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264 results on '"James, C. David"'

1. Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases

Author

Fares, Jawad, Petrosyan, Edgar, Kanojia, Deepak, Dmello, Crismita, Cordero, Alex, Duffy, Joseph T., Yeeravalli, Ragini, Sahani, Mayurbhai H., Zhang, Peng, Rashidi, Aida, Arrieta, Victor A., Ulasov, Ilya, Ahmed, Atique U., Miska, Jason, Balyasnikova, Irina V., James, C. David, Sonabend, Adam M., Heimberger, Amy B., and Lesniak, Maciej S.

Subjects
Thermo Fisher Scientific Inc., Cell death -- Analysis, Scientific equipment and supplies industry -- Analysis, Temsirolimus -- Analysis, Metastasis -- Analysis, Phenothiazine -- Analysis, Drug approval -- Analysis, Cancer -- Analysis, Antiparkinsonian agents -- Analysis, Health care industry
Abstract

A paucity of chemotherapeutic options for metastatic brain cancer limits patient survival and portends poor clinical outcomes. Using a CNS small-molecule inhibitor library of 320 agents known to be blood-brain barrier permeable and approved by the FDA, we interrogated breast cancer brain metastasis vulnerabilities to identify an effective agent. Metixene, an antiparkinsonian drug, was identified as a top therapeutic agent that was capable of decreasing cellular viability and inducing cell death across different metastatic breast cancer subtypes. This agent significantly reduced mammary tumor size in orthotopic xenograft assays and improved survival in an intracardiac model of multiorgan site metastases. Metixene further extended survival in mice bearing intracranial xenografts and in an intracarotid mouse model of multiple brain metastases. Functional analysis revealed that metixene induced incomplete autophagy through N-Myc downstream regulated 1 (NDRG1) phosphorylation, thereby leading to caspase-mediated apoptosis in both primary and brain-metastatic cells, regardless of cancer subtype or origin. CRISPR/Cas9 KO of NDRG1 led to autophagy completion and reversal of the metixene apoptotic effect. Metixene is a promising therapeutic agent against metastatic brain cancer, with minimal reported side effects in humans, which merits consideration for clinical translation., Introduction Metastasis is a hallmark of cancer that remains a primary cause of cancer-related deaths (1). Brain metastases are the most common type of CNS malignancies. They often manifest with [...]

Published
2023
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2. Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

Author

Kouri, Fotini M., primary, Hurley, Lisa A., additional, Daniel, Weston L., additional, Day, Emily S., additional, Hua, Youjia, additional, Hao, Liangliang, additional, Peng, Chian-Yu, additional, Merkel, Timothy J., additional, Queisser, Markus A., additional, Ritner, Carissa, additional, Zhang, Hailei, additional, James, C. David, additional, Sznajder, Jacob I., additional, Chin, Lynda, additional, Giljohann, David A., additional, Kessler, John A., additional, Peter, Marcus E., additional, Mirkin, Chad A., additional, and Stegh, Alexander H., additional

Published
2024
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4. Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

Author

Perrault, Ella N., primary, Shireman, Jack M., additional, Ali, Eunus S., additional, Lin, Peiyu, additional, Preddy, Isabelle, additional, Park, Cheol, additional, Budhiraja, Shreya, additional, Baisiwala, Shivani, additional, Dixit, Karan, additional, James, C. David, additional, Heiland, Dieter H, additional, Ben-Sahra, Issam, additional, Pott, Sebastian, additional, Basu, Anindita, additional, Miska, Jason, additional, and Ahmed, Atique U., additional

Published
2023
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5. Supplementary Table S2 from SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression

Author

Fischietti, Mariafausta, primary, Eckerdt, Frank, primary, Perez, Ricardo E., primary, Guillen Magaña, Jamie N., primary, Mazewski, Candice, primary, Ho, Sang, primary, Gonzalez, Christopher, primary, Streich, Lukas D., primary, Beauchamp, Elspeth M., primary, Heimberger, Amy B., primary, Baran, Aneta H., primary, Yue, Feng, primary, James, C. David, primary, and Platanias, Leonidas C., primary

Published
2023
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6. Supplementary Figures S1-S3, Table S1 from SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression

