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1. The genomic basis of childhood T-lineage acute lymphoblastic leukaemia

Author

Pölönen, Petri, Di Giacomo, Danika, Seffernick, Anna Eames, Elsayed, Abdelrahman, Kimura, Shunsuke, Benini, Francesca, Montefiori, Lindsey E., Wood, Brent L., Xu, Jason, Chen, Changya, Cheng, Zhongshan, Newman, Haley, Myers, Jason, Iacobucci, Ilaria, Li, Elizabeth, Sussman, Jonathan, Hedges, Dale, Hui, Yawei, Diorio, Caroline, Uppuluri, Lahari, Frank, David, Fan, Yiping, Chang, Yunchao, Meshinchi, Soheil, Ries, Rhonda, Shraim, Rawan, Li, Alexander, Bernt, Kathrin M., Devidas, Meenakshi, Winter, Stuart S., Dunsmore, Kimberly P., Inaba, Hiroto, Carroll, William L., Ramirez, Nilsa C., Phillips, Aaron H., Kriwacki, Richard W., Yang, Jun J., Vincent, Tiffaney L., Zhao, Yaqi, Ghate, Pankaj S., Wang, Jian, Reilly, Colleen, Zhou, Xin, Sanders, Mathijs A., Takita, Junko, Kato, Motohiro, Takasugi, Nao, Chang, Bill H., Press, Richard D., Loh, Mignon, Rampersaud, Evadnie, Raetz, Elizabeth, Hunger, Stephen P., Tan, Kai, Chang, Ti-Cheng, Wu, Gang, Pounds, Stanley B., Mullighan, Charles G., and Teachey, David T.

Published
2024
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3. Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Childrens Oncology Group cohort trials.

Author

Teachey, David, Bona, Kira, Aplenc, Richard, Rabin, Karen, Zweidler-McKay, Patrick, Carroll, Andrew, Heerema, Nyla, Gastier-Foster, Julie, Borowitz, Michael, Wood, Brent, Maloney, Kelly, Mattano, Leonard, Larsen, Eric, Angiolillo, Anne, Burke, Michael, Salzer, Wanda, Winter, Stuart, Brown, Patrick, Guest, Erin, Dunsmore, Kimberley, Kairalla, John, Winick, Naomi, Carroll, William, Raetz, Elizabeth, Hunger, Stephen, Loh, Mignon, Devidas, Meenakshi, Gupta, Sumit, Dai, Yunfeng, Chen, Zhiguo, and Winestone, Lena

Subjects
Adolescent, Humans, Child, Male, Female, Young Adult, White People, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Black or African American, Ethnicity, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell
Abstract

BACKGROUND: Previous studies have identified racial and ethnic disparities in childhood acute lymphocytic leukaemia survival. We aimed to establish whether disparities persist in contemporaneous cohorts and, if present, are attributable to differences in leukaemia biology or insurance status. METHODS: Patients with newly diagnosed acute lymphocytic leukaemia in inpatient and outpatient centres in the USA, Canada, Australia, and New Zealand, aged 0-30 years, who had race or ethnicity data available, enrolled on eight completed Childrens Oncology Group trials (NCT00103285, NCT00075725, NCT00408005, NCT01190930, NCT02883049, NCT02112916, NCT02828358, and NCT00557193) were included in this secondary analysis. Race and ethnicity were categorised as non-Hispanic White, Hispanic, non-Hispanic Black, non-Hispanic Asian, and non-Hispanic other. Event-free survival and overall survival were compared across race and ethnicity groups. The relative contribution of clinical and biological disease prognosticators and insurance status was examined through multivariable regression models, both among the entire cohort and among those with B-cell lineage versus T-cell lineage disease. FINDINGS: Between Jan 1, 2004, and Dec 31, 2019, 24 979 eligible children, adolescents, and young adults with acute lymphocytic leukaemia were enrolled, of which 21 152 had race or ethnicity data available. 11 849 (56·0%) were male and 9303 (44·0%) were female. Non-Hispanic White patients comprised the largest racial or ethnic group (13 872 [65·6%]), followed by Hispanic patients (4354 [20·6%]), non-Hispanic Black patients (1517 [7·2%]), non-Hispanic Asian (n=1071 [5·1%]), and non-Hispanic other (n=338 [1·6%]). 5-year event-free survival was 87·4% (95% CI 86·7-88·0%) among non-Hispanic White patients compared with 82·8% (81·4-84·1%; hazard ratio [HR] 1·37, 95% CI 1·26-1·49; p

Published
2023

4. Children's Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma

Author

Teachey, David T, Devidas, Meenakshi, Wood, Brent L, Chen, Zhiguo, Hayashi, Robert J, Hermiston, Michelle L, Annett, Robert D, Archer, J Hunter, Asselin, Barbara L, August, Keith J, Cho, Steve Y, Dunsmore, Kimberly P, Fisher, Brian T, Freedman, Jason L, Galardy, Paul J, Harker-Murray, Paul, Horton, Terzah M, Jaju, Alok I, Lam, Allison, Messinger, Yoav H, Miles, Rodney R, Okada, Maki, Patel, Samir I, Schafer, Eric S, Schechter, Tal, Singh, Neelam, Steele, Amii C, Sulis, Maria Luisa, Vargas, Sarah L, Winter, Stuart S, Wood, Charlotte, Zweidler-McKay, Patrick, Bollard, Catherine M, Loh, Mignon L, Hunger, Stephen P, and Raetz, Elizabeth A

