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5. Supplementary Table 6 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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6. Supplementary Tables 1 - 4 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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7. Supplementary Table 5 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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8. Supplementary Table 3 from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Author

Stone, Jennifer, primary, Thompson, Deborah J., primary, dos Santos Silva, Isabel, primary, Scott, Christopher, primary, Tamimi, Rulla M., primary, Lindstrom, Sara, primary, Kraft, Peter, primary, Hazra, Aditi, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Hall, Per, primary, Jensen, Matt, primary, Cunningham, Julie, primary, Olson, Janet E., primary, Purrington, Kristen, primary, Couch, Fergus J., primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Khaw, Kay-Tee, primary, Smith, Paula, primary, Wareham, Nicholas J., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Douglas, Julie A., primary, Shah, Kaanan P., primary, Chan, Heang-Ping, primary, Helvie, Mark A., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Apicella, Carmel, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Ursin, Giske, primary, Alnaes, Grethe I. Grenaker, primary, Kristensen, Vessela N., primary, Borresen-Dale, Anne-Lise, primary, Gram, Inger Torhild, primary, Bolla, Manjeet K., primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Dennis, Joe, primary, Simard, Jacques, primary, Pharoah, Paul, primary, Dunning, Alison M., primary, Easton, Douglas F., primary, Fasching, Peter A., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and Vachon, Celine M., primary

Published
2023
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9. Supplementary Table 1 from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Author

Stone, Jennifer, primary, Thompson, Deborah J., primary, dos Santos Silva, Isabel, primary, Scott, Christopher, primary, Tamimi, Rulla M., primary, Lindstrom, Sara, primary, Kraft, Peter, primary, Hazra, Aditi, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Hall, Per, primary, Jensen, Matt, primary, Cunningham, Julie, primary, Olson, Janet E., primary, Purrington, Kristen, primary, Couch, Fergus J., primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Khaw, Kay-Tee, primary, Smith, Paula, primary, Wareham, Nicholas J., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Douglas, Julie A., primary, Shah, Kaanan P., primary, Chan, Heang-Ping, primary, Helvie, Mark A., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Apicella, Carmel, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Ursin, Giske, primary, Alnaes, Grethe I. Grenaker, primary, Kristensen, Vessela N., primary, Borresen-Dale, Anne-Lise, primary, Gram, Inger Torhild, primary, Bolla, Manjeet K., primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Dennis, Joe, primary, Simard, Jacques, primary, Pharoah, Paul, primary, Dunning, Alison M., primary, Easton, Douglas F., primary, Fasching, Peter A., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and Vachon, Celine M., primary

Published
2023
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10. Data from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Author

Stone, Jennifer, primary, Thompson, Deborah J., primary, dos Santos Silva, Isabel, primary, Scott, Christopher, primary, Tamimi, Rulla M., primary, Lindstrom, Sara, primary, Kraft, Peter, primary, Hazra, Aditi, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Hall, Per, primary, Jensen, Matt, primary, Cunningham, Julie, primary, Olson, Janet E., primary, Purrington, Kristen, primary, Couch, Fergus J., primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Khaw, Kay-Tee, primary, Smith, Paula, primary, Wareham, Nicholas J., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Douglas, Julie A., primary, Shah, Kaanan P., primary, Chan, Heang-Ping, primary, Helvie, Mark A., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Apicella, Carmel, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Ursin, Giske, primary, Alnaes, Grethe I. Grenaker, primary, Kristensen, Vessela N., primary, Borresen-Dale, Anne-Lise, primary, Gram, Inger Torhild, primary, Bolla, Manjeet K., primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Dennis, Joe, primary, Simard, Jacques, primary, Pharoah, Paul, primary, Dunning, Alison M., primary, Easton, Douglas F., primary, Fasching, Peter A., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and Vachon, Celine M., primary

Published
2023
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11. Supplementary Table 2 from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Author

Stone, Jennifer, primary, Thompson, Deborah J., primary, dos Santos Silva, Isabel, primary, Scott, Christopher, primary, Tamimi, Rulla M., primary, Lindstrom, Sara, primary, Kraft, Peter, primary, Hazra, Aditi, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Hall, Per, primary, Jensen, Matt, primary, Cunningham, Julie, primary, Olson, Janet E., primary, Purrington, Kristen, primary, Couch, Fergus J., primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Khaw, Kay-Tee, primary, Smith, Paula, primary, Wareham, Nicholas J., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Douglas, Julie A., primary, Shah, Kaanan P., primary, Chan, Heang-Ping, primary, Helvie, Mark A., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Apicella, Carmel, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Ursin, Giske, primary, Alnaes, Grethe I. Grenaker, primary, Kristensen, Vessela N., primary, Borresen-Dale, Anne-Lise, primary, Gram, Inger Torhild, primary, Bolla, Manjeet K., primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Dennis, Joe, primary, Simard, Jacques, primary, Pharoah, Paul, primary, Dunning, Alison M., primary, Easton, Douglas F., primary, Fasching, Peter A., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and Vachon, Celine M., primary

