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Your search keyword '"Jiang, Mizu"' showing total 26 results
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26 results on '"Jiang, Mizu"'

15. Mechanosensitive channel MscL induces non-apoptotic cell death and its suppression of tumor growth by ultrasound

Author

Wen, Xiaoxu, primary, Wang, Yingying, additional, Zhu, Zhenya, additional, Guo, Shuangshuang, additional, Qian, Junjie, additional, Zhu, Jinjun, additional, Yang, Zhenni, additional, Qiu, Weibao, additional, Li, Guofeng, additional, Huang, Li, additional, Jiang, Mizu, additional, Tan, Linhua, additional, Zheng, Hairong, additional, Shu, Qiang, additional, and Li, Yuezhou, additional

Published
2023
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20. The Effects of Helicobacter pylori Infection on Gastric Microbiota in Children With Duodenal Ulcer

Author

Zheng, Wei, Zhu, Zhenya, Ying, Jingjing, Long, Gao, Chen, Bo, Peng, Kerong, Li, Fubang, Zhao, Hong, and Jiang, Mizu

Subjects
Microbiology (medical), Microbiology
Abstract

BackgroundHelicobacter pylori (H. pylori) infection is the main cause of chronic gastritis and duodenal ulcer in children. Little is known about the effect of H. pylori on gastric microbiota in children with duodenal ulcer. This study is aimed at the characteristics of gastric microbiota in children with duodenal ulcer on H. pylori infection.MethodsWe studied 23 children diagnosed with duodenal ulcer by gastric endoscopy because of the gastrointestinal symptoms, 15 children were diagnosed with H. pylori infection, while 8 children were without H. pylori infection. Endoscopic mucosal biopsy samples were obtained for DNA extraction. Microbiomes were analyzed by 16S rRNA profiling and microbial functions were predicted using the software Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt).ResultsBacterial richness and diversity of gastric microbiota in duodenal ulcer with H. pylori-positive were lower than those negative. The gastric microbiota in H. pylori-positive group significantly reduced proportions of six phyla and fifteen genera; only Helicobacter taxa were more abundant in H. pylori-positive group. Co-expression network analysis showed a more complex network of interactions in the H. pylori-positive group than that in the H. pylori-negative group. For the predicted functions, lower abundance in the pathways of carbohydrate metabolism, signal transduction, amino acid metabolism, and lipid metabolism were found in H. pylori-positive group than the H. pylori-negative group. H. pylori colonization reduces a microbial community with genotoxic potential in the gastric mucosa of children with duodenal ulcer.ConclusionsThe presence of H. pylori significantly influences gastric microbiota and results in a lower abundance of multiple taxonomic levels in children with duodenal ulcer. Children with duodenal ulcer exhibit a dysbiotic microbial community with genotoxic potential, which is distinct from that of children with H. pylori infection.Clinical Trial Registration[http://www.chictr.org.cn], identifier [ChiCTR1800015190].

Published
2022

25. Severe neonatal anemia affected by massive fetomaternal hemorrhage: a single-center retrospective observational study.

Author

Tao, Enfu, Ye, Diya, Long, Gao, Hu, Yuting, Fu, Qibo, Yuan, Tianming, and Jiang, Mizu

Abstract

Objectives: Massive fetomaternal hemorrhage (FMH) is a rare but sometimes life-threatening event, and surviving neonates may suffer major neurological complications. Severe neonatal anemia (SNA) affected by massive FMH is less reported in the literature. This study aims to explore the clinical characteristics, laboratory diagnoses, treatments and outcomes of SNA affected by massive FMH.Methods: Data were collected retrospectively from the hospital's electronic medical record system. All neonates born in the hospital and admitted to the neonatal unit diagnosed as SNA affected by massive FMH from 1 January 2013 to 31 June 2017 were included.Results: A total of 8 cases of SNA affected by FMH were identified among 6825 neonates admitted to the neonatal unit. They all presented with pallor but without hydrops at birth. Median gestational age and birthweight were 375/7 (360/7‒401/7) weeks and 2,625 (2300‒3050) g, respectively. Median hemoglobin level was 39.5 (25‒53) g/L at birth and 109.5 (94-127) g/L at discharge. Median maternal serum alpha-fetoprotein (AFP) was 3958.5 (1606‒14,330) ng/mL, which was significantly increased. Three out of eight cases manifested as antenatal decreased fetal movement. Only 1 with the lowest initial hemoglobin 25 g/L manifested as characteristic sinusoidal fetal heart rate tracing and suffered severe neonatal asphyxia and hypovolemic shock. Having experienced resuscitation, he was admitted to the neonatal unit and received twice transfusion of cross-matched red blood cells there. Another case with the initial hemoglobin 45 g/L received positive pressure ventilation and once transfusion. All cases were successfully discharged with a median hospital stay of 8 (5-12) days. Follow-up was available for 6 (75%) of 8 neonates (age range 13 months to 50 months), and all infants were observed to be in good condition with normal neurological status. In our series of eight cases, there were no neonatal deaths.Conclusion: This study strengthens the idea that maternal AFP testing is valuable to confirm massive fetomaternal hemorrhage. Surviving neonates of massive FMH might have a good outcome despite severe anemia at birth. [ABSTRACT FROM AUTHOR]

Published
2022
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