Subjects
Clinical Trials and Supportive Activities, Pediatric Cancer, Pediatric, Orphan Drug, Cancer, Rare Diseases, Clinical Research, Childhood Leukemia, Hematology, Pediatric Research Initiative, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Antineoplastic Combined Chemotherapy Protocols, Bortezomib, Child, Disease-Free Survival, Humans, Infant, Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, T-Lymphocytes, Young Adult, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeTo improve the outcomes of patients with T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma (T-LL), the proteasome inhibitor bortezomib was examined in the Children's Oncology Group phase III clinical trial AALL1231, which also attempted to reduce the use of prophylactic cranial radiation (CRT) in newly diagnosed T-ALL.Patients and methodsChildren and young adults with T-ALL/T-LL were randomly assigned to a modified augmented Berlin-Frankfurt-Münster chemotherapy regimen with/without bortezomib during induction and delayed intensification. Multiple modifications were made to the augmented Berlin-Frankfurt-Münster backbone used in the predecessor trial, AALL0434, including using dexamethasone instead of prednisone and adding two extra doses of pegaspargase in an attempt to eliminate CRT in most patients.ResultsAALL1231 accrued 824 eligible and evaluable patients from 2014 to 2017. The 4-year event-free survival (EFS) and overall survival (OS) for arm A (no bortezomib) versus arm B (bortezomib) were 80.1% ± 2.3% versus 83.8% ± 2.1% (EFS, P = .131) and 85.7% ± 2.0% versus 88.3% ± 1.8% (OS, P = .085). Patients with T-LL had improved EFS and OS with bortezomib: 4-year EFS (76.5% ± 5.1% v 86.4% ± 4.0%; P = .041); and 4-year OS (78.3% ± 4.9% v 89.5% ± 3.6%; P = .009). No excess toxicity was seen with bortezomib. In AALL0434, 90.8% of patients with T-ALL received CRT. In AALL1231, 9.5% of patients were scheduled to receive CRT. Evaluation of comparable AALL0434 patients who received CRT and AALL1231 patients who did not receive CRT demonstrated no statistical differences in EFS (P = .412) and OS (P = .600).ConclusionPatients with T-LL had significantly improved EFS and OS with bortezomib on the AALL1231 backbone. Systemic therapy intensification allowed elimination of CRT in more than 90% of patients with T-ALL without excess relapse.

Published
2022

6. Reinfusion of CD19 CAR T cells for relapse prevention and treatment in children with acute lymphoblastic leukemia

Author

Myers, Regina M., Devine, Kaitlin, Li, Yimei, Lawrence, Sophie, Leahy, Allison Barz, Liu, Hongyan, Vernau, Lauren, Callahan, Colleen, Baniewicz, Diane, Kadauke, Stephan, McGuire, Regina, Wertheim, Gerald B., Kulikovskaya, Irina, Gonzalez, Vanessa E., Fraietta, Joseph A., DiNofia, Amanda M., Hunger, Stephen P., Rheingold, Susan R., Aplenc, Richard, June, Carl H., Grupp, Stephan A., Wray, Lisa, and Maude, Shannon L.

Published
2024
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7. Late isolated central nervous system relapse in childhood B‐cell acute lymphoblastic leukemia treated with intensified systemic therapy and delayed reduced dose cranial radiation: A report from the Children's Oncology Group study AALL02P2

Author

Hastings, Caroline, Chen, Yichen, Devidas, Meenakshi, Ritchey, A Kim, Winick, Naomi J, Carroll, William L, Hunger, Stephen P, Wood, Brent L, Marcus, Robert B, and Barredo, Julio C

Subjects
Hematology, Pediatric Research Initiative, Pediatric, Pediatric Cancer, Patient Safety, Rare Diseases, Childhood Leukemia, Cancer, 6.1 Pharmaceuticals, 6.5 Radiotherapy and other non-invasive therapies, Evaluation of treatments and therapeutic interventions, Antineoplastic Combined Chemotherapy Protocols, Central Nervous System, Child, Cranial Irradiation, Humans, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Recurrence, childhood, CNS relapse, leukemia, Clinical Sciences, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis
Abstract

BackgroundPatients with late, ≥18 months postdiagnosis, isolated central nervous relapse (iCNS-R) of B-acute lymphoblastic leukemia (ALL) have excellent outcomes with chemotherapy plus cranial radiotherapy, with 5-year overall survival (OS) approaching 80% in POG 9412. Subsequent relapse and radiation-related morbidity remain the causes of treatment failure and long-term sequelae. COG AALL02P2 aimed to maintain outcomes in patients with late iCNS-R using intensified chemotherapy and a decrease in cranial irradiation from 1800 to 1200 cGy.ProceduresCOG AALL02P2 enrolled 118 eligible patients with B-cell ALL (B-ALL) and late iCNS-R who received intensified systemic therapy, triple intrathecal chemotherapy, and 1200 cGy cranial irradiation delivered at 12 months, with maintenance chemotherapy continuing until 104 weeks postdiagnosis.ResultsThe 3-year event-free survival (EFS) and OS were 64.3% ± 4.5% and 79.6% ± 3.8%, with 46.1% (18/39) of second relapses including the CNS. Of the 112 patients who completed therapy, 78 received protocol-specified radiation. Study enrollment was closed after interim monitoring analysis showed inferior EFS compared to POG 9412. Patients with initial NCI standard-risk classification fared better than high-risk patients.ConclusionsCOG AALL02P2 showed inferior EFS but similar OS compared to POG 9412. Limitations included a small sample size, more intensive prior therapies, and a significant number of patients (34/118, 29%) who did not receive protocol-directed radiation due to early relapse prior to 1 year or did not otherwise follow the treatment plan. New approaches are needed to improve outcome for these patients and determine the optimal timing and dose of cranial radiation in the treatment of iCNS-R.

