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The quality control of testing and inspection laboratories operated in Korea, the United States, and Canada was compared. The basic framework of on-site evaluation operated by each country was similar in terms of evaluation procedure, document evaluation, issuance of verification certificate, and follow-up management. For conducting on-site evaluation and granting the certificate, the preparation materials and evaluation processes are subdivided in Korea, while the dates of granting the certificate are restricted to four times a year in the United States. After receiving accreditation as a testing/inspection laboratories for the first time in Canada, follow-up management is divided into re-evaluation, verification evaluation, and monitoring evaluation.

The concept of physiological link between the gut and the skin, known as the gut-skin axis, has been gaining more evidence recently. Although experimental data from animal and human studies support the existence of the gut-skin axis, in vitro model platforms that can test the hypothesis are lacking. Organ-on-a-chip offers the possibility of connecting different tissues and recapitulating interactions between them. In this study, we report a multiorgan chip that can capture the basic interorgan communication between the gut and the skin. Its modular design enables separate culture and differentiation of the gut and skin tissues, and after assembly the two organs are connected via microfluidic channels than enables perfusion and mass transfer. We showed that the impairment of the gut barrier function exacerbated the adverse effect of fatty acids on skin cells, with decreased viability, increased level of cytokine secretion and human beta defensin-2 (hBD-2), an inflammatory dermal disease marker. Based on these results, we believe that our multiorgan chip can be a novel in vitro platform for recapitulating complex mechanisms underlying the gut-skin axis.