur infusion, direct ink writing, Mechanical engineering and machinery, TJ1-1570
Abstract

Copper (I) sulfide (Cu2S) is a low-cost, earth-abundant, and non-toxic thermoelectric material for applications in the middle–high temperature range (>650 K). Although 3D printing these materials can simplify their manufacturing, elevated temperatures observed during sintering impair their crystal structure and energy conversion efficiency. In this study, we demonstrated a novel post-processing methodology to revert the thermoelectric properties of the 3D printed Cu2-xS materials back to the unimpaired state via sulfur infusion. After printing and sintering, sulfur was infused into the specimens under vacuum to optimize their crystal structure and achieve high thermoelectric efficiency. Chemical analysis and X-ray Diffraction (XRD) tests showed that after the sulfur infusion process, the Cu/S ratio was reverted close to the stoichiometric level. The 3D printed Cu2-xS showed p-type thermoelectric behavior with electrical conductivity peaking at 143 S-cm−1 at 750 K and Seebeck coefficient of 175 µV-K−1 at 627 K. The figure of merit (ZT) value of 1.0 at 780 K was achieved, which is the highest value ever reported for a 3D printed Cu2-xS thermoelectrics at this temperature. The fabrication of environmentally friendly thermoelectric materials with extended dimensional freedom and conversion efficiency has the potential to impact the thermoelectric industry with new energy conversion applications and lowered manufacturing costs.

Published
2023
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19. Host immune‐inflammatory markers to unravel the heterogeneous outcome and assessment of patients with PD‐L1 ≥50% metastatic non‐small cell lung cancer and poor performance status receiving first‐line immunotherapy

Author

Giuseppe L. Banna, Marcello Tiseo, Diego L. Cortinovis, Francesco Facchinetti, Joachim G. J. V. Aerts, Cinzia Baldessari, Raffaele Giusti, Emilio Bria, Francesco Grossi, Rossana Berardi, Alessandro Morabito, Annamaria Catino, Carlo Genova, Francesca Mazzoni, Alain Gelibter, Francesca Rastelli, Marianna Macerelli, Rita Chiari, Stefania Gori, Giovanni Mansueto, Fabrizio Citarella, Luca Cantini, Erika Rijavec, Federica Bertolini, Federico Cappuzzo, Alessandro De Toma, Alex Friedlaender, Giulio Metro, Maria Vittoria Pensieri, Giampiero Porzio, Corrado Ficorella, David J. Pinato, Alessio Cortellini, and Alfredo Addeo

Subjects
immunotherapy, inflammation, neutrophil‐to‐lymphocyte ratio (NLR), non‐small cell lung cancer, performance status, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Patients with programmed cell death‐ligand 1 (PD‐L1) ≥50% metastatic non‐small cell lung cancer (mNSCLC) and ECOG performance status (PS) of 2 treated with first‐line immunotherapy have heterogeneous clinical assessment and outcomes. Methods To explore the role of immune‐inflammatory surrogates by the validated lung immuno‐oncology prognostic score (LIPS) score, including the neutrophil‐to‐lymphocyte ratio (NLR) and the pretreatment use of steroids, alongside other prognostic variables. A retrospective analysis of 128 patients with PS2 and PD‐L1 ≥50% mNSCLC treated between April 2018 and September 2019 with first‐line pembrolizumab in a real‐world setting was performed. Results With a median follow‐up of 15.3 months, the 1‐year overall survival (OS) and median progression‐free survival (PFS) were 32.3% (95% CI: 30.9–33.9) and 3.3 months (95% CI: 1.8–4.7), respectively. The NLR, lactate dehydrogenase (LDH) and pretreatment steroids results were the only significant prognostic factors on the univariate analysis and independent prognostic factors by the multivariate analysis on both OS and PFS. The LIPS score, including the NLR and pretreatment steroids, identified 29 (23%) favourable‐risk patients, with 0 factors, 1‐year OS of 67.6% and median PFS of 8.2 months; 57 (45%) intermediate‐risk patients, with 1 factor, 1‐year OS 32.1% and median PFS 2.7 months; 42 (33%) poor‐risk patients, with both factors, 1‐year OS of 10.7% and median PFS of 1.2 months. Conclusions The assessment of pre‐existing imbalance of the host immune response by combined blood and clinical immune‐inflammatory markers may represent a way to unravel the heterogeneous outcome and assessment of patients with mNSCLC and poor PS in the immune‐oncology setting.

Published
2022
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20. High familial burden of cancer correlates with improved outcome from immunotherapy in patients with NSCLC independent of somatic DNA damage response gene status

Author

Alessio Cortellini, Raffaele Giusti, Marco Filetti, Fabrizio Citarella, Vincenzo Adamo, Daniele Santini, Sebastiano Buti, Olga Nigro, Luca Cantini, Massimo Di Maio, Joachim G. J. V. Aerts, Emilio Bria, Federica Bertolini, Miriam Grazia Ferrara, Michele Ghidini, Francesco Grossi, Annalisa Guida, Rossana Berardi, Alessandro Morabito, Carlo Genova, Francesca Mazzoni, Lorenzo Antonuzzo, Alain Gelibter, Paolo Marchetti, Rita Chiari, Marianna Macerelli, Francesca Rastelli, Luigi Della Gravara, Stefania Gori, Alessandro Tuzi, Michele De Tursi, Pietro Di Marino, Giovanni Mansueto, Federica Pecci, Federica Zoratto, Serena Ricciardi, Maria Rita Migliorino, Francesco Passiglia, Giulio Metro, Gian Paolo Spinelli, Giuseppe L. Banna, Alex Friedlaender, Alfredo Addeo, Corrado Ficorella, Giampiero Porzio, Marcello Tiseo, Marco Russano, Alessandro Russo, and David James Pinato

Subjects
Family history of cancer, DDR genes, NSCLC, Pembrolizumab, Immune checkpoint inhibitors, Immunotherapy, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Family history of cancer (FHC) is a hallmark of cancer risk and an independent predictor of outcome, albeit with uncertain biologic foundations. We previously showed that FHC-high patients experienced prolonged overall (OS) and progression-free survival (PFS) following PD-1/PD-L1 checkpoint inhibitors. To validate our findings in patients with NSCLC, we evaluated two multicenter cohorts of patients with metastatic NSCLC receiving either first-line pembrolizumab or chemotherapy. From each cohort, 607 patients were randomly case–control matched accounting for FHC, age, performance status, and disease burden. Compared to FHC-low/negative, FHC-high patients experienced longer OS (HR 0.67 [95% CI 0.46–0.95], p = 0.0281), PFS (HR 0.65 [95% CI 0.48–0.89]; p = 0.0074) and higher disease control rates (DCR, 86.4% vs 67.5%, p = 0.0096), within the pembrolizumab cohort. No significant associations were found between FHC and OS/PFS/DCR within the chemotherapy cohort. We explored the association between FHC and somatic DNA damage response (DDR) gene alterations as underlying mechanism to our findings in a parallel cohort of 118 NSCLC, 16.9% of whom were FHC-high. The prevalence of ≥ 1 somatic DDR gene mutation was 20% and 24.5% (p = 0.6684) in FHC-high vs. FHC-low/negative, with no differences in tumor mutational burden (6.0 vs. 7.6 Mut/Mb, p = 0.6018) and tumor cell PD-L1 expression. FHC-high status identifies NSCLC patients with improved outcomes from pembrolizumab but not chemotherapy, independent of somatic DDR gene status. Prospective studies evaluating FHC alongside germline genetic testing are warranted.