Published
2021

10. Genomic landscape of Down syndrome–associated acute lymphoblastic leukemia

Author

Li, Zhenhua, Chang, Ti-Cheng, Junco, Jacob J., Devidas, Meenakshi, Li, Yizhen, Yang, Wenjian, Huang, Xin, Hedges, Dale J., Cheng, Zhongshan, Shago, Mary, Carroll, Andrew J., Heerema, Nyla A., Gastier-Foster, Julie, Wood, Brent L., Borowitz, Michael J., Sanclemente, Lauren, Raetz, Elizabeth A., Hunger, Stephen P., Feingold, Eleanor, Rosser, Tracie C., Sherman, Stephanie L., Loh, Mignon L., Mullighan, Charles G., Yu, Jiyang, Wu, Gang, Lupo, Philip J., Rabin, Karen R., and Yang, Jun J.

Published
2023
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11. Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial

Author

Hunger, Stephen P, Tran, Thai Hoa, Saha, Vaskar, Devidas, Meenakshi, Valsecchi, Maria Grazia, Gastier-Foster, Julie M, Cazzaniga, Giovanni, Reshmi, Shalini C, Borowitz, Michael J, Moorman, Anthony V, Heerema, Nyla A, Carroll, Andrew J, Martin-Regueira, Patricia, Loh, Mignon L, Raetz, Elizabeth A, Schultz, Kirk R, Slayton, William B, Cario, Gunnar, Schrappe, Martin, Silverman, Lewis B, and Biondi, Andrea

Published
2023
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12. Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children's Oncology Group cohort trials

Author

Gupta, Sumit, Dai, Yunfeng, Chen, Zhiguo, Winestone, Lena E, Teachey, David T, Bona, Kira, Aplenc, Richard, Rabin, Karen R, Zweidler-McKay, Patrick, Carroll, Andrew J, Heerema, Nyla A, Gastier-Foster, Julie, Borowitz, Michael J, Wood, Brent L, Maloney, Kelly W, Mattano, Leonard A, Jr, Larsen, Eric C, Angiolillo, Anne L, Burke, Michael J, Salzer, Wanda L, Winter, Stuart S, Brown, Patrick A, Guest, Erin M, Dunsmore, Kimberley P, Kairalla, John A, Winick, Naomi J, Carroll, William L, Raetz, Elizabeth A, Hunger, Stephen P, Loh, Mignon L, and Devidas, Meenakshi

Published
2023
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13. The genomic landscape of pediatric acute lymphoblastic leukemia

Author

Brady, Samuel W., Roberts, Kathryn G., Gu, Zhaohui, Shi, Lei, Pounds, Stanley, Pei, Deqing, Cheng, Cheng, Dai, Yunfeng, Devidas, Meenakshi, Qu, Chunxu, Hill, Ashley N., Payne-Turner, Debbie, Ma, Xiaotu, Iacobucci, Ilaria, Baviskar, Pradyuamna, Wei, Lei, Arunachalam, Sasi, Hagiwara, Kohei, Liu, Yanling, Flasch, Diane A., Liu, Yu, Parker, Matthew, Chen, Xiaolong, Elsayed, Abdelrahman H., Pathak, Omkar, Li, Yongjin, Fan, Yiping, Michael, J. Robert, Rusch, Michael, Wilkinson, Mark R., Foy, Scott, Hedges, Dale J., Newman, Scott, Zhou, Xin, Wang, Jian, Reilly, Colleen, Sioson, Edgar, Rice, Stephen V., Pastor Loyola, Victor, Wu, Gang, Rampersaud, Evadnie, Reshmi, Shalini C., Gastier-Foster, Julie, Guidry Auvil, Jaime M., Gesuwan, Patee, Smith, Malcolm A., Winick, Naomi, Carroll, Andrew J., Heerema, Nyla A., Harvey, Richard C., Willman, Cheryl L., Larsen, Eric, Raetz, Elizabeth A., Borowitz, Michael J., Wood, Brent L., Carroll, William L., Zweidler-McKay, Patrick A., Rabin, Karen R., Mattano, Leonard A., Maloney, Kelly W., Winter, Stuart S., Burke, Michael J., Salzer, Wanda, Dunsmore, Kimberly P., Angiolillo, Anne L., Crews, Kristine R., Downing, James R., Jeha, Sima, Pui, Ching-Hon, Evans, William E., Yang, Jun J., Relling, Mary V., Gerhard, Daniela S., Loh, Mignon L., Hunger, Stephen P., Zhang, Jinghui, and Mullighan, Charles G.

