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Cél: Szekunder elemzés révén a szervezett bűnözés 21. századi formájának megismerése és az ellene irányuló fellépés lehetséges eszközeinek a feltérképezése. Vajon elégségesnek bizonyul-e a (büntető)jogi szabályozás és a bűnüldözés eszköztára, vagy más módszerek és lehetőségek irányába kell haladnunk és bővítenünk. Módszertan: A tanulmányban az analízis és szintézis duális egységének, valamint a forráskritikának az alkalmazása valósul meg. Mindezt kiegészíti a felhasznált jelentésekben szereplő adatok további elemzése és értékelése, amely szekunder kutatásnak felel meg. Megállapítások: A 21. században a szervezett bűnözés jellege, csoportdinamizmusa és a hozzá kapcsolódó jellegzetességek megváltoztak. A szerző álláspontja szerint egy eszközzel – mint például a (büntető)jogi szabályozással, vagy például hatékonyabb bűnüldöző technikákkal stb. – nem lehet ellene fellépni. Megoldási alternatívaként a teljes ellehetetlenítés stratégiája szolgálhat, amelynek részleteiről a tanulmányban levont következtetések alapján olvashatunk. Érték: A dolgozat értéke kimutatható a szervezett bűnözés jelenségének feltérképezésére irányuló kutatómunkából, a primer és szekunder adatok elemzéséből és értékeléséből, a következtetések levonásából, valamint a javaslatok megfogalmazásából.

Background: Identification of predictors for atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI) can lead to better long-term results. Our aim was to investigate the association between novel CT imaging markers reflecting the severity of coronary atherosclerosis and the risk of recurrence following PVI. Methods: This study included 80 patients with paroxysmal/persistent AF who underwent PVI. The patients were divided into two groups: Group 1–23 patients with recurrence and Group 2–57 patients without recurrence. Results: Patients with recurrence presented with a more enlarged left atrial diameter and reduced left ventricle EF, as assessed by echocardiography. Elevated calcium scores and right coronary artery (RCA) stenosis were correlated with a higher risk of AF recurrence (25.38 ± 4.1% vs. 9.76 ± 2.32%, p = 0.001). Patients with AF recurrence presented a higher left atrial volume index (LAVI) (61.38 ± 11.12 mm3/m2 vs. 46.34 ± 12.27 mm3/m2, p < 0.0001). The bi-atrial volume index (BAVI) was similarly higher in the AF recurrence group (98.23 ± 14.44 mm3/m2 vs. 76.48 ± 17.61 mm3/m2, p < 0.0001). Increased EAT volumes located around the LA (EAT-LA) were correlated with recurrence (25.55 ± 6.37 vs. 15.54 ± 8.44, p < 0.0001). Conclusions: RCA stenosis, together with atrial volumes and EAT-AS evaluated by CCTA, is associated with the risk of AF recurrence following PVI.

Inflammation is a key factor in the development of atherosclerosis, a disease characterized by the buildup of plaque in the arteries. COVID-19 infection is known to cause systemic inflammation, but its impact on local plaque vulnerability is unclear. Our study aimed to investigate the impact of COVID-19 infection on coronary artery disease (CAD) in patients who underwent computed tomography angiography (CCTA) for chest pain in the early stages after infection, using an AI-powered solution called CaRi-Heart®. The study included 158 patients (mean age was 61.63 ± 10.14 years) with angina and low to intermediate clinical likelihood of CAD, with 75 having a previous COVID-19 infection and 83 without infection. The results showed that patients who had a previous COVID-19 infection had higher levels of pericoronary inflammation than those who did not have a COVID-19 infection, suggesting that COVID-19 may increase the risk of coronary plaque destabilization. This study highlights the potential long-term impact of COVID-19 on cardiovascular health, and the importance of monitoring and managing cardiovascular risk factors in patients recovering from COVID-19 infection. The AI-powered CaRi-Heart® technology may offer a non-invasive way to detect coronary artery inflammation and plaque instability in patients with COVID-19.

