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Abstract The aim of this retrospective study was to evaluate the efficiency and safety of total body irradiation plus cyclophosphamide (TBI/Cy) followed by autogenetic hematopoietic stem cell transplantation (auto-HSCT) in T-LBL/ALL patients that cannot receive allogeneic hematopoietic stem cell transplant (allo-HSCT). Between 2013 and 2023, 24 patients received auto-HSCT following by TBI/Cy, 26 patients underwent allo-HSCT, all patients achieved completed hematopoietic reconstitution after HSCT. The progression free survival (PFS) and overall survival (OS) had no statistically significant differences between the two groups (P = 0.791, HR 1.127, 95%CI 0.456–2.785; P = 0.456, HR 0.685, 95%CI 0.256–1.828). Although the cumulative incidence of relapse was lower for patients who received allo-HSCT than auto-HSCT (P = 0.033, HR 3.707, 95%CI 1.188–11.570, 2-year relapse 11.5% vs. 33.3%), the incidence of non-relapse mortality (NRM) was higher than that in the auto-HSCT group (P = 0.014, HR 0.000, 95%CI -1.000 - -1.000, 2-year NRM, 23.1% vs. 0%). Trough Landmark analysis, the two groups showed a statistically significant difference in 3-year PFS and 4-year OS curves (Figure S2A&B, P = 0.039, HR 0.426, 95%CI 0.163–1.117; P = 0.014, HR 0.317, 95%CI 0.113–0.887). By COX analysis, poor baseline performance status (ECOG-PS ≥ 2) and CNS involvement were risk factors for PFS and OS. In conclusion, TBI/Cy followed by auto-HSCT is a good choice next to allo-HSCT for patients with T-LBL/ALL.

The Absorbing Aerosol Index (AAI) determines the presence and approximate amount of absorbing aerosol particles. The Absorbing Aerosol Sensor (AAS) equipped on the Gaofen-5B satellite was successfully launched and deployed in orbit on September 7, 2021. Following a period of initial on-orbit testing, reliable AAI observational results were collected. The nadir of the AAS had a design spatial resolution of 4 km × 4 km and a current spatial resolution of 2 km × 4 km, which presented significant benefits in the spatial resolution and clear distribution characteristics of pollutants. The results of AAS were validated by comparing with the observed data of Global Ozone Monitoring Experiment-2 (GOME-2) in the Sahara Desert and surrounding areas. In 2022 and 2023, we utilized AAS observations to study the typical pollution processes. These included the spring pollution distribution around the Bohai Sea, the observation and tracking of long-term dust pollution in China in March and April 2023, the distribution of spring pollution in the Indochina Peninsula in April 2023, and the distribution of wildfires in Canada on June 22, 2023. The results were validated and analyzed using data from Tropospheric Monitoring Instrument (TROPOMI), GOME-2, AErosol RObotic NETwork (AERONET) and Moderate-resolution Imaging Spectroradiometer (MODIS). The results of the observation and evaluation revealed that the AAS AAI can provide reliable information for precise observation of air pollutants at a high resolution.

An Ultraviolet-Visible Hyperspectral Sensors (UVS) instrument is an ultraviolet-visible imaging spectrograph equipped with two-dimensional charge-coupled device detectors. It records both the spectrum and the swath perpendicular to the flight direction, offering a wide 112° swath. This configuration enables global daily ground coverage with high spatial resolution. The absolute values of in-orbit solar irradiance can be evaluated using the bidirectional reflectance distribution function (BRDF), with the measurement accuracy directly affecting the accuracy of constituent inversion. This paper outlines the calibration process for the BRDF of the UVS, detailing the calibration methods and equipment used. It also proposes a BRDF model and discusses key coefficients. The accuracy levels of the UVS in the UV1, UV2, and VIS channels were 2.162%, 2.162%, and 2.173%, respectively.

The Ozone Monitoring Suite-Nadir (OMS-N) instrument is the first hyperspectral remote sensor in the ultraviolet band of China’s Fengyun series satellites. It can be used to detect several kinds of atmospheric constituents. This paper describes the prelaunch spectral calibration of the OMS-N onboard FengYun 3F. Several critical spectral parameters including the spectral resolution, spectral dispersion, and the instrument spectral response function were determined through laser-based measurements. A secondary peak of the instrument spectral response function from the short wavelength side of the ultraviolet band was found, and the possible influence on data applications was analyzed using a reference solar model and radiative transfer model. The results indicate that the spectral resolution and spectral accuracy of OMS-N meet the mission requirements. However, the asymmetries in the instrument spectral response function in the ultraviolet band were found near nadir rows, which are expressed as the “asymmetric central peak” and “secondary peak”. The analysis results show that if the influences of the instrument spectral response function “asymmetric central peak” and “secondary peak” in the ultraviolet band are ignored, they will bring an error as large as 5% at the center of the absorption line.