Published
2022
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14. Central nervous system status is prognostic in T-cell acute lymphoblastic leukemia: a Children’s Oncology Group report

Author

Gossai, Nathan P., Devidas, Meenakshi, Chen, Zhiguo, Wood, Brent L., Zweidler-McKay, Patrick A., Rabin, Karen R., Loh, Mignon L., Raetz, Elizabeth A., Winick, Naomi J., Burke, Michael J., Carroll, Andrew J., Esiashvili, Natia, Heerema, Nyla A., Carroll, William L., Hunger, Stephen P., Dunsmore, Kimberly P., Winter, Stuart S., and Teachey, David T.

Published
2023
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16. Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia

Author

Kimura, Shunsuke, Montefiori, Lindsey, Iacobucci, Ilaria, Zhao, Yaqi, Gao, Qingsong, Paietta, Elisabeth M., Haferlach, Claudia, Laird, A. Douglas, Mead, Paul E., Gu, Zhaohui, Stock, Wendy, Litzow, Mark, Rowe, Jacob M., Luger, Selina M., Hunger, Stephen P., Ryland, Georgina L., Schmidt, Breon, Ekert, Paul G., Oshlack, Alicia, Grimmond, Sean M., Rehn, Jacqueline, Breen, James, Yeung, David, White, Deborah L., Aldoss, Ibrahim, Jabbour, Elias J., Pui, Ching-Hon, Meggendorfer, Manja, Walter, Wencke, Kern, Wolfgang, Haferlach, Torsten, Brady, Samuel, Zhang, Jinghui, Roberts, Kathryn G., Blombery, Piers, and Mullighan, Charles G.

Published
2022
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17. Outcomes in adolescent and young adult patients (16 to 30 years) compared to younger patients treated for high-risk B-lymphoblastic leukemia: report from Children’s Oncology Group Study AALL0232

Author

Burke, Michael J., Devidas, Meenakshi, Chen, Zhiguo, Salzer, Wanda L., Raetz, Elizabeth A., Rabin, Karen R., Heerema, Nyla A., Carroll, Andrew J., Gastier-Foster, Julie M., Borowitz, Michael J., Wood, Brent L., Winick, Naomi J., Carroll, William L., Hunger, Stephen P., Loh, Mignon L., and Larsen, Eric C.

Published
2022
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18. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation

Author

Yang, Hongbo, Zhang, Hui, Luan, Yu, Liu, Tingting, Yang, Wentao, Roberts, Kathryn G., Qian, Mao-xiang, Zhang, Bo, Yang, Wenjian, Perez-Andreu, Virginia, Xu, Jie, Iyyanki, Sriranga, Kuang, Da, Stasiak, Lena A., Reshmi, Shalini C., Gastier-Foster, Julie, Smith, Colton, Pui, Ching-Hon, Evans, William E., Hunger, Stephen P., Platanias, Leonidas C., Relling, Mary V., Mullighan, Charles G., Loh, Mignon L., Yue, Feng, and Yang, Jun J.

Published
2022
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20. Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia

Author

Chen, Changya, Yu, Wenbao, Alikarami, Fatemeh, Qiu, Qi, Chen, Chia-hui, Flournoy, Jennifer, Gao, Peng, Uzun, Yasin, Fang, Li, Davenport, James W., Hu, Yuxuan, Zhu, Qin, Wang, Kai, Libbrecht, Clara, Felmeister, Alex, Rozich, Isaiah, Ding, Yang-yang, Hunger, Stephen P., Felix, Carolyn A., Wu, Hao, Brown, Patrick A., Guest, Erin M., Barrett, David M., Bernt, Kathrin M., and Tan, Kai

Published
2022
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23. Germline Genetic NBN Variation and Predisposition to B-cell Acute Lymphoblastic Leukemia in Children

Author

Escherich, Carolin S., primary, Chen, Wenan, additional, Li, Yizhen, additional, Yang, Wenjian, additional, Nishii, Rina, additional, Li, Zhenhua, additional, Raetz, Elizabeth A., additional, Devidas, Meenakshi, additional, wu, gang, additional, Nichols, Kim E, additional, Inaba, Hiroto, additional, Pui, Ching-Hon, additional, Jeha, Sima, additional, Camitta, Bruce Matthew, additional, Larsen, Eric C., additional, Hunger, Stephen P, additional, Loh, Mignon L., additional, and Yang, Jun J., additional

Published
2024
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26. Reply to C.T. Matava et al.

Author

Alexander, Sarah, Kairalla, John A., Gupta, Sumit, Hibbitts, Emily, Weisman, Hannah, Anghelescu, Doralina, Winick, Naomi J., Krull, Kevin R., Salzer, Wanda L., Burke, Michael J., Gore, Lia, Devidas, Meenakshi, Embry, Leanne, Raetz, Elizabeth A., Hunger, Stephen P., Loh, Mignon L., and Hardy, Kristina K.

Published
2024
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27. Germ line genetic NBNvariation and predisposition to B-cell acute lymphoblastic leukemia in children

Author

Escherich, Carolin S., Chen, Wenan, Li, Yizhen, Yang, Wenjian, Nishii, Rina, Li, Zhenhua, Raetz, Elizabeth A., Devidas, Meenakshi, Wu, Gang, Nichols, Kim E., Inaba, Hiroto, Pui, Ching-Hon, Jeha, Sima, Camitta, Bruce M., Larsen, Eric, Hunger, Stephen P., Loh, Mignon L., and Yang, Jun J.

