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21 results on '"Hajdu, Steven"'

5. Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

Author

Genchi, Angela, Semerano, Aurora, Schwarz, Ghil, Dell’Acqua, Beatrice, Gullotta, Giorgia Serena, Sampaolo, Michela, Boeri, Enzo, Quattrini, Angelo, Sanvito, Francesca, Diamanti, Susanna, Bergamaschi, Andrea, Grassi, Stefano, Podini, Paola, Panni, Pietro, Michelozzi, Caterina, Simionato, Franco, Scomazzoni, Francesco, Remida, Paolo, Valvassori, Luca, Falini, Andrea, Ferrarese, Carlo, Michel, Patrik, Saliou, Guillaume, Hajdu, Steven, Beretta, Simone, Roveri, Luisa, Filippi, Massimo, Strambo, Davide, Martino, Gianvito, and Bacigaluppi, Marco

Published
2022
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7. Absorbable gelatin compressed sponge (Gelfoam) embolization of distal external carotid artery branches in intra- arterial chemotherapy for retinoblastoma.

Author

Akkari, Fouad Georges, Stathopoulos, Christina, Puccinelli, Francesco, Hajdu, Steven D., Beck-Popovic, Maja, Munier, Francis L., Saliou, Guillaume, and Bartolini, Bruno

Subjects
CAROTID artery surgery, RETINAL detachment, OPHTHALMIC artery, PATIENT safety, THERAPEUTIC embolization, TREATMENT effectiveness, CANCER chemotherapy, RETINOBLASTOMA, LONGITUDINAL method, SURGICAL sponges, INTRA-arterial infusions, PATHOLOGIC neovascularization
Abstract

Background In intra-arterial chemotherapy for retinoblastoma, a backflow from unreachable external carotid artery branches in the ophthalmic artery can be challenging. Objective To describe a new endovascular technique using Gelfoam pledgets to temporarily occlude distal branches of the external carotid artery to reverse the competitive backflow into the ophthalmic artery in order to perform intra-arterial chemotherapy via the ostium of the ophthalmic artery in selected cases. Methods We queried our prospectively collected database of 327 consecutive patients treated for retinoblastoma by intra-arterial chemotherapy and identified those employing Gelfoam pledgets. We describe this new technique with emphasis on feasibility and safety. Results We treated 11 eyes with 14 infusions of intra-arterial chemotherapy using Gelfoam pledgets to occlude the distal branches of the external carotid artery. We report no perioperative complications due to this occlusion technique. At the ophthalmologic follow-up 1 month after the injection of Gelfoam pledgets, all cases showed tumor regression or stable disease. Two injections into the same eye as the rescue intra-arterial chemotherapy infusion resulted in a transient exudative retinal detachment, and one injection in a heavily pretreated case was followed by iris neovascularization and retinal ischemia. None of the pledget injections led to irreversible vision-threatening intraocular complications. Conclusions Intra-arterial chemotherapy in retinoblastoma using Gelfoam to transiently occlude the distal branches of the external carotid artery and reverse the backflow into the ophthalmic artery seems feasible and safe. Larges series will help to confirm the effectiveness of this new technique. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Cerebral Thrombus Analysis in Infective Endocarditis: Unveiling Composition for Diagnostic Insight

Author

Semerano, Aurora, primary, Dell Acqua, Beatrice, additional, Montano, Manuel, additional, Sanvito, Francesca, additional, Genchi, Angela, additional, Schwarz, Ghil, additional, Bergamaschi, Andrea, additional, Sampaolo, Michela, additional, Gullotta, Giorgia Serena, additional, Falini, Andrea, additional, Panni, Pietro, additional, Agostoni, Elio Clemente, additional, Saliou, Guillaume, additional, Hajdu, Steven David, additional, Roveri, Luisa, additional, Michel, Patrik, additional, Martino, Gianvito, additional, Filippi, Massimo, additional, Strambo, Davide, additional, and Bacigaluppi, Marco, additional

Published
2023
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13. Perfusion Imaging and Clinical Outcome in Acute Minor Stroke With Large Vessel Occlusion

