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In this study, the data of fertility indicators of soil samples (0–20 cm) in 1980s, 2000 and 2015 in Chenzhou city were used, and the soil integrated fertility index (IFI) was calculated. The results showed that the soil pH was decreased, total nitrogen (TN), organic matter (OM), available phosphorus (AP) and potassium (AK), exchangeable calcium (Ca2+), magnesium (Mg2+) and available copper (Cu) contents were increased, total phosphorus (TP), available sulfur (S) and water-soluble chlorine (Cl−) contents were decreased, total potassium (TK), available boron (B), iron (Fe), manganese (Mn) and zinc (Zn) were decreased first and then increased. In 2015, most of the fields were higher in pH, OM, TN, AN, AK, Ca2+, Mg2+, S, Fe, Mn, Cu and Zn, suitable in B, but lower in TP, AP, TK, available molybdenum (Mo) and Cl−. Most of the fields were in the middle grade of IFI in 2000 and 2015, and the mean IFI increased from 0.492 to 0.556 from 2000 to 2015. Thus, for soil improvement, more attention should be paid to adjust soil pH, reduce the application of organic, nitrogen and calcium fertilizers, while increase the fertilizer application of other nutrients.

Taking the 8105 working face of Madaotou Mine as the engineering background, the numerical calculation model of the flow field of the mining face in the extra-thick and spontaneous coal seam was established to analyze the oxygen consumption rate in the goaf, the air intake volume of the working face, and the nitrogen injection(nitrogen injection amount and nitrogen injection position) of the buried pipe in the goaf on the distribution of oxygen concentration in the stope. The research results show that: the low-oxygen environment produced by low-temperature oxidation of the residual coal in the goaf is the precondition of oxygen deficiency in upper corner of working face; with the oxygen consumption rate increases, the oxygen concentration near the working face and the upper corner decreases, and the upper corner oxygen-poor area gradually expands. With the increase of the air intake of the working face, the oxygen concentration of the working face gradually increases, the oxygen concentration of the upper corner gradually decreases, and the oxygen-poor area gradually increases. When the air inlet is greater than 2 778 m3/min, the oxygen-poor area in the upper corner tends to be stable, but the oxygen concentration is still gradually decreasing. With the increase of nitrogen injection amount, the oxygen concentration of the working face and the upper corner drops rapidly. When the nitrogen injection amount is greater than 2 825 m3/h, the pressure of the nitrogen injection port and the working face is out of balance, and a large amount of nitrogen flows into the working face to form low oxygen environment, and at the same time, the degree of oxygen depletion near the upper corner is aggravated; with the depth of the nitrogen injection position, the oxygen concentration of the working face and the upper corner changes little.

Chromodomain helicase DNA-binding protein (CHD) gene family, an ATP (adenosine triphosphate) -dependent chromatin remodeler family, is involved in multiple developmental process and tumor development. However, there have been none pan-cancer analyses of this family. The expression levels, survival profiles, mutation profiles and immune infiltration of the CHD family genes from TCGA and TARGET database were analyzed using online tools or R packages. Interestingly, all types of CHD gene expressions were associated with the prognosis of Neuroblastoma, Acute lymphoblastic leukemia-Phase 3 and Acute Myeloid Leukemia (All P < 0.05). Knock down of CHD7 and CHD9 in K562 (human erythromyeloblastoid leukemia) and HEC-1-B (human endometrial adenocarcinoma) cells significantly inhibit cell proliferation and migration (P < 0.05). Proliferation, colony formation and migration assays were performed in CHD7 and CHD9 knockdown K562 and HBC-1-B cell lines. Mechanisms were also analyzed by PPI and GO ontology for our experiments. Histone modification, especially the methylation of H3K4, might be involved in CHD7 and CHD9 related oncogenesis. Through bioinformatic analysis, we showed CHD genes significantly affected the prognosis of different tumor types, including childhood tumor. Our findings provide new insights into the function and mechanism of CHD gene family, especially in CHD7 and CHD9. [ABSTRACT FROM AUTHOR]

