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With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment?including key data on outcomes to better inform clinical decision making. - Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

Treatise on Estuarine and Coastal Science is the most up-to-date reference work for system based coastal and estuarine ecosystem science and management. It addresses the big issues facing the estuaries and coastal zone; in particular how to best use multi- and inter-disciplinary science to ensure the sustainability of the environment. It focusses on the need to protect and maintain the natural functioning of the estuaries and coasts worldwide while delivering the ecosystem services from which society extract goods and benefits.Structured chapters, written by leaders in the field, include reference lists and additional reading, copious diagrams, case-studies, and especially provide synthesis diagrams and conceptual models of complex issues. The Treatise covers both the natural and social sciences, serving a wide audience which ranges from undergraduate students to established researchers and practitioners.The work avoids autecological studies but focusses on inter-linked physical-chemical-biological-ecosystem processes and associated socio-economic issues in the coastal zone. It examines estuaries and coasts, and their interactions and feedbacks with humanity, from the inland catchment/river basin to the ocean shelf.The new edition builds on and expands the previous version with significant updates and a whole new section on Climate Change and Coastal Ecosystems, covering the resistance and resilience of the estuaries, coasts and other transitional habitats to climate change, thereby determining changes and responses needed over the coming decades. - Comprehensive – a unique resource in the field, Treatise on Estuarine and Coastal Science covers system based coastal and estuarine science and management, linking physical, chemical and biological ecosystem processes with associated socio-economic issues. - Highly regarded: the previous edition was very well received by the market and widely used, with over 50,000 chapter downloads. - Updated and forward-looking: the new edition expands the previous version with significant updates and a whole new section on Climate Change and Coastal Ecosystems, covering the resistance and resilience of the estuaries, coasts and other transitional habitats and responses needed over the coming decades. - Authoritative and accessible – 155 chapters, written by leaders in the field, provide synthesis and conceptual models of complex issues, ensuring that the knowledge within is easily understood by a large audience. - Structured content - all chapters follow a common structure with set headings, making it easier for users to cross-compare and navigate the content.

This book provides an understanding of body dysmorphic disorder (BDD), a psychiatric classification that is characterized by a preoccupation with a perceived or slight imperfection in physical appearance. This disorder lowers quality of life due to time-consuming compulsions intended to hide, fix, or check appearance concerns. Although relatively common, BDD is often not treated appropriately. When untreated, BDD is chronic, severe, and associated with substantial psychosocial impairment and morbidity, including unemployment rates of roughly 40-50%, suicide attempts in 22-28%, and lifetime housebound rates of roughly 30%.This book provides an overview of body dysmorphic disorder (BDD), a psychiatric classification that is characterized by excessively impaired perception of physical attributes that can lead to acute disruption of life activities. BDD is a common disorder, but few clinicians are trained in its assessment and treatment. This volume provides an evidence-based review of the literature for a greater understanding of the nature of the disorder. Most important, it demonstrates how to effectively assess and treat BDD. Evidence-based psychological and pharmacological treatments are presented, and importantly, ineffective treatments are also reviewed. To optimize CBT for BDD, guidelines are provided to address the most common challenges in diagnosis and treatment, including common comorbidities, differential diagnoses with similar disorders, safety management, addressing low insight or motivation, and modifying treatment for special populations including youth, patients from under-represented backgrounds, and BDD variants. Case examples throughout illuminate for practitioners the theoretical and clinical aspects of this complex problem. This an essential volume for practitioners and clinicians-in-training for gaining perspective on the disorder and its efficacious treatment. “Integrating research and clinical wisdom of some of the world's leading BDD experts, this book comprehensively covers the foundational as well as more nuanced approaches to treatment. Clinicians from all experience and skill levels who treat BDD will find this book to be a go-to guide to delivering high quality, evidence-based, and individually tailored care.” Jamie Feusner, MD Professor of Psychiatry, University of Toronto

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. - Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy - Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID - Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases - Supplemented with a website that hosts a Podcast per chapter

