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Lateral ankle ligament injuries occur in connection with inversion traumas and are one of the most common injuries, both in the general population and among athletes. A lateral ankle ligament injury weakens the stabilising structures in the ankle and disposes the ankle joint to prolonged instability. Acute lateral ankle ligament injuries with no suspicion of fracture can be treated and followed up conservatively in the primary health service. In this clinical review article, we emphasise the importance of adequate physical training before referral to an MRI and orthopaedic surgeon for further assessment. Patients with chronic instability who fail to respond to adequate conservative treatment should be referred for surgical assessment.