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1. Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023.

Author

Johannesen TB, Munkstrup C, Edslev SM, Baig S, Nielsen S, Funk T, Kristensen DK, Jacobsen LH, Ravn SF, Bindslev N, Gubbels S, Voldstedlund M, Jokelainen P, Hallstrøm S, Rasmussen A, Kristinsson KG, Fuglsang-Damgaard D, Dessau RB, Olsén AB, Jensen CS, Skovby A, Ellermann-Eriksen S, Jensen TG, Dzajic E, Østergaard C, Lomborg Andersen S, Hoffmann S, Andersen PH, and Stegger M

Subjects
Humans, Streptococcus pyogenes genetics, Seasons, Denmark epidemiology, COVID-19, Streptococcal Infections epidemiology
Abstract

A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus .

Published
2023
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