Published
2022
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23. Prognostic effect of body mass index in patients with advanced NSCLC treated with chemoimmunotherapy combinations

Author

James Artingstall, Alex Friedlaender, Alfredo Addeo, Judith Cave, Massimo Di Maio, Samuel Chan, Alessio Cortellini, Marcello Tiseo, Biagio Ricciuti, Francesco Facchinetti, Benjamin Besse, Joao V Alessi, Mark M Awad, David J Pinato, Giuseppe L Banna, Giuseppe Lamberti, Margarita Majem, Frank Aboubakar Nana, Charles Comins, Thomas Newsom-Davis, Victor R Vaz, Laura Mezquita, Davide Soldato, Filippo G Dall’Olio, Sethupathi Muthuramalingam, Aida Piedra, Elisa Andrini, Teresa Gorría, Delphine Hoton, Lacroix Valerie, Andrea Caglio, Hayley McKenzie, Joanne S Evans, Antonio D'Alessio, and Claudia A M Fulgenzi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction It has been recognized that increasing body mass index (BMI) is associated with improved outcome from immune checkpoint inhibitors (ICIs) in patients with various malignancies including non-small cell lung cancer (NSCLC). However, it is unclear whether baseline BMI may influence outcomes from first-line chemoimmunotherapy combinations.Methods In this international multicenter study, we evaluated the association between baseline BMI, progression-free survival (PFS) and overall survival (OS) in a cohort of patients with stage IV NSCLC consecutively treated with first-line chemoimmunotherapy combinations. BMI was categorized according to WHO criteria.Results Among the 853 included patients, 5.3% were underweight; 46.4% were of normal weight; 33.8% were overweight; and 14.5% were obese. Overweight and obese patients were more likely aged ≥70 years (p=0.00085), never smokers (p

Published
2022
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24. Effects of Solids Accumulation on Greenhouse Gas Emissions, Substrate, Plant Growth and Performance of a Mediterranean Horizontal Flow Treatment Wetland

Author

Alessandro Sacco, Liviana Sciuto, Feliciana Licciardello, Giuseppe L. Cirelli, Mirco Milani, and Antonio C. Barbera

Subjects
wastewater treatment, carbon dioxide emission, clogging, horizontal flow, Phragmites australis, Environmental technology. Sanitary engineering, TD1-1066
Abstract

In treatment wetlands (TWs), solids accumulation can result in hydraulic malfunction, reducing the operation life, and it could enhance biological activity by favoring biofilm development. It is still unknown whether the solids accumulation can affect greenhouse gas (GHG) emissions. This study aims to evaluate the solid concentration along a horizontal flow (HF) TW, and its role in GHG emissions, hydraulics, treatment performance, and vegetation development (Phragmites australis (Cav.) Trin. ex Steud.). The study was carried out in an eight-year-old full-scale HF-TW located in the Mediterranean region (Sicily, Italy). To collect data inside the HF unit, nine observation points (besides the inlet and the outlet) along three 8.5-m-long transects (T1, T2, and T3) were identified. The first transect (close to the inlet zone) showed a hydraulic conductivity (Ks) reduction approximately one order of magnitude higher than the other two. Results highlighted that GHG emissions increased during the summer, when the temperature and solar radiation were higher than in the rest of the year, matching the macrophyte growth rate. Theoretical methane (CH4) emissions followed the trend of volatile solids (VS), which was around 3.5 and 4 times in T1 to T2 and T3. Pore clogging affected carbon dioxide (CO2) emissions, which decreased from T1 to T3, with maximum monthly values in T1 (21.4 g CO2·m−2·d−1) being approximately double with respect to T2 (12.6 g CO2·m−2·d−1) and T3 (10.7 g CO2·m−2·d−1) observed in July. The same trend for chemical oxygen demand (COD) removal efficiency, decreasing from T1 to T3, was observed. Notwithstanding this behavior, the final effluent quality was very satisfactory, with an average value of COD removal efficiency above 90%.

Published
2023
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27. External Validation of a Red Cell-based Blood Prognostic Score in Patients With Metastatic Renal Cell Carcinoma Treated With First- Line Immunotherapy Combinations

Author

MAFFEZZOLI, Michele, primary, SANTONI, Matteo, additional, MAZZASCHI, Giulia, additional, RODELLA, Sara, additional, LAI, Eleonora, additional, MARUZZO, Marco, additional, BASSO, Umberto, additional, BIMBATTI, Davide, additional, IACOVELLI, Roberto, additional, ANGHELONE, Annunziato, additional, FIALA, Ondřej, additional, REBUZZI, Sara Elena, additional, FORNARINI, Giuseppe, additional, LOLLI, Cristian, additional, MASSARI, Francesco, additional, ROSELLINI, Matteo, additional, MOLLICA, Veronica, additional, NASSO, Cecilia, additional, ACUNZO, Alessandro, additional, SILINI, Enrico Maria, additional, QUAINI, Federico, additional, DE FILIPPO, Massimo, additional, BRUNELLI, Matteo, additional, BANNA, Giuseppe L., additional, RESCIGNO, Pasquale, additional, SIGNORI, Alessio, additional, and BUTI, Sebastiano, additional

Published
2023
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29. Ultrasound and computed tomography diagnostics of ovarian cyst rupture with hemoperitoneum

Author

Gulnaz K. Sadykova, Igor S. Zheleznyak, Vladimir V. Ryazanov, Ilya S. Khodkevich, Victor V. Ipatov, Anastasiya Ya. Latysheva, and Mikhail Giuseppe L. Oppedisano

Abstract

The presented article is devoted to the issue of diagnosis of rupture of ovarian cyst complicated by hemoperitoneum. Ovarian apoplexy ranks third in the structure of urgent diseases in gynecology and second among the causes of intra-abdominal bleeding. It is a sudden hemorrhage into the ovarian tissue, accompanied by a violation of the integrity of its tissue and in some cases bleeding into the abdominal cavity, may be asymptomatic or accompanied by the sudden appearance of unilateral pain in the lower abdomen. In the conditions of emergency rest during emergency diagnostics, the main advantage of ultrasound is the ability to perform in any conditions and in any condition of the patient, therefore, this method is considered in the scientific literature as the main one for the initial examination of such patients, nevertheless, in the scientific literature there is information about the differential diagnosis of emergency gynecological conditions accompanied by hemoperitoneum by X-ray computed tomography. The article presents the signs detected during ultrasound diagnostics and computed tomography in case of rupture of an ovarian cyst, systematized on the basis of literature data and our clinical experience. The main ultrasound and CT symptoms are intraperitoneal effusion with the presence of a sentinel thrombus in the injured ovary and cystic formation in the ovary. The combined analysis of these signs will help the practitioner in an urgent situation not only to determine the blood in the abdominal cavity, but also to determine the source of bleeding, as well as to differentiate the rupture of the ovarian cyst from other conditions accompanied by acute abdominal pain syndrome.