With the successful application of artificial intelligence technology in various fields, deep reinforcement learning (DRL) algorithms have applied in active corrective control in the power system to improve accuracy and efficiency. However, the "black-box" nature of deep reinforcement learning models reduces their reliability in practical applications, making it difficult for operators to comprehend the decision-making mechanism. process of these models, thus undermining their credibility. In this paper, a DRL model is constructed based on the Markov decision process (MDP) to effectively address active corrective control issues in a 36-bus system. Furthermore, a feature importance explainability method is proposed, validating that the proposed feature importance-based explainability method enhances the transparency and reliability of the DRL model for active corrective control. [ABSTRACT FROM AUTHOR]

Background and Aims: The effectiveness of immune checkpoint inhibitors (ICIs) in low programmed death ligand 1 (PD‐L1) expression in cervical cancer (CC) patients remains unknown. We aimed to evaluate the efficacy of ICIs in low PD‐L1 expression CC patients. Methods: The study is an individual patient data (IPD)‐based meta‐analysis. IPD were compiled through KMSubtraction and IPDfromKM methodologies from high‐quality randomized clinical trials and single‐arm studies which reported overall survival (OS) or progression‐free survival (PFS) stratified by PD‐L1 expression. Kaplan−Meier curves and Cox regression analysis were employed to evaluate the survival benefits of ICIs. Results: A total of eight studies and 1110 cases were included in the analysis. Within the low PD‐L1 expression subgroup, ICI combination therapy, but not ICI monotherapy, demonstrated significant OS benefits over non‐ICI treatment (hazard ratio [HR] = 0.61, 95% confidence interval [CI]: 0.36−1.04, p = 0.06). Concerning PFS, ICI monotherapy was associated with a negative effect compared to non‐ICI treatment (HR = 4.59, 95% CI: 2.32−9.07, p < 0.001). Notably, both OS and PFS outcomes were unfavorable for ICI monotherapy compared to both non‐ICI and ICI combination therapy in the combined positive score <1 subgroup (OS: HR = 2.60, 95% CI: 1.31−5.16, p = 0.008; PFS: HR = 7.59, 95% CI: 3.53−16.31, p < 0.001). Conclusion: In patients with CC and low PD‐L1 expression, ICI monotherapy may not be considered as the optimal treatment strategy when compared to non‐ICI treatment or ICI combination therapy. Registration: CRD42023395103. [ABSTRACT FROM AUTHOR]

This paper presents the investigation results of a base-isolated RC frame-shear wall structure located in Luding County, Sichuan Province, China, which was damaged by a Ms 6.8 earthquake on September 5, 2022. This recently constructed school office building was about 9 km away from the epicenter. The isolation layer of this building consists of 54 rubber bearings and 12 viscous dampers. These viscous dampers or their connections failed during the earthquake, and the limit state included connection breaking or global buckling of the damper. Also, the superstructure suffered some minor damage. To investigate the cause of structural damages, a nonlinear time-history analysis is conducted using the ground motions recorded by four seismic stations close to the building. The onsite investigation and numerical simulation results revealed the possible reasons for the failure. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to investigate the value of electrocardiograms (ECGs) and serological examinations in the differential diagnosis of acute pulmonary embolism (APE) and acute non-ST elevation myocardial infarction (NSTEMI) in order to reduce the rate of clinical misdiagnosis.Methods: The clinical data of 37 patients with APE and 103 patients with NSTEMI admitted to our hospital were retrospectively analyzed. The differences in the clinical manifestations, ECGs, myocardial zymograms, D-dimers, and troponin (cTn) of the two groups were compared.Results: In the patients with APE, the main symptom-found in 25 cases (67.56%)-was dyspnea, while in the patients with NSTEMI, the main symptom-found in 52 cases (50.49%)-was chest tightness. The incidences of sinus tachycardia and SI QIII TIII in the group of patients with APE were higher than in the group of patients with NSTEMI, and the difference was statistically significant (p < .05). There was no statistical significance in the difference of aspartate aminotransferase and lactate dehydrogenase (LDH) in the two groups (p > .05), although there was a statistically significant difference of creatine kinase (CK) and the creatine kinase isoenzyme-MB (CK-MB) in the two groups (p < .05). The levels of D-dimers and cTn were increased in both groups, but the level of D-dimers in the group of patients with APE was higher than that in the group of patients with NSTEMI.Conclusion: With the occurrence of clinical manifestations like dyspnea, chest tightness, chest pain, and palpitation of unknown causes, the possibility of APE and NSTEMI should be considered. [ABSTRACT FROM AUTHOR]