Author

Seners, Pierre, primary, Arquizan, Caroline, additional, Fontaine, Louis, additional, Ben Hassen, Wagih, additional, Heldner, Mirjam R., additional, Strambo, Davide, additional, Nagel, Simon, additional, Carrera, Emmanuel, additional, Mechtouff, Laura, additional, McCullough-Hicks, Margy, additional, Mohammaden, Mahmoud H., additional, Cottier, Jean-Philippe, additional, Henon, Hilde, additional, Aignatoaie, Andreea, additional, Laksiri, Nadia, additional, Papassin, Jérémie, additional, Lucas, Ludovic, additional, Garnier, Pierre, additional, Triquenot, Aude, additional, Mione, Gioia, additional, Hajdu, Steven, additional, Costalat, Vincent, additional, Potreck, Arne, additional, Detante, Olivier, additional, Bonneville, Fabrice, additional, Berthezene, Yves, additional, Bracard, Serge, additional, Sibon, Igor, additional, Bricout, Nicolas, additional, Boutet, Claire, additional, Mordasini, Pasquale, additional, Michel, Patrik, additional, Oppenheim, Catherine, additional, Olivot, Jean-Marc, additional, Nogueira, Raul G., additional, Albers, Gregory W., additional, Baron, Jean-Claude, additional, Turc, Guillaume, additional, Cognard, Christophe, additional, Marnat, Gaultier, additional, Menegon, Patrice, additional, Ledure, Sylvain, additional, Dargazanli, Cyril, additional, Cho, Tae-Hee, additional, Nighoghossian, Norbert, additional, Eker, Omer, additional, Gouttard, Sylvain, additional, Haussen, Diogo, additional, Debiais, Séverine, additional, Charron, Vladimir, additional, Charron, Nicolas, additional, Leys, Didier, additional, Ozsancak, Canan, additional, Delpech, Mathilde, additional, Brunel, Hervé, additional, Papagiannaki, Chrysanti, additional, Girardin, Emmanuel, additional, Richard, Sébastien, additional, Gory, Benjamin, additional, Zbinden, Martin, additional, Dobrocky, Tomas, additional, Ringelb, Peter, additional, and Möhlenbruch, Markus, additional

Published
2022
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14. Additional file 2 of Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

Author

Genchi, Angela, Semerano, Aurora, Schwarz, Ghil, Dell���Acqua, Beatrice, Gullotta, Giorgia Serena, Sampaolo, Michela, Boeri, Enzo, Quattrini, Angelo, Sanvito, Francesca, Diamanti, Susanna, Bergamaschi, Andrea, Grassi, Stefano, Podini, Paola, Panni, Pietro, Michelozzi, Caterina, Simionato, Franco, Scomazzoni, Francesco, Remida, Paolo, Valvassori, Luca, Falini, Andrea, Ferrarese, Carlo, Michel, Patrik, Saliou, Guillaume, Hajdu, Steven, Beretta, Simone, Roveri, Luisa, Filippi, Massimo, Strambo, Davide, Martino, Gianvito, and Bacigaluppi, Marco

Abstract

Additional file 2: Table S1: General clinical, radiological and laboratory characteristics and comparison between COVID-19 patients and pre-infection LVO stroke patients.

Published
2022
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15. Additional file 1 of Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

Author

Genchi, Angela, Semerano, Aurora, Schwarz, Ghil, Dell���Acqua, Beatrice, Gullotta, Giorgia Serena, Sampaolo, Michela, Boeri, Enzo, Quattrini, Angelo, Sanvito, Francesca, Diamanti, Susanna, Bergamaschi, Andrea, Grassi, Stefano, Podini, Paola, Panni, Pietro, Michelozzi, Caterina, Simionato, Franco, Scomazzoni, Francesco, Remida, Paolo, Valvassori, Luca, Falini, Andrea, Ferrarese, Carlo, Michel, Patrik, Saliou, Guillaume, Hajdu, Steven, Beretta, Simone, Roveri, Luisa, Filippi, Massimo, Strambo, Davide, Martino, Gianvito, and Bacigaluppi, Marco