Published
2023

30. Prevalence and features of delirium in older patients admitted to rehabilitation facilities

Author

Sidoli, Chiara, Zambon, Antonella, Tassistro, Elena, Rossi, Emanuela, Mossello, Enrico, Inzitari, Marco, Cherubini, Antonio, Marengoni, Alessandra, Morandi, Alessandro, Bellelli, Giuseppe, Tarasconi, A, Sella, M, Paternò, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D’Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell’Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Geriatria, A, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambar, V, Saitta, A, Corica, F, Braga, M, Servi, Null, Ettorre, E, Camellini Bellelli, C G, Annoni, G, Marengoni, A, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuar, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl’Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samysalamafahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Di, F, Pezzoni, D, Platto, C, D’Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi Muti, L E, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Riccò, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D’Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Mossello, E, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccalà, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, Saggioro, D, Sidoli, Chiara, Zambon, Antonella, Tassistro, Elena, Rossi, Emanuela, Mossello, Enrico, Inzitari, Marco, Cherubini, Antonio, Marengoni, Alessandra, Morandi, Alessandro, Bellelli, Giuseppe, A Tarasconi, M Sella, G Paternò, G Faggian, C Lucarelli, N De Grazia, C Alberto, L Porcella, I Nardiello, E Chimenti, M Zeni, E Romairone, C Minaglia, C Ceccotti, G Guerra, G Mantovani, F Monacelli, C Minaglia, T Candiani, F Santolini, C Minaglia, M Rosso, V Bono, S Sibilla, P Dal Santo, M Ceci, P Barone, T Schirinzi, A Formenti, G Nastasi, G Isaia, D Gonella, A Battuello, S Casson, D Calvani, F Boni, A Ciaccio, R Rosa, G Sanna, S Manfredini, L Cortese, M Rizzo, R Prestano, A Greco, M Lauriola, G Gelosa, V Piras, M Arena, D Cosenza, A Bellomo, M LaMontagna, L Gabbani, L Lambertucci, S Perego, G Parati, G Basile, V Gallina, G Pilone, C Giudice, L Pietrogrande, M Mosca, I Corazzin, P Rossi, V Nunziata, F D’Amico, A Grippa, S Giardini, R Barucci, A Cossu, L Fiorin, M Arena , M Distefano, M Lunardelli, M Brunori, I Ruffini, E Abraham, A Varutti, E Fabbro, A Catalano, G Martino, D Leotta, A Marchet, G Dell’Aquila, A Scrimieri, M Davoli, M Casella, A Cartei, G Polidori, G Basile, D Brischetto, S Motta, R Saponara, P Perrone, G Russo, D Del, C Car, T Pirina, S Franzoni, A Cotroneo, F Ghiggia, G Volpi, C Menichetti, M Bo, A Panico, P Calogero, G Corvalli, M Mauri, E Lupia, R Manfredini, F Fabbian, A March, M Pedrotti, M Veronesi, E Strocchi, C Borghi, A Bianchetti, A Crucitti, V DiFrancesco, G Fontana, A Geriatria, L Bonanni, F Barbone, C Serrati, G Ballardini, M Simoncelli, G Ceschia, C Scarpa, R Brugiolo, S Fusco, T Ciarambino, C Biagini, E Tonon, M Porta , D Venuti, M DelSette, M Poeta, G Barbagallo, G Trovato, A Delitala, P Arosio, F Reggiani, G Zuliani, B Ortolani, E Mussio, A Girardi, A Coin, G Ruotolo, A Castagna, M Masina, R Cimino, A Pinciaroli, G Tripodi, F Cassadonte, M Vatrano, L Scaglione, P Fogliacco, C Muzzuilini, F Romano, A Padovani, L Rozzini, A Cagnin, F Fragiacomo, G Desideri, E Liberatore, A Bruni, G Orsitto, M Franco, L Bonfrate, M Bonetto, N Pizio, G Magnani, G Cecchetti, A Longo, V Bubba, L Marinan, M Cotelli, M Turla, M Brunori, M Sessa, L Abruzzi, G Castoldi, D LoVetere, C Musacchio, M Novello, A Cavarape, A Bini, A Leonardi, F Seneci, W Grimaldi, F Seneci, F Fimognari, V Bambar, A Saitta, F Corica, M Braga, Servi, E Ettorre , C G Camellini Bellelli, G Annoni, A Marengoni, A Bruni, A Crescenzo, G Noro, R Turco, M Ponzetto, L Giuseppe, B Mazzei, G Maiuri, D Costaggiu, R Damato, E Fabbro, M Formilan, G Patrizia, L Santuar , M Gallucci, C Minaglia, M Paragona, P Bini, D Modica, C Abati, M Clerici, I Barbera, F NigroImperiale, A Manni, C Votino, C Castiglioni, M Di, M Degl’Innocenti, G Moscatelli, S Guerini, C Casini, D Dini, S DeNotariis, F Bonometti, C Paolillo, A Riccardi, A Tiozzo, A SamySalamaFahmy, A Riccardi, C Paolillo, M DiBari, S Vanni, A Scarpa, D Zara, P Ranieri, M Alessandro, P Calogero, G Corvalli, F Di, D Pezzoni, C Platto, V D’Ambrosio, C Ivaldi, P Milia, F DeSalvo, C Solaro, M Strazzacappa, M Bo, A Panico, M Cazzadori, M Bonetto, M Grasso, E Troisi, G Magnani, G Cecchetti, V Guerini, B Bernardini, C Corsini, S Boffelli, A Filippi, K Delpin, B Faraci, E Bertoletti, M Vannucci, P Crippa, A Malighetti, C Caltagirone, S DiSant, D Bettini, F Maltese, M Formilan, G Abruzzese, C Minaglia, D Cosimo, M Azzini, M Cazzadori, M Colombo, G Procino, S Fascendini, F Barocco, P Del, F D’Amico, A Grippa , A Mazzone, M Cottino, G Vezzadini, S Avanzi, C Brambilla, S Orini, F Sgrilli, A Mello, L E Lombardi Muti, B Dijk , S Fenu, C Pes, P Gareri, A Castagna, M Passamonte, R Rigo, L Locusta, L Caser, G Rosso, S Cesarini, R Cozzi, C Santini, P Carbone, I Cazzaniga, R Lovati, A Cantoni, P Ranzani, D Barra, G Pompilio, S Dimori, S Cernesi, C Riccò, F Piazzolla, E Capittini, C Rota, F Gottardi, L Merla, A Barelli, A Millul , G De, G Morrone, M Bigolari, C Minaglia, M Macchi, F Zambon, F D’Amico, F D’Amico, C Pizzorni, G DiCasaleto, G Menculini, M Marcacci, G Catanese, D Sprini, T DiCasalet, M Bocci, S Borga, P Caironi, C Cat, E Cingolani, L Avalli, G Greco, G Citerio, L Gandini, G Cornara, R Lerda, L Brazzi, F Simeone, M Caciorgna, D Alampi, S Francesconi, E Beck, B Antonini, K Vettoretto, M Meggiolaro, E Garofalo, A Bruni, S Notaro, R Varutti, F Bassi, G Mistraletti, A Marino, R Rona, E Rondelli, I Riva, A Cortegiani, L Pistidda, R D’Andrea, L Querci, P Gnesin, M Todeschini, M Lugano, G Castelli, M Ortolani, A Cotoia, S Maggiore, L DiTizio, R Graziani, I Testa, E Ferretti, C Castioni, F Lombardi, R Caserta, M Pasqua, S Simoncini, F Baccarini, M Rispoli, F Grossi, L Cancelliere, M Carnelli, F Puccini, G Biancofiore, A Siniscalchi, C Laici, E Mossello, M Torrini, G Pasetti, S Palmese, R Oggioni, V Mangani, S Pini, M Martelli, E Rigo, F Zuccalà , A Cherri, R Spina, I Calamai, N Petrucci, A Caicedo, F Ferri, P Gritti, N Brienza, R Fonnesu, M Dessena, G Fullin & D Saggioro, VU University medical center, Sidoli, C, Zambon, A, Tassistro, E, Rossi, E, Mossello, E, Inzitari, M, Cherubini, A, Marengoni, A, Morandi, A, Bellelli, G, Tarasconi, A, Sella, M, Paterno, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D'Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell'Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Geriatria, A, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambar, V, Saitta, A, Corica, F, Braga, M, Servi, Ettorre, E, Camellini Bellelli, C, Annoni, G, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuar, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl'Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samysalamafahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Di, F, Pezzoni, D, Platto, C, D'Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi Muti, L, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Ricco, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D'Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccala, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, and Saggioro, D