Abstract

•Heterozygous carriers of deleterious germ line NBNvariants are at risk of B-ALL development.•Protein instability is the main mechanism for loss-of-function variants in the NBNgene.

Published
2024
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30. Outcomes in Children, Adolescents, and Young Adults With Down Syndrome and ALL: A Report From the Children's Oncology Group

Author

Rabin, Karen R., primary, Devidas, Meenakshi, additional, Chen, Zhiguo, additional, Ji, Lingyun, additional, Kairalla, John, additional, Hitzler, Johann K., additional, Yang, Jun J., additional, Carroll, Andrew J., additional, Heerema, Nyla A., additional, Borowitz, Michael J., additional, Wood, Brent L., additional, Roberts, Kathryn G., additional, Mullighan, Charles G., additional, Harvey, Richard C., additional, Chen, I-Ming, additional, Willman, Cheryl L., additional, Reshmi, Shalini C., additional, Gastier-Foster, Julie M., additional, Bhojwani, Deepa, additional, Rheingold, Susan R., additional, Maloney, Kelly W., additional, Mattano, Leonard A., additional, Larsen, Eric C., additional, Schore, Reuven J., additional, Burke, Michael J., additional, Salzer, Wanda L., additional, Winick, Naomi J., additional, Carroll, William L., additional, Raetz, Elizabeth A., additional, Loh, Mignon L., additional, Hunger, Stephen P., additional, and Angiolillo, Anne L., additional

Published
2023
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31. Figure S2 from Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors

Author

Modi, Apexa, primary, Lopez, Gonzalo, primary, Conkrite, Karina L., primary, Su, Chun, primary, Leung, Tsz Ching, primary, Ramanan, Sathvik, primary, Manduchi, Elisabetta, primary, Johnson, Matthew E., primary, Cheung, Daphne, primary, Gadd, Samantha, primary, Zhang, Jinghui, primary, Smith, Malcolm A., primary, Guidry Auvil, Jaime M., primary, Meshinchi, Soheil, primary, Perlman, Elizabeth J., primary, Hunger, Stephen P., primary, Maris, John M., primary, Wells, Andrew D., primary, Grant, Struan F.A., primary, and Diskin, Sharon J., primary

Published
2023
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32. Tables S10-S12 from Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors

Author

Modi, Apexa, primary, Lopez, Gonzalo, primary, Conkrite, Karina L., primary, Su, Chun, primary, Leung, Tsz Ching, primary, Ramanan, Sathvik, primary, Manduchi, Elisabetta, primary, Johnson, Matthew E., primary, Cheung, Daphne, primary, Gadd, Samantha, primary, Zhang, Jinghui, primary, Smith, Malcolm A., primary, Guidry Auvil, Jaime M., primary, Meshinchi, Soheil, primary, Perlman, Elizabeth J., primary, Hunger, Stephen P., primary, Maris, John M., primary, Wells, Andrew D., primary, Grant, Struan F.A., primary, and Diskin, Sharon J., primary

Published
2023
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33. Data from Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors

Author

Modi, Apexa, primary, Lopez, Gonzalo, primary, Conkrite, Karina L., primary, Su, Chun, primary, Leung, Tsz Ching, primary, Ramanan, Sathvik, primary, Manduchi, Elisabetta, primary, Johnson, Matthew E., primary, Cheung, Daphne, primary, Gadd, Samantha, primary, Zhang, Jinghui, primary, Smith, Malcolm A., primary, Guidry Auvil, Jaime M., primary, Meshinchi, Soheil, primary, Perlman, Elizabeth J., primary, Hunger, Stephen P., primary, Maris, John M., primary, Wells, Andrew D., primary, Grant, Struan F.A., primary, and Diskin, Sharon J., primary

Published
2023
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34. Supplementary Information from Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors

Author

Modi, Apexa, primary, Lopez, Gonzalo, primary, Conkrite, Karina L., primary, Su, Chun, primary, Leung, Tsz Ching, primary, Ramanan, Sathvik, primary, Manduchi, Elisabetta, primary, Johnson, Matthew E., primary, Cheung, Daphne, primary, Gadd, Samantha, primary, Zhang, Jinghui, primary, Smith, Malcolm A., primary, Guidry Auvil, Jaime M., primary, Meshinchi, Soheil, primary, Perlman, Elizabeth J., primary, Hunger, Stephen P., primary, Maris, John M., primary, Wells, Andrew D., primary, Grant, Struan F.A., primary, and Diskin, Sharon J., primary

Published
2023
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36. Children's Oncology Group AALL1331: Phase III Trial of Blinatumomab in Children, Adolescents, and Young Adults With Low-Risk B-Cell ALL in First Relapse

Author

Hogan, Laura E., primary, Brown, Patrick A., additional, Ji, Lingyun, additional, Xu, Xinxin, additional, Devidas, Meenakshi, additional, Bhatla, Teena, additional, Borowitz, Michael J., additional, Raetz, Elizabeth A., additional, Carroll, Andrew, additional, Heerema, Nyla A., additional, Zugmaier, Gerhard, additional, Sharon, Elad, additional, Bernhardt, Melanie B., additional, Terezakis, Stephanie A., additional, Gore, Lia, additional, Whitlock, James A., additional, Hunger, Stephen P., additional, and Loh, Mignon L., additional

Published
2023
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37. Assessment of proxy‐reported responses as predictors of motor and sensory peripheral neuropathy in children with B‐lymphoblastic leukemia

