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Taking my trip to a maternity ward to visit my newborn niece as a "clinical case," I visit the phenomenon of digitally surveilling neonates with the self-same devices that were designed to enforce the house-arrest of would-be felons whose noisy place in the cultural imaginary has rendered the neonate's ankle a transgenerational "risk object" in the unconscious collective. In conversation with the ever-emergent genre known as autotheory, I invite the reader to be an accomplice as I "dramatize my unsettlement" contrasting autotheory with Laplanchean "self-theorization" via interludes about temporality, expertise, birth, gender, race, and place that come to life in the tale of The Stork. [ABSTRACT FROM AUTHOR]

With the republication of Adrienne Harris' classic essay, "You must remember this" (Harris, 2009), Psychoanalytic Dialogues continues our new feature, Après Coup. By putting a paper from the early years of the journal in conversation with contemporary readers and writers, we hope to dive into the ways in which psychoanalysts forge relationality in spaces of complexity and contradiction over time, as our experiences- collective, dyadic, or solitary – are always nonlinear and multiply configured. This Apres Coup includes commentaries by Cleonie White, Ph.D. Ken Corbett, Ph.D. Shubha Herlekar, Psy.D. MFT, Victor Donas, M.D. Donnel Stern, Ph.D. and Giuseppe Civitarese, M.D. Ph.D. [ABSTRACT FROM AUTHOR]

Psychoanalytic Dialogues is proud to present a groundbreaking panel on autotheory that pairs Leigh Lyndon's essay, The Ice is Melting, with responses by Gila Ashtor, Masha Borovikova Armyn, Adam Blum, and Maxine Chung Chow. In this brief introduction, autotheory is introduced to frame an emergent conversation that launches from the page, through the potential space carved by readers and writers, to forge an ever more open-source mode of sharing personal experience. [ABSTRACT FROM AUTHOR]

The article discusses the historical hierarchy and division of tasks among mental health practitioners in the United States, particularly in psychoanalytic settings. It highlights the role of psychiatrists as team leaders and primary investigators, social workers as attending to systems, and psychologists as data scientists. The article emphasizes the need to move away from these hierarchical structures and embrace diversity in personal and professional backgrounds and practices. It also explores the themes of belonging, home, and transformation in the context of a chaotic and unsettled world. The article includes personal reflections, autotheoretical essays, and discussions on the work of Adrienne Harris. [Extracted from the article]

The article discusses the concept of arriving and not arriving alone, as well as the importance of being counted in various aspects of life. It explores the obstacles, challenges, risks, and rewards of belonging and changing one's circumstances. The issue of Psychoanalytic Dialogues presented in the article includes panels that delve into the questions of arriving at new emotional, material, political, and social places and what counts in those situations. The article also highlights the work of David Eng and Shinhee Han on racial melancholia and their exploration of the Asian triple consciousness. Additionally, it discusses Stephen Hartman's examination of digitally surveilling neonates and the politics of theory, as well as the papers by Bettina von Lieres and Afarin Kohan on political activation and trauma work. The article concludes by emphasizing the intersections of politics, action, and trauma and the potential for psychoanalysis to shed light on these areas. [Extracted from the article]

The article discusses the process of producing a peer-reviewed journal and the importance of representing a range of voices and perspectives within the field of psychoanalysis. The concept of "holding the center" is explored, which involves fostering controversy and comparative thought while respecting different theoretical schools and interpretations of core concepts. The article also highlights the diverse and chaotic world in which we live and the need to feature a variety of voices to stretch beyond complacency and demagoguery. The issue of Psychoanalytic Dialogues presented in the article includes panels on topics such as splitting, the more-than-human in psychoanalytic theory, the work of Françoise Dolto, and the impact of socio-political trauma on the psyche. [Extracted from the article]

Biliary atresia (BA) is the leading indication for pediatric liver transplantation. Rhesus rotavirus (RRV)-induced murine BA develops an obstructive cholangiopathy that mirrors the human disease. We have previously demonstrated the "SRL" motif on RRV's VP4 protein binds to heat shock cognate 70 protein (Hsc70) facilitating entry into cholangiocytes. In this study, we analyzed how binding to Hsc70 affects viral endocytosis, intracellular trafficking, and uniquely activates the signaling pathway that induces murine BA. Inhibition of clathrin- and dynamin-mediated endocytosis in cholangiocytes following infection demonstrated that blocking dynamin decreased the infectivity of RRV, whereas clathrin inhibition had no effect. Blocking early endosome trafficking resulted in decreased viral titers of RRV, whereas late endosome inhibition had no effect. After infection, TLR3 expression and p-NF-κB levels increased in cholangiocytes, leading to increased release of CXCL9 and CXCL10. Infected mice knocked out for TLR3 had decreased levels of CXCL9 and CXCL10, resulting in reduced NK cell numbers. Human patients with BA experienced an increase in CXCL10 levels, suggesting this as a possible pathway leading to biliary obstruction. Viruses that use Hsc70 for cell entry exploit a clathrin-independent pathway and traffic to the early recycling endosome uniquely activating NF-κB through TLR3, leading to the release of CXCL9 and CXCL10 and inducing NK cell recruitment. These results define how the "SRL" peptide found on RRV's VP4 protein modulates viral trafficking, inducing the host response leading to bile duct obstruction. NEW & NOTEWORTHY In this study, we have determined that the presence of the "SRL" peptide on RRV alters its method of endocytosis and intracellular trafficking through viral binding to heat shock cognate 70 protein. This initiates an inflammatory pathway that stimulates the release of cytokines associated with biliary damage and obstruction.

Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in hepatocellular carcinoma (HCC). GPC3 undergoes extensive posttranslational modification (PTM) including cleavage and glycosylation. This review focuses on the structure and function of GPC3 in liver cancer, highlighting the PTM of the tertiary and quaternary structures of GPC3 as a potential oncogenic regulatory mechanism. We propose that the function of GPC3 in normal development can vary with extensive PTM and that dysregulation of these processes leads to disease. Defining the regulatory impact of these modifications can provide a deeper understanding of the role of GPC3 in oncogenesis, epithelial-mesenchymal transition, and drug development. Through review of current literature, this article provides a unique perspective on the role of GPC3 in liver cancer, focusing on potential regulatory mechanisms of PTM on GPC3 function at the molecular, cellular, and disease level., (©2023 The Authors; Published by the American Association for Cancer Research.)