Subjects
Aging, Disability, Rehabilitation, Delirium, Dementia, Physical restraint, Cross-Sectional Studies, Activities of Daily Living, mental disorders, Prevalence, Humans, Geriatrics and Gerontology, Aged
Abstract

Background: Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation. Aim: We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three editions of the “Delirium Day project”. Methods: We conducted a cross-sectional study in which 1237 older patients (age ≥ 65 years old) admitted to 50 Italian rehabilitation wards during the three editions of the “Delirium Day project” (2015 to 2017) were included. Delirium was evaluated through the 4AT and its motor subtype with the Delirium Motor Subtype Scale. Results: Delirium was detected in 226 patients (18%), and the most recurrent motor subtype was mixed (37%), followed by hypoactive (26%), hyperactive (21%) and non-motor one (16%). In a multivariate Poisson regression model with robust variance, factors associated with delirium were: disability in basic (PR 1.48, 95%CI: 1.17–1.9, p value 0.001) and instrumental activities of daily living (PR 1.58, 95%CI: 1.08–2.32, p value 0.018), dementia (PR 2.10, 95%CI: 1.62–2.73, p value < 0.0001), typical antipsychotics (PR 1.47, 95%CI: 1.10–1.95, p value 0.008), antidepressants other than selective serotonin reuptake inhibitors (PR 1.3, 95%CI: 1.02–1.66, p value 0.035), and physical restraints (PR 2.37, 95%CI: 1.68–3.36, p value < 0.0001). Conclusion: This multicenter study reports that 2 out 10 patients admitted to rehabilitations had delirium on the index day. Mixed delirium was the most prevalent subtype. Delirium was associated with unmodifiable (dementia, disability) and modifiable (physical restraints, medications) factors. Identification of these factors should prompt specific interventions aimed to prevent or mitigate delirium.

