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26 results on '"Hüser, Laura"'

3. Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

Author

Chhabra, Yash, Fane, Mitchell E., Pramod, Sneha, Hüser, Laura, Zabransky, Daniel J., Wang, Vania, Dixit, Agrani, Zhao, Ruzhang, Kumah, Edwin, Brezka, Megan L., Truskowski, Kevin, Nandi, Asmita, Marino-Bravante, Gloria E., Carey, Alexis E., Gour, Naina, Maranto, Devon A., Rocha, Murilo R., Harper, Elizabeth I., Ruiz, Justin, Lipson, Evan J., Jaffee, Elizabeth M., Bibee, Kristin, Sunshine, Joel C., Ji, Hongkai, and Weeraratna, Ashani T.

Published
2024
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5. Stromal changes in the aged lung induce an emergence from melanoma dormancy

Author

Fane, Mitchell E., Chhabra, Yash, Alicea, Gretchen M., Maranto, Devon A., Douglass, Stephen M., Webster, Marie R., Rebecca, Vito W., Marino, Gloria E., Almeida, Filipe, Ecker, Brett L., Zabransky, Daniel J., Hüser, Laura, Beer, Thomas, Tang, Hsin-Yao, Kossenkov, Andrew, Herlyn, Meenhard, Speicher, David W., Xu, Wei, Xu, Xiaowei, Jaffee, Elizabeth M., Aguirre-Ghiso, Julio A., and Weeraratna, Ashani T.

Published
2022
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6. Supplementary Table S4 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
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7. Figure S2 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
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8. Table S2 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
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9. Data from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
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12. Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.

Author

Le Chang, Yanli Ran, Mingpo Yang, Auferkorte, Olivia, Butz, Elisabeth, Hüser, Laura, Haverkamp, Silke, Euler, Thomas, and Schubert, Timm

Subjects
ION channels, RETINAL ganglion cells, ACTIVATION energy, RETINA, ACTION potentials, SODIUM channels, MARKETING channels
Abstract

In the vertebrate retina, several dozens of parallel channels relay information about the visual world to the brain. These channels are represented by the different types of retinal ganglion cells (RGCs), whose responses are rendered selective for distinct sets of visual features by various mechanisms. These mechanisms can be roughly grouped into synaptic interactions and cell-intrinsic mechanisms, with the latter including dendritic morphology as well as ion channel complement and distribution. Here, we investigate how strongly ion channel complement can shape RGC output by comparing two mouse RGC types, the well-described ON alpha cell and a little-studied ON cell that is EGFP-labelled in the Igfbp5 mouse line and displays an unusual selectivity for stimuli with high contrast. Using patch-clamp recordings and computational modelling, we show that a higher activation threshold and a pronounced slow inactivation of the voltage-gated Na+ channels contribute to the distinct contrast tuning and transient responses in ON Igfbp5 RGCs, respectively. In contrast, such a mechanism could not be observed in ON alpha cells. This study provides an example for the powerful role that the last stage of retinal processing can play in shaping RGC responses. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Abstract 431: FOXD1 promotes dedifferentiation and targeted therapy resistance in melanoma by regulating the expression of connective tissue growth factor

Author

Sun, Qian, primary, Novak, Daniel, additional, Hüser, Laura, additional, Poelchen, Juliane, additional, Wu, Huizi, additional, Granados, Karol, additional, Federico, Aniello Federico, additional, Liu, Ke, additional, Steinfass, Tamara, additional, Vierthaler, Marlene, additional, Umansky, Viktor, additional, and Utikal, Jochen, additional

Published
2023
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14. Data from Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling

Author

Fleming, Viktor, primary, Hu, Xiaoying, primary, Weller, Céline, primary, Weber, Rebekka, primary, Groth, Christopher, primary, Riester, Zeno, primary, Hüser, Laura, primary, Sun, Qian, primary, Nagibin, Vasyl, primary, Kirschning, Carsten, primary, Bronte, Vincenzo, primary, Utikal, Jochen, primary, Altevogt, Peter, primary, and Umansky, Viktor, primary

Published
2023
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15. Figures S1-S5, Table S1 from Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling

Author

Fleming, Viktor, primary, Hu, Xiaoying, primary, Weller, Céline, primary, Weber, Rebekka, primary, Groth, Christopher, primary, Riester, Zeno, primary, Hüser, Laura, primary, Sun, Qian, primary, Nagibin, Vasyl, primary, Kirschning, Carsten, primary, Bronte, Vincenzo, primary, Utikal, Jochen, primary, Altevogt, Peter, primary, and Umansky, Viktor, primary

Published
2023
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18. Additional file 4 of Secretogranin II influences the assembly and function of MHC class I in melanoma

Author

Steinfass, Tamara, Poelchen, Juliane, Sun, Qian, Mastrogiulio, Giovanni, Novak, Daniel, Vierthaler, Marlene, Pardo, Sandra, Federico, Aniello, Hüser, Laura, Hielscher, Thomas, Carretero, Rafael, Offringa, Rienk, Altevogt, Peter, Umansky, Viktor, and Utikal, Jochen

Abstract

Additional file 4: Figure S3. IFNγ treatment does not influence the percentage of HLA-ABC-positive cells or SCG2 expression.

