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1. Multi-centre randomised trial of invasive and less invasive surfactant delivery methods showed similar spirometry results at 5-9 years of age

Author

Wolfgang Göpel, Angela Kribs, Claudia Roll, Christian Wieg, Norbert Teig, Thomas Hoehn, Lars Welzing, Matthias Vochem, Marc Hoppenz, Christoph Bührer, Katrin Mehler, Mechthild Hubert, Joachim Eichhorn, Susanne Schmidtke, Tanja Katrin Rausch, Inke Regina König, Christoph Härtel, Bernd Roth, and Egbert Herting

Subjects
Spirometry, Child, Preschool, Pediatrics, Perinatology and Child Health, Intubation, Intratracheal, Humans, Pulmonary Surfactants, General Medicine, Child, Infant, Premature
Abstract

We explored whether subnormal forced expiratory volume within 1 s (FEVThe multi-centre, randomised Nonintubated Surfactant Application trial enrolled 211 preterm infants born at 23-26 weeks of gestation from 13 level III neonatal intensive care units from April 2009 to March 2012. They received surfactant via LISA (n = 107) or after conventional endotracheal intubation (n = 104). The follow-up assessments were carried out by a single team blinded to the group assignments. The main outcome was FEVSpirometry was successful in 102/121 children. The other children died or were lost to follow-up. Median FEVThe proportion of children aged 5-9 years with subnormal FEV

Published
2022

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