Published
2022

32. Prevalence and features of delirium in older patients admitted to rehabilitation facilities: a multicenter study

Author

Sidoli, C, Zambon, A, Tassistro, E, Rossi, E, Mossello, E, Inzitari, M, Cherubini, A, Marengoni, A, Morandi, A, Bellelli, G, Tarasconi, A, Sella, M, Paterno, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D'Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell'Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Geriatria, A, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambar, V, Saitta, A, Corica, F, Braga, M, Servi, Ettorre, E, Camellini Bellelli, C, Annoni, G, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuar, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl'Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samysalamafahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Di, F, Pezzoni, D, Platto, C, D'Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi Muti, L, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Ricco, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D'Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccala, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, Saggioro, D, Sidoli C., Zambon A., Tassistro E., Rossi E., Mossello E., Inzitari M., Cherubini A., Marengoni A., Morandi A., Bellelli G., Tarasconi A., Sella M., Paterno G., Faggian G., Lucarelli C., De Grazia N., Alberto C., Porcella L., Nardiello I., Chimenti E., Zeni M., Romairone E., Minaglia C., Ceccotti C., Guerra G., Mantovani G., Monacelli F., Candiani T., Santolini F., Rosso M., Bono V., Sibilla S., Dal Santo P., Ceci M., Barone P., Schirinzi T., Formenti A., Nastasi G., Isaia G., Gonella D., Battuello A., Casson S., Calvani D., Boni F., Ciaccio A., Rosa R., Sanna G., Manfredini S., Cortese L., Rizzo M., Prestano R., Greco A., Lauriola M., Gelosa G., Piras V., Arena M., Cosenza D., Bellomo A., LaMontagna M., Gabbani L., Lambertucci L., Perego S., Parati G., Basile G., Gallina V., Pilone G., Giudice C., Pietrogrande L., Mosca M., Corazzin I., Rossi P., Nunziata V., D'Amico F., Grippa A., Giardini S., Barucci R., Cossu A., Fiorin L., Distefano M., Lunardelli M., Brunori M., Ruffini I., Abraham E., Varutti A., Fabbro E., Catalano A., Martino G., Leotta D., Marchet A., Dell'Aquila G., Scrimieri A., Davoli M., Casella M., Cartei A., Polidori G., Brischetto D., Motta S., Saponara R., Perrone P., Russo G., Del D., Car C., Pirina T., Franzoni S., Cotroneo A., Ghiggia F., Volpi G., Menichetti C., Bo M., Panico A., Calogero P., Corvalli G., Mauri M., Lupia E., Manfredini R., Fabbian F., March A., Pedrotti M., Veronesi M., Strocchi E., Borghi C., Bianchetti A., Crucitti A., DiFrancesco V., Fontana G., Geriatria A., Bonanni L., Barbone F., Serrati C., Ballardini G., Simoncelli M., Ceschia G., Scarpa C., Brugiolo R., Fusco S., Ciarambino T., Biagini C., Tonon E., Porta M., Venuti D., DelSette M., Poeta M., Barbagallo G., Trovato G., Delitala A., Arosio P., Reggiani F., Zuliani G., Ortolani B., Mussio E., Girardi A., Coin A., Ruotolo G., Castagna A., Masina M., Cimino R., Pinciaroli A., Tripodi G., Cassadonte F., Vatrano M., Scaglione L., Fogliacco P., Muzzuilini C., Romano F., Padovani A., Rozzini L., Cagnin A., Fragiacomo F., Desideri G., Liberatore E., Bruni A., Orsitto G., Franco M., Bonfrate L., Bonetto M., Pizio N., Magnani G., Cecchetti G., Longo A., Bubba V., Marinan L., Cotelli M., Turla M., Sessa M., Abruzzi L., Castoldi G., LoVetere D., Musacchio C., Novello M., Cavarape A., Bini A., Leonardi A., Seneci F., Grimaldi W., Fimognari F., Bambar V., Saitta A., Corica F., Braga M., Ettorre E., Camellini Bellelli C. G., Annoni G., Crescenzo A., Noro G., Turco R., Ponzetto M., Giuseppe L., Mazzei B., Maiuri G., Costaggiu D., Damato R., Formilan M., Patrizia G., Santuar L., Gallucci M., Paragona M., Bini P., Modica D., Abati C., Clerici M., Barbera I., NigroImperiale F., Manni A., Votino C., Castiglioni C., Di M., Degl'Innocenti M., Moscatelli G., Guerini S., Casini C., Dini D., DeNotariis S., Bonometti F., Paolillo C., Riccardi A., Tiozzo A., SamySalamaFahmy A., DiBari M., Vanni S., Scarpa A., Zara D., Ranieri P., Alessandro M., Di F., Pezzoni D., Platto C., D'Ambrosio V., Ivaldi C., Milia P., DeSalvo F., Solaro C., Strazzacappa M., Cazzadori M., Grasso M., Troisi E., Guerini V., Bernardini B., Corsini C., Boffelli S., Filippi A., Delpin K., Faraci B., Bertoletti E., Vannucci M., Crippa P., Malighetti A., Caltagirone C., DiSant S., Bettini D., Maltese F., Abruzzese G., Cosimo D., Azzini M., Colombo M., Procino G., Fascendini S., Barocco F., Del P., Mazzone A., Cottino M., Vezzadini G., Avanzi S., Brambilla C., Orini S., Sgrilli F., Mello A., Lombardi Muti L. E., Dijk B., Fenu S., Pes C., Gareri P., Passamonte M., Rigo R., Locusta L., Caser L., Rosso G., Cesarini S., Cozzi R., Santini C., Carbone P., Cazzaniga I., Lovati R., Cantoni A., Ranzani P., Barra D., Pompilio G., Dimori S., Cernesi S., Ricco C., Piazzolla F., Capittini E., Rota C., Gottardi F., Merla L., Barelli A., Millul A., De G., Morrone G., Bigolari M., Macchi M., Zambon F., Pizzorni C., DiCasaleto G., Menculini G., Marcacci M., Catanese G., Sprini D., DiCasalet T., Bocci M., Borga S., Caironi P., Cat C., Cingolani E., Avalli L., Greco G., Citerio G., Gandini L., Cornara G., Lerda R., Brazzi L., Simeone F., Caciorgna M., Alampi D., Francesconi S., Beck E., Antonini B., Vettoretto K., Meggiolaro M., Garofalo E., Notaro S., Varutti R., Bassi F., Mistraletti G., Marino A., Rona R., Rondelli E., Riva I., Cortegiani A., Pistidda L., D'Andrea R., Querci L., Gnesin P., Todeschini M., Lugano M., Castelli G., Ortolani M., Cotoia A., Maggiore S., DiTizio L., Graziani R., Testa I., Ferretti E., Castioni C., Lombardi F., Caserta R., Pasqua M., Simoncini S., Baccarini F., Rispoli M., Grossi F., Cancelliere L., Carnelli M., Puccini F., Biancofiore G., Siniscalchi A., Laici C., Torrini M., Pasetti G., Palmese S., Oggioni R., Mangani V., Pini S., Martelli M., Rigo E., Zuccala F., Cherri A., Spina R., Calamai I., Petrucci N., Caicedo A., Ferri F., Gritti P., Brienza N., Fonnesu R., Dessena M., Fullin G., Saggioro D., Sidoli, C, Zambon, A, Tassistro, E, Rossi, E, Mossello, E, Inzitari, M, Cherubini, A, Marengoni, A, Morandi, A, Bellelli, G, Tarasconi, A, Sella, M, Paterno, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D'Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell'Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Geriatria, A, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambar, V, Saitta, A, Corica, F, Braga, M, Servi, Ettorre, E, Camellini Bellelli, C, Annoni, G, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuar, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl'Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samysalamafahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Di, F, Pezzoni, D, Platto, C, D'Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi Muti, L, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Ricco, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D'Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccala, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, Saggioro, D, Sidoli C., Zambon A., Tassistro E., Rossi E., Mossello E., Inzitari M., Cherubini A., Marengoni A., Morandi A., Bellelli G., Tarasconi A., Sella M., Paterno G., Faggian G., Lucarelli C., De Grazia N., Alberto C., Porcella L., Nardiello I., Chimenti E., Zeni M., Romairone E., Minaglia C., Ceccotti C., Guerra G., Mantovani G., Monacelli F., Candiani T., Santolini F., Rosso M., Bono V., Sibilla S., Dal Santo P., Ceci M., Barone P., Schirinzi T., Formenti A., Nastasi G., Isaia G., Gonella D., Battuello A., Casson S., Calvani D., Boni F., Ciaccio A., Rosa R., Sanna G., Manfredini S., Cortese L., Rizzo M., Prestano R., Greco A., Lauriola M., Gelosa G., Piras V., Arena M., Cosenza D., Bellomo A., LaMontagna M., Gabbani L., Lambertucci L., Perego S., Parati G., Basile G., Gallina V., Pilone G., Giudice C., Pietrogrande L., Mosca M., Corazzin I., Rossi P., Nunziata V., D'Amico F., Grippa A., Giardini S., Barucci R., Cossu A., Fiorin L., Distefano M., Lunardelli M., Brunori M., Ruffini I., Abraham E., Varutti A., Fabbro E., Catalano A., Martino G., Leotta D., Marchet A., Dell'Aquila G., Scrimieri A., Davoli M., Casella M., Cartei A., Polidori G., Brischetto D., Motta S., Saponara R., Perrone P., Russo G., Del D., Car C., Pirina T., Franzoni S., Cotroneo A., Ghiggia F., Volpi G., Menichetti C., Bo M., Panico A., Calogero P., Corvalli G., Mauri M., Lupia E., Manfredini R., Fabbian F., March A., Pedrotti M., Veronesi M., Strocchi E., Borghi C., Bianchetti A., Crucitti A., DiFrancesco V., Fontana G., Geriatria A., Bonanni L., Barbone F., Serrati C., Ballardini G., Simoncelli M., Ceschia G., Scarpa C., Brugiolo R., Fusco S., Ciarambino T., Biagini C., Tonon E., Porta M., Venuti D., DelSette M., Poeta M., Barbagallo G., Trovato G., Delitala A., Arosio P., Reggiani F., Zuliani G., Ortolani B., Mussio E., Girardi A., Coin A., Ruotolo G., Castagna A., Masina M., Cimino R., Pinciaroli A., Tripodi G., Cassadonte F., Vatrano M., Scaglione L., Fogliacco P., Muzzuilini C., Romano F., Padovani A., Rozzini L., Cagnin A., Fragiacomo F., Desideri G., Liberatore E., Bruni A., Orsitto G., Franco M., Bonfrate L., Bonetto M., Pizio N., Magnani G., Cecchetti G., Longo A., Bubba V., Marinan L., Cotelli M., Turla M., Sessa M., Abruzzi L., Castoldi G., LoVetere D., Musacchio C., Novello M., Cavarape A., Bini A., Leonardi A., Seneci F., Grimaldi W., Fimognari F., Bambar V., Saitta A., Corica F., Braga M., Ettorre E., Camellini Bellelli C. G., Annoni G., Crescenzo A., Noro G., Turco R., Ponzetto M., Giuseppe L., Mazzei B., Maiuri G., Costaggiu D., Damato R., Formilan M., Patrizia G., Santuar L., Gallucci M., Paragona M., Bini P., Modica D., Abati C., Clerici M., Barbera I., NigroImperiale F., Manni A., Votino C., Castiglioni C., Di M., Degl'Innocenti M., Moscatelli G., Guerini S., Casini C., Dini D., DeNotariis S., Bonometti F., Paolillo C., Riccardi A., Tiozzo A., SamySalamaFahmy A., DiBari M., Vanni S., Scarpa A., Zara D., Ranieri P., Alessandro M., Di F., Pezzoni D., Platto C., D'Ambrosio V., Ivaldi C., Milia P., DeSalvo F., Solaro C., Strazzacappa M., Cazzadori M., Grasso M., Troisi E., Guerini V., Bernardini B., Corsini C., Boffelli S., Filippi A., Delpin K., Faraci B., Bertoletti E., Vannucci M., Crippa P., Malighetti A., Caltagirone C., DiSant S., Bettini D., Maltese F., Abruzzese G., Cosimo D., Azzini M., Colombo M., Procino G., Fascendini S., Barocco F., Del P., Mazzone A., Cottino M., Vezzadini G., Avanzi S., Brambilla C., Orini S., Sgrilli F., Mello A., Lombardi Muti L. E., Dijk B., Fenu S., Pes C., Gareri P., Passamonte M., Rigo R., Locusta L., Caser L., Rosso G., Cesarini S., Cozzi R., Santini C., Carbone P., Cazzaniga I., Lovati R., Cantoni A., Ranzani P., Barra D., Pompilio G., Dimori S., Cernesi S., Ricco C., Piazzolla F., Capittini E., Rota C., Gottardi F., Merla L., Barelli A., Millul A., De G., Morrone G., Bigolari M., Macchi M., Zambon F., Pizzorni C., DiCasaleto G., Menculini G., Marcacci M., Catanese G., Sprini D., DiCasalet T., Bocci M., Borga S., Caironi P., Cat C., Cingolani E., Avalli L., Greco G., Citerio G., Gandini L., Cornara G., Lerda R., Brazzi L., Simeone F., Caciorgna M., Alampi D., Francesconi S., Beck E., Antonini B., Vettoretto K., Meggiolaro M., Garofalo E., Notaro S., Varutti R., Bassi F., Mistraletti G., Marino A., Rona R., Rondelli E., Riva I., Cortegiani A., Pistidda L., D'Andrea R., Querci L., Gnesin P., Todeschini M., Lugano M., Castelli G., Ortolani M., Cotoia A., Maggiore S., DiTizio L., Graziani R., Testa I., Ferretti E., Castioni C., Lombardi F., Caserta R., Pasqua M., Simoncini S., Baccarini F., Rispoli M., Grossi F., Cancelliere L., Carnelli M., Puccini F., Biancofiore G., Siniscalchi A., Laici C., Torrini M., Pasetti G., Palmese S., Oggioni R., Mangani V., Pini S., Martelli M., Rigo E., Zuccala F., Cherri A., Spina R., Calamai I., Petrucci N., Caicedo A., Ferri F., Gritti P., Brienza N., Fonnesu R., Dessena M., Fullin G., and Saggioro D.