Cél: A Lewin és kutatótársai által alkotott vezetési stílusok rendészeti szervekben gyakorolt hatásának vizsgálata, amit a szervezetben szolgálatot ellátó, élettapasztalattal és szakmai életúttal rendelkező, kiforrott személyiségek véleménye is formálhat, új megvilágításban tüntethet fel. Módszertan: A kutatást kvantitatív metódus felhasználásával hajtottuk végre, a résztvevők online elérhető kérdőíveket töltöttek ki, amelyeket matematikai statisztikai próbáknak vetettünk alá. Megállapítások: A vezetési stílusokról, a vezető személyéről, az azokhoz köthető attribútumokról reális képet sikerült felállítanunk, egy olyan torzításmentes kép tárult elénk, amely új tudományos eredmények létrejöttét generálta a vezetéstudomány területén. Érték: A rendészettudomány tudásbázisának bővítése, a vezetés- és szervezéstudomány új kutatási eredményeinek szervezeti szinten történő hasznosítása a rendvédelemben. Lewin az elméletét 1938-ban a iowai Gyermekjóléti Kutatási Központban tízéves gyermekek körében végzett kísérlet eredményeképpen fogalmazta meg. Közel 80 év elteltével ennek aktualitását mind az egyén és mind a szervezetek vonatkozásában a társadalmi átalakulási folyamatok jelentős mértékben befolyásolták. Minderre figyelemmel az elmélet újragondolását a horizontálisan és vertikálisan felépülő (szervezeti és szakmai) rendészeti szervek vezetése vonatkozásában is indokolt megvizsgálni, amit a szervezetben szolgálatot ellátó, élettapasztalattal és szakmai életúttal rendelkező, kiforrott személyiségek véleménye is formálhat, új megvilágításban tüntethet fel.

Because it is impossible to comprehensively characterize biodiversity at all levels of organization, conservation prioritization efforts need to rely on surrogates. As species distribution maps of relished groups as well as high-resolution remotely sensed data increasingly become available, both types of surrogates are commonly used. A good surrogate should represent as much of biodiversity as possible, but it often remains unclear to what extent this is the case. Here, we aimed to address this question by assessing how well bird species and habitat diversity represent one another. We conducted our study in Romania, a species-rich country with high landscape heterogeneity where bird species distribution data have only recently started to become available. First, we prioritized areas for conservation based on either 137 breeding bird species or 36 habitat classes, and then evaluated their reciprocal surrogacy performance. Second, we examined how well these features are represented in already existing protected areas. Finally, we identified target regions of high conservation value for the potential expansion of the current network of reserves (as planned under the new EU Biodiversity Strategy for 2030). We found a limited reciprocal surrogacy performance, with bird species performing slightly better as a conservation surrogate for habitat diversity than vice versa. We could also show that areas with a high conservation value based on habitat diversity were represented better in already existing protected areas than areas based on bird species, which varied considerably between species. Our results highlight that taxonomic and environmental (i.e., habitat types) data may perform rather poorly as reciprocal surrogates, and multiple sources of data are required for a full evaluation of protected areas expansion.

Introduction: Autologous native arteriovenous fistula (AVF) created in the non-dominant arm is the gold standard vascular access for dialysis in end-stage renal disease, but the post-surgical vascular access dysfunction causes a reduction in the patient’s quality of life. Creating a functional upper extremity permanent arteriovenous access is limited by the upper limb’s vascular resources, so good management of a complicated arteriovenous fistula may improve patient outcomes. This article highlights the importance of new surgical options in treating complicated AVFs. Case report: We present the case of a patient with a 17-year-old complex radio-cephalic arterio-venous fistula and a series of surgical interventions performed for life salvage in the first place and functional vascular access in the second place. Furthermore, we describe a successfully created uncommon type of fistula in the lower extremity between the great saphenous vein and the anterior tibial artery as the last possible access for hemodialysis in this patient. Results: The patient underwent the first successful dialysis using the newly created lower limb fistula 1 month after the surgery. Conclusion: Applying new surgical techniques to manage AVFs gives a unique chance to improve the quality of life and reduce morbidity and mortality in these patients.

