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Your search keyword '"Herse, Florian"' showing total 14 results
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14 results on '"Herse, Florian"'

1. Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts

Author

Brugger, Beatrice Anna, Neuper, Lena, Guettler, Jacqueline, Forstner, Désirée, Wernitznig, Stefan, Kummer, Daniel, Lyssy, Freya, Feichtinger, Julia, Krappinger, Julian, El-Heliebi, Amin, Bonstingl, Lilli, Moser, Gerit, Rodriguez-Blanco, Giovanny, Bachkönig, Olaf A., Gottschalk, Benjamin, Gruber, Michael, Nonn, Olivia, Herse, Florian, Verlohren, Stefan, Frank, Hans-Georg, Barapatre, Nirav, Kampfer, Cornelia, Fluhr, Herbert, Desoye, Gernot, and Gauster, Martin

Published
2023
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5. USING A MULTI-OMICS LANDSCAPE OF THE MATERNAL-FETAL INTERFACE TO MODEL THE LONGITUDINAL PATHOGENESIS OF EARLY-ONSET PRE-ECLAMPSIA

Author

Nonn, Olivia, primary, Debnath, Olivia, additional, Valdes, Daniela, additional, Frolova, Alina, additional, Haider, Sandra, additional, Verlohren, Stefan, additional, Thilaganathan, Basky, additional, Kaituu-lino, Tuuhevaha J, additional, Tong, Stephen, additional, Staff, Anne Cathrine, additional, Coscia, Fabian, additional, Müller, Dominik N., additional, Dechend, Ralf, additional, Gauster, Martin, additional, Ishaque, Naveed, additional, and Herse, Florian, additional

Published
2024
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6. PRENATAL DIAGNOSTIC OF PREECLAMPSIA

Author

Valdes, Daniela, primary, Andersen, Louise B., additional, Christesen, Henrik, additional, Jorgensen, Jan Stener, additional, Nonn, Olivia, additional, Kräker, Kristin, additional, Müller, Dominik N., additional, Dechend, Ralf, additional, and Herse, Florian, additional

Published
2024
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9. CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta

Author

Forstner, Désirée, primary, Guettler, Jacqueline, additional, Brugger, Beatrice A., additional, Lyssy, Freya, additional, Neuper, Lena, additional, Daxboeck, Christine, additional, Cvirn, Gerhard, additional, Fuchs, Julia, additional, Kraeker, Kristin, additional, Frolova, Alina, additional, Valdes, Daniela S., additional, Stern, Christina, additional, Hirschmugl, Birgit, additional, Fluhr, Herbert, additional, Wadsack, Christian, additional, Huppertz, Berthold, additional, Nonn, Olivia, additional, Herse, Florian, additional, and Gauster, Martin, additional

Published
2023
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11. PS-B05-11: IMPAIRED CELL INTERACTIONS AT THE PRE-ECLAMPTIC MATERNAL-FOETAL INTERFACE

Author

Nonn, Olivia, primary, Debnath, Olivia, additional, Valdes, Daniela, additional, Sallinger, Katja, additional, Secener, Ali Kerim, additional, Haider, Sandra, additional, Tiesmeyer, Sebastian, additional, Coscia, Fabian, additional, Heliebi, Amin El, additional, Tilaganathan, Basky, additional, Mueller, Dominik N, additional, Huppertz, Berthold, additional, Gauster, Martin, additional, Ishaque, Naveed, additional, and Herse, Florian, additional

Published
2023
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13. Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndrome

Author

Nonn, Olivia, primary, Debnath, Olivia, additional, Valdes, Daniela S., additional, Sallinger, Katja, additional, Secener, Ali Kerim, additional, Haider, Sandra, additional, Fischer, Cornelius, additional, Tiesmeyer, Sebastian, additional, Nimo, Jose, additional, Kuenzer, Thomas, additional, Maxian, Theresa, additional, Knöfler, Martin, additional, Karau, Philipp, additional, Bartolomaeus, Hendrik, additional, Kroneis, Thomas, additional, Frolova, Alina, additional, Neuper, Lena, additional, Haase, Nadine, additional, Kräker, Kristin, additional, Kedziora, Sarah, additional, Forstner, Désirée, additional, Verlohren, Stefan, additional, Stern, Christina, additional, Coscia, Fabian, additional, Sugulle, Meryam, additional, Jones, Stuart, additional, Tilaganathan, Basky, additional, Eils, Roland, additional, Huppertz, Berthold, additional, El-Heliebi, Amin, additional, Staff, Anne Cathrine, additional, Müller, Dominik N., additional, Dechend, Ralf, additional, Gauster, Martin, additional, Ishaque, Naveed, additional, and Herse, Florian, additional

Published
2022
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14. Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia.

Author

Nonn O, Debnath O, Valdes DS, Sallinger K, Secener AK, Fischer C, Tiesmeyer S, Nimo J, Kuenzer T, Ulrich J, Maxian T, Knöfler M, Karau P, Bartolomaeus H, Kroneis T, Frolova A, Neuper L, Haase N, Malt A, Müller-Bötticher N, Kräker K, Kedziora S, Forstner D, Eils R, Schmidt-Ullrich R, Haider S, Verlohren S, Stern C, Sugulle M, Jones S, Thilaganathan B, Kaitu'u-Lino TJ, Tong S, Huppertz B, El-Heliebi A, Staff AC, Coscia F, Müller DN, Dechend R, Gauster M, Ishaque N, and Herse F

Abstract

Background: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, and life-long sequelae. Understanding the pathogenesis of preeclampsia is a critical first step toward protecting mother and child from this syndrome and increased risk of cardiovascular disease later in life. However, effective early predictive tests and therapies for preeclampsia are scarce., Methods: To identify novel markers and signaling pathways for early onset preeclampsia, we profiled human maternal-fetal interface units (fetal villi and maternal decidua) from early onset preeclampsia and healthy controls using single-nucleus RNA sequencing combined with spatial transcriptomics. The placental syncytiotrophoblast is in direct contact with maternal blood and forms the barrier between fetal and maternal circulation., Results: We identified different transcriptomic states of the endocrine syncytiotrophoblast nuclei with patterns of dysregulation associated with a senescence-associated secretory phenotype and a spatial dysregulation of senescence in the placental trophoblast layer. Elevated senescence markers were validated in placental tissues of clinical multicenter cohorts. Importantly, several secreted senescence-associated secretory phenotype factors were elevated in maternal blood already in the first trimester. We verified the secreted senescence markers, PAI-1 (plasminogen activator inhibitor 1) and activin A, as identified in our single-nucleus RNA sequencing model as predictive markers before clinical preeclampsia diagnosis., Conclusions: This indicates that increased syncytiotrophoblast senescence appears weeks before clinical manifestation of early onset preeclampsia, suggesting that the dysregulated preeclamptic placenta starts with higher cell maturation resulting in premature and increased senescence-associated secretory phenotype release. These senescence-associated secretory phenotype markers may serve as an additional early diagnostic tool for this syndrome.

Published
2024
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