Abstract

Background: Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation. Aim: We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three editions of the “Delirium Day project”. Methods: We conducted a cross-sectional study in which 1237 older patients (age ≥ 65 years old) admitted to 50 Italian rehabilitation wards during the three editions of the “Delirium Day project” (2015 to 2017) were included. Delirium was evaluated through the 4AT and its motor subtype with the Delirium Motor Subtype Scale. Results: Delirium was detected in 226 patients (18%), and the most recurrent motor subtype was mixed (37%), followed by hypoactive (26%), hyperactive (21%) and non-motor one (16%). In a multivariate Poisson regression model with robust variance, factors associated with delirium were: disability in basic (PR 1.48, 95%CI: 1.17–1.9, p value 0.001) and instrumental activities of daily living (PR 1.58, 95%CI: 1.08–2.32, p value 0.018), dementia (PR 2.10, 95%CI: 1.62–2.73, p value < 0.0001), typical antipsychotics (PR 1.47, 95%CI: 1.10–1.95, p value 0.008), antidepressants other than selective serotonin reuptake inhibitors (PR 1.3, 95%CI: 1.02–1.66, p value 0.035), and physical restraints (PR 2.37, 95%CI: 1.68–3.36, p value < 0.0001). Conclusion: This multicenter study reports that 2 out 10 patients admitted to rehabilitations had delirium on the index day. Mixed delirium was the most prevalent subtype. Delirium was associated with unmodifiable (dementia, disability) and modifiable (physical restraints, medications) factors. Identification of these factors should prompt specific interventions aimed to prevent or mitigate delirium.

Published
2022

33. Differential prognostic effect of systemic inflammation in patients with non–small cell lung cancer treated with immunotherapy or chemotherapy: A post hoc analysis of the phase 3 <scp>OAK</scp> trial

Author

Alessio Cortellini, Biagio Ricciuti, Hossein Borghaei, Abdul Rafeh Naqash, Antonio D'Alessio, Claudia A. M. Fulgenzi, Alfredo Addeo, Giuseppe L. Banna, and David James Pinato

Subjects
Inflammation, Male, Cancer Research, Kelch-Like ECH-Associated Protein 1, Lung Neoplasms, NF-E2-Related Factor 2, DNA Helicases, Nuclear Proteins, Docetaxel, Prognosis, B7-H1 Antigen, ErbB Receptors, Proto-Oncogene Proteins p21(ras), Oncology, Carcinoma, Non-Small-Cell Lung, Humans, Immunologic Factors, Immunotherapy, Cell-Free Nucleic Acids, Transcription Factors
Abstract

A proinflammatory diathesis, as measured by the neutrophil to lymphocyte ratio (NLR), heralds an adverse disease course for non-small cell lung cancer (NSCLC).This post hoc analysis used data from the phase 3 OAK trial (NCT02008227), which randomized previously treated patients with NSCLC to atezolizumab or docetaxel. The main objective was assessing the differential impact of the pretreatment NLR on overall survival according to the treatment modality. In addition, patients' genomic characteristics were assessed according to their inflammatory status with a circulating free DNA (cfDNA) next-generation sequencing (NGS) analysis.In all, 600 and 575 patients with NLR data were included in the atezolizumab and docetaxel cohorts, respectively, with a median NLR of 4 (interquartile range, 2.6-6.7) for the pooled population. An NLR ≥4 was associated with a positive smoking status (88.6% vs. 78.1%; p .01), male sex (66.4% vs. 57.6%; p = .01), a worse performance status (71.3% vs. 55.2%; p .01), a higher number of metastatic sites (63.2% vs. 51.6%; p = .01), squamous histology (32.1% vs. 21.4%; p .01), and tissue KRAS mutations (30% vs. 18.7%; p = .02) but not with programmed death ligand 1 (PD-L1) expression or the tissue epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) status. A pretreatment NLR ≥4 was more strongly associated with mortality after atezolizumab (adjusted hazard ratio [HR], 1.64; 95% confidence interval [CI], 1.35-2.01) versus docetaxel (HR, 1.32; 95% CI, 1.08-1.60; multivariable [MVA] interaction p = .08). The HR for an increased risk of death for PD-L1-negative/NLR ≥4 patients (compared with PD-L1-positive/NLR 4 patients) was significantly higher in the atezolizumab cohort (MVA interaction p = .01). The exclusion of EGFR/ALK-positive patients further increased the prognostic ability of the baseline NLR in favor of atezolizumab (MVA interaction p = .02). Pretreatment cfDNA data from NGS showed that patients with a high blood tumor mutation burden (cutoff, 16 mut/Mb) had a higher median NLR (4.6 vs. 3.7; p = .01). After adjustments for multiple comparisons, none of the selected variants of interest (EGFR, KRAS, TP53, KEAP1, STK11, SMARCA4, ARID1A, and targeted DNA damage response and repair genes) were significantly associated with the NLR.A low baseline NLR identified patients with NSCLC who derived a greater survival benefit from atezolizumab in comparison with those identified in the docetaxel cohort. The NLR could complement PD-L1 expression in tailoring treatment in this setting.