Published
2023
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19. Additional file 5 of Secretogranin II influences the assembly and function of MHC class I in melanoma

Author

Steinfass, Tamara, Poelchen, Juliane, Sun, Qian, Mastrogiulio, Giovanni, Novak, Daniel, Vierthaler, Marlene, Pardo, Sandra, Federico, Aniello, Hüser, Laura, Hielscher, Thomas, Carretero, Rafael, Offringa, Rienk, Altevogt, Peter, Umansky, Viktor, and Utikal, Jochen

Abstract

Additional file 5: Figure S4. SCG2 OE melanoma cells are more resistant to T cell-mediated cytotoxicity.

Published
2023
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20. Additional file 3 of Secretogranin II influences the assembly and function of MHC class I in melanoma

Author

Steinfass, Tamara, Poelchen, Juliane, Sun, Qian, Mastrogiulio, Giovanni, Novak, Daniel, Vierthaler, Marlene, Pardo, Sandra, Federico, Aniello, Hüser, Laura, Hielscher, Thomas, Carretero, Rafael, Offringa, Rienk, Altevogt, Peter, Umansky, Viktor, and Utikal, Jochen

Abstract

Additional file 3: Figure S2. Correlation of high SCG2 expression with decreased MHC class I surface presentation on melanoma cells.

Published
2023
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22. Additional file 1 of Secretogranin II influences the assembly and function of MHC class I in melanoma

Author

Steinfass, Tamara, Poelchen, Juliane, Sun, Qian, Mastrogiulio, Giovanni, Novak, Daniel, Vierthaler, Marlene, Pardo, Sandra, Federico, Aniello, Hüser, Laura, Hielscher, Thomas, Carretero, Rafael, Offringa, Rienk, Altevogt, Peter, Umansky, Viktor, and Utikal, Jochen

Abstract

Additional file 1: Table S1. KEGG pathway analysis showing pathways predicted to be decreased in WM266-4 and C32 SCG2 OE melanoma cells compared to their control (EV). Table S2. Gene ontology pathway analysis showing pathways predicted to be decreased in WM266-4 and C32 SCG2 OE melanoma cells compared to their control (EV). Table S3. Reactome pathway analysis showing pathways predicted to be decreased in WM266-4 and C32 SCG2 OE melanoma cells compared to their control (EV).

Published
2023
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26. Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression.

Author

Zabransky DJ, Chhabra Y, Fane ME, Kartalia E, Leatherman JM, Hüser L, Zimmerman JW, Delitto D, Han S, Armstrong TD, Charmsaz S, Guinn S, Pramod S, Thompson ED, Hughes SJ, O'Connell J, Egan JM, Jaffee EM, and Weeraratna AT

Subjects
Animals, Mice, Growth Differentiation Factor 15 genetics, Growth Differentiation Factor 15 therapeutic use, Proto-Oncogene Proteins c-akt, Pancreas pathology, Fibroblasts pathology, Tumor Microenvironment, Cell Line, Tumor, Pancreatic Neoplasms pathology, Cancer-Associated Fibroblasts pathology
Abstract

Pancreatic cancer is more prevalent in older individuals and often carries a poorer prognosis for them. The relationship between the microenvironment and pancreatic cancer is multifactorial, and age-related changes in nonmalignant cells in the tumor microenvironment may play a key role in promoting cancer aggressiveness. Because fibroblasts have profound impacts on pancreatic cancer progression, we investigated whether age-related changes in pancreatic fibroblasts influence cancer growth and metastasis. Proteomics analysis revealed that aged fibroblasts secrete different factors than young fibroblasts, including increased growth/differentiation factor 15 (GDF-15). Treating young mice with GDF-15 enhanced tumor growth, whereas aged GDF-15 knockout mice showed reduced tumor growth. GDF-15 activated AKT, rendering tumors sensitive to AKT inhibition in an aged but not young microenvironment. These data provide evidence for how aging alters pancreatic fibroblasts and promotes tumor progression, providing potential therapeutic targets and avenues for studying pancreatic cancer while accounting for the effects of aging., Significance: Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer microenvironment in driving tumor progression. See related commentary by Isaacson et al., p. 1185., (©2024 American Association for Cancer Research.)

Published
2024
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