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Your search keyword '"Hussain, Rafiqul"' showing total 14 results
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14 results on '"Hussain, Rafiqul"'

5. Conjunctival epithelial cells resist productive SARS-CoV-2 infection

Author

Jackson, Robert M., Hatton, Catherine F., Spegarova, Jarmila Stremenova, Georgiou, Maria, Collin, Joseph, Stephenson, Emily, Verdon, Bernard, Haq, Iram J., Hussain, Rafiqul, Coxhead, Jonathan M., Mudhar, Hardeep-Singh, Wagner, Bart, Hasoon, Megan, Davey, Tracey, Rooney, Paul, Khan, C.M. Anjam, Ward, Chris, Brodlie, Malcolm, Haniffa, Muzlifah, Hambleton, Sophie, Armstrong, Lyle, Figueiredo, Francisco, Queen, Rachel, Duncan, Christopher J.A., and Lako, Majlinda

Published
2022
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6. Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

Author

Hatton, Catherine F., Botting, Rachel A., Dueñas, Maria Emilia, Haq, Iram J., Verdon, Bernard, Thompson, Benjamin J., Spegarova, Jarmila Stremenova, Gothe, Florian, Stephenson, Emily, Gardner, Aaron I., Murphy, Sandra, Scott, Jonathan, Garnett, James P., Carrie, Sean, Powell, Jason, Khan, C. M. Anjam, Huang, Lei, Hussain, Rafiqul, Coxhead, Jonathan, Davey, Tracey, Simpson, A. John, Haniffa, Muzlifah, Hambleton, Sophie, Brodlie, Malcolm, Ward, Chris, Trost, Matthias, Reynolds, Gary, and Duncan, Christopher J. A.

Published
2021
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8. Deciphering the spatio-temporal transcriptional and chromatin accessibility of human retinal organoid development at the single cell level

Author

Dorgau, Birthe, primary, Collin, Joseph, additional, Rozanska, Agata, additional, Boczonadi, Veronika, additional, MoyaMolina, Marina, additional, Hussain, Rafiqul, additional, Coxhead, Jonathan, additional, Dhanaseelan, Tamilvendhan, additional, Armstrong, Lyle, additional, Queen, Rachel, additional, and Lako, Majlinda, additional

Published
2023
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9. Single cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration

Author

Collin, Joseph, primary, Hasoon, Megan S R, additional, Zerti, Darin, additional, Hammadi, Sarah, additional, Dorgau, Birthe, additional, Clarke, Lucy, additional, Steel, David, additional, Hussain, Rafiqul, additional, Coxhead, Jonathan, additional, Lisgo, Steven, additional, Queen, Rachel, additional, and Lako, Majlinda, additional

Published
2023
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10. Heteroplasmic mitochondrial DNA variants in cardiovascular diseases

Author

Calabrese, Claudia, primary, Pyle, Angela, additional, Griffin, Helen, additional, Coxhead, Jonathan, additional, Hussain, Rafiqul, additional, Braund, Peter S, additional, Li, Linxin, additional, Burgess, Annette, additional, Munroe, Patricia B, additional, Little, Louis, additional, Warren, Helen R, additional, Cabrera, Claudia, additional, Hall, Alistair, additional, Caulfield, Mark J, additional, Rothwell, Peter M, additional, Samani, Nilesh J, additional, Hudson, Gavin, additional, and Chinnery, Patrick F., additional

Published
2022
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11. pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation

Author

Rozanska, Agata, primary, Cerna-Chavez, Rodrigo, additional, Queen, Rachel, additional, Collin, Joseph, additional, Zerti, Darin, additional, Dorgau, Birthe, additional, Beh, Chia Shyan, additional, Davey, Tracey, additional, Coxhead, Jonathan, additional, Hussain, Rafiqul, additional, Al-Aama, Jumana, additional, Steel, David H, additional, Benvenisty, Nissim, additional, Armstrong, Lyle, additional, Parulekar, Manoj, additional, and Lako, Majlinda, additional

Published
2022
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12. Conjunctival epithelial cells resist productive SARS-CoV-2 infection

Author

Jackson, Robert M, primary, Hatton, Catherine F, additional, Spegarova, Jarmila Stremenova, additional, Georgiou, Maria, additional, Collin, Joseph, additional, Stephenson, Emily, additional, Verdon, Bernard, additional, Haq, Iram J, additional, Hussain, Rafiqul, additional, Coxhead, Jonathan M, additional, Mudhar, Hardeep-Singh, additional, Wagner, Bart, additional, Hasoon, Megan, additional, Davey, Tracey, additional, Rooney, Paul, additional, Anjam Khan, C.M., additional, Ward, Chris, additional, Brodlie, Malcolm, additional, Haniffa, Muzlifah, additional, Hambleton, Sophie, additional, Armstrong, Lyle, additional, Figueiredo, Francisco, additional, Queen, Rachel, additional, Duncan, Christopher J A, additional, and Lako, Majlinda, additional