Psychology: Perspectives and Connections is a comprehensive introduction to psychology designed to guide students to move beyond what may seem obvious and reevaluate the their thoughts and beliefs. In every chapter the text emphasizes four key goals:•Challenging assumptions: A chapter-opening feature starts students questioning their beliefs about the discipline.•Thinking scientifically: A framework for testing assumptions builds critical thinking skills, and in-depth analyses of high-interest research studies in every chapter help students apply those skills.•Making science accessible: The text helps students develop scientific literacy.•Applying psychology to everyday life: Innovative features demonstrate how psychological research can directly affect people's lives.Enhanced by the extensive and ever-expanding resources in McGraw Hill Connect's digital platform, Psychology: Perspectives and Connections helps students engage with and synthesize the broad content of the course.

Encyclopedia of Toxicology, Fourth Edition is the most extensive compendium surveying the full scope of toxicology, including its chemical, biological and physical (e.g., radiation) perspectives. Spanning nine volumes, this new edition comprises 1150 thoroughly revised and 70 entirely new entries authored by experts in their respective fields, selected by a globally recognized board who have brought rigorous editorial skills to the project. New areas covered in this release include the bourgeoning field of computational toxicology, research applications of alternatives to animal testing, the rise in development and use of consumer products and their effects on populations, and the increasing introduction and use of pharmaceutical ingredients and their interactions. Other chapters of note cover artificial intelligence models of toxicological exposure and effects, extractables and leachable testing, climate change implications for humans, animals and the environment, screening models, -omics, tools such as sequence alignment to predict across species susceptibility, and much more. - Includes contributions from a world-renowned editorial board and expert contributors with wide-ranging backgrounds in toxicology - Thoroughly updated with the latest advances in the science - Contains concise and accessible content, providing an authoritative reference resource for non-specialists and readers from undergraduate level upwards, as well as advanced healthcare providers - Covers new topics such as computational toxicology, alternatives to animal testing, pharmaceutical ingredients, artificial intelligence models of toxicological exposure and effects, wildfires and effects of their smoke, vaping, high throughput transcriptomics, and the effect of environmental chemicals on the microbiome

Huntington's disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents adistinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.

Since its emergence in late 2019, COVID-19 has sparked global catastrophe, taking the lives of millions around the world. This pandemic has deeply challenged the global community across sectors, including health and economics. Constantly evolving information led to millions of publications related to the disease in less than two years, a ground-breaking magnitude in the world of academic. This book “Critical Care and COVID-19” summarizes what we know about COVID-19 as it pertains to epidemiology, pathology, therapeutics, and effects on different organ systems. It also dives into the mental health challenges as a result of COVID-19, the nursing and respiratory therapist journey, and lessons learned from the frontline. This 25-chapter book covers the COVID-19 spectrum and benefits clinicians, nurses, respiratory therapists, pharmacists, and regulators.

This book discusses new and innovative trends and techniques in the removal of toxic and refractory pollutants by means of various microbial biotechnology processes from wastewater, both on the laboratory and industrial scales. The book also highlights the main factors contributing to the removal of toxic pollutants as well as recycling, environmental impact, and wastewater policies after heavy metal removal. In addition, it assesses the potential application of several existing bioremediation techniques and introduces new cutting-edge emerging technologies. This book significantly contributes to the wastewater treatment plant industry so that the treatment systems can serve better and more resiliently for the purpose. This book is designed for engineers, scientists, and other professionals who are seeking introductory knowledge of the principles of environmental bioremediation technology and for students who are interested in the environmental microbiology and bioremediation fields.

Las enfermedades que tienen implicancia sobre el pulgar impactan en su función y consecuentemente en el desempeño ocupacional de las personas. La articulación carpometacarpiana del pulgar presenta una paradójica relación entre movilidad y estabilidad que le confiere una alta complejidad mecánica, y continuamente está sujeta a grandes esfuerzos y movimientos repetitivos durante su uso que conducen a cambios degenerativos en individuos susceptibles. Esta degeneración se traduce en una osteoartritis. El libro da cuenta del trabajo de investigación de la Dra. Alejandra Lucía Tuljak desarrollado a los fines de detectar el efecto del entrenamiento propioceptivo en la recuperación funcional de personas con artrosis de la articulación carpometacarpiana del primer dedo, a partir de la comparación de un protocolo de tratamiento conservador clásico vs. un protocolo de tratamiento conservador clásico con inclusión de ejercicios para entrenamiento propioceptivo.