Published
2022

34. Immunotherapy-related adverse events in real-world patients with advanced non-small cell lung cancer on chemoimmunotherapy: a Spinnaker study sub-analysis

Author

Anpalakhan, Shobana, primary, Huddar, Prerana, additional, Behrouzi, Roya, additional, Signori, Alessio, additional, Cave, Judith, additional, Comins, Charles, additional, Cortellini, Alessio, additional, Addeo, Alfredo, additional, Escriu, Carles, additional, McKenzie, Hayley, additional, Barone, Gloria, additional, Murray, Lisa, additional, Pinato, David J., additional, Ottensmeier, Christian, additional, Campos, Sara, additional, Muthuramalingam, Sethupathi, additional, Chan, Samuel, additional, Gomes, Fabio, additional, and Banna, Giuseppe L., additional

Published
2023
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37. Data from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Yeung, Choh, primary, Gibson, Anna E., primary, Issaq, Sameer H., primary, Oshima, Nobu, primary, Baumgart, Joshua T., primary, Edessa, Leah D., primary, Rai, Ganesha, primary, Urban, Daniel J., primary, Johnson, Michelle S., primary, Benavides, Gloria A., primary, Squadrito, Giuseppe L., primary, Yohe, Marielle E., primary, Lei, Haiyan, primary, Eldridge, Sandy, primary, Hamre, John, primary, Dowdy, Tyrone, primary, Ruiz-Rodado, Victor, primary, Lita, Adrian, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Larion, Mioara, primary, Helman, Lee J., primary, Stott, Gordon M., primary, Krishna, Murali C., primary, Hall, Matthew D., primary, Darley-Usmar, Victor, primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
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38. Supplemental Table 1 from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Yeung, Choh, primary, Gibson, Anna E., primary, Issaq, Sameer H., primary, Oshima, Nobu, primary, Baumgart, Joshua T., primary, Edessa, Leah D., primary, Rai, Ganesha, primary, Urban, Daniel J., primary, Johnson, Michelle S., primary, Benavides, Gloria A., primary, Squadrito, Giuseppe L., primary, Yohe, Marielle E., primary, Lei, Haiyan, primary, Eldridge, Sandy, primary, Hamre, John, primary, Dowdy, Tyrone, primary, Ruiz-Rodado, Victor, primary, Lita, Adrian, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Larion, Mioara, primary, Helman, Lee J., primary, Stott, Gordon M., primary, Krishna, Murali C., primary, Hall, Matthew D., primary, Darley-Usmar, Victor, primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
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39. Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Yeung, Choh, primary, Gibson, Anna E., primary, Issaq, Sameer H., primary, Oshima, Nobu, primary, Baumgart, Joshua T., primary, Edessa, Leah D., primary, Rai, Ganesha, primary, Urban, Daniel J., primary, Johnson, Michelle S., primary, Benavides, Gloria A., primary, Squadrito, Giuseppe L., primary, Yohe, Marielle E., primary, Lei, Haiyan, primary, Eldridge, Sandy, primary, Hamre, John, primary, Dowdy, Tyrone, primary, Ruiz-Rodado, Victor, primary, Lita, Adrian, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Larion, Mioara, primary, Helman, Lee J., primary, Stott, Gordon M., primary, Krishna, Murali C., primary, Hall, Matthew D., primary, Darley-Usmar, Victor, primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
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40. Supplemental Figures 1-14 from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Yeung, Choh, primary, Gibson, Anna E., primary, Issaq, Sameer H., primary, Oshima, Nobu, primary, Baumgart, Joshua T., primary, Edessa, Leah D., primary, Rai, Ganesha, primary, Urban, Daniel J., primary, Johnson, Michelle S., primary, Benavides, Gloria A., primary, Squadrito, Giuseppe L., primary, Yohe, Marielle E., primary, Lei, Haiyan, primary, Eldridge, Sandy, primary, Hamre, John, primary, Dowdy, Tyrone, primary, Ruiz-Rodado, Victor, primary, Lita, Adrian, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Larion, Mioara, primary, Helman, Lee J., primary, Stott, Gordon M., primary, Krishna, Murali C., primary, Hall, Matthew D., primary, Darley-Usmar, Victor, primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
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41. Could hydraulic parameters variation affect the vegetation development in treatment wetlands?

Author

Liviana Sciuto, Alessandro Sacco, Giuseppe L. Cirelli, Antonio C. Barbera, and Feliciana Licciardello

Abstract

Treatment wetlands (TWs) are complex ecosystems due to variable conditions of hydrology, soil hydraulics, plants and microbiological species diversity and mutual interactions. On the one hand, hydraulics plays a vital role on the treatment performance and on the life cycle of TWs, on the other hand, the vegetation substantially contributes to remove and to retain pollutants. As well known, the unavoidable and progressive clogging phenomenon in TWs affects their hydraulics. A lack of knowledge still remains to what extend hydraulic parameters variation can affect the vegetation developments in TWs. To answer to this question, the Phragmites australis development in comparison with hydraulic characteristics was monitored in a 8 years old - horizontal flow (HF) TW located in Mediterranean area (Eastern Sicily, Italy). Data were collected in nine observation points equally distributed along three transects established at 8.5 m (T1), at 17 m (T2) and at 25.5 m (T3) from the inlet. The falling head (FH) test was conducted to assess the hydraulic conductivity (Ks) variation in the HF-unit. Residence time distribution (RTD) analysis was performed to evaluate the real hydraulic retention time (HRT) and the hydraulic efficiency parameter (λ). Finally, the saturation method was applied for substrates porosity (φ) determination. In the HF-TW a morphological and chemical characterization of Phragmites australis above-ground biomass was carried out in 2022. In particular, plants density (in terms of culms number) and height (m) were measured at the end of the growing season (July). In each transect of the HF-TW, fresh weight (g), dry matter (DM, %), ash (%), volatile solids (VS, %), pH, Total Kjeldahl Nitrogen (TKN, % of DM) and fiber content (cellulose, hemicellulose and lignin) were estimated. Preliminary results showed a strong positive regression between DM and both Ks (R2 = 0.78) and porosity values (R2 = 0.97) observed in the HF-TW. This study could contribute to help plant operators to understand hydraulic characteristics effects on the biomass, to improve TWs treatment efficiency, system management and lifespan.Keywords: Wastewater treatment, Phragmites australis, plants growth, hydraulic characteristics, substrate.Acknowledgments: This research was funded by the University of Catania-PIAno di inCEntivi per la RIcerca di Ateneo 2020/2022—Linea di Intervento 3 “Starting Grant” and the PhD Course in Agricultural, Food and Environmental Science (Di3A, University of Catania).

