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Your search keyword '"Inositol -- Physiological aspects"' showing total 18 results
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18 results on '"Inositol -- Physiological aspects"'

1. Inositol Hexaphosphate (InsP6) Activates the HDAC1/3 Epigenetic Axis toMaintain Intestinal Barrier Function

Subjects
Physiological aspects, Epigenetic inheritance -- Physiological aspects, Physical fitness -- Physiological aspects, Inositol -- Physiological aspects, Enzymes -- Physiological aspects
Abstract

2024 OCT 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2024

2. Physiological functions of calcium signaling via Orai1 in cancer

Author

Umemura, Masanari, Nakakaji, Rina, and Ishikawa, Yoshihiro

Subjects
Silencing (Short story), T cells -- Physiological aspects, Inositol -- Physiological aspects, Metastasis -- Physiological aspects, Phosphoproteins -- Physiological aspects, Squamous cell carcinoma -- Physiological aspects, G proteins -- Physiological aspects, B cells -- Physiological aspects, Fc receptors -- Physiological aspects, Psychology and mental health
Abstract

Intracellular calcium (Ca.sup.2+) signaling regulates many cellular functions, including cell proliferation and migration, in both normal cells and cancer cells. Store-operated Ca.sup.2+ entry (SOCE) is a major mechanism by which Ca.sup.2+ is imported from the extracellular space to the intracellular space, especially in nonexcitable cells. Store-operated Ca.sup.2+ entry (SOCE) is also a receptor-regulated Ca.sup.2+ entry pathway that maintains Ca.sup.2+ homeostasis by sensing reduced Ca.sup.2+ levels in the endoplasmic reticulum (ER). In general, the activation of G protein-coupled receptors (GPCRs) or immunoreceptors, such as T-cell, B-cell and Fc receptors, results in the production of inositol 1,4,5-trisphosphate (IP.sub.3). IP.sub.3 binds to IP.sub.3 receptors located in the ER membrane. The, IP.sub.3 receptors in the ER membrane trigger a rapid and transient release of Ca.sup.2+ from the ER store. The resulting depletion of ER Ca.sup.2+ concentrations is sensed by the EF-hand motif of stromal interaction molecule (STIM), i.e., calcium sensor, which then translocates to the plasma membrane (PM). STIM interacts with Orai Ca.sup.2+ channel subunits (also known as CRACM1) on the PM, leading to Ca.sup.2+ influx from the extracellular space to increase intracellular Ca.sup.2+ concentrations. The physiological functions of Orai and STIM have been studied mainly with respect to their roles in the immune system. Based on numerous previous studies, Orai channels (Orai1, Orai2 and Orai3 channels) control Ca.sup.2+ release-activated Ca.sup.2+ (CRAC) currents and contribute to SOCE currents in other types of cells, including various cancer cells. There are many reports that Orai1 is involved in cell proliferation, migration, metastasis, apoptosis and epithelial-mesenchymal transition (EMT) in various cancers. We previously found that Orai1 plays important roles in cell apoptosis and migration in melanoma. Recently, we reported novel evidence of Orai1 in human oral squamous cell carcinoma (OSCC) cells and human cardiac fibroblasts (HCFs). In this review, we present multiple physiological functions of Orai1 in various cancer cells and cardiac fibroblasts, including our findings. Keywords: Calcium, Orai1, EP4, Store-operated-calcium entry (SOCE), Cancer, Cardiac fibroblast, Author(s): Masanari Umemura[sup.1], Rina Nakakaji[sup.1] and Yoshihiro Ishikawa[sup.1] Introduction Calcium (Ca[sup.2+]) plays important roles as a second messenger in almost all cell types. Ca[sup.2+] release-activated Ca[sup.2+] (CRAC) channels mediate a [...]

Published
2023
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4. Pyruvate kinase modulates the link between b-cell fructose metabolism and insulin secretion

Subjects
Inositol -- Physiological aspects, Fructose -- Physiological aspects, Insulin -- Physiological aspects, Glucose metabolism -- Physiological aspects, Health
Abstract

2024 SEP 2 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- According to news reporting based on a preprint abstract, our journalists obtained the following quote [...]

Published
2024

5. New Burkitt Lymphoma Data Have Been Reported by Researchers at University Medical Center Gottingen (Sh2 Domain-containing Inositol 5-phosphatases Support the Survival of Burkitt Lymphoma Cells By Promoting Energy Metabolism)

Subjects
Medical centers -- Physiological aspects, Inositol -- Physiological aspects, Non-Hodgkin's lymphomas -- Physiological aspects, Phosphatases -- Physiological aspects, Burkitt's lymphoma -- Physiological aspects, Health
Abstract

2024 JUN 17 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- New research on Oncology - Burkitt Lymphoma is the subject of a report. According to [...]