In order to further improve the efficiency of mine dust reduction, this paper focuses on a new ultrasonic atomization dust reduction method based on the heterogeneous condensation mechanism. The DPM and Mixture dual models are used to numerically simulate the motion flow field and dust diffusion in the ultrasonic atomization dust reduction device. The optimal solution of the parameters of the new ultrasonic atomization dust reduction device was obtained, and combined with the simulation results and the heterogeneous condensation mechanism, we developed an ultrasonic atomization dust reduction experiment platform and carried out the dust reduction experiment. The vertical distance and diameter of the dust suction port of the new ultrasonic atomization dust suppression device are the main factors that affect the air flow movement area and mode inside the device. In this experiment, the vertical distance of the dust suction port is 1.1 m, and the dust particles can fully communicate with each other when the diameter is 0.2 m. For water mist contact, the time of ultrasonic atomization to reduce dust is more suitable. The results show that the new ultrasonic atomization dust reduction method has good atomization and dust reduction performance, and the purification effect of respirable dust is particularly significant, and the dust reduction efficiency reaches 93.54%.

Objectives The study aimed to identify factors influencing the severity of primary immune thrombocytopenia (ITP) during pregnancy, develop a predictive model for treatment response, and report maternal and neonatal outcomes associated with severe ITP. Design A retrospective analysis was conducted on 155 pregnancies with severe ITP between January 2018 and April 2023 at a tertiary critical maternity referral center in Shanghai, China. Participants/Materials The study included 155 pregnancies diagnosed with severe ITP, divided into groups based on the lowest platelet count (&lt;30×109/L vs. 30-50×109/L) and first-line treatment response (Non-response vs. Response). Setting The study was conducted at Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, a tertiary critical maternity rescue referral center. Methods Clinical characteristics and outcomes were compared between groups. A multivariable logistic regression model was used to identify factors associated with the severity of ITP. A prediction model for treatment response was established using LASSO-logistic regression and internally validated. Results ITP severity was found to be correlated with low maximum amplitude (MA) of thrombelastography (TEG) (OR 5.43, 95% CI 1.48 to 16.00, p=0.002), bleeding events (OR 4.91, 95% CI 1.62 to 14.86, p=0.005), and low reticulocytes (OR 2.40×10-7, 95% CI 1.06×10-13 to 0.55, p=0.04). Of the 118 patients who received first-line therapy, 52 (44%) responded. The dataset was randomly split into a training (N=99) and test (N=23) set with a ratio of 8:2. A predictive nomogram was created and internally validated showing good discrimination. The model yielded an area under receiver operating characteristic curve (ROC) of 0.78 (0.69 to 0.87) and 0.85 (0.67 to 1.00) in the training and validation cohort, respectively. Earlier delivery and high rate of NICU admission occurred with severe ITP and treatment failure. Limitations The study was limited by a relatively small sample size and the retrospective observational design, which imposed limitations on the assessment of treatment efficacy. Conclusions We identified clinical predictors of ITP severity and treatment resistance during pregnancy. A nomogram predicting first-line response was validated. These findings can facilitate clinical decision-making and counseling regarding this challenging pregnancy complication., (The Author(s). Published by S. Karger AG, Basel.)