Urbanization has resulted in the widespread development of built-up areas, often without considering the local geology and geomorphology. To improve risk assessments related to landslides, it is essential to determine the physical and chemical properties of sediments. The aim of this study is to exemplify an already mobilized and reworked layer based on granulometric properties of the sediments and characterize the chemical and physical properties which have changed during or after the mass movement. Ten red clay layers were sampled near Kulcs (Hungary) from a sliding surface and its environment. We measured grain size distribution, major element and modal composition, furthermore, conduct particle shape analysis, respectively. Grain size distribution suggest that samples from the sliding surface are weathered, with the exhibiting reworking characteristics. We calculate the weathering index from the major elements, which, in combination with the particle shape analyses of the silt fractions, indicate that the morphological parameters of the samples are in relation with weathering index. According to our results, while a fresh sliding event leaves marks on the granulometric properties, the main process which affects the grain morphology is the chemical abrasion (post the mass movement) and not the landslide event. [ABSTRACT FROM AUTHOR]

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This paper presents a solution for full integration of a Type-II compensation circuit for DC-DC buck converters. It employs a novel active circuit based on capacitor multiplier, able to emulate the R-series-C ensemble within the conventional Gm-RC compensation network. The proposed solution was used to design a current-mode DC-DC buck converter for automotive applications. The implementation of key circuits in a 180 nm CMOS process is presented in some detail. Simulation results demonstrate that the converter meets all design requirements: it provides a 5 V output voltage over wide ranges of the input voltage, 6 V to 45 V, and load current, between 10 mA and 300 mA. Its frequency and transient responses compare well against the performance of a similar converter that employs a conventional Gm-RC compensation circuit. It consumes 20 $\mu \text{A}$ more, but requires significantly less die area, than its counterpart. Furthermore, the tuning required to compensate for process and temperature variations is realized by programming the multiplication factor of the capacitor multiplier.

An electrical storm is a life-threatening emergency characterized by recurrent and sustained ventricular tachycardia (VT) or ventricular fibrillation (VF). The clinical presentation of electrical storms can vary widely, requiring a systematic evaluation and personalized management approach. The management of electrical storms should be individualized based on the specific clinical presentation and underlying heart disease. We present a rare case of an electrical storm triggered by a catecholamine crisis induced by a paraganglioma, highlighting the critical role of early diagnosis and management of paraganglioma-related complications. [ABSTRACT FROM AUTHOR]

β2-microglobulin (β2m), the light chain of the MHC-I complex, is associated with dialysis-related amyloidosis (DRA). Recently, a hereditary systemic amyloidosis was discovered, caused by a naturally occurring D76N β2m variant, which showed a structure remarkably similar to the wild-type (WT) protein, albeit with decreased thermodynamic stability and increased amyloidogenicity. Here, we investigated the role of the D76N mutation in the amyloid formation of β2m by point mutations affecting the Asp76-Lys41 ion-pair of WT β2m and the charge cluster on Asp38. Using a variety of biophysical techniques, we investigated the conformational stability and partial unfolding of the native state of the variants, as well as their amyloidogenic propensity and the stability of amyloid fibrils under various conditions. Furthermore, we studied the intermolecular interactions of WT and mutant proteins with various binding partners that might have in vivo relevance. We found that, relative to WT β2m, the exceptional amyloidogenicity of the pathogenic D76N β2m variant is realized by the deleterious synergy of diverse effects of destabilized native structure, higher sensitivity to negatively charged amphiphilic molecules (e.g., lipids) and polyphosphate, more effective fibril nucleation, higher conformational stability of fibrils, and elevated affinity for extracellular components, including extracellular matrix proteins.