Published
2023

43. Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Christine M. Heske, Leonard M. Neckers, Victor Darley-Usmar, Matthew D. Hall, Murali C. Krishna, Gordon M. Stott, Lee J. Helman, Mioara Larion, Jack F. Shern, Arnulfo Mendoza, Adrian Lita, Victor Ruiz-Rodado, Tyrone Dowdy, John Hamre, Sandy Eldridge, Haiyan Lei, Marielle E. Yohe, Giuseppe L. Squadrito, Gloria A. Benavides, Michelle S. Johnson, Daniel J. Urban, Ganesha Rai, Leah D. Edessa, Joshua T. Baumgart, Nobu Oshima, Sameer H. Issaq, Anna E. Gibson, and Choh Yeung

Abstract

A description of additional supplemental methods

Published
2023

44. Supplemental Figures 1-14 from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Christine M. Heske, Leonard M. Neckers, Victor Darley-Usmar, Matthew D. Hall, Murali C. Krishna, Gordon M. Stott, Lee J. Helman, Mioara Larion, Jack F. Shern, Arnulfo Mendoza, Adrian Lita, Victor Ruiz-Rodado, Tyrone Dowdy, John Hamre, Sandy Eldridge, Haiyan Lei, Marielle E. Yohe, Giuseppe L. Squadrito, Gloria A. Benavides, Michelle S. Johnson, Daniel J. Urban, Ganesha Rai, Leah D. Edessa, Joshua T. Baumgart, Nobu Oshima, Sameer H. Issaq, Anna E. Gibson, and Choh Yeung

Abstract

Combined Supplementary Data file containing: Figure S1. Proliferation assays using NCI-737 and NCI-006 in an expanded panel of EWS cell lines. Figure S2. Effects of additional siRNA sequences against LDHA and LDHB in an expanded panel of EWS cell lines. Figure S3. Effects of additional siRNA sequences against EWS-FLI1 on LDHA and LDHB and additional ChIP-seq data. Figure S4. LDH expression, basal activity and in vitro early time course inhibition in EWS cell lines. Figure S5. Steady state levels of pyruvate and lactate and 13C-tracing experiments from 13C-U-glucose. Figure S6. Effects of NCI-737 and NCI-006 on ECAR measurements. Figure S7. Effects of NCI-737 on OCR measurements. Figure S8. Effects of NCI-737 on ECAR measurements of expanded panel of EWS cell lines. Figure S9. Results of oral dosing of LDH inhibitors in EWS xenograft models. Figure S10. Results of IV pilot studies of LDH inhibitors in EWS xenograft models. Figure S11. Additional growth rate and pharmacokinetic data for EWS xenograft models. Figure S12. Additional growth rate and necrosis data for EWS xenograft models. Figure S13. Depiction of of changes in lactate and pyruvate peaks and lactate/pyruvate ratio by hyperpolarized 13C-MR spectroscopy in EWS xenograft models. Figure S14. Measurements of toxicity in animals treated with NCI-737.

Published
2023

45. Data from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Christine M. Heske, Leonard M. Neckers, Victor Darley-Usmar, Matthew D. Hall, Murali C. Krishna, Gordon M. Stott, Lee J. Helman, Mioara Larion, Jack F. Shern, Arnulfo Mendoza, Adrian Lita, Victor Ruiz-Rodado, Tyrone Dowdy, John Hamre, Sandy Eldridge, Haiyan Lei, Marielle E. Yohe, Giuseppe L. Squadrito, Gloria A. Benavides, Michelle S. Johnson, Daniel J. Urban, Ganesha Rai, Leah D. Edessa, Joshua T. Baumgart, Nobu Oshima, Sameer H. Issaq, Anna E. Gibson, and Choh Yeung

Abstract

Altered cellular metabolism, including an increased dependence on aerobic glycolysis, is a hallmark of cancer. Despite the fact that this observation was first made nearly a century ago, effective therapeutic targeting of glycolysis in cancer has remained elusive. One potentially promising approach involves targeting the glycolytic enzyme lactate dehydrogenase (LDH), which is overexpressed and plays a critical role in several cancers. Here, we used a novel class of LDH inhibitors to demonstrate, for the first time, that Ewing sarcoma cells are exquisitely sensitive to inhibition of LDH. EWS-FLI1, the oncogenic driver of Ewing sarcoma, regulated LDH A (LDHA) expression. Genetic depletion of LDHA inhibited proliferation of Ewing sarcoma cells and induced apoptosis, phenocopying pharmacologic inhibition of LDH. LDH inhibitors affected Ewing sarcoma cell viability both in vitro and in vivo by reducing glycolysis. Intravenous administration of LDH inhibitors resulted in the greatest intratumoral drug accumulation, inducing tumor cell death and reducing tumor growth. The major dose-limiting toxicity observed was hemolysis, indicating that a narrow therapeutic window exists for these compounds. Taken together, these data suggest that targeting glycolysis through inhibition of LDH should be further investigated as a potential therapeutic approach for cancers such as Ewing sarcoma that exhibit oncogene-dependent expression of LDH and increased glycolysis.Significance:LDHA is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma.

Published
2023

46. Supplemental Table 1 from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Christine M. Heske, Leonard M. Neckers, Victor Darley-Usmar, Matthew D. Hall, Murali C. Krishna, Gordon M. Stott, Lee J. Helman, Mioara Larion, Jack F. Shern, Arnulfo Mendoza, Adrian Lita, Victor Ruiz-Rodado, Tyrone Dowdy, John Hamre, Sandy Eldridge, Haiyan Lei, Marielle E. Yohe, Giuseppe L. Squadrito, Gloria A. Benavides, Michelle S. Johnson, Daniel J. Urban, Ganesha Rai, Leah D. Edessa, Joshua T. Baumgart, Nobu Oshima, Sameer H. Issaq, Anna E. Gibson, and Choh Yeung

Abstract

Table S1. List of all 94 Oncolead cell lines tested with corresponding IC50 values for NCI-737 and NCI-006.

Published
2023

49. One-year nutrition counselling in the context of a Mediterranean diet reduced the dietary inflammatory index in women with breast cancer: a role for the dietary glycemic index

Author

Vitale, Sara, primary, Palumbo, Elvira, additional, Polesel, Jerry, additional, Hebert, James R., additional, Shivappa, Nitin, additional, Montagnese, Concetta, additional, Porciello, Giuseppe, additional, Calabrese, Ilaria, additional, Luongo, Assunta, additional, Prete, Melania, additional, Pica, Rosa, additional, Grimaldi, Maria, additional, Crispo, Anna, additional, Esindi, Nadia, additional, Falzone, Luca, additional, Mattioli, Veronica, additional, Martinuzzo, Valentina, additional, Poletto, Luigina, additional, Cubisino, Serena, additional, Dainotta, Patrizia, additional, De Laurentiis, Michelino, additional, Pacilio, Carmen, additional, Rinaldo, Massimo, additional, Thomas, Guglielmo, additional, D'Aiuto, Massimiliano, additional, Serraino, Diego, additional, Massarut, Samuele, additional, Ferraù, Francesco, additional, Rossello, Rosalba, additional, Catalano, Francesca, additional, Banna, Giuseppe L., additional, Messina, Francesco, additional, Gatti, Davide, additional, Riccardi, Gabriele, additional, Libra, Massimo, additional, Celentano, Egidio, additional, Jenkins, David J. A., additional, and Augustin, Livia S. A., additional

Published
2023
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50. A novel immunotherapy prognostic score for patients with pretreated advanced urInary TrAct CArcinoma from the subgroup analysis of the SAUL study: the ITACA Score

Author

FORNARINI, Giuseppe, primary, REBUZZI, Sara E., additional, BUTI, Sebastiano, additional, RESCIGNO, Pasquale, additional, MERSEBURGER, Axel, additional, STERNBERG, Cora N., additional, de GIORGI, Ugo, additional, BASSO, Umberto, additional, MARUZZO, Marco, additional, GIANNATEMPO, Patrizia, additional, PONZANO, Marta, additional, GIUNTA, Emilio F., additional, CATALANO, Fabio, additional, MURIANNI, Veronica, additional, DAMASSI, Alessandra, additional, CREMANTE, Malvina, additional, GANDINI, Annalice, additional, PUGLISI, Silvia, additional, LLAJA OBISPO, Miguel A., additional, SIGNORI, Alessio, additional, and BANNA, Giuseppe L., additional

Published
2022
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