While the prevalence of obesity in US men and women is nearly equivalent, obesity management in women requires a different approach that considers age and life stage in development including sexual maturation/reproduction, menopause and post-menopause. In this review, the diagnosis and treatment of obesity using lifestyle modification, pharmacotherapy and metabolic and bariatric surgery are discussed from a women's health perspective, with emphasis on management during pregnancy and post-partum., Competing Interests: Declaration of Competing Interest VRJ is consultant for Novo Nordisk. FCS is advisor/consultant for Novo Nordisk, Eli Lilly, Pfizer, Boehringer Ingelheim, Currax, Rhythm, Gelesis and Calibrate., (Copyright © 2023 Elsevier Inc. All rights reserved.)