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At present, in drilling design and evaluation, the shape of hydraulic flushing hole is usually equivalent to cylinder, which is one of the important bases to determine the effective extraction radius. However, the shape of hole is subject to the joint action of many factors, so the scientific nature of the equivalent shape to cylinder remains to be discussed. By adopting the factors of gravity, friction, water force and in-situ stress of coal and rock mass, and introducing the parallel Bergmark-Roos equation and PKN model, the BR-PKN equation describing the pore shape is established, and the pore shape is reconstructed by MATLAB. In order to verify its accuracy, data are collected and analyzed by using YZD18.5 logging tool in the field, and the hole section is drawn. The equivalent ellipsoidal and cylindrical holes are simulated by COMSOL. The results show that the shape of the holes drawn by MATLAB is ellipsoid with different three axes. The shape of the drawn hole is basically consistent with that in MATLAB. Compared with cylindrical holes, the extraction radius, desorption surface area and effective extraction volume of quasi-ellipsoid holes are 93%, 80% and 117% respectively, which provides a basis for drilling layout.

Clarifying the impact of driving forces on multi-temporal-scale (annual, quarterly and monthly) runoff changes is of great significance for watershed water resource planning. Based on monthly runoff data and meteorological data of the Jialing River (JLR) during 1982–2020, the Mann–Kendall tendency testing approach was first applied to analyze variation tendencies of multi-timescale runoff. Then, abrupt variation years of runoff were determined using Pettitt and cumulative anomaly mutation testing approaches. The ABCD model was employed for simulating hydrological change processes in the base period and variation period. Finally, influences of climatic and anthropic factors on multi-scalar runoff were computed using the multi-scalar Budyko formula. The following conclusions were drawn in this study: (1) The mutation year of discharge was 1993; (2) the monthly runoff in the JLR presented a "single peak" distribution, and the concentration degree and concentration period in the JLR both showed an insignificant reduction trend; (3) anthropic factors were the dominant factor for spring runoff variations; climatic factors were the dominant factor on annual, summer, fall and winter runoff variations; (4) except for November, climatic factors were the dominant factor causing runoff changes in the other 11 months. This study has important reference value for water resource allocation and flood control decisions in the JLR. [ABSTRACT FROM AUTHOR]

Purpose: The crucial role of N6-methyladenosine (m6A) methylation in anti-tumor immunity and immunotherapy has been broadly depicted. However, the molecular phenotypic linkages between m6A modification pattern and immunological ecosystem are expected to be disentangled in hepatocellular carcinoma (HCC), for immunotherapeutic unresponsiveness circumvention and combination with promising drug agents. Methods: Modification patterns of m6A methylation were qualitatively dissected according to the large-scale HCC samples profiling. We then determined the immune phenotypic linkages by systematically evaluating their tumor microenvironment composition, immune/stromal-relevant signature, immune checkpoints correlation, and prognostic value. Individual quantification of m6A methylation pattern was achieved by m6Ascore construction, intensified by longitudinal single-cell analysis of immunotherapy cohort and validated by the transcriptomic profiles of our in-hospital GDPH-HCC cohort. Candidate therapeutic agents were also screened out. Results: Three distinct m6A methylation patterns were determined in high accordance with inflamed-, excluded-, and desert-immunophenotype. To be precise, Immune-inflamed high-m6Ascore group was characterized by activated immunity with favorable prognosis. Stromal activation and absence of immune cell infiltration were observed in low-m6Ascore phenotype, linked to impaired outcome. Patients with low-m6Ascore demonstrated diminished responses and clinical benefits for cohorts receiving immunotherapy. The above credible linkage between m6A methylation pattern and tumor immune microenvironment was robustly validated in our GDPH-HCC cohort. Single-cell dynamic change of m6A methylation level in exhausted CD8 T cell and fibroblast was depicted in immunotherapy cohort fore and art. Derived from m6A methylation pattern, seven potential frontline drug agents were recognized as promising choice for high-m6Ascore patients. Conclusion: Our work bridged the credible linkage between epigenetics and anti-tumor immunity in HCC, unraveling m6A modification pattern as immunological indicator and predictor for immunotherapy. Individualized m6Ascore facilitated strategic choices to maximize therapy-responsive possibility. [ABSTRACT FROM AUTHOR]

What Is Already Known About This Topic?: Little is known about the epidemiology, natural history, and transmission patterns of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant. Monitoring the evolution of viral fitness of SARS-CoV-2 in the host population is key for preparedness and response planning., What Is Added by This Report?: We analyzed a successfully contained local outbreak of Delta that took place in Hunan, China, and provided estimates of time-to-key event periods, infectiousness over time, and risk factors for SARS-CoV-2 infection and transmission for a still poorly understood variant., What Are the Implications for Public Health Practice?: Our findings simultaneously shed light on both the characteristics of the Delta variant, by identifying key age groups, risk factors, and transmission pathways, and planning a future response effort against SARS-CoV-2., (Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2023.)

Introduction: The objective of this paper was to assess the epidemiology of rabies in Hunan Province, analyze the associated factors, understand the status of prevention and treatment after rabies exposure, evaluate the effectiveness of prevention and treatment, and provide a scientific basis for formulating effective prevention and control measures., Methods: The surveillance data of rabies in Hunan Province in 2020 were collected and analyzed by descriptive epidemiological method., Results: In 2020, a total of 59 cases of rabies were reported in Hunan Province, with an incidence rate of 0.09/100,000. Overall, 42 cases (71.19%) were due to animal bites and 43 cases (72.88%) were of grade III. The proportion of hand and combined injury of hand was the highest (40.68%). A total of 603,261 cases of rabies exposure were reported from the rabies post-exposure prophylaxis (PEP) clinic in Hunan Province. Dogs were the main animal causing injuries, accounting for 74.21%. Only 83,418 (13.84%) of the animals had a clear immune history, and a total of 11 dog attacks were reported in Hunan Province. The average immunity rate of dogs in the whole province was 30.98%. In 2020, 554 dogs were sampled in the whole province; 20 of them were positive for a positivity rate of 3.61%., Conclusions: Rabies in Hunan Province in 2020 had a relatively low prevalence. Failure to treat wounds, immunoglobulin injections, and vaccination after exposure were the main causes of rabies. Therefore, post-exposure management of rabies should be further strengthened to reduce the risk of rabies for high-risk populations., (Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2022.)