Published
2023
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12. Erratum: Mammakarzinom beim Mann

Author

Preuss, Caroline, additional, Wunderle, Marius, additional, Hack, Carolin C., additional, Beckmann, Matthias W., additional, Wenkel, Evelyn, additional, Jud, Sebastian, additional, and Heindl, Felix, additional

Published
2023
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13. Mammakarzinom beim Mann

Author

Preuss, Caroline, additional, Wunderle, Marius, additional, Hack, Carolin C., additional, Beckmann, Matthias W., additional, Wenkel, Evelyn, additional, Jud, Sebastian, additional, and Heindl, Felix, additional

Published
2023
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14. Mammakarzinom beim Mann.

Author

Preuss, Caroline, Wunderle, Marius, Hack, Carolin C., Beckmann, Matthias W., Wenkel, Evelyn, Jud, Sebastian Michael, and Heindl, Felix

Published
2023
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15. Epidemiology, risk factors, and genetics of endometrial cancer

Author

Tempfer, Clemens, Steinke-Lange, Verena, Aretz, Stefan, Schmutzler, Rita, Ortmann, Olaf, Roemer, Thomas, Hanf, Volker, Widhalm, Simone, Reents, Nicola, Jud, Sebastian, Kommoss, Stefan, Nothacker, Monika, Bloedt, Susanne, Tempfer, Clemens, Steinke-Lange, Verena, Aretz, Stefan, Schmutzler, Rita, Ortmann, Olaf, Roemer, Thomas, Hanf, Volker, Widhalm, Simone, Reents, Nicola, Jud, Sebastian, Kommoss, Stefan, Nothacker, Monika, and Bloedt, Susanne

Abstract

Background Endometrial cancer (EC) is the fifth most common female malignancy and the most common pelvic malignancy. Effective strategies for early detection, prevention, and genetic assessment are discussed in this article. Aim To review the literature on epidemiology, risk factors, and genetics. Materials and Methods This article is based on the current recommendations of the German Society of Obstetrics and Gynecology for the diagnosis and treatment of women with EC. The current literature was summarized based on expert knowledge. Systematic searches in the Medline database and in Cochrane Reviews were performed. The quality of the evidence was rated according to the 2011 Oxford classification. Recommendations and statements were formulated by a representative group using structured consensus methods. Results In Germany, 2.7% of cancer-specific deaths are due to EC. The incidence of EC increases with age and the disease is most often diagnosed in the age group of 75- to 79-year-old women. The lifetime risk of EC is 1.9%. Risk-modulating factors of EC include long-term use of estrogens, progestogen therapy, oral contraceptives, high body mass index, and impaired glucose metabolism. In addition, physical activity and dietary aspects, such as the amount of fat and red meat consumed, as well as soja foods, dietary fibers, vitamins, and specific beverages such as tea and coffee, play an important etiological role. EC also has a genetic component. Immunohistochemical and/or molecular screening is warranted for all patients with EC and has a significant impact on the genetic counselling of affected families as well as on treatment decisions.

Published
2022

17. Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022) - Part 2 with Recommendations on the Therapy of Precancerous Lesions and Early-stage Endometrial Cancer, Surgical Therapy, Radiotherapy and Drug-based Therapy, Follow-up Care, Recurrence and Metastases, Psycho-oncological Care, Palliative Care, Patient Education, and Rehabilitative and Physiotherapeutic Care.

Author

Emons G, Steiner E, Vordermark D, Uleer C, Paradies K, Tempfer C, Aretz S, Cremer W, Hanf V, Mallmann P, Ortmann O, Römer T, Schmutzler RK, Horn LC, Kommoss S, Lax S, Schmoeckel E, Mokry T, Grab D, Reinhardt M, Steinke-Lange V, Brucker SY, Kiesel L, Witteler R, Fleisch MC, Friedrich M, Höcht S, Lichtenegger W, Mueller M, Runnebaum I, Feyer P, Hagen V, Juhasz-Böss I, Letsch A, Niehoff P, Zeimet AG, Battista MJ, Petru E, Widhalm S, van Oorschot B, Panke JE, Weis J, Dauelsberg T, Haase H, Beckmann MW, Jud S, Wight E, Prott FJ, Micke O, Bader W, Reents N, Henscher U, Schallenberg M, Rahner N, Mayr D, Kreißl M, Lindel K, Mustea A, Strnad V, Goerling U, Bauerschmitz GJ, Langrehr J, Neulen J, Ulrich UA, Nothacker MJ, Blödt S, Follmann M, Langer T, Wenzel G, Weber S, and Erdogan S