Published
2024

6. Study Data from Nanjing Medical University Update Understanding of Colon Cancer (Isyna1 Is a New Diagnostic and Prognostic Marker of Colorectal Cancer That Promotes Proliferation and Migration of Malignant Cells)

Subjects
Oncology, Experimental -- Physiological aspects, Inositol -- Physiological aspects, Colorectal cancer -- Diagnosis -- Prognosis, Enzymes -- Physiological aspects, Cancer -- Research, Business, Health, Health care industry
Abstract

2024 MAR 12 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology - Colon Cancer have been published. According to news reporting [...]

Published
2024

7. Findings from University of Western Australia Broaden Understanding of Genomics and Genetics (Discovery and Heterologous Biosynthesis of Glycosylated Polyketide Luteodienoside a Reveals Unprecedented Glucinol-mediated Product Offloading By a ...)

Subjects
Australia. Research Council, Inositol -- Physiological aspects, Genetic research -- Physiological aspects, Biosynthesis -- Physiological aspects, Carnitine -- Physiological aspects, Health, University of Western Australia
Abstract

2024 MAR 1 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Genomics and Genetics have been published. According to news [...]

Published
2024

8. Regulation of a single Inositol 1-Phosphate Synthase homeolog by HSFA6B contributes to fiber yield maintenance under drought conditions in upland cotton (Updated February 7, 2024)

Subjects
Inositol -- Physiological aspects, Droughts -- Physiological aspects, Crop yields -- Physiological aspects, Phosphates -- Physiological aspects, Biological sciences, Health
Abstract

2024 FEB 20 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- According to news reporting based on a preprint abstract, our journalists obtained the following [...]

Published
2024

9. IPMK modulates insulin-mediated suppression of hepatic glucose production (Updated April 19, 2022)

Subjects
Inositol -- Physiological aspects, Dextrose -- Physiological aspects, Insulin resistance -- Physiological aspects, Insulin -- Physiological aspects, Glucose -- Physiological aspects, Physical fitness -- Physiological aspects, Health
Abstract

2022 MAY 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2022

11. IPMK modulates insulin-mediated suppression of hepatic glucose production

Subjects
Inositol -- Physiological aspects, Dextrose -- Physiological aspects, Insulin resistance -- Physiological aspects, Insulin -- Physiological aspects, Glucose -- Physiological aspects, Physical fitness -- Physiological aspects, Health
Abstract

2022 APR 2 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2022

12. Research Results from National University of Singapore Update Understanding of Biological Factors (Myo-Inositol Moderates Glucose-Induced Effects on Human Placental [superscript]13C-Arachidonic Acid Metabolism)

Subjects
Arachidonic acid -- Physiological aspects, Inositol -- Physiological aspects, Dextrose -- Physiological aspects, Unsaturated fatty acids -- Physiological aspects, Glucose -- Physiological aspects, Biological sciences, Health, National University of Singapore
Abstract

2022 NOV 1 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on biological factors is now available. According to news originating from [...]

Published
2022

13. Researchers at Johns Hopkins University Have Reported New Data on Proinsulin (Activation of the Canonical Er Stress Ire1-xbp1 Pathway By Insulin Regulates Glucose and Lipid Metabolism)

Subjects
United States. National Institutes of Health, Inositol -- Physiological aspects, Dextrose -- Physiological aspects, Protein binding -- Physiological aspects, Insulin -- Physiological aspects, Stress (Physiology) -- Physiological aspects, Glucose -- Physiological aspects, Glucose metabolism -- Physiological aspects, Proteins -- Physiological aspects, Health, Johns Hopkins University
Abstract

2022 OCT 17 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Peptide Proteins - Proinsulin have been published. According to news reporting [...]

Published
2022

15. New Ubiquitins Data Have Been Reported by Investigators at State University of New York (SUNY) Upstate Medical University [Binding of the Erlin1/2 Complex To the Third Intralumenal Loop of Ip(3)R1 Triggers Its Ubiquitin-proteasomal Degradation]

Subjects
Biological research, Biology, Experimental, Ubiquitin-proteasome system -- Research, Inositol -- Physiological aspects, Protein binding -- Research, Biodegradation -- Research, Cell receptors -- Physiological aspects, Biological sciences, Health
Abstract

2022 JUL 19 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteins - Ubiquitins. According to news reporting out of [...]

Published
2022

17. National University Colombia Researchers Broaden Understanding of Cellular Neuroscience (Modulation of Gq/PLC-Mediated Signaling by Acute Lithium Exposure)

Subjects
Inositol -- Physiological aspects, Neurosciences -- Physiological aspects, Biological sciences, Health
Abstract

2022 MAR 1 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in cellular neuroscience. According to news originating from Bogota, Colombia, [...]

Published
2022

18. Ministry of Agriculture and Rural Affairs Researchers Have Provided New Data on Physiology [Effects of Dietary Inositol Supplementation on Growth, Digestive Performance, Antioxidant Capacity, and Body Composition of Golden Pompano (Trachinotus ...]

Subjects
Inositol -- Physiological aspects, Actinopterygii -- Physiological aspects -- Food and nutrition, Biological sciences, Health
Abstract

2022 MAR 1 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on physiology is now available. According to news reporting from Guangzhou, [...]

Published
2022

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