1. Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease
- Author
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Kui Toh Gerard Leong, Fazlur Jaufeerally, Carolyn S.P. Lam, Kai M. Eggers, Roberto Latini, Alberto Aimo, Robert N. Doughty, Hean Yee Ong, Josep Lupón, Inder S. Anand, Giuseppe Vergaro, Kurt Huber, Ida Gustafsson, Richard W. Troughton, Yasuchika Takeishi, Michele Emdin, Tze P. Ng, Lidia Staszewsky, Claudio Passino, Antoni Bayes-Genis, Akiomi Yoshihisa, James L. Januzzi, Poh Shuan Daniel Yeo, Rudolf A. de Boer, A. Mark Richards, Hans-Peter Brunner-La Rocca, Thor Ueland, Greg D. Gamble, Cardiovascular Centre (CVC), RS: Carim - H02 Cardiomyopathy, MUMC+: MA Med Staf Spec Cardiologie (9), and Cardiologie
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Gastroenterology ,Severity of Illness Index ,Pulmonary Disease ,Pulmonary Disease, Chronic Obstructive ,Troponin T ,Interquartile range ,Natriuretic Peptide ,Chronic Obstructive/mortality ,Internal medicine ,Forced Expiratory Volume ,Natriuretic Peptide, Brain ,medicine ,Natriuretic peptide ,Humans ,In patient ,Aged ,Troponin T/blood ,Heart Failure ,COPD ,Ejection fraction ,Heart Failure/mortality ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Comorbidity ,Interleukin-1 Receptor-Like 1 Protein ,Peptide Fragments ,Hospitalization ,Pulmonary Disease, Chronic Obstructive/mortality ,Heart failure ,Interleukin-1 Receptor-Like 1 Protein/blood ,Female ,Natriuretic Peptide, Brain/blood ,Brain/blood ,Cardiology and Cardiovascular Medicine ,business ,Peptide Fragments/blood ,Biomarkers ,Biomarkers/blood - Abstract
AIMS: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).METHODS: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.RESULTS: Patients had a median age of 66 years (interquartile interval 57-74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487-2725), 17 ng/l (9-31) and 30 ng/ml (22-44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P CONCLUSIONS: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.
- Published
- 2022