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Your search keyword '"Ivashkevich, Oleg A."' showing total 22 results
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22 results on '"Ivashkevich, Oleg A."'

15. Deprotometalation-Iodolysis and Direct Iodination of 1-Arylated 7-Azaindoles: Reactivity Studies and Molecule Properties

Author

Ameur Messaoud, Mohamed Yacine Ameur, primary, Bentabed-Ababsa, Ghenia, additional, Fajloun, Ziad, additional, Hamze, Monzer, additional, Halauko, Yury S., additional, Ivashkevich, Oleg A., additional, Matulis, Vadim E., additional, Roisnel, Thierry, additional, Dorcet, Vincent, additional, and Mongin, Florence, additional

Published
2021
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18. Front Cover: Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer (Chem. Eur. J. 28/2024).

Author

Katkova, Svetlana A., Bunev, Alexander S., Gasanov, Rovshan E., Khochenkov, Dmitry A., Kulsha, Andrey V., Ivashkevich, Oleg A., Serebryanskaya, Tatiyana V., and Kinzhalov, Mikhail A.

Subjects
TRIPLE-negative breast cancer, ALUMINUM alloys, PALLADIUM compounds
Abstract

The article titled "Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer" discusses the use of a palladium compound to target aggressive tumors while sparing normal cells and tissues. The authors draw inspiration from the protective figure of Pallas Athena, which symbolizes the original meaning of the word "palladium." The research article provides more detailed information on this topic and can be accessed using the provided DOI. [Extracted from the article]

Published
2024
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20. O‐Isopropylferrocenesulfonate: Synthesis of Polysubstituted Derivatives and Electrochemical Study.

Author

Erb, William, Wen, Min, Pierre Hurvois, Jean, Mongin, Florence, Halauko, Yury S., Ivashkevich, Oleg A., Matulis, Vadim E., and Roisnel, Thierry

Subjects
HALOGENS, SULFONAMIDES, METALS, FERROCENE, CHIRALITY
Abstract

Few studies have been reported on the synthesis of ferrocenesulfonates up to now. Here, we describe the use of ortho‐deprotometalation and "halogen dance" reactions to easily reach original derivatives. Further functionalizations using cross‐coupling and metal/halogen exchange were also performed from iodinated derivatives. Finally, while the electrochemical properties of selected ferrocenesulfonates were evaluated and compared with the corresponding sulfonamide derivatives, halogen bonds were observed at the solid state for iodinated derivatives of ferrocenesulfonates. [ABSTRACT FROM AUTHOR]

Published
2021
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21. From 2- to 3-Substituted Ferrocene Carboxamides or How to Apply Halogen “Dance” to the Ferrocene Series

Author

Tazi, Mehdi, Erb, William, Halauko, Yury S., Ivashkevich, Oleg A., Matulis, Vadim E., Roisnel, Thierry, Dorcet, Vincent, and Mongin, Florence

Abstract

Two methods were compared to convert ferrocene into N,N-diisopropylferrocenecarboxamide, N,N-diethylferrocenecarboxamide, N,N-dimethylferrocenecarboxamide, and (4-morpholinocarbonyl)ferrocene, namely, deprotometalation followed by trapping using dialkylcarbamoyl chlorides and amide formation from the intermediate carboxylic acid. The four ferrocenecarboxamides were functionalized at C2; in the case of the less hindered and more sensitive amides, recourse to a mixed lithium–zinc 2,2,6,6-tetramethylpiperidino-based base allowed us to achieve the reactions. Halogen migration using lithium amides was next optimized. Whereas it appeared impossible to isolate the less hindered 3-iodoferrocenecarboxamides, 3-iodo-N,N-diisopropylferrocenecarboxamide proved stable and was converted to new 1,3-disubstituted ferrocenes by Suzuki coupling or amide reduction. DFT calculations were used to rationalize the results obtained.

Published
2024
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22. Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer.

Author

Katkova SA, Bunev AS, Gasanov RE, Khochenkov DA, Kulsha AV, Ivashkevich OA, Serebryanskaya TV, and Kinzhalov MA

Subjects
Humans, Female, Cell Line, Tumor, Palladium chemistry, Methane analogs & derivatives, Methane chemistry, Methane pharmacology, Triple Negative Breast Neoplasms drug therapy, Triple Negative Breast Neoplasms pathology, Coordination Complexes chemistry, Coordination Complexes pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Cell Proliferation drug effects
Abstract

Invited for the cover of this issue are Tatiyana Serebryanskaya, Mikhail Kinzhalov and co-workers at St. Petersburg State University, the Research Institute for Physical Chemical Problems, Belarusian State University, Togliatti State University and Blokhin National Medical Research Center of Oncology. The image depicts the shield of Pallas Athena with the structure of a palladium carbene complex that protects against triple-negative breast cancer. Read the full text of the article at 10.1002/chem.202400101., (© 2024 Wiley-VCH GmbH.)

Published
2024
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