Author

Fischietti, Mariafausta, primary, Eckerdt, Frank, primary, Perez, Ricardo E., primary, Guillen Magaña, Jamie N., primary, Mazewski, Candice, primary, Ho, Sang, primary, Gonzalez, Christopher, primary, Streich, Lukas D., primary, Beauchamp, Elspeth M., primary, Heimberger, Amy B., primary, Baran, Aneta H., primary, Yue, Feng, primary, James, C. David, primary, and Platanias, Leonidas C., primary

Published
2023
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7. Data from SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression

Author

Fischietti, Mariafausta, primary, Eckerdt, Frank, primary, Perez, Ricardo E., primary, Guillen Magaña, Jamie N., primary, Mazewski, Candice, primary, Ho, Sang, primary, Gonzalez, Christopher, primary, Streich, Lukas D., primary, Beauchamp, Elspeth M., primary, Heimberger, Amy B., primary, Baran, Aneta H., primary, Yue, Feng, primary, James, C. David, primary, and Platanias, Leonidas C., primary

Published
2023
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8. Data from NT113, a Pan-ERBB Inhibitor with High Brain Penetrance, Inhibits the Growth of Glioblastoma Xenografts with EGFR Amplification

Author

Yoshida, Yasuyuki, primary, Ozawa, Tomoko, primary, Yao, Tsun-Wen, primary, Shen, Wang, primary, Brown, Dennis, primary, Parsa, Andrew T., primary, Raizer, Jeffrey J., primary, Cheng, Shi-Yuan, primary, Stegh, Alexander H., primary, Mazar, Andrew P., primary, Giles, Francis J., primary, Sarkaria, Jann N., primary, Butowski, Nicholas, primary, Nicolaides, Theodore, primary, and James, C. David, primary

Published
2023
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9. Supplementary Figures 1-2 from NT113, a Pan-ERBB Inhibitor with High Brain Penetrance, Inhibits the Growth of Glioblastoma Xenografts with EGFR Amplification

Author

Yoshida, Yasuyuki, primary, Ozawa, Tomoko, primary, Yao, Tsun-Wen, primary, Shen, Wang, primary, Brown, Dennis, primary, Parsa, Andrew T., primary, Raizer, Jeffrey J., primary, Cheng, Shi-Yuan, primary, Stegh, Alexander H., primary, Mazar, Andrew P., primary, Giles, Francis J., primary, Sarkaria, Jann N., primary, Butowski, Nicholas, primary, Nicolaides, Theodore, primary, and James, C. David, primary

Published
2023
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10. Data from An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Author

Guo, Deliang, primary, Reinitz, Felicia, primary, Youssef, Mary, primary, Hong, Cynthia, primary, Nathanson, David, primary, Akhavan, David, primary, Kuga, Daisuke, primary, Amzajerdi, Ali Nael, primary, Soto, Horacio, primary, Zhu, Shaojun, primary, Babic, Ivan, primary, Tanaka, Kazuhiro, primary, Dang, Julie, primary, Iwanami, Akio, primary, Gini, Beatrice, primary, DeJesus, Jason, primary, Lisiero, Dominique D., primary, Huang, Tiffany T., primary, Prins, Robert M., primary, Wen, Patrick Y., primary, Robins, H. Ian, primary, Prados, Michael D., primary, DeAngelis, Lisa M., primary, Mellinghoff, Ingo K., primary, Mehta, Minesh P., primary, James, C. David, primary, Chakravarti, Arnab, primary, Cloughesy, Timothy F., primary, Tontonoz, Peter, primary, and Mischel, Paul S., primary

Published
2023
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12. Supplementary Figure 3 from NT113, a Pan-ERBB Inhibitor with High Brain Penetrance, Inhibits the Growth of Glioblastoma Xenografts with EGFR Amplification

Author

Yoshida, Yasuyuki, primary, Ozawa, Tomoko, primary, Yao, Tsun-Wen, primary, Shen, Wang, primary, Brown, Dennis, primary, Parsa, Andrew T., primary, Raizer, Jeffrey J., primary, Cheng, Shi-Yuan, primary, Stegh, Alexander H., primary, Mazar, Andrew P., primary, Giles, Francis J., primary, Sarkaria, Jann N., primary, Butowski, Nicholas, primary, Nicolaides, Theodore, primary, and James, C. David, primary

Published
2023
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13. Data from Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation

Author

Bell, Jonathan B., primary, Eckerdt, Frank, primary, Dhruv, Harshil D., primary, Finlay, Darren, primary, Peng, Sen, primary, Kim, Seungchan, primary, Kroczynska, Barbara, primary, Beauchamp, Elspeth M., primary, Alley, Kristen, primary, Clymer, Jessica, primary, Goldman, Stewart, primary, Cheng, Shi-Yuan, primary, James, C. David, primary, Nakano, Ichiro, primary, Horbinski, Craig, primary, Mazar, Andrew P., primary, Vuori, Kristiina, primary, Kumthekar, Priya, primary, Raizer, Jeffrey, primary, Berens, Michael E., primary, and Platanias, Leonidas C., primary

Published
2023
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15. Supplementary Figures S1 - S2 from Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation

Author

Bell, Jonathan B., primary, Eckerdt, Frank, primary, Dhruv, Harshil D., primary, Finlay, Darren, primary, Peng, Sen, primary, Kim, Seungchan, primary, Kroczynska, Barbara, primary, Beauchamp, Elspeth M., primary, Alley, Kristen, primary, Clymer, Jessica, primary, Goldman, Stewart, primary, Cheng, Shi-Yuan, primary, James, C. David, primary, Nakano, Ichiro, primary, Horbinski, Craig, primary, Mazar, Andrew P., primary, Vuori, Kristiina, primary, Kumthekar, Priya, primary, Raizer, Jeffrey, primary, Berens, Michael E., primary, and Platanias, Leonidas C., primary

Published
2023
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16. Supplementary Methods from Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation

Author

Bell, Jonathan B., primary, Eckerdt, Frank, primary, Dhruv, Harshil D., primary, Finlay, Darren, primary, Peng, Sen, primary, Kim, Seungchan, primary, Kroczynska, Barbara, primary, Beauchamp, Elspeth M., primary, Alley, Kristen, primary, Clymer, Jessica, primary, Goldman, Stewart, primary, Cheng, Shi-Yuan, primary, James, C. David, primary, Nakano, Ichiro, primary, Horbinski, Craig, primary, Mazar, Andrew P., primary, Vuori, Kristiina, primary, Kumthekar, Priya, primary, Raizer, Jeffrey, primary, Berens, Michael E., primary, and Platanias, Leonidas C., primary

Published
2023
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17. Supplementary Table S1 from Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation

Author

Bell, Jonathan B., primary, Eckerdt, Frank, primary, Dhruv, Harshil D., primary, Finlay, Darren, primary, Peng, Sen, primary, Kim, Seungchan, primary, Kroczynska, Barbara, primary, Beauchamp, Elspeth M., primary, Alley, Kristen, primary, Clymer, Jessica, primary, Goldman, Stewart, primary, Cheng, Shi-Yuan, primary, James, C. David, primary, Nakano, Ichiro, primary, Horbinski, Craig, primary, Mazar, Andrew P., primary, Vuori, Kristiina, primary, Kumthekar, Priya, primary, Raizer, Jeffrey, primary, Berens, Michael E., primary, and Platanias, Leonidas C., primary

Published
2023
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18. Data from Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

Author

McKinney, Andrew, primary, Lindberg, Olle R., primary, Engler, Jane R., primary, Chen, Katharine Y., primary, Kumar, Anupam, primary, Gong, Henry, primary, Lu, Kan V., primary, Simonds, Erin F., primary, Cloughesy, Timothy F., primary, Liau, Linda M., primary, Prados, Michael, primary, Bollen, Andrew W., primary, Berger, Mitchel S., primary, Shieh, Joseph T.C., primary, James, C. David, primary, Nicolaides, Theodore P., primary, Yong, William H., primary, Lai, Albert, primary, Hegi, Monika E., primary, Weiss, William A., primary, and Phillips, Joanna J., primary

Published
2023
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19. Data from Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model

Author

Lee, Gina, primary, Auffinger, Brenda, primary, Guo, Donna, primary, Hasan, Tanwir, primary, Deheeger, Marc, primary, Tobias, Alex L., primary, Kim, Jeong Yeon, primary, Atashi, Fatemeh, primary, Zhang, Lingjiao, primary, Lesniak, Maciej S., primary, James, C. David, primary, and Ahmed, Atique U., primary

Published
2023
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20. Data from De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients

Author

Akhavan, David, primary, Pourzia, Alexandra L., primary, Nourian, Alex A., primary, Williams, Kevin J., primary, Nathanson, David, primary, Babic, Ivan, primary, Villa, Genaro R., primary, Tanaka, Kazuhiro, primary, Nael, Ali, primary, Yang, Huijun, primary, Dang, Julie, primary, Vinters, Harry V., primary, Yong, William H., primary, Flagg, Mitchell, primary, Tamanoi, Fuyuhiko, primary, Sasayama, Takashi, primary, James, C. David, primary, Kornblum, Harley I., primary, Cloughesy, Tim F., primary, Cavenee, Webster K., primary, Bensinger, Steven J., primary, and Mischel, Paul S., primary

Published
2023
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22. Supplementary Tables 1-2 from NT113, a Pan-ERBB Inhibitor with High Brain Penetrance, Inhibits the Growth of Glioblastoma Xenografts with EGFR Amplification

Author

Yoshida, Yasuyuki, primary, Ozawa, Tomoko, primary, Yao, Tsun-Wen, primary, Shen, Wang, primary, Brown, Dennis, primary, Parsa, Andrew T., primary, Raizer, Jeffrey J., primary, Cheng, Shi-Yuan, primary, Stegh, Alexander H., primary, Mazar, Andrew P., primary, Giles, Francis J., primary, Sarkaria, Jann N., primary, Butowski, Nicholas, primary, Nicolaides, Theodore, primary, and James, C. David, primary

Published
2023
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23. Supplementary Figure 4 from NT113, a Pan-ERBB Inhibitor with High Brain Penetrance, Inhibits the Growth of Glioblastoma Xenografts with EGFR Amplification

Author

Yoshida, Yasuyuki, primary, Ozawa, Tomoko, primary, Yao, Tsun-Wen, primary, Shen, Wang, primary, Brown, Dennis, primary, Parsa, Andrew T., primary, Raizer, Jeffrey J., primary, Cheng, Shi-Yuan, primary, Stegh, Alexander H., primary, Mazar, Andrew P., primary, Giles, Francis J., primary, Sarkaria, Jann N., primary, Butowski, Nicholas, primary, Nicolaides, Theodore, primary, and James, C. David, primary

Published
2023
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24. Supplementary Figure 1 from De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients

Author

Akhavan, David, primary, Pourzia, Alexandra L., primary, Nourian, Alex A., primary, Williams, Kevin J., primary, Nathanson, David, primary, Babic, Ivan, primary, Villa, Genaro R., primary, Tanaka, Kazuhiro, primary, Nael, Ali, primary, Yang, Huijun, primary, Dang, Julie, primary, Vinters, Harry V., primary, Yong, William H., primary, Flagg, Mitchell, primary, Tamanoi, Fuyuhiko, primary, Sasayama, Takashi, primary, James, C. David, primary, Kornblum, Harley I., primary, Cloughesy, Tim F., primary, Cavenee, Webster K., primary, Bensinger, Steven J., primary, and Mischel, Paul S., primary

Published
2023
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25. Supplementary Figure 1 from MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma

Author

Bell, Jonathan B., primary, Eckerdt, Frank D., primary, Alley, Kristen, primary, Magnusson, Lisa P., primary, Hussain, Hridi, primary, Bi, Yingtao, primary, Arslan, Ahmet Dirim, primary, Clymer, Jessica, primary, Alvarez, Angel A., primary, Goldman, Stewart, primary, Cheng, Shi-Yuan, primary, Nakano, Ichiro, primary, Horbinski, Craig, primary, Davuluri, Ramana V., primary, James, C. David, primary, and Platanias, Leonidas C., primary

Published
2023
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27. Data from MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma

Author

Bell, Jonathan B., primary, Eckerdt, Frank D., primary, Alley, Kristen, primary, Magnusson, Lisa P., primary, Hussain, Hridi, primary, Bi, Yingtao, primary, Arslan, Ahmet Dirim, primary, Clymer, Jessica, primary, Alvarez, Angel A., primary, Goldman, Stewart, primary, Cheng, Shi-Yuan, primary, Nakano, Ichiro, primary, Horbinski, Craig, primary, Davuluri, Ramana V., primary, James, C. David, primary, and Platanias, Leonidas C., primary

Published
2023
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29. Supplementary Figure 2 from De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients

Author

Akhavan, David, primary, Pourzia, Alexandra L., primary, Nourian, Alex A., primary, Williams, Kevin J., primary, Nathanson, David, primary, Babic, Ivan, primary, Villa, Genaro R., primary, Tanaka, Kazuhiro, primary, Nael, Ali, primary, Yang, Huijun, primary, Dang, Julie, primary, Vinters, Harry V., primary, Yong, William H., primary, Flagg, Mitchell, primary, Tamanoi, Fuyuhiko, primary, Sasayama, Takashi, primary, James, C. David, primary, Kornblum, Harley I., primary, Cloughesy, Tim F., primary, Cavenee, Webster K., primary, Bensinger, Steven J., primary, and Mischel, Paul S., primary

Published
2023
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30. Supplementary Figures 1-7 from Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model

Author

Lee, Gina, primary, Auffinger, Brenda, primary, Guo, Donna, primary, Hasan, Tanwir, primary, Deheeger, Marc, primary, Tobias, Alex L., primary, Kim, Jeong Yeon, primary, Atashi, Fatemeh, primary, Zhang, Lingjiao, primary, Lesniak, Maciej S., primary, James, C. David, primary, and Ahmed, Atique U., primary

Published
2023
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31. Supplementary Methods, Figures 1-9 from An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Author

Guo, Deliang, primary, Reinitz, Felicia, primary, Youssef, Mary, primary, Hong, Cynthia, primary, Nathanson, David, primary, Akhavan, David, primary, Kuga, Daisuke, primary, Amzajerdi, Ali Nael, primary, Soto, Horacio, primary, Zhu, Shaojun, primary, Babic, Ivan, primary, Tanaka, Kazuhiro, primary, Dang, Julie, primary, Iwanami, Akio, primary, Gini, Beatrice, primary, DeJesus, Jason, primary, Lisiero, Dominique D., primary, Huang, Tiffany T., primary, Prins, Robert M., primary, Wen, Patrick Y., primary, Robins, H. Ian, primary, Prados, Michael D., primary, DeAngelis, Lisa M., primary, Mellinghoff, Ingo K., primary, Mehta, Minesh P., primary, James, C. David, primary, Chakravarti, Arnab, primary, Cloughesy, Timothy F., primary, Tontonoz, Peter, primary, and Mischel, Paul S., primary

Published
2023
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32. Supplementary Figure S1 from Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

Author

McKinney, Andrew, primary, Lindberg, Olle R., primary, Engler, Jane R., primary, Chen, Katharine Y., primary, Kumar, Anupam, primary, Gong, Henry, primary, Lu, Kan V., primary, Simonds, Erin F., primary, Cloughesy, Timothy F., primary, Liau, Linda M., primary, Prados, Michael, primary, Bollen, Andrew W., primary, Berger, Mitchel S., primary, Shieh, Joseph T.C., primary, James, C. David, primary, Nicolaides, Theodore P., primary, Yong, William H., primary, Lai, Albert, primary, Hegi, Monika E., primary, Weiss, William A., primary, and Phillips, Joanna J., primary

Published
2023
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33. Supplementary Figure 1 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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35. Supplementary Figure 3 from Identification and Analysis of In Vivo VEGF Downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies

Author

Brauer, Matthew J., primary, Zhuang, Guanglei, primary, Schmidt, Maike, primary, Yao, Jenny, primary, Wu, Xiumin, primary, Kaminker, Joshua S., primary, Jurinka, Stefanie S., primary, Kolumam, Ganesh, primary, Chung, Alicia S., primary, Jubb, Adrian, primary, Modrusan, Zora, primary, Ozawa, Tomoko, primary, James, C. David, primary, Phillips, Heidi, primary, Haley, Benjamin, primary, Tam, Rachel N.W., primary, Clermont, Anne C., primary, Cheng, Jason H., primary, Yang, Sherry X., primary, Swain, Sandra M., primary, Chen, Daniel, primary, Scherer, Stefan J., primary, Koeppen, Hartmut, primary, Yeh, Ru-Fang, primary, Yue, Peng, primary, Stephan, Jean-Philippe, primary, Hegde, Priti, primary, Ferrara, Napoleone, primary, Singh, Mallika, primary, and Bais, Carlos, primary

Published
2023
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36. Supplementary Tables from Glioblastoma-Derived IL6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth

Author

Lamano, Jonathan B., primary, Lamano, Jason Balquidera, primary, Li, Yuping D., primary, DiDomenico, Joseph D., primary, Choy, Winward, primary, Veliceasa, Dorina, primary, Oyon, Daniel E., primary, Fakurnejad, Shayan, primary, Ampie, Leonel, primary, Kesavabhotla, Kartik, primary, Kaur, Rajwant, primary, Kaur, Gurvinder, primary, Biyashev, Dauren, primary, Unruh, Dusten J., primary, Horbinski, Craig M., primary, James, C. David, primary, Parsa, Andrew T., primary, and Bloch, Orin, primary

Published
2023
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38. Supplementary Methods from Glioblastoma-Derived IL6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth

Author

Lamano, Jonathan B., primary, Lamano, Jason Balquidera, primary, Li, Yuping D., primary, DiDomenico, Joseph D., primary, Choy, Winward, primary, Veliceasa, Dorina, primary, Oyon, Daniel E., primary, Fakurnejad, Shayan, primary, Ampie, Leonel, primary, Kesavabhotla, Kartik, primary, Kaur, Rajwant, primary, Kaur, Gurvinder, primary, Biyashev, Dauren, primary, Unruh, Dusten J., primary, Horbinski, Craig M., primary, James, C. David, primary, Parsa, Andrew T., primary, and Bloch, Orin, primary

Published
2023
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40. Supplementary Figure 9 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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41. Supplementary Figure from Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models

Author

Li, Fuyang, primary, Bondra, Kathryn M., primary, Ghilu, Samson, primary, Studebaker, Adam, primary, Liu, Qianqian, primary, Michalek, Joel E., primary, Kogiso, Mari, primary, Li, Xiao-Nan, primary, Kalapurakal, John A., primary, James, C. David, primary, Burma, Sandeep, primary, Kurmasheva, Raushan T., primary, and Houghton, Peter J., primary

Published
2023
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42. Supplementary Figures from IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma

Author

Ladomersky, Erik, primary, Zhai, Lijie, primary, Lenzen, Alicia, primary, Lauing, Kristen L., primary, Qian, Jun, primary, Scholtens, Denise M., primary, Gritsina, Galina, primary, Sun, Xuebing, primary, Liu, Ye, primary, Yu, Fenglong, primary, Gong, Wenfeng, primary, Liu, Yong, primary, Jiang, Beibei, primary, Tang, Tristin, primary, Patel, Ricky, primary, Platanias, Leonidas C., primary, James, C. David, primary, Stupp, Roger, primary, Lukas, Rimas V., primary, Binder, David C., primary, and Wainwright, Derek A., primary

Published
2023
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43. Supplementary Figure 5 from The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas

Author

Gini, Beatrice, primary, Zanca, Ciro, primary, Guo, Deliang, primary, Matsutani, Tomoo, primary, Masui, Kenta, primary, Ikegami, Shiro, primary, Yang, Huijun, primary, Nathanson, David, primary, Villa, Genaro R., primary, Shackelford, David, primary, Zhu, Shaojun, primary, Tanaka, Kazuhiro, primary, Babic, Ivan, primary, Akhavan, David, primary, Lin, Kelly, primary, Assuncao, Alvaro, primary, Gu, Yuchao, primary, Bonetti, Bruno, primary, Mortensen, Deborah S., primary, Xu, Shuichan, primary, Raymon, Heather K., primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, James, C. David, primary, Kroemer, Guido, primary, Heath, James R., primary, Hege, Kristen, primary, Chopra, Rajesh, primary, Cloughesy, Timothy F., primary, and Mischel, Paul S., primary

Published
2023
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44. Supplementary Table 1 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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45. Supplementary Figure 1 from Identification and Analysis of In Vivo VEGF Downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies

Author

Brauer, Matthew J., primary, Zhuang, Guanglei, primary, Schmidt, Maike, primary, Yao, Jenny, primary, Wu, Xiumin, primary, Kaminker, Joshua S., primary, Jurinka, Stefanie S., primary, Kolumam, Ganesh, primary, Chung, Alicia S., primary, Jubb, Adrian, primary, Modrusan, Zora, primary, Ozawa, Tomoko, primary, James, C. David, primary, Phillips, Heidi, primary, Haley, Benjamin, primary, Tam, Rachel N.W., primary, Clermont, Anne C., primary, Cheng, Jason H., primary, Yang, Sherry X., primary, Swain, Sandra M., primary, Chen, Daniel, primary, Scherer, Stefan J., primary, Koeppen, Hartmut, primary, Yeh, Ru-Fang, primary, Yue, Peng, primary, Stephan, Jean-Philippe, primary, Hegde, Priti, primary, Ferrara, Napoleone, primary, Singh, Mallika, primary, and Bais, Carlos, primary