Author

Rodwin, Rozalyn L., primary, DelRocco, Natalie J., additional, Hibbitts, Emily, additional, Devidas, Meenakshi, additional, Whitley, Moira K., additional, Mohrmann, Caroline E., additional, Schore, Reuven J., additional, Raetz, Elizabeth, additional, Winick, Naomi J., additional, Hunger, Stephen P., additional, Loh, Mignon L., additional, Hockenberry, Marilyn J., additional, Ma, Xiaomei, additional, Angiolillo, Anne L., additional, Ness, Kirsten K., additional, Kairalla, John A., additional, and Kadan‐Lottick, Nina S., additional

Published
2023
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38. Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors

Author

Modi, Apexa, primary, Lopez, Gonzalo, additional, Conkrite, Karina L., additional, Su, Chun, additional, Leung, Tsz Ching, additional, Ramanan, Sathvik, additional, Manduchi, Elisabetta, additional, Johnson, Matthew E., additional, Cheung, Daphne, additional, Gadd, Samantha, additional, Zhang, Jinghui, additional, Smith, Malcolm A., additional, Guidry Auvil, Jaime M., additional, Meshinchi, Soheil, additional, Perlman, Elizabeth J., additional, Hunger, Stephen P., additional, Maris, John M., additional, Wells, Andrew D., additional, Grant, Struan F.A., additional, and Diskin, Sharon J., additional

Published
2023
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39. S107: IDENTIFICATION AND CHARACTERIZATION OF GERMLINE NBN VARIANTS RELATED TO B-ALL PREDISPOSITION

Author

Escherich, Carolin, primary, Chen, Wenan, additional, Yang, Wenjian, additional, Teachey, David T., additional, Raetz, Elizabeth A., additional, Devidas, Meenakshi, additional, Wu, Gang, additional, Nichols, Kim E., additional, Inaba, Hiroto, additional, Pui, Ching-Hon, additional, Jeha, Sima, additional, Hunger, Stephen P., additional, Loh, Mignon L., additional, and Yang, Jun J., additional

Published
2023
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40. MRD at the end of induction and EFS in T-cell lymphoblastic lymphoma: Children’s Oncology Group trial AALL1231

Author

Hayashi, Robert J., Hermiston, Michelle L., Wood, Brent L., Teachey, David T., Devidas, Meenakshi, Chen, Zhiguo, Annett, Robert D., Asselin, Barbara L., August, Keith, Cho, Steve, Dunsmore, Kimberly P., Freedman, Jason Lawrence, Galardy, Paul J., Harker-Murray, Paul, Horton, Terzah M., Jaju, Alok, Lam, Allison, Messinger, Yoav H., Miles, Rodney R., Okada, Maki, Patel, Samir, Schafer, Eric S., Schechter, Tal, Shimano, Kristin A., Singh, Neelam, Steele, Amii, Sulis, Maria L., Vargas, Sarah L., Winter, Stuart S., Wood, Charlotte, Zweidler-McKay, Patrick A., Loh, Mignon L., Hunger, Stephen P., Raetz, Elizabeth A., Bollard, Catherine M., and Allen, Carl E.

Published
2024
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41. Correction: Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG AALL0932

Author

Schore, Reuven J., primary, Angiolillo, Anne L., additional, Kairalla, John A., additional, Devidas, Meenakshi, additional, Rabin, Karen R., additional, Zweidler-McKay, Patrick, additional, Borowitz, Michael J., additional, Wood, Brent, additional, Carroll, Andrew J., additional, Heerema, Nyla A., additional, Relling, Mary V., additional, Hitzler, Johann, additional, Kadan-Lottick, Nina S., additional, Maloney, Kelly, additional, Wang, Cindy, additional, Carroll, William L., additional, Winick, Naomi J., additional, Raetz, Elizabeth A., additional, Loh, Mignon L., additional, and Hunger, Stephen P., additional

Published
2023
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42. Data from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Author

Chonghaile, Triona Ni, primary, Roderick, Justine E., primary, Glenfield, Cian, primary, Ryan, Jeremy, primary, Sallan, Stephen E., primary, Silverman, Lewis B., primary, Loh, Mignon L., primary, Hunger, Stephen P., primary, Wood, Brent, primary, DeAngelo, Daniel J., primary, Stone, Richard, primary, Harris, Marian, primary, Gutierrez, Alejandro, primary, Kelliher, Michelle A., primary, and Letai, Anthony, primary

Published
2023
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43. Supplementary Figure S6 from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Author

Chonghaile, Triona Ni, primary, Roderick, Justine E., primary, Glenfield, Cian, primary, Ryan, Jeremy, primary, Sallan, Stephen E., primary, Silverman, Lewis B., primary, Loh, Mignon L., primary, Hunger, Stephen P., primary, Wood, Brent, primary, DeAngelo, Daniel J., primary, Stone, Richard, primary, Harris, Marian, primary, Gutierrez, Alejandro, primary, Kelliher, Michelle A., primary, and Letai, Anthony, primary

Published
2023
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44. Data from Evaluation of the In Vitro and In Vivo Efficacy of the JAK Inhibitor AZD1480 against JAK-Mutated Acute Lymphoblastic Leukemia