Published
2021
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13. Heteroplasmic mitochondrial DNA variants in cardiovascular diseases

Author

Claudia Calabrese, Angela Pyle, Helen Griffin, Jonathan Coxhead, Rafiqul Hussain, Peter S Braund, Linxin Li, Annette Burgess, Patricia B Munroe, Louis Little, Helen R Warren, Claudia Cabrera, Alistair Hall, Mark J Caulfield, Peter M Rothwell, Nilesh J Samani, Gavin Hudson, Patrick F. Chinnery, Calabrese, Claudia [0000-0002-8941-2620], Pyle, Angela [0000-0003-3860-4531], Coxhead, Jonathan [0000-0002-6128-9560], Hussain, Rafiqul [0000-0002-1436-8944], Braund, Peter S [0000-0001-8540-5709], Li, Linxin [0000-0002-3636-8355], Burgess, Annette [0000-0003-3442-8083], Munroe, Patricia B [0000-0002-4176-2947], Little, Louis [0000-0002-4250-4181], Warren, Helen R [0000-0003-0511-1386], Cabrera, Claudia [0000-0002-2205-5315], Rothwell, Peter M [0000-0001-9739-9211], Chinnery, Patrick [0000-0002-7065-6617], Apollo - University of Cambridge Repository, and Chinnery, Patrick F [0000-0002-7065-6617]

Subjects
Medicine and health sciences, Cancer Research, Mitochondrial Diseases, Biology and life sciences, DNA, Mitochondrial, Mitochondria, Cardiovascular Diseases, Hypertension, Mutation, Genetics, Humans, Molecular Biology, Genetics (clinical), Ecology, Evolution, Behavior and Systematics, Research Article
Abstract

Funder: National Institute for Health Research, Funder: NIHR Oxford Biomedical Research Centre; funder-id: http://dx.doi.org/10.13039/501100013373, Funder: Wellcome Trust; funder-id: http://dx.doi.org/10.13039/100004440, Funder: Wolfson Foundation; funder-id: http://dx.doi.org/10.13039/501100001320, Funder: British Heart Foundation, Mitochondria are implicated in the pathogenesis of cardiovascular diseases (CVDs) but the reasons for this are not well understood. Maternally-inherited population variants of mitochondrial DNA (mtDNA) which affect all mtDNA molecules (homoplasmic) are associated with cardiometabolic traits and the risk of developing cardiovascular disease. However, it is not known whether mtDNA mutations only affecting a proportion of mtDNA molecules (heteroplasmic) also play a role. To address this question, we performed a high-depth (~1000-fold) mtDNA sequencing of blood DNA in 1,399 individuals with hypertension (HTN), 1,946 with ischemic heart disease (IHD), 2,146 with ischemic stroke (IS), and 723 healthy controls. We show that the per individual burden of heteroplasmic single nucleotide variants (mtSNVs) increases with age. The age-effect was stronger for low-level heteroplasmies (heteroplasmic fraction, HF, 5-10%), likely reflecting acquired somatic events based on trinucleotide mutational signatures. After correcting for age and other confounders, intermediate heteroplasmies (HF 10-95%) were more common in hypertension, particularly involving non-synonymous variants altering the amino acid sequence of essential respiratory chain proteins. These findings raise the possibility that heteroplasmic mtSNVs play a role in the pathophysiology of hypertension.

Published
2022

14. Deep phenotyping of T regulatory cells in psoriatic arthritis highlights targetable mechanisms of disease.

Author

McTaggart T, Lim JX, Smith KJ, Heaney B, McDonald D, Hulme G, Hussain R, Coxhead J, Degnan AE, Isaacs J, Pratt A, and Amarnath S

Abstract

Regulatory T cells (Tregs) are immune regulatory T cells that are vital for controlling inflammation. The role of Tregs in inflammatory diseases namely Psoriatic Arthritis (PsA) is still poorly understood. The underlying reason being a lack of robust unbiased analysis to test the immune regulatory phenotype of human Tregs. Here, we propose that checkpoint receptors can identify functional Tregs in PsA. Using unbiased BD Rhapsody TM single cell analysis, we have analyzed the expression pattern of checkpoint receptors in Tregs and found that PsA Tregs are enriched in the expression of CTLA4, TIGIT, PD-1 and GITR while TIM3 was downregulated. Furthermore, PD-1 + Tregs in PsA had an increased type 1 phenotype and expressed the protease asparaginyl endopeptidase. By harnessing the PD-1 signaling pathway and inhibiting asparaginyl endopeptidase, PsA Treg function was significantly enhanced in in-vitro suppressor assays. Next, we interrogated the cell interaction pathways of Tregs in PsA and found a diminished crosstalk with circulating osteoclast precursors (OCP) through the CD244:CD48 co-receptor pathways. Therapeutically, PsA Treg function could be enhanced by modulating PD-1 and osteoclast interactions. Our study suggests unconventional immune cell crosstalk with Tregs is severely diminished in PsA., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
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