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163 results on '"Ji, Shunrong"'

8. MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors

Author

Ye Zeng, Chen Haidi, Ji Shunrong, Hu Yuheng, Lou Xin, Zhang Wuhu, Jing Desheng, Fan Guixiong, Zhang Yue, Chen Xuemin, Zhuo Qifeng, Chen Jie, Xu Xiaowu, Yu Xianjun, Xu Jin, Qin Yi, and Gao Heli

Subjects
pancreatic neuroendocrine tumor, MEN1, ferroptosis, mTOR signaling, SCD1, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Pancreatic neuroendocrine tumor (pNET) is the second most common malignant tumors of the pancreas. Multiple endocrine neoplasia 1 ( MEN1) is the most frequently mutated gene in pNETs and MEN1-encoded protein, menin, is a scaffold protein that interacts with transcription factors and chromatin-modifying proteins to regulate various signaling pathways. However, the role of MEN1 in lipid metabolism has not been studied in pNETs. In this study, we perform targeted metabolomics analysis and find that MEN1 promotes the generation and oxidation of polyunsaturated fat acids (PUFAs). Meanwhile lipid peroxidation is a hallmark of ferroptosis, and we confirm that MEN1 promotes ferroptosis by inhibiting the activation of mTOR signaling which is the central hub of metabolism. We show that stearoyl-coA desaturase (SCD1) is the downstream of MEN1-mTOR signaling and oleic acid (OA), a metabolite of SCD1, recues the lipid peroxidation caused by MEN1 overexpression. The negative correlation between MEN1 and SCD1 is further verified in clinical specimens. Furthermore, we find that BON-1 and QGP-1 cells with MEN1 overexpression are more sensitive to everolimus, a widely used drug in pNETs that targets mTOR signaling. In addition, combined use everolimus with ferroptosis inducer, RSL3, possesses a more powerful ability to kill cells, which may provide a new strategy for the comprehensive therapy of pNETs.

Published
2022
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10. Clinical study of robot and laparoscopic minimally invasive surgery for well-differentiated pancreatic neuroendocrine tumors

Author

LIU Wensheng, JI Shunrong, ZHUO Qifeng, GAO Heli, SHI Yihua, XU Wenyan, LIU Mengqi, LI Zheng, YU Xianjun, CHEN Jie, XU Xiaowu

Subjects
pancreatic neuroendocrine tumor, minimally invasive surgery, robotic surgery, local excision of tumor, function-preserving operation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background and purpose: Pancreatic neuroendocrine tumor (pNET) is a rare tumor. At present, there is still a lack of large-scale clinical research data to summarize the clinical effect of minimally invasive technology in the treatment of pNET. This study analyzed the clinical data of pNET patients undergoing surgical treatment, in order to provide reference for the surgical treatment of pNET. Methods: The clinical data of 118 patients with well-differentiated pNET undergoing minimally invasive surgery admitted by the Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center from September 2018 to July 2022 were retrospectively analyzed. The patients were divided into robot group (n=17) and laparoscopic group (n=101) according to the minimally invasive operation mode. According to the surgical resection mode, they were divided into regular resection group (n=86) and local resection group (n=32). The clinical data of operation and postoperation were collected and analyzed. Results: Of the 118 patients who underwent minimally invasive surgery on pNET included in this study, 17 were in the robot group, and 101 were in the laparoscopic group. There were 32 cases in local resection group and 86 cases in regular resection group. There was no significant difference between robot group and laparoscopic group in operation time and intraoperative bleeding (P>0.05). The operation time of local resection group [(145.3±55.5) min] was significantly shorter compared with regular resection group [(247.4±94.7) min](P 0.05). The incidence of postoperative b-pancreatic fistula was higher in the local resection group than in the regular resection group (P

Published
2022
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11. Updates on medical treatment for neuroendocrine neoplasm

Author

LIANG Yun, JI Shunrong, YU Xianjun, CHEN Jie

Subjects
neuroendocrine neoplasms, medicine, clinical trial, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Neuroendocrine neoplasm (NEN) is a group of heterogeneous malignancies arising from neuroendocrine cells and peptidergic neurons. According to its cell differentiation, NEN can be divided into two distinct groups as well-differentiated neuroendocrine tumor (NET) and poorly-differentiated neuroendocrine carcinoma (NEC). For advanced NEN, medication is the preferred treatment. In this article, we reviewed current clinical trials in medical treatment for NEN and aimed to provide treatment reference in clinical practice.