Subjects
cardiovascular diseases
Abstract

Additional file 1: Figure S1. Structural and immune characterization of thrombi of stroke patients with COVID-19 or pre-existing infections. (A) Characterization of the structural components. RBCs+ area median [IQR] in thrombi of COVID-19: 62.9 [IQR 25.9-73.8] and pre-infections stroke patients: 42.6 [IQR 30.4-58.5]; p=0.73; CD61+ area in thrombi of COVID-19: 41 [IQR 13-48] and pre-infections stroke patients: 25 [IQR 15.1-43.9]; p=0.68; vWF+ area in thrombi of COVID-19: 33 [IQR 20.8-41.5] and pre-inf: 43 [IQR 35.3-50]; p=0.19; Fibrin+ area in COVID-19: 27.1 [IQR 9.2-50.4] and pre-infections stroke patients: 8.8 [IQR 2.6-33.4]; p=0.15, Mann Whitney. (B) Characterization of the immune cell signature. Neutrophil number, MPO+ cells/mm2, median [IQR], in thrombi of COVID-19: 2110 [IQR 1754-2580] and pre-infections stroke patients: 985.1 [IQR 690.7-1573] p=0.008; NET content, CitH3+ area in thrombi of COVID-19: 8.4 [IQR 6.6-50.7] and pre-infections stroke patients: 12.2 [IQR 4.1-32.2] p=0.69; T cells number, CD3+ cells/mm2 in thrombi of COVID-19: 61.6 [IQR 48.1-91.6] and pre-infections stroke patients: 117.4 [IQR 31.7-144.9] p=0.92; B cells number, CD20+ cells/mm2 in thrombi of COVID-19: 6.3 [IQR 5.2-14.3] and pre-infections stroke patients: 20.8 [IQR 6.6-32.6] p=0.17, Mann Whitney. (C) Neutrophil to lymphocyte ratio (tNLR) in thrombi of COVID-19: 30.3 [IQR 25.9-44.4] and pre-infections stroke patients: 8.2 [IQR 5.9-19.1] p=0.02; macrophages number, CD68 PGM1+ cells/mm2 in thrombi of COVID-19: 623.4 [IQR 455.9-1588] and pre-infections stroke patients: 580 [IQR 206.7-1639] p=0.54; complement C5b-C9+ area in thrombi of COVID-19: 0.1028 [IQR 0.013- 0.206] and pre-infections stroke patients: 0.037 [IQR 0.004- 0.762] p=0.918, Mann Whitney. C. Quantification of ACE2 (median [IQR]) ACE2+ area in thrombi of COVID-19: 0.05 [IQR 0.01-0.06] and pre-infections stroke patients: 0.5 [IQR 0.02-1.7] p=0.34 and endothelial cells, CD34+ area in thrombi of COVID-19: 0.23 [IQR 0.12-0.71] and pre-infections stroke patients: 0.07 [IQR 0.05-0.24] p=0.06, Mann Whitney. The graphs represent the median and IQR, each dot in the scatter plot represents the thrombus of one patient, n=7 and n=8-10 for thrombi of COVID-19 and pre-infection stroke patients respectively.

Published
2022
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18. ASPECTS-based selection for late endovascular treatment: a retrospective two-site cohort study.

Author

Nannoni, Stefania, Kaesmacher, Johannes, Ricciardi, Federico, Strambo, Davide, Dunet, Vincent, Hajdu, Steven, Saliou, Guillaume, Mordasini, Pasquale, Hakim, Arsany, Arnold, Marcel, Gralla, Jan, Fischer, Urs, and Michel, Patrik

Subjects
ENDOVASCULAR surgery, INTERNAL carotid artery, STROKE patients
Abstract

Introduction: The DAWN trial demonstrated the effectiveness of late endovascular treatment in acute ischemic stroke patients selected on the basis of a clinical-core mismatch. We explored in a real-world sample of endovascular treatment patients if a clinical-ASPECTS (Alberta Stroke Program Early CT Score) mismatch was associated with an outcome benefit after late endovascular treatment. Methods: We retrospectively analyzed all consecutive acute ischemic stroke patients admitted 6–24 h after last proof of good health in two stroke centers, with initial National Institutes of Health Stroke Scale (NIHSS) ≥10 and an internal carotid artery or M1 occlusion. We defined clinical-ASPECTS mismatch as NIHSS ≥ 10 and ASPECTS ≥ 7, or NIHSS ≥ 20 and ASPECTS ≥ 5. We assessed the interaction between the presence of the clinical-ASPECTS mismatch and late endovascular treatment using ordinal shift analysis of the three-month modified Rankin Scale and adjusting for multiple confounders. Results: The included 337 patients had a median age of 73 years (IQR = 61–82), admission NIHSS of 18 (15–22), and baseline ASPECTS of 7 (5–9). Out of 196 (58.2%) patients showing clinical-ASPECTS mismatch, 146 (74.5%) underwent late endovascular treatment. Among 141 (41.8%) mismatch negative patients, late endovascular treatment was performed in 72 (51.1%) patients. In the adjusted analysis, late endovascular treatment was significantly associated with a better outcome in the presence of clinical-ASPECTS mismatch (adjusted odd ratio, aOR = 2.83; 95% confidence interval, CI: 1.48–5.58) but not in its absence (aOR = 1.32; 95%CI: 0.61–2.84). The p -value for the interaction term between clinical-ASPECTS mismatch and late endovascular treatment was 0.073. Conclusions: In our retrospective two-site analysis, late endovascular treatment seemed effective in the presence of a clinical-ASPECTS mismatch, but not in its absence. If confirmed in randomized trials, this finding could support the use of an ASPECTS-based selection for late endovascular treatment decisions, obviating the need for advanced imaging. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