Abstract

Summary The S3-guideline on endometrial cancer, first published in April 2018, was reviewed in its entirety between April 2020 and January 2022 and updated. The review was carried out at the request of German Cancer Aid as part of the Oncology Guidelines Program and the lead coordinators were the German Society for Gynecology and Obstetrics (DGGG), the Gynecology Oncology Working Group (AGO) of the German Cancer Society (DKG) and the German Cancer Aid (DKH). The guideline update was based on a systematic search and assessment of the literature published between 2016 and 2020. All statements, recommendations and background texts were reviewed and either confirmed or amended. New statements and recommendations were included where necessary. Aim The use of evidence-based risk-adapted therapies to treat low-risk women with endometrial cancer prevents unnecessarily radical surgery and avoids non-beneficial adjuvant radiation therapy and/or chemotherapy. For women with endometrial cancer and a high risk of recurrence, the guideline defines the optimum level of radical surgery and indicates whether chemotherapy and/or adjuvant radiation therapy is necessary. This should improve the survival rates and quality of life of these patients. The S3-guideline on endometrial cancer and the quality indicators based on the guideline aim to provide the basis for the work of certified gynecological cancer centers. Methods The guideline was first compiled in 2018 in accordance with the requirements for S3-level guidelines and was updated in 2022. The update included an adaptation of the source guidelines identified using the German Instrument for Methodological Guideline Appraisal (DELBI). The update also used evidence reviews which were created based on selected literature obtained from systematic searches in selected literature databases using the PICO process. The Clinical Guidelines Service Group was tasked with carrying out a systematic search and assessment of the literature. Their results were used by interdisciplinary working groups as a basis for developing suggestions for recommendations and statements which were then modified during structured online consensus conferences and/or additionally amended online using the DELPHI process to achieve a consensus. Recommendations Part 2 of this short version of the guideline provides recommendations on the treatment of precancerous lesions and early-stage endometrial cancer, surgical treatment, radiotherapy and drug-based therapy, follow-up, recurrence, and metastasis of endometrial cancer as well as the state of psycho-oncological care, palliative care, patient education, rehabilitative and physiotherapeutic care., Competing Interests: Conflict of Interest/Interessenkonflikt The conflicts of interest of the authors are listed in the long German-language version of the guideline. Die Interessenkonflikte der Autoren sind in der Langfassung der Leitlinie aufgelistet., (Thieme. All rights reserved.)

Published
2023
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18. Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022). Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer, Geriatric Assessment and Supply Structures.

Author

Emons G, Steiner E, Vordermark D, Uleer C, Paradies K, Tempfer C, Aretz S, Cremer W, Hanf V, Mallmann P, Ortmann O, Römer T, Schmutzler RK, Horn LC, Kommoss S, Lax S, Schmoeckel E, Mokry T, Grab D, Reinhardt M, Steinke-Lange V, Brucker SY, Kiesel L, Witteler R, Fleisch MC, Friedrich M, Höcht S, Lichtenegger W, Mueller M, Runnebaum I, Feyer P, Hagen V, Juhasz-Böss I, Letsch A, Niehoff P, Zeimet AG, Battista MJ, Petru E, Widhalm S, van Oorschot B, Panke JE, Weis J, Dauelsberg T, Haase H, Beckmann MW, Jud S, Wight E, Prott FJ, Micke O, Bader W, Reents N, Henscher U, Schallenberg M, Rahner N, Mayr D, Kreißl M, Lindel K, Mustea A, Strnad V, Goerling U, Bauerschmitz GJ, Langrehr J, Neulen J, Ulrich UA, Nothacker MJ, Blödt S, Follmann M, Langer T, Wenzel G, Weber S, and Erdogan S