Published
2022
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13. Laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic ductal adenocarcinoma: protocol of a multicenter, open-label randomized clinical trial (CSPAC-5)

Author

Liu, Xinran, primary, Li, Zheng, additional, Zhuo, Qifeng, additional, Tang, Wenjie, additional, Liu, Wensheng, additional, Shi, Yihua, additional, Xu, Wenyan, additional, Gao, Heli, additional, Liu, Mengqi, additional, Chen, Haidi, additional, Chen, Chen, additional, Zhou, Chenjie, additional, Ji, Shunrong, additional, Xu, Xiaowu, additional, and Yu, Xianjun, additional

Published
2024
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21. Cancer immunometabolism: advent, challenges, and perspective.

Author

Dang, Qin, Li, Borui, Jin, Bing, Ye, Zeng, Lou, Xin, Wang, Ting, Wang, Yan, Pan, Xuan, Hu, Qiangsheng, Li, Zheng, Ji, Shunrong, Zhou, Chenjie, Yu, Xianjun, Qin, Yi, and Xu, Xiaowu

Subjects
IMMUNE checkpoint proteins, CELL populations, METABOLIC reprogramming, CELL physiology, TUMOR microenvironment
Abstract

For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive immunomodulation. Given this, we focus on changes in immunometabolism, a converging series of biochemical events that alters immune cell function, propose the immune roles played by diversified metabolic derivatives and enzymes, emphasize the key metabolism-related checkpoints in distinct immune cell types, and discuss the ongoing and upcoming realities of clinical treatment. It is expected that future research will reduce the current limitations of immunotherapy and provide a positive hand in immune responses to exert a broader therapeutic role. Highlights: 1. Attempting to delineate the complex and multidimensional interplays between metabolites (or metabolic enzymes) and predominant immune cell populations. 2. Metabolic checkpoints of immune cells are described and the contribution of these metabolic targets to determine the metabolic adaptations of distinct immune cells in specific tissue environments is emphasized. 3. Proposed cancer-immunometabolism subcycle, enriching the theoretical foundation of the cancer-immunology field. 4. Metabolism-induced disturbances in the acid-base balance of the tumor microenvironment have non-redundant effects on immunotherapy. 5. Pending challenges and clinical concerns in metabolic insights were addressed. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Reconsidering the role of prophylactic pancreaticojejunostomy in pancreatic enucleation: balancing the benefits and risks.

Author

Shi, Yihua, Li, Zheng, Li, Borui, Chen, Haidi, Chen, Chen, Ji, Shunrong, Yu, Xianjun, and Xu, Xiaowu

Subjects
ENUCLEATION of the eye, PANCREATIC duct, GASTROINTESTINAL hemorrhage, PANCREATIC fistula, QUALITY of life
Abstract

Background: The incidence of postoperative pancreatic fistula (POPF) following enucleation is high, and prophylactic pancreaticojejunostomy (PPJ) is frequently performed. Minimally invasive enucleation (MEN) has been demonstrated to be safe and feasible, leaving most enucleation wounds exposed. Methods: The clinical data of 40 patients who underwent open enucleation with PPJ at our center between 2012 and 2021 were compared with those of 80 patients who underwent MEN. Results: The MEN group had better outcomes than the PPJ group in terms of intraoperative bleeding (50.0 versus 100.0 mL), postoperative semi‐liquid diet recovery (2.0 versus 5.0 days), and postoperative length of stay (7.7 versus 12.5 days). While the MEN group had higher rates of complex enucleation (60.0% versus 40.0%), main pancreatic duct repair (32.5% versus 10.0%), discharge with drains (48.8% versus 25.0%), and grade B POPFs (47.5% versus 17.5%). Both surgical methods effectively preserved pancreatic function; however, two patients in the PPJ group experienced severe haemorrhaging and died. Additionally, during the follow‐up period, gastrointestinal bleeding was found and discomfort in the surgical area was reported. Conclusion: Pancreatic enucleation combined with PPJ should be avoided, and although a biochemical or grade B POPF may develop after MEN, it can be compensated for by preserving pancreatic function and ensuring a good long‐term quality of life in the patients. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Figure S2 from MEN1 Degradation Induced by Neddylation and the CUL4B–DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression

Author

Xu, Junfeng, primary, Ye, Zeng, primary, Zhuo, Qifeng, primary, Gao, Heli, primary, Qin, Yi, primary, Lou, Xin, primary, Zhang, Wuhu, primary, Wang, Fei, primary, Wang, Yan, primary, Jing, Desheng, primary, Fan, Guixiong, primary, Zhang, Yue, primary, Chen, Xuemin, primary, Chen, Jie, primary, Xu, Xiaowu, primary, Yu, Xianjun, primary, and Ji, Shunrong, primary

Published
2023
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29. Table S4 from MEN1 Degradation Induced by Neddylation and the CUL4B–DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression

Author

Xu, Junfeng, primary, Ye, Zeng, primary, Zhuo, Qifeng, primary, Gao, Heli, primary, Qin, Yi, primary, Lou, Xin, primary, Zhang, Wuhu, primary, Wang, Fei, primary, Wang, Yan, primary, Jing, Desheng, primary, Fan, Guixiong, primary, Zhang, Yue, primary, Chen, Xuemin, primary, Chen, Jie, primary, Xu, Xiaowu, primary, Yu, Xianjun, primary, and Ji, Shunrong, primary

Published
2023
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30. Data from MEN1 Degradation Induced by Neddylation and the CUL4B–DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression

Author

Xu, Junfeng, primary, Ye, Zeng, primary, Zhuo, Qifeng, primary, Gao, Heli, primary, Qin, Yi, primary, Lou, Xin, primary, Zhang, Wuhu, primary, Wang, Fei, primary, Wang, Yan, primary, Jing, Desheng, primary, Fan, Guixiong, primary, Zhang, Yue, primary, Chen, Xuemin, primary, Chen, Jie, primary, Xu, Xiaowu, primary, Yu, Xianjun, primary, and Ji, Shunrong, primary

Published
2023
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39. Supplementary Figure legend from FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer

Author

Ji, Shunrong, primary, Qin, Yi, primary, Liang, Chen, primary, Huang, Run, primary, Shi, Si, primary, Liu, Jiang, primary, Jin, Kaizhou, primary, Liang, Dingkong, primary, Xu, Wenyan, primary, Zhang, Bo, primary, Liu, Liang, primary, Liu, Chen, primary, Xu, Jin, primary, Ni, Quanxing, primary, Chiao, Paul J., primary, Li, Min, primary, and Yu, Xianjun, primary

Published
2023
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40. Supplementary Table S3 from FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer

Author

Ji, Shunrong, primary, Qin, Yi, primary, Liang, Chen, primary, Huang, Run, primary, Shi, Si, primary, Liu, Jiang, primary, Jin, Kaizhou, primary, Liang, Dingkong, primary, Xu, Wenyan, primary, Zhang, Bo, primary, Liu, Liang, primary, Liu, Chen, primary, Xu, Jin, primary, Ni, Quanxing, primary, Chiao, Paul J., primary, Li, Min, primary, and Yu, Xianjun, primary

Published
2023
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41. Supplementary Figure S2 from FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer

Author

Ji, Shunrong, primary, Qin, Yi, primary, Liang, Chen, primary, Huang, Run, primary, Shi, Si, primary, Liu, Jiang, primary, Jin, Kaizhou, primary, Liang, Dingkong, primary, Xu, Wenyan, primary, Zhang, Bo, primary, Liu, Liang, primary, Liu, Chen, primary, Xu, Jin, primary, Ni, Quanxing, primary, Chiao, Paul J., primary, Li, Min, primary, and Yu, Xianjun, primary