Author

Angela Genchi, Aurora Semerano, Ghil Schwarz, Beatrice Dell’Acqua, Giorgia Serena Gullotta, Michela Sampaolo, Enzo Boeri, Angelo Quattrini, Francesca Sanvito, Susanna Diamanti, Andrea Bergamaschi, Stefano Grassi, Paola Podini, Pietro Panni, Caterina Michelozzi, Franco Simionato, Francesco Scomazzoni, Paolo Remida, Luca Valvassori, Andrea Falini, Carlo Ferrarese, Patrik Michel, Guillaume Saliou, Steven Hajdu, Simone Beretta, Luisa Roveri, Massimo Filippi, Davide Strambo, Gianvito Martino, Marco Bacigaluppi, Genchi, Angela, Semerano, Aurora, Schwarz, Ghil, Dell'Acqua, Beatrice, Gullotta, Giorgia Serena, Sampaolo, Michela, Boeri, Enzo, Quattrini, Angelo, Sanvito, Francesca, Diamanti, Susanna, Bergamaschi, Andrea, Grassi, Stefano, Podini, Paola, Panni, Pietro, Michelozzi, Caterina, Simionato, Franco, Scomazzoni, Francesco, Remida, Paolo, Valvassori, Luca, Falini, Andrea, Ferrarese, Carlo, Michel, Patrik, Saliou, Guillaume, Hajdu, Steven, Beretta, Simone, Roveri, Luisa, Filippi, Massimo, Strambo, Davide, Martino, Gianvito, Bacigaluppi, Marco, Genchi, A, Semerano, A, Schwarz, G, Dell'Acqua, B, Gullotta, G, Sampaolo, M, Boeri, E, Quattrini, A, Sanvito, F, Diamanti, S, Bergamaschi, A, Grassi, S, Podini, P, Panni, P, Michelozzi, C, Simionato, F, Scomazzoni, F, Remida, P, Valvassori, L, Falini, A, Ferrarese, C, Michel, P, Saliou, G, Hajdu, S, Beretta, S, Roveri, L, Filippi, M, Strambo, D, Martino, G, and Bacigaluppi, M

Subjects
Male, Mechanical Thrombolysis, Neutrophils, Brain Ischemia, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Humans, Endovascular treatment, Prospective Studies, cardiovascular diseases, RC346-429, Aged, Aged, 80 and over, Immunity, Cellular, Ischemic stroke, SARS-CoV-2, Research, Neutrophil, COVID-19, Thrombosis, Angiotensin-Converting Enzyme 2/blood, Angiotensin-Converting Enzyme 2/genetics, Angiotensin-Converting Enzyme 2/immunology, Brain Ischemia/blood, Brain Ischemia/genetics, Brain Ischemia/immunology, COVID-19/blood, COVID-19/genetics, COVID-19/immunology, Female, Immunity, Cellular/physiology, Intracranial Thrombosis/blood, Intracranial Thrombosis/genetics, Intracranial Thrombosis/immunology, Mechanical Thrombolysis/methods, Middle Aged, Neutrophils/immunology, Neutrophils/metabolism, SARS-CoV-2/genetics, SARS-CoV-2/immunology, SARS-CoV-2/metabolism, Stroke/blood, Stroke/genetics, Stroke/immunology, SARS-CoV2, Stroke, Thrombosi, Neurology. Diseases of the nervous system, Angiotensin-Converting Enzyme 2, Neurology (clinical), Intracranial Thrombosis
Abstract

Coronavirus disease 2019 (COVID-19) is associated with an increased risk of thrombotic events. Ischemic stroke in COVID-19 patients entails high severity and mortality rates. Here we aimed to analyze cerebral thrombi of COVID-19 patients with large vessel occlusion (LVO) acute ischemic stroke to expose molecular evidence for SARS-CoV-2 in the thrombus and to unravel any peculiar immune-thrombotic features. We conducted a systematic pathological analysis of cerebral thrombi retrieved by endovascular thrombectomy in patients with LVO stroke infected with COVID-19 (n = 7 patients) and non-covid LVO controls (n = 23). In thrombi of COVID-19 patients, the SARS-CoV-2 docking receptor ACE2 was mainly expressed in monocytes/macrophages and showed higher expression levels compared to controls. Using polymerase chain reaction and sequencing, we detected SARS-CoV-2 Clade20A, in the thrombus of one COVID-19 patient. Comparing thrombus composition of COVID-19 and control patients, we noted no overt differences in terms of red blood cells, fibrin, neutrophil extracellular traps (NETs), von Willebrand Factor (vWF), platelets and complement complex C5b-9. However, thrombi of COVID-19 patients showed increased neutrophil density (MPO+ cells) and a three-fold higher Neutrophil-to-Lymphocyte Ratio (tNLR). In the ROC analysis both neutrophils and tNLR had a good discriminative ability to differentiate thrombi of COVID-19 patients from controls. In summary, cerebral thrombi of COVID-19 patients can harbor SARS-CoV2 and are characterized by an increased neutrophil number and tNLR and higher ACE2 expression. These findings suggest neutrophils as the possible culprit in COVID-19-related thrombosis. Graphical Abstract

Published
2022

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