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Background: The skin condition of women is different at different ages, and skin surface lipids are also different. According to the "7–7 theory" of the Huangdi Neijing, the physiological condition of women changes significantly every 7 years, and women aged 22–28 are in the "4–7" stage as mentioned in the "7–7 theory" of the Huangdi Neijing. Women's skin is in different states at different ages and produces different lipids. Objectives: To explore the key lipids that contribute to skin differences between women aged 22–28 and 29–35 years, and to explore the relationship with physiological parameters and daily routine. Methods: Differential lipids were detected and screened between 22–28 year old (group D1) and 29–35 year old (group D2) dry‐skinned women using UPLC‐Q‐TOF‐MS and correlated between the two groups with questionnaires and physiological parameters based on basic information, lifestyle habits, work situation, and emotional stress. Results: The results showed that all of the eight major classes of lipids had the highest expression in the D2 group, with the largest differences in glycerophospholipids, glycerol esters, and fatty acids. The BMI value of D2 group was higher than that of D1 group, the skin elasticity index (R2) and brightness index (L, a, ITA values) were lower than that of D1 group, and Cer (d18:0/16:0) was positively correlated with the R2, L, a, and ITA, and LMSP01080056 (N,N‐dimethyl‐Safingol) was positively correlated with the b‐value, the LMSPGP03020013, LMSPGP03020014, LMSP03020024 were significantly negatively correlated with R2. Conclusions: Cer(d18:0/16:0) is a neurosphingol that inhibits elastase expression. N,N‐dimethyl‐Safingol readily undergoes oxidation to form yellow‐brown solids. The macromolecular structure and excessive carbonyl structure of [LMGP0302] are susceptible to cross‐linking and carbonyl stress reactions, which accelerate skin aging and reduce skin elasticity, and thus, they may be key lipids contributing to skin differences between the two age groups. [ABSTRACT FROM AUTHOR]

Background: Skin microbiota are involved in the skin physiological functions and are also affected by the skin physiological characteristics. Objective: To better understand the skin microbial characteristics of facial cheek skin and the relationship with skin physiological characteristics. Methods: By bacterial 16S rRNA gene sequencing, the authors studied the facial cheek skin microbial characteristics of 85 cases of young women aged 18‐25 years. Results: Healthy young woman's cheek skin bacterial composition was relatively stable. Dry skin has high bacterial diversity and richness, and oily skin has low bacterial diversity and richness. Cutibacterium was significantly enriched in oily skin and was significantly negatively correlated with other genera such as Streptococcus (r > 0.5). There were significant positive correlations among other genera of enrichment in dry and neutral skin such as Streptococcus and Rothia (r > 0.8). Skin sebum level was significantly negatively correlated with bacterial alpha diversity index. The combined abundance of Cutibacterium acnes and Staphylococcus epidermidis was significantly positively correlated with sebum secretion (r > 0.5). Conclusions: The skin sebum secretion and bacterial interaction were the important factors driving the young females' cheek skin bacterial community structure. [ABSTRACT FROM AUTHOR]