Published
2023
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42. Supplementary Materials and Methods from PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells

Author

Liang, Chen, primary, Shi, Si, primary, Liu, Mingyang, primary, Qin, Yi, primary, Meng, Qingcai, primary, Hua, Jie, primary, Ji, Shunrong, primary, Zhang, Yuqing, primary, Yang, Jingxuan, primary, Xu, Jin, primary, Ni, Quanxing, primary, Li, Min, primary, and Yu, Xianjun, primary

Published
2023
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43. FigureS1 from MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer

Author

Hu, Qiangsheng, primary, Qin, Yi, primary, Ji, Shunrong, primary, Shi, Xiuhui, primary, Dai, Weixing, primary, Fan, Guixiong, primary, Li, Shuo, primary, Xu, Wenyan, primary, Liu, Wensheng, primary, Liu, Mengqi, primary, Zhang, Zheng, primary, Ye, Zeng, primary, Zhou, Zhijun, primary, Yang, Jingxuan, primary, Zhuo, Qifeng, primary, Yu, Xianjun, primary, Li, Min, primary, and Xu, Xiaowu, primary

Published
2023
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45. Supplementary Tables from PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells

Author

Liang, Chen, primary, Shi, Si, primary, Liu, Mingyang, primary, Qin, Yi, primary, Meng, Qingcai, primary, Hua, Jie, primary, Ji, Shunrong, primary, Zhang, Yuqing, primary, Yang, Jingxuan, primary, Xu, Jin, primary, Ni, Quanxing, primary, Li, Min, primary, and Yu, Xianjun, primary

Published
2023
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46. Supplementary Data from MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer

Author

Hu, Qiangsheng, primary, Qin, Yi, primary, Ji, Shunrong, primary, Shi, Xiuhui, primary, Dai, Weixing, primary, Fan, Guixiong, primary, Li, Shuo, primary, Xu, Wenyan, primary, Liu, Wensheng, primary, Liu, Mengqi, primary, Zhang, Zheng, primary, Ye, Zeng, primary, Zhou, Zhijun, primary, Yang, Jingxuan, primary, Zhuo, Qifeng, primary, Yu, Xianjun, primary, Li, Min, primary, and Xu, Xiaowu, primary

Published
2023
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47. Supplementary Figures with Figure legends from PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells

Author

Liang, Chen, primary, Shi, Si, primary, Liu, Mingyang, primary, Qin, Yi, primary, Meng, Qingcai, primary, Hua, Jie, primary, Ji, Shunrong, primary, Zhang, Yuqing, primary, Yang, Jingxuan, primary, Xu, Jin, primary, Ni, Quanxing, primary, Li, Min, primary, and Yu, Xianjun, primary

Published
2023
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48. Data from MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer

Author

Hu, Qiangsheng, primary, Qin, Yi, primary, Ji, Shunrong, primary, Shi, Xiuhui, primary, Dai, Weixing, primary, Fan, Guixiong, primary, Li, Shuo, primary, Xu, Wenyan, primary, Liu, Wensheng, primary, Liu, Mengqi, primary, Zhang, Zheng, primary, Ye, Zeng, primary, Zhou, Zhijun, primary, Yang, Jingxuan, primary, Zhuo, Qifeng, primary, Yu, Xianjun, primary, Li, Min, primary, and Xu, Xiaowu, primary

Published
2023
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49. MEN1 Degradation Induced by Neddylation and the CUL4B–DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression

Author

Xu, Junfeng, primary, Ye, Zeng, additional, Zhuo, Qifeng, additional, Gao, Heli, additional, Qin, Yi, additional, Lou, Xin, additional, Zhang, Wuhu, additional, Wang, Fei, additional, Wang, Yan, additional, Jing, Desheng, additional, Fan, Guixiong, additional, Zhang, Yue, additional, Chen, Xuemin, additional, Chen, Jie, additional, Xu, Xiaowu, additional, Yu, Xianjun, additional, and Ji, Shunrong, additional

Published
2023
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