Psychological Disorders: A Scientist-Practitioner Approach takes an empathetic look at various psychological conditions, helping you understand that human behaviors are complex and subject to many forces. New co-authors Danae Hudson and Brooke Whisenhunt enliven the text's hallmark scientist-practitioner approach with current perspectives and innovative pedagogy that targets the most common misconceptions about psychological disorders. The 5th Edition incorporates the newest research from the DSM-5-TR, and emphasizes reducing the stigma of psychological disorders and issues of diversity. New Pseudoscientific Practices: Examining the Evidence features guide you to think critically about a questionable treatment, practice or claim. These features present a 4-step process to help you hone your critical thinking skills and expand your understanding of key disorders and their prescribed treatments.

The Oxford Handbook of Obsessive Compulsive and Spectrum Disorders reviews current literature on obsessive compulsive disorder and its associated spectrum conditions -- body dysmorphic disorder, hoarding, trichotillomania, tic disorders, and Tourette's Syndrome. Authored by leading experts in these fields, these 27 chapters summarize and synthesize current findings, providing an authoritative guide for practice and research in this unique subject area. With sections dedicated to phenomenology and epidemiology, biological features, genetic factors, neurological features, and cognitive processing models for understanding how people with OCD and spectrum conditions respond to information. Authors then examine family and social relationships and personality features, and how these factors can affect an individual with an OC spectrum disorder, especially older adults, children, and adolescents. Theoretical models for understanding these disorders and newer experimental therapies for treating them are also presented. A final chapter examines some of the most challenging research issues and understudied aspects of these psychiatric problems, especially hoarding, with hopes that this volume will encourage original research performed by practitioners.

Multidisciplinary Diagnostic Imaging provides in-depth guidance on applying the principles of radiologic-nuclear medicine correlation to the interpretation of imaging for diagnostic, prognostic, and predictive indications. Describing the clinical implications of all major imaging modalities, this comprehensive professional reference offers one-stop coverage of the common diagnostic applications encountered by nuclear medicine physicians and radiologists in day-to-day practice. The book develops the nuclear diagnostic skills necessary to interpret combined imaging modalities and correlate radiologic findings using a disease- and organ-based approach to radiologic interpretation. Thematically organized sections explore a variety of pathologies including diseases of the head and neck, gastrointestinal tract, and pulmonary, endocrine, and central nervous system. Written by internationally recognized experts, this important resource:

In the context of rising adverse effects of climate change on agriculture, there is a need for advanced methods and practices to manage soils for production of food and energy. This book presents the latest advances in microbial processes that control plant growth, with focus on genomic tools, microbial interactions with the plant and soils habitats, mobilization of plant nutrients, agricultural waste management, biodegradation, bioremediation, carbon sequestration, land reclamation, plant growth promotion, suppression of plant pathogens, induced systemic resistance and tolerance against biotic and abiotic stresses.

The depletion of fossil fuel reserves and concerns for environmental degradation due to the fossil fuel burning have led the scientific community to look for alternative renewable energy sources. Among the available renewable energy sources, bioenergy derived from biomass and waste resources have great potential to not only prevent environmental pollution but also be a carbon neutral energy source. In addition, adaptation of this technology could streamline new green products, alternative energy sources into real-world applications and promote a circular economy towards zero-waste approach. This book tries to bridge the existing knowledge gap in the area of bioenergy resources. The first two chapters provide introduction to the anaerobic digestion (AD) technologies and direct interspecies electron transfer in AD. The next three chapters are on biomass pretreatment technologies for process improvement. The sixth to eighth chapter discuses biogas and other by-product production from specific wastes such from dairy, food and agricultural solid waste. The following two chapters focuses on the downstream processing of anaerobic digestate and on biochar production. Integration of AD in biorefineries using bioelectrochemical systems, syngas fermentation and electricity production are discussed in the next three chapters. The final two chapters elaborates on life cycle assessment of AD based technologies.