This paper presents the prelaunch radiometric calibration of the Ozone Monitor Suite-Nadir (OMS-N) instrument, a vital payload on the FY-3F satellite. FY-3F achieved a successful launch on 3 August 2023. The radiance calibration of the OMS-N instrument was achieved using an integrating sphere, with known exit radiance ascertained through a transferring radiometer. The calibration model incorporates six energy levels. The Solar Simulator Standard System was employed to validate the calibration results, selecting specific rows to represent varying spatial dimensions. Considering the influence of xenon lamp characteristic peaks and transmission errors during the calibration process, the average deviation remained within 2.3% for the VIS channel, 3% for the UV1 channel, and 2.2% for the UV2 channel. Furthermore, the uncertainty of the radiometric calibration was analyzed. The results indicated an absolute uncertainty of 2.33% for both the UV1 and UV2 channels and 1.69% for the VIS channel. The relative uncertainty was 1.84% for both the UV1 and UV2 channels and 1.45% for the VIS channel. The obtained calibration coefficients are accurate and reliable and can be used for the inversion of product parameters, which is of great significance to the quantitative application of satellite data and the advancement of scientific research on quantitative remote sensing.

Spectral calibration consists of the calibration of wavelengths and the measurement of the instrument’s spectral response function (SRF). Unlike conventional slits, the absorbed aerosol sensors (AAS) are used as a slit homogenizer, in which the SRF is not a conventional Gaussian curve. To be more precise, the SRF is the convolution of the slit function of the spectrometer, the line spread function of the optical system, and the detector response function. The SRF of the slit homogenizer is a flat-topped multi-Gaussian function. Considering the convenience of fitting, a super-Gaussian function, which has a distribution similar to the flat-topped multi-Gaussian function, is employed to fit the measured data in a spectral calibration. According to the results, the SRF’s shapes resembling a Gaussian curve with a flat top could be derived, which contains a full width at half maximum (FWHM) of 1.78–1.82 nm for the AAS. The results show that the correlation is about 0.99, which indicates the usefulness of the fitting function that could better characterize the SRF of the instrument.

The Absorbing Aerosol Sensor (AAS) is carried on the Gao-Fen 5B (GF-5B) satellite, and it allows for the measurement of solar backscatter radiation by the atmosphere in the UV–Vis bands. The AAS is an imaging spectrometer that employs CCD for capturing both a continuous spectrum and the cross-track orientation with a 114° wide swath. The broad field of view provides daily global envelopment with a 4 km spatial resolution at the nadir. This paper mainly analyzes the initial working status of the instrument in orbit, including wavelength calibration, radiometric calibration, detector performance, and product availability. Preliminary observations indicate the ability of the AAS to monitor absorbing aerosols like dust, biomass burning, volcano ash, and some pollution aerosols and to identify the aerosol events in China and other regions with high spatial resolution.

Invasive candidiasis is the primary reason for the increased cases of mortality in a medical environment. The resistance spectra of Candida species to antifungal drugs have gradually expanded. Particularly, the resistance spectra of Candida auris are the most prominent. Hsp90 plays a protective role in the stress response of fungi and facilitates their virulence. In contrast, Hsp90 inhibitors can improve the resistance of fungi to antifungal drugs by regulating the heat resistance of Hsp90, which destroys the integrity of the fungal cell walls. Hsp90 inhibitors thus offer a great potential to reduce or address fungal drug resistance. The drugs tested for the resistance include itraconazole, voriconazole, posaconazole, fluconazole, and 17-AAG. A total of 20 clinical strains of Candida were investigated. The broth microdilution checkerboard technique, as adapted from the CLSI M27-A4 method, was applied in this study. We found that 17-AAG alone exerted limited antifungal activity against all tested strains. The MIC range of 17-AAG was 8 to >32 μg/ml. A synergy was observed among 17-AAG and itraconazole, voriconazole, and posaconazole against 10 (50%), 7 (35%), and 13 (65%) of all isolates, respectively. Moreover, the synergy between 17-AAG and fluconazole was observed against 5 (50%) strains of azole-resistant Candida. However, no antagonism was recorded overall. Our result adequately verifies the influence of 17-AAG on the formation of Candida spp. biofilm. Moreover, we determined that with the use of rhodamine 6G to detect drug efflux and that of dihydrorhodamine-123 to detect intracellular reactive oxygen species (ROS), treatment with 17-AAG combined with azole drugs could inhibit the efflux pump of fungi and promote the accumulation of ROS in the fungal cells, thereby inducing fungal cell apoptosis. Thus, the mechanism of 17-AAG combined with azoles can kill fungi. Our results thus provide a new idea to further explore drugs against drug-resistant Candida spp.