Abstract

Summary The S3-guideline on endometrial cancer, first published in April 2018, was reviewed in its entirety between April 2020 and January 2022 and updated. The review was carried out at the request of German Cancer Aid as part of the Oncology Guidelines Program and the lead coordinators were the German Society for Gynecology and Obstetrics (DGGG), the Gynecology Oncology Working Group (AGO) of the German Cancer Society (DKG) and the German Cancer Aid (DKH). The guideline update was based on a systematic search and assessment of the literature published between 2016 and 2020. All statements, recommendations and background texts were reviewed and either confirmed or amended. New statements and recommendations were included where necessary. Aim The use of evidence-based risk-adapted therapies to treat women with endometrial cancer of low risk prevents unnecessarily radical surgery and avoids non-beneficial adjuvant radiation therapy and/or chemotherapy. For women with endometrial cancer and a high risk of recurrence, the guideline defines the optimum level of radical surgery and indicates whether chemotherapy and/or adjuvant radiation therapy is necessary. This should improve the survival rates and quality of life of these patients. The S3-guideline on endometrial cancer and the quality indicators based on the guideline aim to provide the basis for the work of certified gynecological cancer centers. Methods The guideline was first compiled in 2018 in accordance with the requirements for S3-level guidelines and was updated in 2022. The update included an adaptation of the source guidelines identified using the German Instrument for Methodological Guideline Appraisal (DELBI). The update also used evidence reviews which were created based on selected literature obtained from systematic searches in selected literature databases using the PICO process. The Clinical Guidelines Service Group was tasked with carrying out a systematic search and assessment of the literature. Their results were used by interdisciplinary working groups as a basis for developing suggestions for recommendations and statements which were then modified during structured online consensus conferences and/or additionally amended online using the DELPHI process to achieve a consensus. Recommendations Part 1 of this short version of the guideline provides recommendations on epidemiology, screening, diagnosis, and hereditary factors. The epidemiology of endometrial cancer and the risk factors for developing endometrial cancer are presented. The options for screening and the methods used to diagnose endometrial cancer are outlined. Recommendations are given for the prevention, diagnosis, and therapy of hereditary forms of endometrial cancer. The use of geriatric assessment is considered and existing structures of care are presented., Competing Interests: Conflict of Interest/Interessenkonflikt The conflicts of interest of the authors are listed in the long German-language version of the guideline./Die Interessenkonflikte der Autoren sind in der Langfassung der Leitlinie aufgelistet., (© Thieme Medical Publishers.)

Published
2023
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19. [Breast cancer in men].

Author

Preuss C, Wunderle M, Hack CC, Beckmann MW, Wenkel E, Jud S, and Heindl F

Subjects
Humans, Male, Cognition, Risk Factors, Breast Neoplasms, Male diagnosis, Breast Neoplasms, Male genetics, Breast Neoplasms, Male therapy, Physicians
Abstract

Male breast cancer is an unknown field for many practitioners. Patients often see different doctors before the correct diagnosis is made - often too late. This article is intended to point out risk factors, initiation of diagnostics and therapy. In the dawning age of molecular medicine, we will also take a look at genetics., Competing Interests: Erklärung zu finanziellen Interessen Forschungsförderung erhalten: nein; Honorar/geldwerten Vorteil für Referententätigkeit erhalten: ja, von einer anderen Institution (Pharma- oder Medizintechnikfirma usw.); Bezahlter Berater/interner Schulungsreferent/Gehaltsempfänger: ja, von einer anderen Institution (Pharma- oder Medizintechnikfirma usw.); Patent/Geschäftsanteile/Aktien (Autor/Partner, Ehepartner, Kinder) an im Bereich der Medizin aktiven Firma: nein; Patent/Geschäftsanteile/Aktien (Autor/Partner, Ehepartner, Kinder) an zu Sponsoren dieser Fortbildung bzw. durch die Fortbildung in ihren Geschäftsinteressen berührten Firma: nein. Erklärung zu nichtfinanziellen Interessen Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht., (Thieme. All rights reserved.)

Published
2023
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20. [Correction: Breast cancer in men].

Author

Preuss C, Wunderle M, Hack CC, Beckmann MW, Wenkel E, Jud S, and Heindl F

Abstract

Competing Interests: Erklärung zu finanziellen Interessen Forschungsförderung erhalten: nein; Honorar/geldwerten Vorteil für Referententätigkeit erhalten: ja, von einer anderen Institution (Pharma- oder Medizintechnikfirma usw.); Bezahlter Berater/interner Schulungsreferent/Gehaltsempfänger: ja, von einer anderen Institution (Pharma- oder Medizintechnikfirma usw.); Patent/Geschäftsanteile/Aktien (Autor/Partner, Ehepartner, Kinder) an im Bereich der Medizin aktiven Firma: nein; Patent/Geschäftsanteile/Aktien (Autor/Partner, Ehepartner, Kinder) an zu Sponsoren dieser Fortbildung bzw. durch die Fortbildung in ihren Geschäftsinteressen berührten Firma: nein. Erklärung zu nichtfinanziellen Interessen Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht.

Published
2023
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