Published
2023
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46. Supplementary Materials and Data from Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations

Author

Zhang, Daniel Y., primary, Dmello, Crismita, primary, Chen, Li, primary, Arrieta, Victor A., primary, Gonzalez-Buendia, Edgar, primary, Kane, J. Robert, primary, Magnusson, Lisa P., primary, Baran, Aneta, primary, James, C. David, primary, Horbinski, Craig, primary, Carpentier, Alexandre, primary, Desseaux, Carole, primary, Canney, Michael, primary, Muzzio, Miguel, primary, Stupp, Roger, primary, and Sonabend, Adam M., primary

Published
2023
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47. Supplementary Methods, Tables 1 - 3 from Identification and Analysis of In Vivo VEGF Downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies

Author

Brauer, Matthew J., primary, Zhuang, Guanglei, primary, Schmidt, Maike, primary, Yao, Jenny, primary, Wu, Xiumin, primary, Kaminker, Joshua S., primary, Jurinka, Stefanie S., primary, Kolumam, Ganesh, primary, Chung, Alicia S., primary, Jubb, Adrian, primary, Modrusan, Zora, primary, Ozawa, Tomoko, primary, James, C. David, primary, Phillips, Heidi, primary, Haley, Benjamin, primary, Tam, Rachel N.W., primary, Clermont, Anne C., primary, Cheng, Jason H., primary, Yang, Sherry X., primary, Swain, Sandra M., primary, Chen, Daniel, primary, Scherer, Stefan J., primary, Koeppen, Hartmut, primary, Yeh, Ru-Fang, primary, Yue, Peng, primary, Stephan, Jean-Philippe, primary, Hegde, Priti, primary, Ferrara, Napoleone, primary, Singh, Mallika, primary, and Bais, Carlos, primary

Published
2023
Full Text
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48. Supplemental Table 1 from BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas

Author

Olow, Aleksandra, primary, Mueller, Sabine, primary, Yang, Xiaodong, primary, Hashizume, Rintaro, primary, Meyerowitz, Justin, primary, Weiss, William, primary, Resnick, Adam C., primary, Waanders, Angela J., primary, Stalpers, Lukas J.A., primary, Berger, Mitchel S., primary, Gupta, Nalin, primary, James, C. David, primary, Petritsch, Claudia K., primary, and Haas-Kogan, Daphne A., primary

Published
2023
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49. Supplementary Figure 4 from The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas

Author

Gini, Beatrice, primary, Zanca, Ciro, primary, Guo, Deliang, primary, Matsutani, Tomoo, primary, Masui, Kenta, primary, Ikegami, Shiro, primary, Yang, Huijun, primary, Nathanson, David, primary, Villa, Genaro R., primary, Shackelford, David, primary, Zhu, Shaojun, primary, Tanaka, Kazuhiro, primary, Babic, Ivan, primary, Akhavan, David, primary, Lin, Kelly, primary, Assuncao, Alvaro, primary, Gu, Yuchao, primary, Bonetti, Bruno, primary, Mortensen, Deborah S., primary, Xu, Shuichan, primary, Raymon, Heather K., primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, James, C. David, primary, Kroemer, Guido, primary, Heath, James R., primary, Hege, Kristen, primary, Chopra, Rajesh, primary, Cloughesy, Timothy F., primary, and Mischel, Paul S., primary

Published
2023
Full Text
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50. Supplemental Figure 2 from BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas

Author

Olow, Aleksandra, primary, Mueller, Sabine, primary, Yang, Xiaodong, primary, Hashizume, Rintaro, primary, Meyerowitz, Justin, primary, Weiss, William, primary, Resnick, Adam C., primary, Waanders, Angela J., primary, Stalpers, Lukas J.A., primary, Berger, Mitchel S., primary, Gupta, Nalin, primary, James, C. David, primary, Petritsch, Claudia K., primary, and Haas-Kogan, Daphne A., primary

Published
2023
Full Text
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