Author

Suryani, Santi, primary, Bracken, Lauryn S., primary, Harvey, Richard C., primary, Sia, Keith C.S., primary, Carol, Hernan, primary, Chen, I-Ming, primary, Evans, Kathryn, primary, Dietrich, Philipp A., primary, Roberts, Kathryn G., primary, Kurmasheva, Raushan T., primary, Billups, Catherine A., primary, Mullighan, Charles G., primary, Willman, Cheryl L., primary, Loh, Mignon L., primary, Hunger, Stephen P., primary, Houghton, Peter J., primary, Smith, Malcolm A., primary, and Lock, Richard B., primary

Published
2023
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45. Supplementary Data from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, primary, Tasian, Sarah K., primary, Sulis, Maria Luisa, primary, Stevenson, Kristen, primary, Blonquist, Traci M., primary, Apsel Winger, Beth, primary, Cooper, Todd M., primary, Pauly, Melinda, primary, Maloney, Kelly W., primary, Burke, Michael J., primary, Brown, Patrick A., primary, Gossai, Nathan, primary, McNeer, Jennifer L., primary, Shukla, Neerav N., primary, Cole, Peter D., primary, Kahn, Justine M., primary, Chen, Jing, primary, Barth, Matthew J., primary, Magee, Jeffrey A., primary, Gennarini, Lisa, primary, Adhav, Asmani A., primary, Clinton, Catherine M., primary, Ocasio-Martinez, Nicole, primary, Gotti, Giacomo, primary, Li, Yuting, primary, Lin, Shan, primary, Imamovic, Alma, primary, Tognon, Cristina E., primary, Patel, Tasleema, primary, Faust, Haley L., primary, Contreras, Cristina F., primary, Cremer, Anjali, primary, Cortopassi, Wilian A., primary, Garrido Ruiz, Diego, primary, Jacobson, Matthew P., primary, Dharia, Neekesh V., primary, Su, Angela, primary, Robichaud, Amanda L., primary, Saur Conway, Amy, primary, Tarlock, Katherine, primary, Stieglitz, Elliot, primary, Place, Andrew E., primary, Puissant, Alexandre, primary, Hunger, Stephen P., primary, Kim, Annette S., primary, Lindeman, Neal I., primary, Gore, Lia, primary, Janeway, Katherine A., primary, Silverman, Lewis B., primary, Tyner, Jeffrey W., primary, Harris, Marian H., primary, Loh, Mignon L., primary, and Stegmaier, Kimberly, primary

Published
2023
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46. Data from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, primary, Tasian, Sarah K., primary, Sulis, Maria Luisa, primary, Stevenson, Kristen, primary, Blonquist, Traci M., primary, Apsel Winger, Beth, primary, Cooper, Todd M., primary, Pauly, Melinda, primary, Maloney, Kelly W., primary, Burke, Michael J., primary, Brown, Patrick A., primary, Gossai, Nathan, primary, McNeer, Jennifer L., primary, Shukla, Neerav N., primary, Cole, Peter D., primary, Kahn, Justine M., primary, Chen, Jing, primary, Barth, Matthew J., primary, Magee, Jeffrey A., primary, Gennarini, Lisa, primary, Adhav, Asmani A., primary, Clinton, Catherine M., primary, Ocasio-Martinez, Nicole, primary, Gotti, Giacomo, primary, Li, Yuting, primary, Lin, Shan, primary, Imamovic, Alma, primary, Tognon, Cristina E., primary, Patel, Tasleema, primary, Faust, Haley L., primary, Contreras, Cristina F., primary, Cremer, Anjali, primary, Cortopassi, Wilian A., primary, Garrido Ruiz, Diego, primary, Jacobson, Matthew P., primary, Dharia, Neekesh V., primary, Su, Angela, primary, Robichaud, Amanda L., primary, Saur Conway, Amy, primary, Tarlock, Katherine, primary, Stieglitz, Elliot, primary, Place, Andrew E., primary, Puissant, Alexandre, primary, Hunger, Stephen P., primary, Kim, Annette S., primary, Lindeman, Neal I., primary, Gore, Lia, primary, Janeway, Katherine A., primary, Silverman, Lewis B., primary, Tyner, Jeffrey W., primary, Harris, Marian H., primary, Loh, Mignon L., primary, and Stegmaier, Kimberly, primary

Published
2023
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47. Supplementary Materials and Methods, Supplementary Tables 1 through 9, and Supplementary Figures 1 through 8 from Evaluation of the In Vitro and In Vivo Efficacy of the JAK Inhibitor AZD1480 against JAK-Mutated Acute Lymphoblastic Leukemia

Author

Suryani, Santi, primary, Bracken, Lauryn S., primary, Harvey, Richard C., primary, Sia, Keith C.S., primary, Carol, Hernan, primary, Chen, I-Ming, primary, Evans, Kathryn, primary, Dietrich, Philipp A., primary, Roberts, Kathryn G., primary, Kurmasheva, Raushan T., primary, Billups, Catherine A., primary, Mullighan, Charles G., primary, Willman, Cheryl L., primary, Loh, Mignon L., primary, Hunger, Stephen P., primary, Houghton, Peter J., primary, Smith, Malcolm A., primary, and Lock, Richard B., primary

Published
2023
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48. Data from Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia

Author

Montefiori, Lindsey E., primary, Bendig, Sonja, primary, Gu, Zhaohui, primary, Chen, Xiaolong, primary, Pölönen, Petri, primary, Ma, Xiaotu, primary, Murison, Alex, primary, Zeng, Andy, primary, Garcia-Prat, Laura, primary, Dickerson, Kirsten, primary, Iacobucci, Ilaria, primary, Abdelhamed, Sherif, primary, Hiltenbrand, Ryan, primary, Mead, Paul E., primary, Mehr, Cyrus M., primary, Xu, Beisi, primary, Cheng, Zhongshan, primary, Chang, Ti-Cheng, primary, Westover, Tamara, primary, Ma, Jing, primary, Stengel, Anna, primary, Kimura, Shunsuke, primary, Qu, Chunxu, primary, Valentine, Marcus B., primary, Rashkovan, Marissa, primary, Luger, Selina, primary, Litzow, Mark R., primary, Rowe, Jacob M., primary, den Boer, Monique L., primary, Wang, Victoria, primary, Yin, Jun, primary, Kornblau, Steven M., primary, Hunger, Stephen P., primary, Loh, Mignon L., primary, Pui, Ching-Hon, primary, Yang, Wenjian, primary, Crews, Kristine R., primary, Roberts, Kathryn G., primary, Yang, Jun J., primary, Relling, Mary V., primary, Evans, William E., primary, Stock, Wendy, primary, Paietta, Elisabeth M., primary, Ferrando, Adolfo A., primary, Zhang, Jinghui, primary, Kern, Wolfgang, primary, Haferlach, Torsten, primary, Wu, Gang, primary, Dick, John E., primary, Klco, Jeffery M., primary, Haferlach, Claudia, primary, and Mullighan, Charles G., primary

Published
2023
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49. Figure S5 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, primary, Tasian, Sarah K., primary, Sulis, Maria Luisa, primary, Stevenson, Kristen, primary, Blonquist, Traci M., primary, Apsel Winger, Beth, primary, Cooper, Todd M., primary, Pauly, Melinda, primary, Maloney, Kelly W., primary, Burke, Michael J., primary, Brown, Patrick A., primary, Gossai, Nathan, primary, McNeer, Jennifer L., primary, Shukla, Neerav N., primary, Cole, Peter D., primary, Kahn, Justine M., primary, Chen, Jing, primary, Barth, Matthew J., primary, Magee, Jeffrey A., primary, Gennarini, Lisa, primary, Adhav, Asmani A., primary, Clinton, Catherine M., primary, Ocasio-Martinez, Nicole, primary, Gotti, Giacomo, primary, Li, Yuting, primary, Lin, Shan, primary, Imamovic, Alma, primary, Tognon, Cristina E., primary, Patel, Tasleema, primary, Faust, Haley L., primary, Contreras, Cristina F., primary, Cremer, Anjali, primary, Cortopassi, Wilian A., primary, Garrido Ruiz, Diego, primary, Jacobson, Matthew P., primary, Dharia, Neekesh V., primary, Su, Angela, primary, Robichaud, Amanda L., primary, Saur Conway, Amy, primary, Tarlock, Katherine, primary, Stieglitz, Elliot, primary, Place, Andrew E., primary, Puissant, Alexandre, primary, Hunger, Stephen P., primary, Kim, Annette S., primary, Lindeman, Neal I., primary, Gore, Lia, primary, Janeway, Katherine A., primary, Silverman, Lewis B., primary, Tyner, Jeffrey W., primary, Harris, Marian H., primary, Loh, Mignon L., primary, and Stegmaier, Kimberly, primary

Published
2023
Full Text
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50. Supplementary Tables from Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia

Author

Montefiori, Lindsey E., primary, Bendig, Sonja, primary, Gu, Zhaohui, primary, Chen, Xiaolong, primary, Pölönen, Petri, primary, Ma, Xiaotu, primary, Murison, Alex, primary, Zeng, Andy, primary, Garcia-Prat, Laura, primary, Dickerson, Kirsten, primary, Iacobucci, Ilaria, primary, Abdelhamed, Sherif, primary, Hiltenbrand, Ryan, primary, Mead, Paul E., primary, Mehr, Cyrus M., primary, Xu, Beisi, primary, Cheng, Zhongshan, primary, Chang, Ti-Cheng, primary, Westover, Tamara, primary, Ma, Jing, primary, Stengel, Anna, primary, Kimura, Shunsuke, primary, Qu, Chunxu, primary, Valentine, Marcus B., primary, Rashkovan, Marissa, primary, Luger, Selina, primary, Litzow, Mark R., primary, Rowe, Jacob M., primary, den Boer, Monique L., primary, Wang, Victoria, primary, Yin, Jun, primary, Kornblau, Steven M., primary, Hunger, Stephen P., primary, Loh, Mignon L., primary, Pui, Ching-Hon, primary, Yang, Wenjian, primary, Crews, Kristine R., primary, Roberts, Kathryn G., primary, Yang, Jun J., primary, Relling, Mary V., primary, Evans, William E., primary, Stock, Wendy, primary, Paietta, Elisabeth M., primary, Ferrando, Adolfo A., primary, Zhang, Jinghui, primary, Kern, Wolfgang, primary, Haferlach, Torsten, primary, Wu, Gang, primary, Dick, John E., primary, Klco, Jeffery M., primary, Haferlach, Claudia, primary, and Mullighan, Charles G., primary

Published
2023
Full Text
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